A Deep Learning Framework with Spherical Harmonic Encoding for 3D Joint Angle Analysis and Injury Prediction

The accurate prediction of cardiovascular disease (CVD) or heart disease is an essential and challenging task to treat a patient efficiently before occurring a heart attack. Many deep learning and machine learning frameworks have been developed recently to predict cardiovascular disease in intelligent healthcare. However, a lack of data-recognized and appropriate prediction methodologies meant that most existing strategies failed to improve cardiovascular disease prediction accuracy. This paper presents an intelligent healthcare framework based on a deep learning model to detect cardiovascular heart disease, motivated by present issues. Initially, the proposed system compiles data on heart disease from multiple publicly accessible data sources. To improve the quality of the dataset, effective pre-processing techniques are used including (i) the interquartile range (IQR) method used to identify and eliminate outliers; (ii) the data standardization technique used to handle missing values; (iii) and the ‘K-Means SMOTE’ oversampling method is used to address the issue of class imbalance. Using the Enhanced Binary Grasshopper Optimization Algorithm (EBHOA), the dataset’s appropriate features are chosen. Finally, the presence and absence of CVD are predicted using the Enhanced MobileNetV2 (EMobileNetV2) model. Training and evaluation of the proposed approach were conducted using the UCI Heart Disease and Framingham Heart Study datasets. We obtained excellent results by comparing the results with the most recent methods. The proposed approach beats the current approaches concerning performance evaluation metrics, according to experimental results. For the UCI Heart Disease dataset, the proposed research achieves a higher accuracy of 98.78%, precision of 99%, recall of 99% and F1 score of 99%. For the Framingham dataset, the proposed research achieves a higher accuracy of 99.39%, precision of 99.50%, recall of 99.50%, and F1 score of 99%. The proposed deep learning-based classification model combined with an effective feature selection technique yielded the best results. This innovative method has the potential to enhance the accuracy and consistency of heart disease prediction, which would be advantageous for clinical practice and patient care.

A comprehensive empirical study on bug characteristics of deep learning frameworks

Deep learning (DL) frameworks serve as the backbone for a wide range of artificial intelligence applications. However, bugs within DL frameworks can cascade into critical issues in higher-level applications, jeopardizing reliability and security. While numerous techniques have been proposed to detect bugs in DL frameworks, research exploring common API patterns across frameworks and the potential risks they entail remains limited. Notably, many DL frameworks expose similar APIs with overlapping input parameters and functionalities, rendering them vulnerable to shared bugs, where a flaw in one API may extend to analogous APIs in other frameworks. To address this challenge, we propose MirrorFuzz, an automated API fuzzing solution to discover shared bugs in DL frameworks. MirrorFuzz operates in three stages: First, MirrorFuzz collects historical bug data for each API within a DL framework to identify potentially buggy APIs. Second, it matches each buggy API in a specific framework with similar APIs within and across other DL frameworks. Third, it employs large language models (LLMs) to synthesize code for the API under test, leveraging the historical bug data of similar APIs to trigger analogous bugs across APIs. We implement MirrorFuzz and evaluate it on four popular DL frameworks (TensorFlow, PyTorch, OneFlow, and Jittor). Extensive evaluation demonstrates that MirrorFuzz improves code coverage by 39.92% and 98.20% compared to state-of-the-art methods on TensorFlow and PyTorch, respectively. Moreover, MirrorFuzz discovers 315 bugs, 262 of which are newly found, and 80 bugs are fixed, with 52 of these bugs assigned CNVD IDs.

