Застосування проґрамного забезпечення DDS PRO для планування двобічної сагітальної остеотомії нижньої щелепи: опис клінічного випадку

BACKGROUND: The combined course of avascular necrosis of the femoral head and septic arthritis of the hip joint is extremely rare and not always timely diagnosed. Analysis of specialized foreign literature revealed only single descriptions of clinical cases of combined lesions of the hip joint (avascular necrosis of the femoral head and septic arthritis). However, these studies do not describe the surgical treatment algorithms of patients. While analyzing the sources of domestic literature for the last 10 years, we did not encounter descriptions of such clinical cases. CLINICAL CASE DESCRIPTION: A 38-year-old patient was diagnosed with avascular necrosis of the femoral head with concomitant septic arthritis of the hip joint. During the preoperative period, a diagnostic puncture of the hip joint with subsequent cytologic and microbiological examination of synovial fluid was performed. Growth of the Staphylococcus aureus strain was observed. Because primary hip arthroplasty was contraindicated and isolated conservative treatment of bacterial arthritis aggravated the course of avascular necrosis, the patient underwent two-stage surgical treatment. The first stage was femoral head resection with installation of a spherical cement spacer impregnated with antibiotics, and the second stage was total hip arthroplasty after the inflammatory process had subsided. The postoperative period of each surgical stage proceeded without complications. It was possible to achieve microorganism eradication; eliminate the chronic inflammatory process, which was confirmed clinically and laboratory; ensure the possibility of total hip arthroplasty; and restore the limb-bearing capacity, extent of motion in the joint, and quality of life of the patient. CONCLUSION: The clinical observation confirms the need for detailed diagnosis in patients with an atypical course of avascular necrosis of the femoral head and demonstrates a successful treatment option in such cases.

Background. The article describes a clinical case of a successful surgical treatment of a large size follicular cyst pushing the anterior-inferior wall of the left maxillary sinus and the lower nasal concha, with the maxillary alveolar process osteoplasty.
 Clinical case description. According to the results of cone beam computed tomography, the size of the follicular cyst before the treatment was 45.423.339.7 mm. After the endodontic treatment, cystectomy, cystostomy, plastic surgery of the alveolar process of the upper jaw, the bone defect is reduced by two times, disconnected from the oral cavity.
 Conclusion. By the example of the presented clinical case, it has been shown that large jaw cysts require a multi-stage treatment with the participation of narrow specialists of related profiles.

Background: Currently, there is a tendency to increasing the proportion of knee joint organ-preserving surgeries. High tibial osteotomy (HTO) has proven itself a good method for the treatment of the knee joint varus deformity in extra-articular deformity cases. The question of the perfect angle of correction, which will not significantly impair the biomechanics of the knee and adjacent joints, remains controversial, as well as the issue of preventing excessive hypercorrection as an osteotomy complication.
 Clinical case description: A clinical case of a 59-year-old patient who underwent primary and revision HTOs is analyzed in this article. The patient had a varus deformity of the left lower limb with isolated medial knee osteoarthritis. The patients body mass index (BMI) was 28 kg/m2. The patient complained only of pain and a limited range of motion in the knee joint. According to the arthroscopy and magnetic resonance imaging (MRI) data, there was a cartilage damage classified as Outerbridge 4 stage of the medial compartment. There were no signs of a lateral compartment cartilage damage and patellofemoral joint arthritis. The varus deformity of the knee joint was 10. The patient underwent a medial high tibial open wedge osteotomy. During the preoperative planning, topograms of the lower limb with weight bearing were used. The clinical status before the operation, according to the used scales, was as follows: Knee injury and Osteoarthritis Outcome Score (KOOS) 46 points, Visual Analogue Scale (VAS) 7 cm, American Orthopaedic Foot and Ankle Society (AOFAS) 92 points. 6 months after the initial surgery, the clinical status was as follows: knee joint VAS 1 cm, ankle joint VAS 5 cm, KOOS 88 points, AOFAS 63 points. During the clinical examination and according to the instrumental studies, excessive valgus hypercorrection of 11.2 was noted. Also, the tibial plafond inclination (TPI) and the talar inclination (TI) were significantly increased. 1.5 years after the primary osteotomy, a revision closed wedge osteotomy was performed. The valgus deformity of the knee joint became 3, the axis of the ankle joint changed to the normal values. The clinical and functional results 6 months after the revision osteotomy were the following: KOOS 92 points, AOFAS 99 points, pain in the knee and ankle joint 1 cm by the VAS scale.
 Conclusions: The case showed that the careful preoperative planning and the use of additional methods for monitoring the intraoperative correction were important. Excessive valgus hypercorrection promotes good regeneration of the medial compartment cartilage; however, it overloads a lateral compartment and adversely affects the ankle joint and foot.

