ACP-MHCNN: an accurate multi-headed deep-convolutional neural network to predict anticancer peptides

Background Incidence rate of thyroid cancer is steadily increasing due to overdiagnosis and overtreatment. Thyroid ultrasound is commonly used to diagnose thyroid cancer. The aim of this study is to examine the accuracy of using deep convolutional neural network (DCNN) models to improve diagnosis of thyroid cancer by analyzing sonographic imaging data from clinical thyroid ultrasound. Methods A total of 131,731 sonographic images from 17,627 thyroid cancer patients and 180,668 sonographic images from 25,325 controls used as training set were obtained from Tianjin Cancer Hospital. Images from anatomical sites that did not have cancer according to location sign on the image were not included. All thyroid cancer patients and 13·2% of controls (51,255 images) were confirmed by pathological reports. DCNN is a specific type of neural network optimized for image recognition. We trained two DCNN models on the training set and subsequently evaluated the performance on one independent internal (Tianjin, 1,118 individuals) and two external (Jilin,154 individuals; Weihai, 1,420 individuals) validation sets. Individuals in the validation sets all have pathological examinations. We compared the specificity/sensitivity of DCNN models with the performance of six thyroid ultrasound radiologists on these three validation sets. Findings DCNN model achieved high performance in identifying thyroid cancer patients versus six experience radiologists: for Tianjin validation set, sensitivity was 92·2% versus 96·9% (95% CI 89·7% - 94·3% vs. 93·9% - 98·6%; p = 0·003), and specificity was 85·6% versus 59·4% (95% CI 82·4% - 88·4% vs. 53% - 65·6%; p < 0·0001); for Jilin validation set, sensitivity was 84·3% versus 92·9% (95% CI 73·6% - 91·9% vs. 84·1% - 97·6%; p = 0·05), and specificity was 86·9% versus 57·1% (95% CI 77·8% - 93·3% vs. 45·9% - 67·9%; p < 0·0001); for Weihai validation set, sensitivity was 84·5% versus 89% (95% CI 81·2% - 87·4% vs. 81·9% - 94%; p = 0·2), and specificity was 87·5% versus 68·6% (95% CI 85·1% - 89·6% vs. 60·7% - 75·8%; p < 0·0001). Interpretation DCNN models exhibited high accuracy, sensitivity, and specificity in identifying thyroid cancer patients at levels comparable to or higher than six experienced radiologists. Conferred by the high specificity of DCNN models, the rate of overdiagnosis and overtreatment of patients with thyroid cancer is expected to decrease. This supports future application of the deep learning models to clinical practice for thyroid cancer diagnosis. However, further validation of these DCNN models in prospective clinical trials is warranted. Funding The Program for Changjiang Scholars and Innovative Research Team in University in China (IRT_14R40), National Natural Science Foundation of China (31801117). Citation Format: Xiangchun Li, Sheng Zhang, Qiang Zhang, Xi Wei, Yi Pan, Jing Zhao, Xiaojie Xin, Xiaoqing Wang, Fan Yang, Jianxin Li, Meng Yang, Qinghua Wang, Xiangqian Zheng, Yanhui Zhao, Lun Zhang, Xudong Wang, Zhimin Zheng, Christopher T. Whitlow, Metin N. Gurcan, Boris Pasche, Ming Gao, Wei Zhang, Kexin Chen. Diagnosis of thyroid cancer using deep convolutional neural network models applied to sonographic images from clinical ultrasound exams [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1394.

Deep learning-based computed tomography applied to the diagnosis of rib fractures