Objective: To design a deep transfer learning framework for modeling fluence map predictions for stereotactic body radiation therapy (SBRT) of adrenal cancer and similar sites that usually have a small number of cases. Approach: We developed a transfer learning framework for adrenal SBRT planning that leverages knowledge in a pancreas SBRT planning model. Treatment plans from the two sites had different dose prescriptions and beam settings but both prioritized gastrointestinal sparing. A base framework was first trained with 100 pancreas cases. This framework consists of two convolutional neural networks (CNN), which predict individual beam doses (BD-CNN) and fluence maps (FM-CNN) sequentially for 9-beam intensity-modulated radiation therapy (IMRT) plans. Forty-five adrenal plans were split into training/validation/test sets with the ratio of 20/10/15. The base BD-CNN was re-trained with transfer learning using 5/10/15/20 adrenal training cases to produce multiple candidate adrenal BD-CNN models. The base FM-CNN was directly used for adrenal cases. The deep learning (DL) plans were evaluated by several clinically relevant dosimetric endpoints, producing a percentage score relative to the clinical plans. Main results: Transfer learning significantly reduced the number of training cases and training time needed to train such a DL framework. The adrenal transfer learning model trained with 5/10/15/20 cases achieved validation plan scores of 85.4/91.2/90.7/89.4, suggesting that model performance saturated with 10 training cases. Meanwhile, a model using all 20 adrenal training cases without transfer learning only scored 80.5. For the final test set, the 5/10/15/20-case models achieved scores of 73.5/75.3/78.9/83.3. Significance: It is feasible to use deep transfer learning to train an IMRT fluence prediction framework. This technique could adapt to different dose prescriptions and beam configurations. This framework potentially enables DL modeling for clinical sites that have a limited dataset, either due to few cases or due to rapid technology evolution.

Accurate and effective classification of plant diseases is critical for increasing yield and quality in agricultural production, minimizing economic losses through early detection of diseases, and implementing sustainable agriculture approaches. In this study, an approach for the detection and classification of plant leaf diseases is presented. We compare the performance of machine learning and deep learning-based models, and we use GAN-based data synthesis methods on a dataset we created to improve the model performance. For machine learning methods, ResNet-based feature extraction is performed and XGBoost, Random Forest, SVM, and InceptionV3 models are evaluated. In contrast, AlexNet, VGG16, VGG19, DenseNet, and ResNet models are examined within the scope of deep learning. The study was analyzed in three classes Phytophthora Infestans, Potassium Deficiency, and Healthy, and tested on data obtained from 21 different plant species. According to the model performances obtained, the deep learning-based ResNet model showed the highest success in all performance metrics and achieved 99% accuracy, showing superior performance compared to other methods. In the study, a comprehensive evaluation of multiple classification, GAN-based data synthesis, machine learning, and deep learning models was carried out. A valuable contribution was made to the existing studies in the literature.

Accurate prediction and confirmation of mechanical properties are critical for the reliable design and deployment of sustainable aluminum–agro-waste composites (AWCs). This study presents a confirmatory analytical–experimental–deep machine learning (DML) framework for the identification of true material properties under multi-response conditions. Experimental characterization yielded mean tensile strength of 190.61 MPa, compressive strength of 287.16 MPa, flexural strength of 243.94 MPa, wear rate of 5.46 × 10⁻⁶ mm³ /N·m, coefficient of friction of 0.34, and fatigue life of 5.86 × 10⁵ cycles, with low variability observed in strength-related properties and higher dispersion in tribological and fatigue responses. Isolated analytical predictions produced comparable estimates for tensile (189.60 MPa), compressive (296.42 MPa), flexural (255.75 MPa), and fatigue properties (5.97 × 10⁵ cycles), but failed to reliably capture tribological behavior, yielding a non-physical negative wear rate (− 4.06 mm³/N·m) and an overestimated coefficient of friction (0.45). Consolidated analytical modeling improved agreement for tensile (187.60 MPa), compressive (285.63 MPa), flexural (244.88 MPa), and fatigue life (5.86 × 10⁵ cycles), yet significantly deviated in tribological predictions, producing unrealistically high wear rate (0.20 mm³/N·m) and coefficient of friction (2.84). To resolve these discrepancies, DML models—implemented via a deep convolutional neural network (ID-CNN) and a hybrid residual CNN guided by a residual-based loss function—were employed to reconcile analytical (isolated/consolidated) predictions with experimental data. The DML framework successfully minimized analytical–experimental residuals and confirmed true predictive reliability for compressive strength, flexural strength, coefficient of friction, and fatigue life, while consistently identifying wear rate as falsely predicted across analytical frameworks. These findings establish DML as both a predictive and diagnostic tool, enabling discrimination between truly confirmed and analytically unstable properties. The proposed framework offers a scalable, data-informed pathway for optimized composite design, process refinement, and industrial adoption, with potential extension to multi-scale modeling and real-time process monitoring. Residual-based DML loss quantifies and minimizes analytical–experimental prediction errors. • Residual-based DML loss quantifies and minimizes analytical–experimental prediction errors. • Integrated analytical–DML modeling confirms strength, fatigue, and friction properties. • Bulk properties converge, while wear rate shows persistent tribological uncertainty. • The framework supports reliable certification and sustainable composite design.