Relevance. Crouzon syndrome is a craniostenosis due to combination of cranial bones hypoplasia and premature ectocranial sutures fusion resulting in deformation of cerebral and facial cranium. Deformations of facial cranium are responsible for exophthalmos and corneoconjunctival xerosis and can lead to spontaneous eyeball dislocation. Clinical case description. The clinical case of bilateral eyeball dislocation in a patient (right eye at the age of 1 year 2 months, left — at 1 year 4 months) due to untimely original reconstructive surgery is presented. The blepharorrhaphy and osteotomy of cranio-orbital-zygomaxillary complex with installation of two distraction correction instruments on maxillary bone and two on frontal bone, distance osteogenesis, fronto-temporal region remodelling were performed at the age of 3 years 2 months. Conclusion. Crouzon syndrome is incurable illness that demands timely functional and cosmetic correction. Prognosis for this disease is unfavourable. These days the child is 8 years old: physical development delay and mental retardation progression as well as psychoneurological disorders are recorded.

Background. Atopic dermatitis (AD) manifests during the first year of life in majority of all cases. The early disease onset is associated with the development of comorbid atopic conditions within the «atopic march» phenomenon. The AD pathogenesis is associated with genetic predisposition, epidermal barrier dysfunction, and immune dysregulation. T2-inflammation specifically determines the entire immune cascade of inflammatory reactions, and, thus, dictates the need of early drug intervention to modify the disease course. Clinical case description. This article presents two clinical cases of severe AD in children under 6 years of age. The treatment of both cases included genetically engineered biologic drug dupilumab. Continuous therapy for 4–5 months made it possible to relieve the skin manifestations of the disease.Conclusion. AD, manifesting in infancy, is associated with high risk of developing other atopic spectrum diseases in older age. The timely onset of biological therapy allows us to affect immune dysregulation, and thereby to prevent the comorbid atopic conditions development.

Background: The main aim of Cardiac Resynchronization Therapy (CRT) is a positive response of the patient, particularly, reduction of the symptoms and improvement of the heart contractility, that can be reached in 5070% of patients. The possibility of appropriate positioning the left ventricular (LV) lead is of great importance for the response to CRT. Certain instruments and technical approaches are used for the placement of the LV lead. Here, we describe the use of the orthodromic snare technique, which is quite rare in practice, but allows one to overcome some anatomical obstacles.
 Clinical case description: Patient A., suffering from the heart failure with a low ejection fraction and left bundle branch block, was admitted to the hospital for CRT implantation. Before the operation, all the necessary routine instrumental and laboratory diagnostics was performed. During the operation, venography of the cardiac veins revealed unsuitability of the lateral cardiac vein for the placement of the LV lead due to its very small diameter. The posterolateral vein was suitable for the LV lead implantation but still had some anatomical difficulties: an acute angle of inflow and local stenosis in the proximal segment. During the procedure, the following techniques were used without success: positioning the LV lead by a simple translational movement forward, a subselective catheter, introduction of several coronary guides in order to smooth out the acute angle of inflow. These circumstances warranted the use of the orthodromic snare technique for a successful LV lead placement.
 Conclusion: This clinical case illustrates the possibility of a safe and effective use of the orthodromic snare technique for LV lead implantation. Such anatomical difficulties as a small diameter, acute angle of inflow, local stenosis have also been illustrated and discussed.