The aim of the present study was to explore the diagnostic value of a deep convolutional neural network (DCNN) model for the diagnosis of pulmonary nodules in adolescent and young adult patients with osteosarcoma. For the present study, 675 chest CT images were retrospectively collected from 109 patients with clinically confirmed osteosarcoma who underwent chest CT examination at Hangzhou Third People's Hospital (Hangzhou, China) from March 2011 to February 2022. CT images were then evaluated using the DCNN and manual models. Subsequently, pulmonary nodules of osteosarcoma were divided into calcified nodules, solid nodules, partially solid nodules and ground glass nodules using the DCNN model. Those patients with osteosarcoma who were diagnosed and treated were followed up to observe dynamic changes in the pulmonary nodules. A total of 3,087 nodules were detected, while 278 nodules were missed compared with those determined using the reference standard given by the consensus of three Experienced radiologists., which was analyzed by two diagnostic radiologists. In the manual model group, 2,442 nodules were detected, while 657 nodules were missed. The DCNN model showed significantly higher sensitivity and specificity compared with the manual model (sensitivity, 0.923 vs. 0.908; specificity, 0.552 vs. 0.351; P<0.05). In addition, the DCNN model yielded an area under the curve (AUC) value of 0.795 [95% confidence interval (CI), 0.743-0.846], outperforming that of the manual model (AUC, 0.687; 95% CI, 0.629-0.732; P<0.05). The film reading time of the DCNN model was also significantly shorter compared with that of the manual model [mean ± standard deviation (SD); 173.25±24.10 vs. 328.32±22.72 sec; P<0.05)]. The AUC of calcified nodules, solid nodules, partially solid nodules and ground glass nodules was calculated to be 0.766, 0.771, 0.761 and 0.796, respectively, using the DCNN model. Using this model, the majority of the pulmonary nodules were detected in patients with osteosarcoma at the initial diagnosis (69/109, 62.3%), and the majority of these were found with multiple pulmonary nodules instead of a single nodule (71/109, 65.1% vs. 38/109, 34.9%). These data suggest that, compared with the manual model, the DCNN model proved to be beneficial for the detection of pulmonary nodules in adolescent and young adult patients with osteosarcoma, which may reduce the time of artificial radiograph reading. In conclusion, the proposed DCNN model, developed using data from 675 chest CT images retrospectively collected from 109 patients with clinically confirmed osteosarcoma, may be used as an effective tool to evaluate pulmonary nodules in patients with osteosarcoma.

BackgroundSurgical process modeling automatically identifies surgical phases, and further improvement in recognition accuracy is expected with deep learning. Surgical tool or time series information has been used to improve the recognition accuracy of a model. However, it is difficult to collect this information continuously intraoperatively. The present study aimed to develop a deep convolution neural network (CNN) model that correctly identifies the surgical phase during laparoscopic cholecystectomy (LC).MethodsWe divided LC into six surgical phases (P1–P6) and one redundant phase (P0). We prepared 115 LC videos and converted them to image frames at 3 fps. Three experienced doctors labeled the surgical phases in all image frames. Our deep CNN model was trained with 106 of the 115 annotation datasets and was evaluated with the remaining datasets. By depending on both the prediction probability and frequency for a certain period, we aimed for highly accurate surgical phase recognition in the operation room.ResultsNine full LC videos were converted into image frames and were fed to our deep CNN model. The average accuracy, precision, and recall were 0.970, 0.855, and 0.863, respectively.ConclusionThe deep learning CNN model in this study successfully identified both the six surgical phases and the redundant phase, P0, which may increase the versatility of the surgical process recognition model for clinical use. We believe that this model can be used in artificial intelligence for medical devices. The degree of recognition accuracy is expected to improve with developments in advanced deep learning algorithms.

Electricity theft is harmful to power grids. Integrating information flows with energy flows, smart grids can help to solve the problem of electricity theft owning to the availability of massive data generated from smart grids. The data analysis on the data of smart grids is helpful in detecting electricity theft because of the abnormal electricity consumption pattern of energy thieves. However, the existing methods have poor detection accuracy of electricity theft since most of them were conducted on one-dimensional (1-D) electricity consumption data and failed to capture the periodicity of electricity consumption. In this paper, we originally propose a novel electricity-theft detection method based on wide and deep convolutional neural networks (CNN) model to address the above concerns. In particular, wide and deep CNN model consists of two components: the wide component and the deep CNN component. The deep CNN component can accurately identify the nonperiodicity of electricity theft and the periodicity of normal electricity usage based on 2-D electricity consumption data. Meanwhile, the wide component can capture the global features of 1-D electricity consumption data. As a result, wide and deep CNN model can achieve the excellent performance in electricity-theft detection. Extensive experiments based on realistic dataset show that wide and deep CNN model outperforms other existing methods.

The theoretical basis of the discrete random sample batch classification is not clear and the sample division is not scientific during the process of Deep Convolutional Neural Network (DCNN) model training. Aiming at the problems above, starting from the DCNN detection recognition mechanism, the theory of random discrete samples is given and proved, and a scientific quantitative batch of sample input method is proposed. Combined with image preprocessing, based on the strategy of random dispersion of samples, and scientifically quantified sample input batches, the DCNN model is trained with limited label samples, and then the CT image recognition of pulmonary nodules is carried out. Experimental results based on the LIDC-ID-RI public dataset show that the sensitivity, specificity, and accuracy of the proposed method have reached 96.40%, 95.60%, and 96.00%, respectively. Compared with the multiscale convolutional neural network method and the multiscale multimode image fusion method, the recognition accuracy of the proposed method is improved by 1.6 and 3.49 percentage points, respectively.

