Yeshiva of Greater Washington

BackgroundFood Is Medicine interventions show promise for improving cardiovascular health outcomes, particularly for addressing disparities affecting Black and Hispanic populations. However, their development often lacks community co‐creation. Human‐centered design approaches can enhance the acceptability and feasibility of interventions through co‐design processes. We aimed to co‐design the THRIVE program (Adaptive Personalized Dietitian Coaching and Messaging With Produce Prescriptions to Improve Healthy Dietary Behaviors) among Black and Hispanic adults with hypertension living in healthy food priority areas in Maryland.MethodsUsing social cognitive theory and the human‐centered design double‐diamond framework, 3 iterative co‐design sessions were conducted. The first session included an orientation/listening (virtual), followed by 2 in‐person prototyping and process mapping sessions. Participants included community residents with hypertension, health care providers, local food system representatives, and community organization leaders. Data collection included detailed session notes, post‐session surveys, prototypes, and documentation of visual outputs. Content analysis identified key implementation themes.ResultsThirty‐six community stakeholders (29 female, 6 male, 17 English‐speaking, 18 Spanish‐speaking/bilingual) participated. Three primary themes emerged: (1) health care system integration, emphasizing personalized dietitian support with cultural competency; (2) food access and education, highlighting flexible produce prescription programs with practical nutrition education; and (3) community empowerment, emphasizing peer support networks. Process evaluation demonstrated high engagement, with 100% reporting valued contributions and 92% recommending similar approaches for future cardiovascular interventions.ConclusionsHuman‐centered design effectively guided community engagement in the development of a contextually tailored Food Is Medicine intervention. Integrating human‐centered design with implementation science creates more effective, equitable, and sustainable health interventions for addressing complex health challenges.

Stress-induced memory impairment is a prevalent issue among students, impacting academic performance and cognitive well-being.There is a negative impact of stress hormones, primarily glucocorticoids, on memory processes such as encoding and retrieval.In contrast, aerobic exercise mitigates stress levels and promotes memory function by increasing hippocampal neurogenesis and brain-derived neurotrophic factor (BDNF) concentration.This paper presents evidence from numerous studies on rats and humans to demonstrate the benefits of exercise on reducing stress and enhancing memory, both of which are crucial for academic success.I found that given the busy schedules of students, regular exercise is a practical and efficient method to combat the harmful effects of stress on memory.Further research should identify specific types and durations of exercise to optimize cognitive benefits for students.

[ESP] La presencia de pectenotoxinas (PTX) en los moluscos fue descubierta debido a su elevada toxicidad aguda en el bioensayo en ratón mediante inyección intraperitoneal de extractos lipofílicos. Los estudios en animales indican que son mucho menos potentes vía oral y que no inducen diarrea. En este trabajo, hemos caracterizado la respuesta citotóxica de la PTX-2 in vitro en dos líneas celulares, las células de Caco-2 y las células de neuroblastoma, incluyendo marcadores de citotoxicidad y de apoptosis. Hemos evaluado los potentes cambios estructurales que provoca la PTX-2 sobre ambos modelos celulares, el desprendimiento del sustrato, el redondeamiento celular y los cambios en el citoesqueleto, así como la integridad de la membrana plasmática que no se ve afectada por la PTX-2 en ninguna de las líneas celulares estudiadas. Por otro lado, hemos abordado el estudio de distintos marcadores de apoptosis: potencial de membrana de mitocondria, fragmentación del DNA y activación de caspasas. Entre ellos el que más se ve afectado por el tratamiento celular con la PTX-2 es el potencial de membrana de mitocondria, mientras que otros marcadores o no se ven afectados o el efecto es poco relevante.