Background. Mucopolysaccharidosis type I (MPS I) is a disease known for over 100 years. Implementation of new management approaches for MPS I requires from doctor to clearly differentiate subtypes of this disease for the effective and rational use of treatment methods. Clinical case description. Girl B. with early MPS I onset during the neonatal period. Symptoms of musculoskeletal system damage were the following: feet adduction and hip joints dysplasia. Further follow-up at the age of 6 months has shown linear growth retardation, umbilical hernia, and exudative otitis. Psychomotor development up to 1 year of age was delayed. Coarse facial features by the age 1.5 years along with orthopedic problems, exudative otitis, and umbilical hernia led to mucopolysaccharidosis diagnosis. The diagnosis of mucopolysaccharidosis type I was established according to clinical findings, enzyme diagnostics (significant decrease in lysosomal enzyme alpha-L-iduronidase activity — 0.26 μmol/l/h; reference values from 1.96), and molecular genetic testing (pathogenic variant c.208C>T (Gln70Ter) in exon 2 and nucleotide variant of unknown clinical value c.1524G>C (p.Glu508Asp) in exon 10 of IDUA gene in compound heterozygous state). Echocardiography has revealed structural changes in the mitral valve and minimal aortic insufficiency. Abdominal ultrasound has revealed signs of hepatomegaly, hydrocalycosis, right-side pyelectasia, kidneys’ sizes lesser than the age norms. Abdominal magnetic resonance imaging has shown simple kidney cysts. Conclusion. The major feature of this clinical case is the complexity of differential diagnosis between the severe form of MPS I, Hurler syndrome, and milder form, Hurler–Scheie syndrome. Molecular genetic testing has revealed the presence of the frequent pathogenic variant c.208C>T (Gln70Ter) in the IDUA gene associated with severe disease course and nucleotide variant c.1524G>C (p.Glu508Asp) with undefined clinical significance, thus, additional examination is necessary. Functional analysis of the novel variant is required to establish its role in protein function. It will help more precisely determine the disease form and predict its severity. Combination of MPS I and polycystic kidney disease in the proband is unique case.

Background. Long QT syndrome is hereditary disease, cardiac canalopathy variant, characterized by syncope and high risk of sudden cardiac death due to occurrence of polymorphic ventricular tachycardia (VT), torsade de pointes, and ventricular fibrillation. Acute respiratory viral infection may aggravate clinical course of primary electrical heart diseases. Clinical case description. 14-year-old female patient was transferred to infectious diseases hospital from another hospital with positive PCR test on new coronavirus infection (COVID-19) after loss of consciousness in November 2021. Syncope was first noted at the age of 12, however then did not recur, and their examination and treatment were postponed due to the COVID-19 pandemic. Syncopal states continued during COVID-19. Cardiac examination was performed at infectious diseases hospital: recurrent VT, torsade de pointes, was diagnosed along with QT interval prolongation. The girl's condition has improved after the treatment and selection of antiarrhythmic therapy. 15 days later negative PCR test for SARS-CoV-2 was received, and the patient was transferred to specialized hospital, where the long QT syndrome was confirmed, and dual-chamber cardioverter defibrillator was installed. Conclusion. This clinical case demonstrates that ARVI can aggravate the course of existing primary arrhythmia and emphasizes the crucial role of timely diagnosis and integrated approach to the management of patients with genetically determined cardiac arrhythmias.

Background: The presented clinical case shows a version of successful step-by-step medical care for a patient with a dissecting aneurysm of the ascending aorta involving the trunk of the left coronary artery in a vascular center without a cardiac surgical support. Clinical case description: The patient was admitted to the Kostroma Regional Vascular Center with the symptoms of Acute Coronary Syndrome. During the examination in the clinic, the diagnosis of acute coronary syndrome with ST segment elevation was confirmed, and a dissecting aneurysm of the ascending aorta was also revealed. According to emergency coronary angiography, the dissection of the left coronary artery trunk was visualized, and the left coronary artery trunk was successfully stented with a bare metal stent. Later, the patient was transferred to a federal center, where aortic prosthetic reconstruction was performed. Conclusion: In patients with a dissecting thoracic aortic aneurysm involving the trunk of the left coronary artery and acute myocardial damage, who are admitted to a vascular center without a cardiac surgery support, the following step-by-step treatment strategy is likely to be effective: stenting the trunk of the left coronary artery with a bare metal stent and a further transfer to a center of cardiac surgery for a surgical treatment.

