Zahnklinik Bochum

As the anatomy of proximal contact areas affects the risk of dental caries in primary molars, this study aimed to assess the impact of different resin and matrix systems on the geometry of reproduced proximal surfaces in primary molars. Sixty mandibular primary first molar typodont teeth were prepared with standardized disto-occlusal cavities. Two experimental groups were created: Group I utilized GC UniFil Flow and Filtek Z250 XT; Group II utilized SDR Plus Bulk Fill Flowable Composite and Ceram.x Spectra ST. Each group was further subdivided into the Palodent V3 sectional matrix system (P) and the Tofflemire matrix system (T). Digital evaluations were then performed to calculate discrepancies. Significant discrepancies were found only between Group IT and Group IIP in the middle third (P < 0.05). Average root mean square values at proximal contact surfaces did not differ significantly among the groups. The proximal surface shape was also not significantly different. Within the limits of this study, the reproduced proximal surface geometry was not significantly affected by the type of resin and matrix system.

Hinweis des Verlags. Der Verlag bleibt in Hinblick auf geografische Zuordnungen und Gebietsbezeichnungen in veröffentlichten Karten und Institutsadressen neutral.

Primary cutaneous B-cell lymphomas (CBCL) are a group of rare malignant skin diseases that represent approximately 20%-30% of all primary cutaneous lymphomas (PCL). Previous studies revealed impaired health-related quality of life (HRQoL) in patients diagnosed with primary cutaneous T-cell lymphoma (CTCL). Currently, only small-sized studies investigated HRQoL in CBCL patients and lacked detailed analysis of respective subtypes. This study aims to investigate HRQoL in CBCL patients to identify independent factors of HRQoL impairment in CBCL patients. One hundred CBCL patients were recruited from eight German PCL centres in this multicentric, cross-sectional study from 2021 to 2022. The patients completed the dermatologic HRQoL questionnaire Skindex-29 and an investigator-designed 'CBCL-Questionnaire' with additional questions on HRQoL and clinical characteristics. The Skindex-29 revealed that HRQoL in CBCL patients is impaired on a mild to moderate level. The multiple regression analysis identified parameters like worries about dying, feeling prejudiced/discriminated and impairment of daily activities to be independently associated with impairment of HRQoL. Highest scores for HRQoL impairment were found in patients with primary cutaneous follicle centre lymphoma while on rituximab treatment and in patients with primary cutaneous marginal zone lymphoma while on watchful waiting. HRQoL is impaired in CBCL patients, even though, in the face of indolent disease course and favourable prognosis in the majority of cases. Of note, our investigator-designed tool identified worries about dying, feeling prejudiced/discriminated, and the type of treatment to have a negative impact on patients' HRQoL. Our study highlights the importance of a thorough patient-doctor communication to capture overall disease burden because generic HRQoL tools might lack of disease-specific items.

Although hemispheric surgeries are among the most effective procedures for drug-resistant epilepsy (DRE) in the pediatric population, there is a large variability in seizure outcomes at the group level. A recently developed HOPS score provides individualized estimation of likelihood of seizure freedom to complement clinical judgement. The objective of this study was to develop a freely accessible online calculator that accurately predicts the probability of seizure freedom for any patient at 1-, 2-, and 5-years post-hemispherectomy. Retrospective data of all pediatric patients with DRE and seizure outcome data from the original Hemispherectomy Outcome Prediction Scale (HOPS) study were included. The primary outcome of interest was time-to-seizure recurrence. A multivariate Cox proportional-hazards regression model was developed to predict the likelihood of post-hemispheric surgery seizure freedom at three time points (1-, 2- and 5- years) based on a combination of variables identified by clinical judgment and inferential statistics predictive of the primary outcome. The final model from this study was encoded in a publicly accessible online calculator on the International Network for Epilepsy Surgery and Treatment (iNEST) website (https://hops-calculator.com/). The selected variables for inclusion in the final model included the five original HOPS variables (age at seizure onset, etiologic substrate, seizure semiology, prior non-hemispheric resective surgery, and contralateral fluorodeoxyglucose-positron emission tomography [FDG-PET] hypometabolism) and three additional variables (age at surgery, history of infantile spasms, and magnetic resonance imaging [MRI] lesion). Predictors of shorter time-to-seizure recurrence included younger age at seizure onset, prior resective surgery, generalized seizure semiology, FDG-PET hypometabolism contralateral to the side of surgery, contralateral MRI lesion, non-lesional MRI, non-stroke etiologies, and a history of infantile spasms. The area under the curve (AUC) of the final model was 73.0%. Online calculators are useful, cost-free tools that can assist physicians in risk estimation and inform joint decision-making processes with patients and families, potentially leading to greater satisfaction. Although the HOPS data was validated in the original analysis, the authors encourage external validation of this new calculator.

Goethes Faust ist in vollem Wortsinne ein Lebensprojekt. Die Arbeit am Faust in ursprünglicher Gestalt beginnt in den frühen 1770er Jahren; 1831 wird das Manuskript von Faust II abgeschlossen und versiegelt. Insgesamt ist der Faust, mit Blick auf die durch die Wette mit Mephistopheles praktisch unendlich erweiterten Möglichkeiten der Handlungsautonomie seiner Zentralfigur, eine großangelegte literarische Reflexion der Bestimmung des Menschen. Letztlich demonstriert das Drama nahezu unbegrenzte menschliche Handlungsautonomie und deren Kosten und Opfer. Der erste Teil der Tragödie wird dominiert von dem Trauerspiel um Margarete, sie ist das erste Opfer Fausts. Der zweite Teil der Tragödie führt die Titelfigur, sämtliche formalen Bestimmungen eines regelmäßigen Dramas sprengend, in unterschiedlichen Handlungs- oder Erfahrungsfeldern vor: Politik, Ökonomie, Krieg, Naturbeherrschung und (verbrecherisches) Unternehmertum, Erfahrung von Schönheit im Feld der literarischen Simulation. Insbesondere der Faust II reflektiert in vielfachem Sinne die Möglichkeiten dramatischen Sprechens, dramatischer Formen und ihre Tradition.

Goethes Lebenszeit umspannt die wohl bedeutendste Umbruchsperiode zur Moderne hin, die von Historikern so genannte „Sattelzeit“. In diese Periode fällt die Evolution gesellschaftlicher Organisation von einer ständischen Ordnung der Gesellschaft in der Frühen Neuzeit hin zu einer modernen, nach gesellschaftlichen Funktionssystemen differenzierten sozialen Ordnung und die entsprechenden Auffassungen und Konflikte menschlicher Individualität. Dies sind z.T. Konflikte und Problemstellungen, die bis heute ungelöst sind — und die in Goethes literarischem Werk auf vielfältige Weise reflektiert oder thematisiert werden. Damit erweisen sich diese Texte — in der Mannigfaltigkeit, in der sie literarische Gattungstraditionen aufnehmen und fort- oder umschreiben, in ihrer thematischen Breite und auch in ihrer Schönheit — als Dokumente dieses historischen Umbruchs und als aktuell.