The track misregistration (TMR) required to achieve gigabit areal densities is calculated for a set of components based on the average bit error rate for a file. The average error rate is a statistical average, based on the TMR of the file, of the on-track and off-track error rate. The on-track and off-track error rates are dependent on squeeze from adjacent tracks. In this analysis, the average error rate is calculated using measured error rate profiles of the center track. For a file average soft error rate of 1*10/sup -6/, the results show, for a particular head/disk combination designed for gigabit recording and operating at a linear density of 158 kbpi, that a track pitch of 4.0 mu m (3.35 ktpi) can be achieved with a TMR of 0.635 mu m. Obtaining this TMR value in a file is one of the challenges to recording of 1 Gb/in/sup 2/ in magnetic storage products. >

Detection of moisture content in salted sea cucumbers by hyperspectral and low field nuclear magnetic resonance based on deep learning network framework

To identify the feasibility of deep learning-based diagnostic models for detecting and assessing lower-extremity fatigue fracture severity on plain radiographs. This retrospective study enrolled 1151 X-ray images (tibiofibula/foot: 682/469) of fatigue fractures and 2842 X-ray images (tibiofibula/foot: 2000/842) without abnormal presentations from two clinical centers. After labeling the lesions, images in a center (tibiofibula/foot: 2539/1180) were allocated at 7:1:2 for model construction, and the remaining images from another center (tibiofibula/foot: 143/131) for external validation. A ResNet-50 and a triplet branch network were adopted to construct diagnostic models for detecting and grading. The performances of detection models were evaluated with sensitivity, specificity, and area under the receiver operating characteristic curve (AUC), while grading models were evaluated with accuracy by confusion matrix. Visual estimations by radiologists were performed for comparisons with models. For the detection model on tibiofibula, a sensitivity of 95.4%/85.5%, a specificity of 80.1%/77.0%, and an AUC of 0.965/0.877 were achieved in the internal testing/external validation set. The detection model on foot reached a sensitivity of 96.4%/90.8%, a specificity of 76.0%/66.7%, and an AUC of 0.947/0.911. The detection models showed superior performance to the junior radiologist, comparable to the intermediate or senior radiologist. The overall accuracy of the diagnostic model was 78.5%/62.9% for tibiofibula and 74.7%/61.1% for foot in the internal testing/external validation set. The deep learning-based models could be applied to the radiological diagnosis of plain radiographs for assisting in the detection and grading of fatigue fractures on tibiofibula and foot. • Fatigue fractures on radiographs are relatively difficult to detect, and apt to be misdiagnosed. • Detection and grading models based on deep learning were constructed on a large cohort of radiographs with lower-extremity fatigue fractures. • The detection model with high sensitivity would help to reduce the misdiagnosis of lower-extremity fatigue fractures.

Developers of deep learning applications (shortened as application developers) commonly use deep learning frameworks in their projects. However, due to time pressure, market competition, and cost reduction, developers of deep learning frameworks (shortened as framework developers) often have to sacrifice software quality to satisfy a shorter completion time. This practice leads to technical debt in deep learning frameworks, which results in the increasing burden to both the application developers and the framework developers in future development.In this paper, we analyze the comments indicating technical debt (self-admitted technical debt) in 7 of the most popular open-source deep learning frameworks. Although framework developers are aware of such technical debt, typically the application developers are not. We find that: 1) there is a significant number of technical debt in all the studied deep learning frameworks. 2) there is design debt, defect debt, documentation debt, test debt, requirement debt, compatibility debt, and algorithm debt in deep learning frameworks. 3) the majority of the technical debt in deep learning framework is design debt (24.07% - 65.27%), followed by requirement debt (7.09% - 31.48%) and algorithm debt (5.62% - 20.67%). In some projects, compatibility debt accounts for more than 10%. These findings illustrate that technical debt is common in deep learning frameworks, and many types of technical debt also impact the deep learning applications. Based on our findings, we highlight future research directions and provide recommendations for practitioners.