Recent studies have demonstrated that a well designed deep convolutional neural network (CNN) model achieves competitive performances on detecting the presence of secret message in digital images, compared with the classical rich model based steganalysis. In this paper, we propose to investigate a category of very deep CNN model–the deep residual network (DRN), for steganalysis. DRN is suitable for steganalysis from two aspects. For the first, the DRN model usually contains a large number of network layers, which proves to be effective to capture the complex statistics of digital images. For the second, DRN's residual learning (ResL) method actively strengthens the signal coming from secret messages, which is extremely beneficial for the discrimination between cover images and stego images. Comprehensive experiments on standard dataset show that the DRN model achieves very low detection error rates for the state of arts steganographic algorithms. It also outperforms the classical rich model method and several recently proposed CNN based methods.

The diabetic foot ulcer (DFU) is a severe complication that affects approximately 33% of diabetes patients globally, often leading to limb amputation if not detected early. This study introduces an automated approach for identifying and classifying DFU using transfer learning. DFU is typically categorized into ischemic and infection states, which are challenging to distinguish visually. We evaluate the effectiveness of pretrained Deep Convolutional Neural Network (DCNN) models for autonomous DFU detection. Seven models are compared: EfficientNetB0, DenseNet121, ResNet101, VGG16, MobileNetV2, InceptionV3, and InceptionResNetV2. Additionally, we propose E-DFu-Net, a novel model derived from existing architectures, designed to mitigate overfitting. Experimental results demonstrate that E-DFu-Net achieves remarkable performance, with 97% accuracy in ischemia classification and 92% in infection classification. This advancement enhances current methodologies and aids practitioners in effectively detecting DFU cases.

Cancer is the second leading cause of death globally, and use of therapeutic peptides to target and kill cancer cells has received considerable attention in recent years. Identification of anticancer peptides (ACPs) through wet-lab experimentation is expensive and often time consuming; therefore, development of an efficient computational method is essential to identify potential ACP candidates prior to in vitro experimentation. In this study, we developed support vector machine- and random forest-based machine-learning methods for the prediction of ACPs using the features calculated from the amino acid sequence, including amino acid composition, dipeptide composition, atomic composition, and physicochemical properties. We trained our methods using the Tyagi-B dataset and determined the machine parameters by 10-fold cross-validation. Furthermore, we evaluated the performance of our methods on two benchmarking datasets, with our results showing that the random forest-based method outperformed the existing methods with an average accuracy and Matthews correlation coefficient value of 88.7% and 0.78, respectively. To assist the scientific community, we also developed a publicly accessible web server at www.thegleelab.org/MLACP.html.

e18052 {\rtf1\ansi\ansicpg936\cocoartf1347\cocoasubrtf570 {\fonttbl\f0\froman\fcharset0 Times-Roman;\f1\fnil\fcharset0 Calibri;\f2\fswiss\fcharset0 Helvetica; \f3\fnil\fcharset134 STHeitiSC-Light;\f4\froman\fcharset0 TimesNewRomanPSMT;} {\colortbl;\red255\green255\blue255;\red0\green0\blue0;} \paperw11900\paperh16840\margl1440\margr1440\vieww25400\viewh13600\viewkind0 \deftab720 \pard\pardeftab720 \f0\fs24 \cf2 \expnd0\expndtw0\kerning0 \outl0\strokewidth0 \strokec2 AI platform in mammagraphy to screening breast cancer: a sole center experence. \f1\fs21 \cf0 \kerning1\expnd0\expndtw0 \outl0\strokewidth0 \ \pard\pardeftab720\ri714\qj \cf0 Background: The aim of this study was to use deep convolutional neural network (DCNN) to relieve radiologists ' burden and to minimize misses and interpretation errors of suspicious lesions at digital mammography. Methods: We developed and trained the DCNN model on the training set, then validated it in an internal validation set. The labeled data were used for training the DCNN model, and the mass detection, calcification detection and benign and malignant diagnosis were interpreted respectively. After verifying the feasibility of the DCNN model in the diagnosis of breast cancer, we gradually increased the number of cases in the training set and established the verification set to test the training results. The latest training sets include 21100 atlas of our hospital between April 2010 and October 2017, among which the malignant case atlas is 1774. Each atlas contains 2 ipsilateral mammography images. The verification set includes 1307 atlas, among which the malignant case atlas is 248. Results: The DCNN model achieved high performance in identifying breast cancer patients in the validation sets tested, with sensitivity of 98.02%, specificity of 91.86% \f3 \'a3\'ac \f2 and area under the curve values of 0.9813. As for mass detection, we reached a recall rate of 89.6% on the premise of lowing the false positive to 0.168%. For the latest clinical data between October 2018 and November 2018 including 1043 atlas from 576 patients, the sensitivity was 78.6% (95%CI 62.8-89.1) versus 90.5% (95%CI 76.5 \f4 - \f2 96.9; p=0.021) and specificity was 93.4% (95%CI 91.6 \f4 - \f2 94.8) versus 82.7% (95%CI 80.2 \f4 - \f2 85 \f4 . \f2 0; p&lt;0.0001). Conclusions: The DCNN model showed improved specificity in diagnosis breast cancer compared with a group of skilled radiologists. As the number of cases in the training set increases, the capacity of DCNN model will be further improved.

