Yiwu Science and Technology Research Institute

• Vacuum processing loads antioxidant enzyme inside a mucus-adapted probiotic carrier. • Construct survives gastric transit and releases active enzyme in the intestine. • Therapy reduces oxidative stress and mucosal inflammation in zebrafish colitis. • Microbiota remodeling parallels recovery of anxiety behavior in colitis zebrafish. Inflammatory bowel disease (IBD) arises from oxidative stress, immune dysregulation, and microbial imbalance, and often extends to neuropsychiatric comorbidities via gut–immune–brain axis disruption. Here we present Akkermansia muciniphila engineered by vacuum-assisted intracellular loading of superoxide dismutase (SOD@AKK) as a living therapeutic for chronic IBD. Unlike free SOD, SOD@AKK withstood gastric stress and enabled sustained intestinal release of active enzyme. In a chronic zebrafish IBD model, SOD@AKK markedly reduced oxidative burden, suppressed pro-inflammatory cytokines, restored epithelial integrity, and rebalanced microbial communities. Notably, it also alleviated anxiety-like behavior, linking ecological and immunological repair to behavioral recovery. These findings establish SOD@AKK as a site-specific, multi-functional bio-intervention that integrates redox detoxification with microbiota reprogramming, offering a blueprint for next-generation microbiome-based therapeutics in IBD and related neuroimmune disorders.

ABSTRACTMetal halide perovskite quantum dots (PQDs) are promising emitters for light conversion but suffer from poor compatibility and scalability in polymer composites. Herein, we report a one‐step, solvent‐free mechanochemical strategy for the in situ synthesis of CsPbX3 (Br/Cl) QDs within halogenated butyl rubber (HIIR) via open‐mill shear, yielding monodisperse 2.6 nm CsPbBr3 QDs uniformly embedded in a topological entanglement network. The CsPbX3/HIIR composite exhibited a narrow emission at 515 nm (FWHM 17 nm), photoluminescence quantum yield of 91%, and ultra‐long lifetime of 1189 ns. Spectroscopic and mechanistic studies revealed that the in situ‐generated IIR‐OOCC17H35 chains create an interfacial allyl ester passivation layer that suppresses surface traps and blocks H2O/O2 ingress. Consequently, films retained > 90% initial intensity after 30‐day ambient storage, 99.8% after 30‐day water immersion, and 44% after 500 h blue‐light irradiation (5000 nit). Flexible white LEDs achieved standard white emission (0.333, 0.338), color‐rendering index of 55.7, and wide color gamut of 132% NTSC. The low‐cost and high‐efficiency manufacturing process can be readily scaled to 17 × 17 cm2 films, offering an industrially viable route for stretchable displays, X‐ray scintillators, and wearable photonics.

Abstract Different from traditional ferroelectrics whose polarization stems from ionic displacements mediated by phonons, electronic ferroelectrics exhibit spontaneous polarization originating from polar electronic ordering. Such electronic mechanisms promise devices with ultrafast switching speeds, lower energy consumption, and enhanced resilience to fatigue and depolarization fields inherent in conventional ferroelectrics. While early candidates are restricted to rare oxides and organic charge‐transfer salts, emerging systems—particularly 2D van der Waals moiré heterostructures—have significantly broadened this materials landscape. This review comprehensively examines ferroelectrics governed by electronic mechanisms, categorizing them according to microscopic origins, including spin correlations, charge ordering, orbital interactions, charge‐transfer instabilities, and excitonic phenomena. Representative materials span multiferroics, molecular crystals, and engineered van der Waals architectures. Crucially, we evaluate whether their ferroelectricity qualifies as purely electronic —defined by the absence of ionic displacements during polarization reversal—synthesizing recent theoretical and experimental advances to establish a unified framework for this evolving paradigm.

Optoelectronic synapses use optical signals as modulation inputs and offer advantages such as low-power consumption, non-contact operation, and high parallelism. However, devices operating in the visible and near-infrared regions are susceptible to ambient light interference, leading to signal distortion and high background noise. In contrast, optoelectronic synaptic devices working in a solar-blind region are impervious to external ambient interference, enabling them to achieve stable and high-fidelity signal transmission effectively. Ga2O3 as a wide bandgap with inherent oxygen-vacancy defects has strong deep-ultraviolet light sensitivity, making it an ideal material for solar-blind optoelectronic synapses. Here, high-performance solar-blind synaptic devices were prepared using nanowire network interfacial effects and nitrogen doping to modulate oxygen vacancies. Notably, the paired-pulse facilitation index increased by approximately 1.2 fold after doping. In handwritten digit recognition experiments, the recognition accuracy of the doped device exceeded 90%, representing an improvement of nearly 15% compared to the undoped counterpart. Furthermore, leveraging its enhanced light perception and strong memory characteristics, a precise optical encryption communication scheme with strong anti-interference capability was also designed. The optoelectronic synaptic devices based on element regulated Ga2O3 nanowire network provide a new way for the development of the next generation of high-performance solar-blind optoelectronic neuromorphic systems.