This research introduces an advanced blended instructional model for college-level English as second language education, integrating traditional in-person teaching with cutting-edge online learning components powered by Conditional Random Field (CRF) techniques within a deep learning framework. As a hybrid paradigm, blended learning has gained prominence in higher education due to its ability to enhance student engagement and learning outcomes. The CRF-based model optimizes pedagogical strategies through dynamic, adaptive, and personalized learning experiences, addressing diverse cognitive profiles and preferences. It integrates various instructional modalities—classroom interactions, digital resources, and interactive activities—into a cohesive framework, with CRF algorithms modeling sequential dependencies crucial for language acquisition tasks such as syntactic parsing and part-of-speech tagging. These foundational tasks enable students to internalize linguistic structures, fostering proficiency in English. By leveraging advanced deep learning architectures like recurrent neural networks (RNNs) and transformer models alongside large-scale linguistic datasets, the model achieves significant gains in accuracy, generalization, and responsiveness to individual learner needs. Empirical results demonstrate a 16% improvement in overall English proficiency and a 27% enhancement in reading comprehension compared to traditional methods, underscoring the transformative potential of AI-driven methodologies in language education. This study not only advances theoretical insights into instructional design but also establishes a robust framework for optimizing higher education through the integration of deep learning techniques.

Women's cancers, signified by breast adenocarcinoma and non-small-cell lung cancers, are a significant threat to women's health. Across the globe, the leading cause of death for women is a group of tumors referred to as "female-oriented cancers". The most recent researches in the classification of molecular tumors is the analysis of women's cancers using RNA-Seq data for precision cancer diagnoses. Furthermore, discovering the different genes’ patterns behaviors will lead to predict the cancer-specific biomarkers to early diagnosis and detection of cancer-specific in women. An overfit model will be resulted due to the high-dimensional data of RNA-Seq from a small samples of data. In this work, we propose a filter-based selection approach for a deep learning-based classification model. In addition, hybrid classification models have been proposed to be compared with the new modified deep learning model. The Experiments’ analysis showed that the proposed filter-based selection approach for a deep learning-based classification model performed better than the other hybrid models in terms of performance evaluation metrics, with an accuracy of 96.7% for RNA-Seq breast adenocarcinoma data and 95.5% for RNA-Seq non-small-cell lung cancer data.

COVID-19 pandemic has indeed plunged the global community especially African countries into an alarming difficult situationculminating into a great deal amounts of catastrophes such as economic recession, political instability and loss of jobs. Thepandemic spreads exponentially and causes loss of lives. Following the outbreak of the omicron new variant of concern,forecasting and identification of the COVID-19 infection cases is very vital for government at various levels. Hence, havingknowledge of the spread at a particular point in time, swift actions can be taken by government at various levels with a view toaccordingly formulate new policies and modalities towards minimizing the trajectory of the consequences of COVID-19 pandemicto both public health and economic sectors. Here, a potent combination of Convolutional Neural Network (CNN) learning algorithm along with Long Short Term Memory(LSTM) learning algorithm has been proposed in this work in order to produce a hybrid of a deep learning algorithm ConvolutionalNeural Network - Long Short Term Memory (CNN-LSTM) for forecasting COVID-19 infection cases particularly in Nigeria, SouthAfrica and Botswana. Forecasting models for COVID-19 infection cases in Nigeria, South Africa and Botswana, were developedfor 10 days using deep learning-based approaches namely CNN, LSTM and CNN-LSTM deep learning algorithm respectively. The models were evaluated on the basis of four standard performance evaluation metrics which include accuracy, MSE, MAEand RMSE respectively. However, the CNN-LSTM deep learning-based forecasting model achieved the best accuracy of98.30%, 97.60%, and 97.74% for Nigeria, South Africa and Botswana respectively; and in the same manner, achieved lesserMSE, MAE and RMSE values compared to models developed with CNN and LSTM respectively. Taken together, the CNN-LSTM deep learning-based forecasting model for COVID-19 infection cases in Nigeria, South Africaand Botswana dramatically surpasses the two other DL based forecasting models (CNN and LSTM) for COVID-19 infectioncases in Nigeria, South Africa and Botswana in terms of not only the best accuracy of with 98.30%, 97.60%, and 97.74% but alsoin terms of lesser MSE, MAE and RMSE.

