A Deep Discontinuity-Preserving Image Registration Network

The image navigation and registration (INR) performance assessment for the Geostationary Operational Environmental Satellite-R (GOES-R) Advanced Baseline Imager (ABI) is an image registration process at the subpixel level, which involves the registration of images from GOES-R ABI with corresponding images from Landsat at the same scene. We present an optimized image registration algorithm for GOES-R ABI INR performance assessment (GAIPA): a gradient descent algorithm with a Sobel edge-enhancement procedure and a normalized lookup table (NLUT) image transformation (GDSN), which is an area-based image registration approach with Pearson correlation as the similarity metric. Sobel edge enhancements increase the sensitivity of Pearson correlations that lead to much improved registration accuracy. NLUT transformations minimize radiance differences between GOES-R ABI images acquired at different times and Landsat reference images on image registration outcomes, which lead to improvements in correlation values and quality of image registration outputs. Evaluations of registration accuracy and quality metrics in GDSN show considerable improvements in computational efficiency, registration accuracy, and quality over the approach implemented on the image INR performance assessment tool set. Pearson correlations can be effective and robust similarity metrics in image registration at the subpixel level with implementing Sobel edge enhancement and NLUT transformation. The statistical analysis of the image registration outputs for GAIPA shows the new algorithm provides considerable improvements in reducing the uncertainties in the registration outputs.

Deformable image registration by combining uncertainty estimates from supervoxel belief propagation.

Medical image registration is essential and a key step in many advanced medical image tasks. In recent years, medical image registration has been applied to many clinical diagnoses, but large deformation registration is still a challenge. Deep learning‐based methods typically have higher accuracy but do not involve spatial transformation, which ignores some desirable properties, including topology preservation and the invertibility of transformation, for medical imaging studies. On the other hand, diffeomorphic registration methods achieve a differentiable spatial transformation, which guarantees topology preservation and invertibility of transformation, but registration accuracy is low. Therefore, a diffeomorphic deformation registration with CNN is proposed, based on a symmetric architecture, simultaneously estimating forward and inverse deformation fields. CNN with Efficient Channel Attention is used to better capture the spatial relationship. Deformation fields are optimized explicitly and implicitly to enhance the invertibility of transformations. An extensive experimental evaluation is performed using two 3D datasets. The proposed method is compared with different state‐of‐the‐art methods. The experimental results show excellent registration accuracy while better guaranteeing the diffeomorphic transformation.

Improved Rapid Corner Detection Algorithm in Medical Image

Although a considerable amount of research has been devoted to the registration of medical images, a good proportion of this has been performed on rigid regions of the anatomy. This has tended to limit the practical value of such research. The registration of medical images which are non-rigid in nature is a seemingly difficult and not fully investigated problem. This paper presents an elastic transformation method which is used to perform matching of non-rigid medical images, that is, two-dimensional images of a region of the body such as the thorax or abdomen which exhibits a high level of elasticity. Some forms of elastic transformation may be more localized in scope than others, which leads to the categorization of elastic transformation methods into local and semi-local methods. This paper demonstrates the use of local elastic spatial transformations in matching non-rigid medical images. These transformations are illustrated by matching corresponding computed tomography and magnetic resonance images of the thorax.

Nonrigid multimodal image registration remains a challenging task in medical image processing and analysis. The structural representation (SR)-based registration methods have attracted much attention recently. However, the existing SR methods cannot provide satisfactory registration accuracy due to the utilization of hand-designed features for structural representation. To address this problem, the structural representation method based on the improved version of the simple deep learning network named PCANet is proposed for medical image registration. In the proposed method, PCANet is firstly trained on numerous medical images to learn convolution kernels for this network. Then, a pair of input medical images to be registered is processed by the learned PCANet. The features extracted by various layers in the PCANet are fused to produce multilevel features. The structural representation images are constructed for two input images based on nonlinear transformation of these multilevel features. The Euclidean distance between structural representation images is calculated and used as the similarity metrics. The objective function defined by the similarity metrics is optimized by L-BFGS method to obtain parameters of the free-form deformation (FFD) model. Extensive experiments on simulated and real multimodal image datasets show that compared with the state-of-the-art registration methods, such as modality-independent neighborhood descriptor (MIND), normalized mutual information (NMI), Weber local descriptor (WLD), and the sum of squared differences on entropy images (ESSD), the proposed method provides better registration performance in terms of target registration error (TRE) and subjective human vision.

