Abstracts

Tadashi Nagashima; Hiroshi Nishimura; Akiko Takahashi; Seinosuke Ueda; Kazuyuki Morioka; Koji Okihara; Hiromi Ike; Yoshitaka Tamada; Norio Iijima; Seiji Hayashi; Akihiko Ishihara; Michinori Hasegawa; Fumihiko Suwa; Yasuhiko Ibata; Shinichi Izumi; Yuko Senba; Masashi Shin; Yoshitaka Hishikawa; Takehiko Koji; Toshiki Iwasaka; Shinobu Umemura; Kochi Kakimoto; Haruko Koizumi; R Yoshiyuki Osamura; Shuji Yamashita; Atsushi Takayanagi; Atsuko Ishizuya-Oka; Ryohei Katoh; Akira Yokoyama; Dongfang Yang; Masataka Itoh; Shinichi Takahashi; Hitoshi Ishida; Syouzou Saito; Hayato Kawakami; Hiroshi Hirano; Tateo Daimon; Kazuhiro Kawai; Katsuko Kataoka; Etsuko Suzaki; Kinji Ito; Minako Hoshida; Michiko Hayashi; Athuko Ito; Dong-Hua Yang; Shinichiro Tsuyama; Hiromi Takano‐Ohmuro; Noriaki Andoh; Haruo Ohtani; Norio Miyoshi; Kazuhiro Karaya; Masakatsu Watanabe; Masaru Fukuda; Toshihiro Kobayashi; Harumichi Seguchi; Yoshimaro Ishikawa; Keiichi Tsukinoki; Tomoko Imaizumi; Yoshiko Miyoshi; Takayuki Yamamoto; Yoshihisa Watanabe; Kazunari Karakida; Masanori Iwasa; Sakon Noriki; Yukio Imamura; Kazuo Komiyama; Masahiro Okaue; Yasuyuki Oda; Tadao Okano; Atsuko Ito; Kohsuke Chida; Yasuhide Mitsumoto; Hiroshi Hikita; Takeshi Okanoue; Takanori Hattori; Shouichi Arai; Naoki Tani; Masayoshi Nakanishi; Chouhei Sakakura; Takeshi Mazaki; Yasunari Tsuchihashi; Hisakazu Yamagishi; Nobuki Nakamura; Eri Miyagi; Koich Suzuki; Akihiro Hemmi; Yoshika Sakamoto; Takaaki Ito; K Nakano; Ken‐Ichi Iyama; Fumiko Date; Hironobu Sasano; Hirokazu Furuta; Shinsuke Masuda; Tetsuro Takamatsu; Yoshifumi Tajima; Mina Kawasaki; J Ohno; Kaoru Kusama; Kenzou Uchida

doi:10.1267/ahc.32.535

Abstract

Growth hormone-releasing hormone (GHRH) is a well-known hypothalamic hormone that stimulates the synthesis and release of growth hormone (GH) as well as the proliferation of GH-producing cells in the anterior pituitary gland. Recent reports have shown GHRH synthesis in pituitary somatotroph adenomas, but GHRH immunoreactivity has not been demonstrated in the previous studies. In order to confirm the role of locally generated GHRH for the progression of somatotroph adenomas, we investigated the expression of GHRH in 25 pituitary somatotroph adenomas immunohistochemically using both conventional avidin-biotin-complex (ABC) method and novel catalyzed signal amplified (CSA) system.