- Research Article
- 10.54254/2755-2721/2025.ld30217
Multi-Armed Bandits and Clinical Medicine: A Survey of Algorithms, Evaluation, and Applications
- Dec 03, 2025
- Applied and Computational Engineering
- Xiwen Guo
Personalized medicine and adaptive clinical trials aim to match optimal treatment plans to individual patients while validating new therapies. Traditional fixed-design trials have limitations, including resource wastage and scarce data. Artificial intelligence has led to the development of dynamic decision algorithms like the Multi-Armed Bandit (MAB) algorithm, which balances exploration and exploitation in treatment allocation. Researchers aim to integrate MAB with clinical needs while adhering to ethical guidelines. This paper discusses the use of Multi-armed Bandit (MAB) algorithms in medicine, highlighting their potential for optimizing treatment allocation and improving patient outcomes, despite ethical constraints and limited data, and their application in contextual and reinforcement learning settings. This research highlight key clinical applications such as adaptive dose-finding, personalized treatment selection, and digital health interventions, supported by both trial-based data and large-scale public datasets like MIMIC-III. Simulation studies are also discussed as a necessary complement to real-world data, facilitating algorithm validation under ethical and logistical constraints. Comparative evaluation of algorithms demonstrates that Bayesian methods, particularly Thompson Sampling and contextual bandits, often provide a more robust balance between efficiency and safety. However, challenges remain in scalability, interpretability, and regulatory acceptance. This research conclude by identifying promising directions for future research, including the integration of deep reinforcement learning and causal inference, which may further enhance the role of MABs in advancing personalized medicine and adaptive clinical trial design.
Read more