An Augmented Lagrangian Approach to Conically Constrained Nonmonotone Variational Inequality Problems

Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence

Clinical-Grade <i>Garcinia cambogia</i> Extract Removes Calcium Oxalate Kidney Stones in Both Genetic and Non-Genetic <i>Drosophila</i> Models of Nephrolithiasis

The three-dimensional (3D) spot-scanning method is one of the most commonly used irradiation methods in charged particle beam radiotherapy. Generally, spot-scanning beam delivery utilizes the same size pencil beam to irradiate the tumor targets. Here we propose a spot-scanning beam delivery method with laterally- and longitudinally-mixed size pencil beams for heavy ion radiotherapy. This uses pencil beams with a bigger spot size in the lateral direction and wider mini spread-out Bragg peak (mini-SOBP) to irradiate the inner part of a target volume, and pencil beams with a smaller spot size in the lateral direction and narrower mini-SOBP to irradiate the peripheral part of the target volume. Instead of being controlled by the accelerator, the lateral size of the pencil beam was adjusted by inserting Ta scatterers in the beam delivery line. The longitudinal size of the pencil beam (i.e. the width of the mini-SOBP) was adjusted by tilting mini ridge filters along the beam direction. The new spot-scanning beam delivery using carbon ions was investigated theoretically and compared with traditional spot-scanning beam delivery. Our results show that the new spot-scanning beam delivery has smaller lateral penumbra, steeper distal dose fall-off and the dose homogeneity (1-standard deviation/mean) in the target volume is better than 95%.

Persistent Clonal Expansion of Vδ3 and Vδ4 T Cells in T-ALL Case with Minimal Residual Disease after HSCT

Using data taken at 29 center-of-mass energies between 4.16 and 4.70 GeV with the BESIII detector at the Beijing Electron Positron Collider corresponding to a total integrated luminosity of approximately 18.8 , the process is observed for the first time with a statistical significance of . The average Born cross sections in the energy ranges of (4.160, 4.380) GeV, (4.400, 4.600) GeV and (4.610, 4.700) GeV are measured to be fb, fb and fb, respectively, where the first uncertainties are statistical and the second are systematic. The line shapes of the and invariant mass spectra are consistent with phase space distributions, indicating that no hexaquark or di-baryon state is observed.

We report transport measurements on Josephson junctions consisting of Bi2Te3 topological insulator (TI) thin films contacted by superconducting Nb electrodes. For a device with junction length L = 134 nm, the critical supercurrent I c can be modulated by an electrical gate which tunes the carrier type and density of the TI film. I c can reach a minimum when the TI is near the charge neutrality regime with the Fermi energy lying close to the Dirac point of the surface state. In the p-type regime the Josephson current can be well described by a short ballistic junction model. In the n-type regime the junction is ballistic at 0.7 K < T < 3.8 K while for T < 0.7 K the diffusive bulk modes emerge and contribute a larger I c than the ballistic model. We attribute the lack of diffusive bulk modes in the p-type regime to the formation of p–n junctions. Our work provides new clues for search of Majorana zero mode in TI-based superconducting devices.

Since the use of a quantum channel is very expensive for transmitting large messages, it is vital to develop an effective quantum compression encoding scheme that is easy to implement. Given that, with the single-photon spin-orbit entanglement, we propose a quantum secret sharing scheme using orbital angular momentum onto multiple spin states based on Fibonacci compression encoding. In our proposed scheme, we can represent the frequency of any secret message which is typically collection of bits encodings of text or integers as a bitstring using the base Fibonacci sequence, which is encoded multiple spin states for secret shares transmitted to participants. We demonstrate that Fibonacci compression encoding carries excellent properties that enable us to achieve more robust quantum secret sharing schemes with fewer number of photons.

The magnetic field and density behaviors of various thermodynamic quantities of strange quark matter under compact star conditions are investigated in the framework of the thermodynamically self-consistent quasiparticle model. For individual species, a larger number density leads to a larger magnetic field strength threshold that aligns all particles parallel or antiparallel to the magnetic field. Accordingly, in contrast to the finite baryon density effect which reduces the spin polarization of magnetized strange quark matter, the magnetic field effect leads to an enhancement of it. We also compute the sound velocity as a function of the baryon density and find the sound velocity shows an obvious oscillation with increasing density. Except for the oscillation, the sound velocity grows with increasing density, similar to the zero-magnetic field case, and approaches the conformal limit at high densities from below.