Background. The likelihood of foreign bodies presence in the wound exists in almost any injury to the skin. The consequences of their ingress into the body are extremely varied: from the complete absence of symptoms to systemic toxicity, depending both on the nature of the embedded agent and on the way of its penetration. The data of the anamnesis and clinical examination of foreign bodies are not always convincing, and the results of conventional radiography, even with X-ray-positive foreign bodies, are often nonspecific. The parenteral ingression of metallic mercury is rare. In contrast to its access through the respiratory or digestive tract, this route has not been adequately studied. This clinical report is devoted to the clinical case of deliberate self-administration of metallic mercury into the soft tissues of the upper limb. Clinical case description. A 24-year-old patient sought medical help 2 years after the injury and tried to hide its circumstances during taking his anamnesis. Ultrasound played a decisive role in making the diagnosis (foreign body) and revealing its nature (metallic mercury). This indicates the high information content and specificity of ultrasound which exceeded the X-ray capabilities. Despite no signs of general and local toxicity, the presence of mercury in the body is unacceptable and requires the surgical treatment. Our case showed that mercury in soft tissues was limited to granuloma or was fixed inside fibrous tissue. This made it possible to remove it radically. Conclusion. Our observation suggests that ultrasound, in contrast to X-ray, is able to present a specific picture of the existence of metallic mercury in soft tissues. Therefore, it is advisable to include ultrasound in the examination algorithm if any foreign body (especially mercury) is suspected to detect or clarify its nature. If mercury is detected in soft tissues, the radical surgical treatment can be successfully performed, since the reaction of tissues around the mercury material (in the form of granuloma and the confinement of mercury spheres in a conglomerate of fibrous tissue) makes it possible to avoid the spread of mercury along the wound channel.

Background: Thoracic outlet syndrome compression of the brachial plexus in the area between the clavicle and the first rib is a commonly spread and important pathology. It occurs, as usual, after a trauma or due to an anatomical malformation of this area. Thoracic outlet syndrome can be combined with a shoulder joint pathology. In the case of a conservative treatment's failure, the standard surgical procedure is decompression of the brachial plexus in the thoracic aperture. This procedure is usually done via an open approach. The development of the endoscopic surgical technique of decompression allows reducing the risk of complications and recurrences, improving the cosmetic result and relieving the rehabilitation period. Clinical case description: A 73-year-old female patient with a clinical picture of posttraumatic brachial plexopathy and a massive shoulder rotator cuff tear. The patient underwent a conservative treatment for 6 months after the trauma without a significant improvement. To confirm the diagnosis, ENMG and an ultrasound investigation of the brachial plexus, as well as MRI of the shoulder joint were performed. Simultaneous shoulder joint arthroscopy with subacromial spacer implantation and brachial plexus decompression in the thoracic aperture were performed to the patient. According to the VAS-scale (Visual Analogue Scale), the severity of pain syndrome before the surgery was 10 cm, while 6 months after the surgery, it decreased to 1 cm. According to the DASH scale (Disabilities of the Arm, Shoulder, and Hand), the dysfunction of the of shoulder joint before the surgery was 76 points, while 6 months after the surgery, it decreased to 12 points. The range of motion in the shoulder joint before the surgery was as follows: flexion 105, abduction 95, external rotation 15, which increased to 160, 165, and 45, respectively, 6 months after the surgery. Conclusion: The results allow us to characterize the method of simultaneous shoulder joint arthroscopy and endoscopic decompression of the brachial plexus in the thoracic aperture as a low-traumatic and effective technique. The technique provides complete brachial plexus decompression in the thoracic aperture which promotes restoration of the function of the upper extremity and shoulder joint, and elimination of pain syndrome from the upper extremity area.

Background . The development of central nervous system (CNS) malformations may occur due to antenatal infection. Specific pathomorphological changes in CNS structures require further study. Clinical Case Description . The autopsy morphological study of the brain of a child who had antenatal toxoplasma and cytomegalovirus infections and who died at the age of 2 years was performed. Thickening of the pia mater with cloudy surface due to edema and focal sclerosis, generalized thrombosis of superior sagittal sinus, sinus rectus and sinus transverses, absence of corpus callosum, major commissural fibers, opened third ventricle and vermis of cerebellum agenesia, as well as mixed forms of obstructive hydrocephalus were revealed. Diffuse gliosis with glial cysts in the periventricular zones were revealed at histological examination of the alba. Pseudocysts filled with toxoplasms were identified in the cysts’ wall. Signs of productive vasculitis were noted. Comparison of pathomorphological changes in the brain and internal organs with anamnestic data of the patient (toxoplasma and cytomegalovirus infection during recent pregnancy, brain abnormality of the fetus on the second ultrasound screening at 21–22 weeks of gestation) and the results of histological examination of placenta was carried out to prove the correlation of antenatal infection with the development of brain anomalies. Pathognomonic signs of cytomegalovirus infection and toxoplasmosis were revealed in the placenta: cytomegalic cells, vascular thrombosis, white infarcts, fibrinoid necrosis of basal lamina, placental hypoplasia. Toxoplasmic cysts were detected in chorionic villae stroma, parietal thophoblast, amnion, decidual tissue. Conclusion . Antenatal viral-parasitic infection may be the cause of brain anomalies of the fetus. However, the child had no specific signs of cytomegalovirus infection (such as cytomegalic cells — owl eye cells), even when the placenta had pathomorphological changes typical for this infection. It can be assumed that the development of brain anomaly in this child could be associated with toxoplasma infection.