Medical image registration is an integral part of various clinical applications including image guidance, motion tracking, therapy assessment and diagnosis. We present a robust approach for mono-modal and multi-modal medical image registration. To this end, we propose the novel shape operator based local image distance (SOLID) which estimates the similarity of images by comparing their second-order curvature information. Our similarity metric is rigorously tailored to be suitable for comparing images from different medical imaging modalities or image contrasts. A critical element of our method is the extraction of local features using higher-order shape information, enabling the accurate identification and registration of smaller structures. In order to assess the efficacy of the proposed similarity metric, we have implemented a variational image registration algorithm that relies on the principle of matching the curvature information of the given images. The performance of the proposed algorithm has been evaluated against various alternative state-of-the-art variational registration algorithms. Our experiments involve mono-modal as well as multi-modal and cross-contrast co-registration tasks in a broad variety of anatomical regions. Compared to the evaluated alternative registration methods, the results indicate a very favorable accuracy, precision and robustness of the proposed SOLID method in various highly challenging registration tasks.

Objective. This paper proposes a novel approach for the longitudinal registration of PET imaging acquired for the monitoring of patients with metastatic breast cancer. Unlike with other image analysis tasks, the use of deep learning (DL) has not significantly improved the performance of image registration. With this work, we propose a new registration approach to bridge the performance gap between conventional and DL-based methods: medical image registration method regularized by architecture (MIRRBA). Approach. MIRRBA is a subject-specific deformable registration method which relies on a deep pyramidal architecture to parametrize the deformation field. Diverging from the usual deep-learning paradigms, MIRRBA does not require a learning database, but only a pair of images to be registered that is used to optimize the network's parameters. We applied MIRRBA on a private dataset of 110 whole-body PET images of patients with metastatic breast cancer. We used different architecture configurations to produce the deformation field and studied the results obtained. We also compared our method to several standard registration approaches: two conventional iterative registration methods (ANTs and Elastix) and two supervised DL-based models (LapIRN and Voxelmorph). Registration accuracy was evaluated using the Dice score, the target registration error, the average Hausdorff distance and the detection rate, while the realism of the registration obtained was evaluated using Jacobian's determinant. The ability of the different methods to shrink disappearing lesions was also computed with the disappearing rate. Main results. MIRRBA significantly improved all metrics when compared to DL-based approaches. The organ and lesion Dice scores of Voxelmorph improved by 6% and 52% respectively, while the ones of LapIRN increased by 5% and 65%. Regarding conventional approaches, MIRRBA presented comparable results showing the feasibility of our method. Significance. In this paper, we also demonstrate the regularizing power of deep architectures and present new elements to understand the role of the architecture in DL methods used for registration.

Medical image segmentation and registration are two tasks to analyze the anatomical structures in clinical research. Still, deep-learning solutions utilizing the connections between segmentation and registration remain underdiscovered. This article designs a joint learning framework named RSegNet that can realize concurrent deformable registration and segmentation by minimizing an integrated loss function, including three parts: diffeomorphic registration loss, segmentation similarity loss, and dual-consistency supervision loss. The probabilistic diffeomorphic registration branch could benefit from the auxiliary segmentations available from the segmentation branch to achieve anatomical consistency and better deformation regularity by dual-consistency supervision. Simultaneously, the segmentation performance could also be improved by data augmentation based on the registration with well-behaved diffeomorphic guarantees. Experiments on the human brain 3-D magnetic resonance images have been implemented to demonstrate the effectiveness of our approach. We trained and validated RSegNet with 1000 images and tested its performances on four public datasets, which shows that our method successfully yields concurrent improvements of both segmentation and registration compared with separately trained networks. Specifically, our method can increase the accuracy of segmentation and registration by 7.0% and 1.4%, respectively, in terms of Dice scores. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Note to Practitioners</i> —Registration and segmentation of medical images are two significant tasks in medical research and clinical application. However, most existing approaches consider these two tasks independently while neglecting the potential association between them. Therefore, we suggest a new approach that combines these two tasks into one joint deep learning framework, boosting registration, and segmentation performance by introducing dual-consistency supervision. Besides, our framework could generate outputs within 1 s by taking an affinely aligned medical image pair as input, which is suitable for time-critical requirements in a clinic. We tested it on four public datasets and achieved state-of-the-art performance to demonstrate the proposed method’s feasibility and robustness. Furthermore, our proposed RSegNet is a general learning framework suitable for various image modalities and anatomical structures. Hence, we expect our framework to serve as a practical clinical tool to speed up medical image analysis procedures and improve diagnostic accuracy.

