- Conference Article
11
- 10.1109/bibe50027.2020.00027
Chaos Game Representations & Deep Learning for Proteome-Wide Protein Prediction
- Oct 01, 2020
- Kevin Dick + 1 more +1
Chaos Game Representation (CGR) is an emerging means of visualising and representing genomic and proteomic sequences. There exist many open questions related to its effective application to various computational tasks. In this work, we begin to address some of these questions by comparing four variants of the Chaos Game to generate CGR imagery as part of a multi-class classification task to identify the source organism for a given protein. We propose a novel nodal configuration for icosagon and 20-flake CGRs. Using two datasets, we performed fine-tuning using seven deep convolutional neural network (CNN) architectures and report modest performance over random among the 56 test conditions, highlighting certain shortcomings in effectively leveraging CGR in conjunction with deep CNN architectures. Many of the insights from this work will serve to orient subsequent protein-related studies involving CGR-based encoding and be generally applicable to disparate domains seeking to leverage CGR for sequence-type data.
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