Relapsing polychondritis (RPC) is a rare disease, its diagnosis presents certain difficulties. This is due to the absence of characteristic clinical manifestations at the initial stages of the disease, late diagnosis and difficulties in selecting adequate therapy.The article presents a review of the literature on the diagnosis and treatment of RPC, as well as a clinical case with tracheobronchial tree and other organ systems involvement in the absence of classical auricular involvement.

BACKGROUND: Chronic nonbacterial osteomyelitis is a rare autoinflammatory bone disease with periods of relapses and remissions. No etiotropic therapy, diagnostic and treatment standards exist, patients are observed by rheumatologists, immunologists, and orthopedist. They receive symptomatic, anti-inflammatory treatment, broad-spectrum antibiotics, immunosuppressants to control inflammation, which helps to prevent new or to reduce existing pathological foci. CLINICAL CASE DESCRIPTION: This article describes the effect of immune therapy and osteotropic treatment with zoledronic acid combination in a patient with chronic non-bacterial osteomyelitis. In a clinical observation involving comprehensive examination, including radiological (radiography, computed tomography and magnetic resonance imaging) and laboratory methods, a positive outcome was achieved using conservative methods of treatment in a patient with chronic non-bacterial sternum osteomyelitis. CONCLUSION: Thus, a combination of bisphosphonates and immunotherapy may be promising in the treatment of chronic non-bacterial osteomyelitis. However, it is unknown as to how long the remission will last and what treatment program is necessary for the final disease resolution.

Background. Myopia is a serious medical and social problem specifically due to the high risk of such complications as cataracts, myopic maculopathy, glaucoma, and retinal detachment. Children with connective tissue dysplasia (CTD) syndrome are most subjected to myopia. Prevention of myopia progression in children remains the only effective way to prevent myopic maculopathy. Significant progress in this field has been achieved via optical technologies developed on the basis of peripheral defocus theory. Clinical case description. Patient, 10 years old, with CTD, mild myopia of both eyes with rapid progression, myopic maculopathy, grade 1. Ophthalmic status: spheroequivalent refraction — right eye (–)1.5 diopters / left eye (–)1.75 diopters; vision acuity with monocular correction — 1.0. Fundoscopy: optic disc is pale pink, with clear borders, arteries and veins are well-proportioned, their courses and calibers are intact; choriocapillary layer attenuation in the macular and paramacular zones, “parquet fundus”; areas of pigment redistribution on peripheral retina; no atrophic foci detected; anterior-posterior axis of the right and left eyes — 26.2 and 26.3 mm, respectively. Optical coherence tomography (OCT) has revealed retinal thinning in the upper and nasal sectors in the right eye during the first assessment. The left eye has demonstrated losses of retinal thickness within the middle parafoveal zone and significant thinning in the upper segment. Optical therapy with HAL spectacle lenses (inducing volumetric myopic peripheral defocus) was assigned to control myopia to slow down the pathological axial growth of the child's eyes and to stabilize refraction. 4 months of wearing glasses with HAL lenses has led to the stabilization of dystrophic changes in retina, signs of improvement in several sectors by were observed on OCT. No negative changes were revealed in all parafoveal segments of the left eye. The child was recommended to continue wearing glasses with HAL lenses with dynamic follow-up every 3 months. Conclusion. CTD in children is associated with high risk of complications in case of myopia progression, moreover, retinal pathology can occur even with mild myopia. Optical therapy with HAL spectacle lenses is effective and safe first treatment of choice in the control of myopia in children with CTD, and opens new opportunities in prevention of progressive myopia disabling complications in children, whose treatment results were not previously sufficient.