Diagnosing burns in humans has become critical, as early identification can save lives. The manual process of burn diagnosis is time-consuming and complex, even for experienced doctors. Machine learning (ML) and deep convolutional neural network (CNN) models have emerged as the standard for medical image diagnosis. The ML-based approach typically requires handcrafted features for training, which may result in suboptimal performance. Conversely, DL-based methods automatically extract features, but designing a robust model is challenging. Additionally, shallow DL methods lack long-range feature dependency, decreasing efficiency in various applications. We implemented several deep CNN models, ResNeXt, VGG16, and AlexNet, for human burn diagnosis. The results obtained from these models were found to be less reliable since shallow deep CNN models need improved attention modules to preserve the feature dependencies. Therefore, in the proposed study, the feature map is divided into several categories, and the channel dependencies between any two channel mappings within a given class are highlighted. A spatial attention map is built by considering the links between features and their locations. Our attention-based model BuRnGANeXt50 kernel and convolutional layers are also optimized for human burn diagnosis. The earlier study classified the burn based on depth of graft and non-graft. We first classified the burn based on the degree. Subsequently, it is classified into graft and non-graft. Furthermore, the proposed model performance is evaluated on Burns_BIP_US_database. The sensitivity of the BuRnGANeXt50 is 97.22% and 99.14%, respectively, for classifying burns based on degree and depth. This model may be used for quick screening of burn patients and can be executed in the cloud or on a local machine. The code of the proposed method can be accessed at https://github.com/dhirujis02/Journal.git for the sake of reproducibility.

The accuracy in diagnosing prostate cancer (PCa) has increased with the development of multiparametric magnetic resonance imaging (mpMRI). Biparametric magnetic resonance imaging (bpMRI) was found to have a diagnostic accuracy comparable to mpMRI in detecting PCa. However, prostate MRI assessment relies on human experts and specialized training with considerable inter-reader variability. Deep learning may be a more robust approach for prostate MRI assessment. Here we present a method for autosegmenting the prostate zone and cancer region by using SegNet, a deep convolution neural network (DCNN) model. We used PROSTATEx dataset to train the model and combined different sequences into three channels of a single image. For each subject, all slices that contained the transition zone (TZ), peripheral zone (PZ), and PCa region were selected. The datasets were produced using different combinations of images, including T2-weighted (T2W) images, diffusion-weighted images (DWI) and apparent diffusion coefficient (ADC) images. Among these groups, the T2W + DWI + ADC images exhibited the best performance with a dice similarity coefficient of 90.45% for the TZ, 70.04% for the PZ, and 52.73% for the PCa region. Image sequence analysis with a DCNN model has the potential to assist PCa diagnosis.

For the purpose of applying information technology to the creation of ink style painting, the algorithm of ink painting rendering based on the deep learning framework and convolutional neural network model is designed and improved. Firstly, the ink style rendering program is written in Python. Secondly, VGG under Caffe architecture and Illustration 2Vec models are transplanted to TensorFlow architecture, and the image is rendered in ink style based on deep learning framework and convolutional neural network model. Finally, based on Node.js, the server-side program for image ink style rendering is built. Among them, Express is adopted as the Web-side framework, and the front-end page effect is completed. The results show that the ink rendering logic program is applicable, and the expected purpose is achieved.

Forecasting solar power is essential for increasing solar power plants' competitiveness in the energy market and reducing reliance on fossil fuels for social and economic advancement. The novel method of forecasting solar Photovoltaic (PV) power output through the use of deep learning and machine learning techniques specifically, Deep Neural Network (DNN) and Convolutional Neural Network (CNN) models is presented in this research. To anticipate solar energy generation, our technique uses pertinent weather characteristics and historical PV power data as inputs. Although several PV power forecasting models in the literature have varying degrees of accuracy, our CNN and DNN models provide a clear benefit by obtaining important features from raw local data. With this skill, precise short-term projections of solar PV power output from a few hours to several days-can be made. In addition, the integration of naive seasonal forecasting with CNN and DNN models improves the precision of short-term power generation forecasts by identifying complex dependencies and periodic patterns in the data. All things considered, our suggested method offers a viable way to raise the accuracy and efficiency of solar energy forecasting, which will help the energy industry embrace sustainable energy sources more widely.

iACP-DFSRA: Identification of Anticancer Peptides Based on a Dual-channel Fusion Strategy of ResCNN and Attention