Age-related hearing impairment (ARHI) is a complex degenerative disease in the elderly. As multiple factors interact during the development of ARHI, it is important to elucidate the major influencing factors to understand and prevent ARHI. We aimed to identify risk factors associated with the development of ARHI with a retrospective cohort from 2001 to 2010. The records of the adult subjects over 40 years of age who consecutively underwent a comprehensive health checkup including pure-tone audiometry at the Health Promotion Center were reviewed. During this period, 1560 subjects who underwent pure-tone audiometry more than twice, had no other otologic diseases, and were followed-up more than 2 years were included. A pure-tone average (PTA: 0.5, 1, 2, 4 kHz) was calculated. Development of ARHI was defined as a PTA at follow-up more than 10 dB greater than the baseline PTA. Times to the first development of ARHI were investigated. Overall, 12.7% of subjects developed ARHI within the first 4 years. High blood ionized calcium (hazard ratio [HR] 0.084), albumin (HR 0.239), systolic blood pressure (HR 0.577), thyroid hormone (T3) (HR 0.593), and alpha fetoprotein levels (HR 0.883) were associated with decreased hazard for the development of ARHI. In contrast, high blood high-density lipoprotein (HR 2.105), uric acid (HR 1.684), total protein (HR 1.423), and total bilirubin levels (HR 1.220) were potential risk factors for the development of ARHI. Development of ARHI is common among the aged population, and a variety of factors may interact during this process. The results of this study can be used for counseling of adults at high-risk of developing ARHI with regard to regular audiological check-up.

Fibrotic changes are initiated early in acute respiratory distress syndrome. This may involve overproliferation of alveolar type II cells. In an animal model of acute respiratory distress syndrome, we have shown that the administration of an adenoviral vector overexpressing the 70-kd heat shock protein (AdHSP) limited pathophysiological changes. We hypothesized that this improvement may be modulated, in part, by an early AdHSP-induced attenuation of alveolar type II cell proliferation. Laboratory investigation. Hadassah-Hebrew University and University of Pennsylvania animal laboratories. Sprague-Dawley Rats (250 g). Lung injury was induced in male Sprague-Dawley rats via cecal ligation and double puncture. At the time of cecal ligation and double puncture, we injected phosphate-buffered saline, AdHSP, or AdGFP (an adenoviral vector expressing the marker green fluorescent protein) into the trachea. Rats then received subcutaneous bromodeoxyuridine. In separate experiments, A549 cells were incubated with medium, AdHSP, or AdGFP. Some cells were also stimulated with tumor necrosis factor-alpha. After 48 hrs, cytosolic and nuclear proteins from rat lungs or cell cultures were isolated. These were subjected to immunoblotting, immunoprecipitation, electrophoretic mobility shift assay, fluorescent immunohistochemistry, and Northern blot analysis. Alveolar type I cells were lost within 48 hrs of inducing acute respiratory distress syndrome. This was accompanied by alveolar type II cell proliferation. Treatment with AdHSP preserved alveolar type I cells and limited alveolar type II cell proliferation. Heat shock protein 70 prevented overexuberant cell division, in part, by inhibiting hyperphosphorylation of the regulatory retinoblastoma protein. This prevented retinoblastoma protein ubiquitination and degradation and, thus, stabilized the interaction of retinoblastoma protein with E2F1, a key cell division transcription factor. : Heat shock protein 70-induced attenuation of cell proliferation may be a useful strategy for limiting lung injury when treating acute respiratory distress syndrome if consistent in later time points.

data and the design approach for the sensor module. 2 ' 3 In November 1976, a research and development program was established at NSWC/WOL to complete the necessary component research on the magnetic sensor and sensor electronics, battery evaluation and the design testing and fabrication of twenty SPVD magnetic sensor modules and housings. The program was subsequently modified to include additional component research in a newly invented omnidirectional microstrip antenna, RF oscillator and transmitter, telemetry link encoder and decoder, and development problems and associated underestimates incurred during the fabrication of the twenty SPVD systems. This final report covers all SPVD component research and development and is divided into seven major areas of 'nvestigation: (1) magnetometer development, (2) sensor system electronics development, (3) telemetry link encoder/decoder development, (4) telemetry link oscillator/transmitter development, (5) antenna development, (6) tele,,etry receiver and battery evaluations, and (7) mechanical component design and development.