Brain tumor detection and medical image registration are critical tasks in neuroimaging, enabling accurate diagnosis, treatment planning, and follow-up monitoring. Magnetic Resonance Imaging (MRI) remains the preferred modality for visualizing tumor morphology, while image registration facilitates the alignment of multimodal scans for enhanced clinical interpretation. This survey reviews recent advances in deep learning-based methods for brain tumor classification and medical image registration, focusing on Convolutional Neural Networks (CNNs), transfer learning architectures (e.g., VGG-19, ResNet, DenseNet201), and modern registration frameworks including supervised, unsupervised, GAN-based, and reinforcement learning approaches. A comprehensive analysis of 50+ peer-reviewed studies highlights state-of-the-art performance, with brain tumor classification achieving up to 97.5% precision (CNN + FCM) and 96.97% accuracy (DWT+PCA+DNN), while multimodal MRI registration methods report Dice Similarity Coefficient (DSC) values exceeding 0.90 and reduced Target Registration Error (TRE) compared to traditional deformable registration techniques. Trends indicate a shift toward hybrid models combining segmentation and registration, domain adaptation for cross-dataset generalization, and lightweight frameworks for real-time clinical deployment. In conclusion, deep learning approaches have significantly advanced the accuracy, efficiency, and automation of brain tumor detection and medical image registration. However, challenges such as limited annotated multimodal datasets, robust similarity measures for heterogeneous modalities, and the integration of clinically interpretable AI models remain open for future research.

To develop a cardiac computed tomographic (CT) method with which to determine extracellular volume (ECV) fraction, with cardiac magnetic resonance (MR) imaging as the reference standard. Study participants provided written informed consent to participate in this institutional review board-approved study. ECV was measured in healthy subjects and patients with heart failure by using cardiac CT and cardiac MR imaging. Paired Student t test, linear regression analysis, and Pearson correlation analysis were used to determine the relationship between cardiac CT and MR imaging ECV values and clinical parameters. Twenty-four subjects were studied. There was good correlation between myocardial ECV measured at cardiac MR imaging and that measured at cardiac CT (r = 0.82, P < .001). As expected, ECV was higher in patients with heart failure than in healthy control subjects for both cardiac CT and cardiac MR imaging (P = .03, respectively). For both cardiac MR imaging and cardiac CT, ECV was positively associated with end diastolic and end systolic volume and inversely related to ejection fraction (P < .05 for all). Mean radiation dose was 1.98 mSv ± 0.16 (standard deviation) for each cardiac CT acquisition. ECV at cardiac CT and that at cardiac MR imaging showed good correlation, suggesting the potential for myocardial tissue characterization with cardiac CT.

Conventional approaches to image registration consist of time consuming iterative methods. Most current deep learning (DL) based registration methods extract deep features to use in an iterative setting. We propose an end-to-end DL method for registering multimodal images. Our approach uses generative adversarial networks (GANs) that eliminates the need for time consuming iterative methods, and directly generates the registered image with the deformation field. Appropriate constraints in the GAN cost function produce accurately registered images in less than a second. Experiments demonstrate their accuracy for multimodal retinal and cardiac MR image registration.

Improvement of medical diagnosis, aided computer surgeries and tumor identification requires an accurate image registration approaches. The registration of multimodal medical images is more complicated than the registration of unimodal medical images due to the variation in luminance between the images. In this paper, an accurate multimodal image registration approach using artificial immune system (AIS) is proposed and the affine transformation model is used in contrast to the most of the related works which assumed rigid transformation model or similarity transformation model. In the proposed approach the LL bands of the discrete wavelet transform (DWT) for the images are used and the normalized mutual information (NMI) is used as a fitness function. The proposed approach achieves good result in the case of noiseless images, noisy images and partial data loss from one of the images. Moreover, the proposed approach does not need any feature extraction or refinement step. To demonstrate the robustness of the proposed approach, it has been compared with two multimodal medical image registration approaches.

Symmetric transformer-based network for unsupervised image registration

Deformable medical image registration plays an important role in clinical diagnosis and treatment. Recently, the deep learning (DL) based image registration methods have been widely investigated and showed excellent performance in computational speed. However, these methods cannot provide enough registration accuracy because of insufficient ability in representing both the global and local features of the moving and fixed images. To address this issue, this paper has proposed the transformer based image registration method. This method uses the distinctive transformer to extract the global and local image features for generating the deformation fields, based on which the registered image is produced in an unsupervised way. Our method can improve the registration accuracy effectively by means of self-attention mechanism and bi-level information flow. Experimental results on such brain MR image datasets as LPBA40 and OASIS-1 demonstrate that compared with several traditional and DL based registration methods, our method provides higher registration accuracy in terms of dice values.KeywordsImage registrationDeep learningTransformerRegistration accuracy