This chapter presents a generic scheme for generating prediction rules based on rough set approach for stock market prediction. To increase the efficiency of the prediction process, rough sets with Boolean reasoning discretization algorithm is used to discretize the data. Rough set reduction technique is applied to find all the reducts of the data, which contains the minimal subset of attributes that are associated with a class label for prediction. Finally, rough sets dependency rules are generated directly from all generated reducts. Rough confusion matrix is used to evaluate the performance of the predicted reducts and classes. For comparison, the results obtained using rough set approach were compared to that of artificial neural networks and decision trees. Empirical results illustrate that rough set approach achieves a higher overall prediction accuracy reaching over 97% and generates more compact and fewer rules than neural networks and decision tree algorithm.