PurposeChronic atrophic gastritis (CAG) is a prevalent condition that can undergo precancerous lesions of gastric cancer (PLGC) and thus progression to gastric cancer. Weifuchun (WFC), a traditional Chinese herbal compound, is employed in CAG treatment and microbial homeostasis modulation. We aimed to explore the role of WFC in CAG from the perspective of gastrointestinal microbiota.MethodsPLGC rats were developed by N-methyl-N’-nitro-N-nitrosoguanidine treatment. Then, various doses of WFC were administered to the rats and WFC compositions were analyzed. The pathological changes and inflammatory markers of the rats were assessed. Key proteins in the interleukin (IL)-6/Janus Kinase 1/Signal Transducer and Activator of Transcription 3 (JAK1/STAT3) pathway were evaluated, alongside fecal microbial analysis through 16S ribosomal DNA sequencing.ResultsMost compounds identified from WFC were nucleosides, flavones, organic acids, phenylpropanoids and other components. WFC treatment alleviated intestinal metaplasia and dysplasia caused by atrophic gastritis in PLGC rats. WFC also reduced inflammatory marker levels, and inhibited the IL-6/JAK1/STAT3 pathway for PLGC rats. The higher the dose of WFC was administrated, the better the effects on the aforementioned results. Simultaneously, WFC improved the CAG gastrointestinal microbiota homeostasis. Interestingly, WFC increased Coprocuccus abundance, which was significantly correlated with proliferating cell nuclear antigen and IL-6 levels.ConclusionsWFC alleviated PLGC by regulating the balance of gastrointestinal microbiota and influencing the IL-6/JAK1/STAT3 pathway, revealing the potential connection between gastrointestinal microbiota and CAG progression. This study is the first to link gastrointestinal microbiota homeostasis and IL-6/JAK1/STAT3 pathway, providing novel insights into WFC’s multi-targeted therapeutic mechanism on CAG.

On-chip inductors enable high integration in radio-frequency electronics, critical for compact, power-efficient systems. However, they often occupy a large chip area due to low inductance density (D, defined as the total inductance per unit area) that scales sublinearly with conductor length (l) in planar architectures. Here, we present a three-dimensional rolled-up, magnetically integrated microinductor technology with record-high inductance density. By exploiting a superlinear scaling law (D ∝ l2.4) via 3D winding with magnetic thin films, our devices achieve 8333 nH/mm² at 0.55 GHz—over two orders of magnitude higher than conventional planar inductors. This breakthrough stems from a 3D geometry in which strained layers confine multiple turns in a compact tubular volume, intensifying local fields and flux linkage while reducing leakage. A wafer-scale, CMOS-compatible process yields self-assembled coils that roll 10 mm of planar conductors into ~240 μm-diameter microcoils. The high inductance density, low substrate losses, and GHz operation make magnetically integrated inductors suited for more compact radio-frequency systems-on-chip and high-frequency power modules and next-generation Internet of Things/5G/6G applications.

BackgroundThrombocytopenia (TP) has been associated with poor clinical outcomes in geriatric patients in the intensive care unit (ICU). However, the factors leading to TP in critically ill older patients are not clear. In this study, we aimed to investigate the primary factors influencing TP in geriatric patients in the ICU, as well as to evaluate the relationship between TP and adverse clinical outcomes.MethodsBetween 2010 and 2020, 5,848 geriatric patients were initially admitted to the ICU at Dongyang People's Hospital, with 3,147 ultimately included in the study. Lasso regression was used to screen for relevant variables, followed by multivariate logistic regression analysis. Propensity score matching (PSM) was used to further assess the impact of TP on in-hospital mortality. Validation of findings was conducted using the Medical Information Mart for Intensive Care database.Results32.6% of geriatric ICU patients developed TP during their stay. Compared with the non-TP group, the TP group showed significant increases in disease severity, hormone use, vasoactive drug use, and sepsis rates, as well as in-hospital mortality, mechanical ventilation use, duration of ICU stay, and hospitalization costs (p < 0.001). Lasso regression screening identified 24 relevant variables, and 32.6% of patients developed TP during their ICU stay. Sensitivity analyses and PSM confirmed a strong association between TP and increased in-hospital mortality.ConclusionsTP is common among geriatric patients in ICU and is associated with poor prognosis. This study identified several important factors influencing TP, highlighting valuable implications for the early identification of high-risk patients and the development of individualized treatment strategies.Supplementary InformationThe online version contains supplementary material available at 10.1186/s12877-025-06577-2.