Deep learning (DL) frameworks are essential to DL-based software systems, and framework bugs may lead to substantial disasters, thus requiring effective testing. Researchers adopt DL models or single interfaces as test inputs and analyze their execution results to detect bugs. However, floating-point errors, inherent randomness, and the complexity of test inputs make it challenging to analyze execution results effectively, leading to existing methods suffering from a lack of suitable test oracles. Some researchers utilize metamorphic testing to tackle this challenge. They design Metamorphic Relations (MRs) based on input data and parameter settings of a single framework interface to generate equivalent test inputs, ensuring consistent execution results between original and generated test inputs. Despite their promising effectiveness, they still face certain limitations. (1) Existing MRs overlook structural complexity, limiting test input diversity. (2) Existing MRs focus on limited interfaces, which limits generalization and necessitates additional adaptations. (3) Their detected bugs are related to the result consistency of single interfaces and far from those exposed in multi-interface combinations and runtime metrics (e.g., resource usage). To address these limitations, we propose ModelMeta, a model-level metamorphic testing method for DL frameworks with four MRs focused on the structure characteristics of DL models. ModelMeta augments seed models with diverse interface combinations to generate test inputs with consistent outputs, guided by the QR-DQN strategy. It then detects bugs through fine-grained analysis of training loss/gradients, memory/GPU usage, and execution time. We evaluate the effectiveness of ModelMeta on three popular DL frameworks (i.e., MindSpore, PyTorch, and ONNX) with 17 DL models from ten real-world tasks ranging from image classification to object detection. Results demonstrate that ModelMeta outperforms state-of-the-art baselines from the perspective of test coverage and diversity of generated test inputs. Regarding bug detection, ModelMeta has identified 31 new bugs, of which 27 have been confirmed, and 11 have been fixed. Among them, seven bugs existing methods cannot detect, i.e., five wrong resource usage bugs and two low-efficiency bugs. These results demonstrate the practicality of our method.

Background and objective: Despite fast evolution cycles in deep learning methodologies for medical imaging in radiotherapy, auto-segmentation solutions rarely run in clinics due to the lack of open-source frameworks feasible for processing DICOM RT Structure Sets. Besides this shortage, available open-source DICOM RT Structure Set converters rely exclusively on 2D reconstruction approaches leading to pixelated contours with potentially low acceptance by healthcare professionals. PyRaDiSe, an open-source, deep learning framework independent Python package, addresses these issues by providing a framework for building auto-segmentation solutions feasible to operate directly on DICOM data. In addition, PyRaDiSe provides profound DICOM RT Structure Set conversion and processing capabilities; thus, it applies also to auto-segmentation-related tasks, such as dataset construction for deep learning model training.Methods: The PyRaDiSe package follows a holistic approach and provides DICOM data handling, deep learning model inference, pre-processing, and post-processing functionalities. The DICOM data handling allows for highly automated and flexible handling of DICOM image series, DICOM RT Structure Sets, and DICOM registrations, including 2D-based and 3D-based conversion from and to DICOM RT Structure Sets. For deep learning model inference, extending given skeleton classes is straightforwardly achieved, allowing for employing any deep learning framework. Furthermore, a profound set of pre-processing and post-processing routines is included that incorporate partial invertibility for restoring spatial properties, such as image origin or orientation.Results: The PyRaDiSe package, characterized by its flexibility and automated routines, allows for fast deployment and prototyping, reducing efforts for auto-segmentation pipeline implementation. Furthermore, while deep learning model inference is independent of the deep learning framework, it can easily be integrated into famous deep learning frameworks such as PyTorch or Tensorflow. The developed package has successfully demonstrated its capabilities in a research project at our institution for organs-at-risk segmentation in brain tumor patients. Furthermore, PyRaDiSe has shown its conversion performance for dataset construction.Conclusions: The PyRaDiSe package closes the gap between data science and clinical radiotherapy by enabling deep learning segmentation models to be easily transferred into clinical research practice. PyRaDiSe is available on https://github.com/ubern-mia/pyradise and can be installed directly from the Python Package Index using pip install pyradise.