Oral arsenic plus retinoic acid versus intravenous arsenic plus retinoic acid for non-high-risk acute promyelocytic leukaemia: a non-inferiority, randomised phase 3 trial

Few studies have assessed the role of individual plasma cholesterol levels in the association between egg consumption and the risk of cardiovascular diseases. This research aims to simultaneously explore the associations of self-reported egg consumption with plasma metabolic markers and these markers with the risk of cardiovascular disease (CVD). Totally 4778 participants (3401 CVD cases subdivided into subtypes and 1377 controls) aged 30-79 were selected based on the China Kadoorie Biobank. Targeted nuclear magnetic resonance was used to quantify 225 metabolites in baseline plasma samples. Linear regression was conducted to assess associations between self-reported egg consumption and metabolic markers, which were further compared with associations between metabolic markers and CVD risk. Egg consumption was associated with 24 out of 225 markers, including positive associations for apolipoprotein A1, acetate, mean HDL diameter, and lipid profiles of very large and large HDL, and inverse associations for total cholesterol and cholesterol esters in small VLDL. Among these 24 markers, 14 were associated with CVD risk. In general, the associations of egg consumption with metabolic markers and of these markers with CVD risk showed opposite patterns. In the Chinese population, egg consumption is associated with several metabolic markers, which may partially explain the protective effect of moderate egg consumption on CVD. This work was supported by the National Natural Science Foundation of China (81973125, 81941018, 91846303, 91843302). The CKB baseline survey and the first re-survey were supported by a grant from the Kadoorie Charitable Foundation in Hong Kong. The long-term follow-up is supported by grants (2016YFC0900500, 2016YFC0900501, 2016YFC0900504, 2016YFC1303904) from the National Key R&D Program of China, National Natural Science Foundation of China (81390540, 81390541, 81390544), and Chinese Ministry of Science and Technology (2011BAI09B01). The funders had no role in the study design, data collection, data analysis and interpretation, writing of the report, or the decision to submit the article for publication.

In this work, we study the optical properties of a class of magnetically charged rotating black hole spacetimes. The black holes in question are assumed to be immersed in the quintessence field, and subsequently, the resulting black hole shadows are expected to be modified by the presence of dark energy. We investigate the photon region and the black hole shadow, especially their dependence on the relevant physical conditions, such as the quintessence state parameter, angular momentum, and magnetic charge magnitude. The photon regions depend sensitively on the horizon structure and possess intricate features. Moreover, from the viewpoint of a static observer, we explore a few observables, especially those associated with the distortion of the observed black hole shadows.

Combination of spatial transcriptomics analysis and retrospective study reveals liver infection of SARS-COV-2 is associated with clinical outcomes of COVID-19.

Level of evidence supporting the Chinese cardiovascular disease clinical practice guidelines and its evolution in the past two decades

Two-dimensional surface-enhanced Raman scattering (SERS) substrates have drawn intense attention due to their excellent spectral reproducibility, high uniformity and perfect anti-interference ability. However, the inferior detection sensitivity and low enhancement have limited the practical application of two-dimensional SERS substrates. To address this issue, we propose that the interaction between the MoTe2 substrate and the analyte rhodamine 6G molecules could be remarkably enhanced by the introduced p-doping effect and lattice distortion of MoTe2 via hydrogen plasma treatment. After the treatment, the SERS is greatly improved, the enhancement factor of probe molecules reaches 1.83 × 106 as well as the limit of detection concentration reaches 10−13 M. This method is anticipated to afford new enhancement probability for other 2D materials, even non-metal oxide semiconductor SERS substrates.

Nonlinear evolution of multiple toroidal Alfvén eigenmodes (TAEs) driven by fast ions is self-consistently investigated by kinetic simulations in toroidal plasmas. To clearly identify the effect of nonlinear coupling on the beam ion loss, simulations over single-n modes are also carried out and compared with those over multiple-n modes, and the wave-particle resonance and particle trajectory of lost ions in phase space are analyzed in detail. It is found that in the multiple-n case, the resonance overlap occurs so that the fast ion loss level is rather higher than the sum loss level that represents the summation of loss over all single-n modes in the single-n case. Moreover, increasing fast ion beta βh can not only significantly increase the loss level in the multiple-n case but also significantly increase the loss level increment between the single-n and multiple-n cases. For example, the loss level in the multiple-n case for βh = 6.0% can even reach 13% of the beam ions and is 44% higher than the sum loss level calculated from all individual single-n modes in the single-n case. On the other hand, when the closely spaced resonance overlap occurs in the multiple-n case, the release of mode energy is increased so that the widely spaced resonances can also take place. In addition, phase space characterization is obtained in both single-n and multiple-n cases.