The significant impact of irrigation on the natural and ecological situation in the zone of irrigated agriculture in Kazakhstan was determined by the concept of irrigation development in Central Asia and Kazakhstan. The problem of reducing the existing environmental conditions on the irrigated lands of Kazakhstan, especially in the Southern and South-Eastern regions, and the normalization of the ecological and meliorative situation are directly related to various water management regions of Kyrgyzstan and Uzbekistan. The Syrdarya river, which flows among these countries, comes to us with a water salinity of 1,75 g/l. They are also contaminated with pesticides, organochlorine pesticides – DDT (dichlorodiphenyltrichloroethane) and HCH (hexachlorocyclohexane), used on irrigated land. Water salinity is also increasing in the territories of Kazakhstan. In general, on irrigated lands, as a result of salt intake from irrigation waters, there was an increase in salt reserves in soils and ground waters. Their intensity largely depends on the salinity of irrigation water and the volume of water intake. As a result of regulating the flow of the river. An irreversible soil-ecological process is taking place in the Syrdarya with great intensity, where the development of irrigated land and the volume of CDW (collector-drainage water) and wastewater discharged into the rivers in the upper reaches of the rivers has been widely developed.