The incipient fault detection of a complex industrial process is a challenging problem for traditional dynamic detection methods. Traditional dynamic detection methods usually decouple the correlations among the variables and dynamic correlations simultaneously, which makes the two types of correlations mixed and may lead to performance deterioration in long-sequence dynamic detection. Some incipient faults may not change the amplitudes of process variables but change the long-sequence dynamic features. Based on the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$T^{2}$</tex-math> </inline-formula> statistic and matrix multiplication transformation ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$T^{2}$</tex-math> </inline-formula> S-MMT), traditional dynamic detection methods can detect many faults effectively. However, the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$T^{2}$</tex-math> </inline-formula> S-MMT can not effectively detect some incipient faults due to the above two types of correlations mixed. In order to overcome the shortcomings of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$T^{2}$</tex-math> </inline-formula> S-MMT and improve the detection ability of some incipient faults, this paper proposes a fault detection method based on the dynamic k-nearest neighbor model and Dual Control Chart (DKNN-DCC), which can improve the incipient fault detection performance by using long-sequence dynamic detection. The proposed method is verified by the Tennessee Eastman (TE) process and the continuously stirred tank reactor (CSTR) process. The experimental results show the effectiveness of the proposed method in incipient fault detection compared with traditional dynamic detection methods. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Note to Practitioners</i> —This paper presents a novel incipient fault detection method, which directly mines the long-sequence dynamic abnormal information from the process variable and overcomes the problem of some abnormal information being submerged in the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$T^{2}$</tex-math> </inline-formula> statistic calculated based on the matrix multiplication transformation. The proposed method can detect incipient faults that are not easily detected by some traditional methods and can help operators find the abnormal and avoid more serious losses. The structure of the proposed method jumps out of the frameworks of traditional dynamic detection methods, which is feasible to apply to different stable industrial processes.