- Book Chapter
1
- 10.1002/9781119857983.ch5
Deep Learning and Precision Medicine
- Sep 16, 2022
- Selvasudha Nandakumar + 7 more +7
The healthcare system is transforming as a result of new technology invention and implementation, which promotes therapeutic interventions and treatment outcomes for improved patient care. Numerous diverse parameters like gene variation, sociodemographics, lifestyle/environmental elements, should be measured to expedite precision/personalized medicine (PM). As a result, one of the most important difficulties in PM is bridging the translational gap in the clinical context by transforming big, multimodal data into decision support tools. Deep learning (DL) offers a novel technique to overcome these challenges, enabling the building or acquisition of accuracy, multimodal predictive models that could help the PM vision become a reality shortly. DL along with modern artificial intelligence (AI), in particular, provides tools in the form of algorithms that could pave the way for an individualized malignancy treatment in a more precise and customized manner by allowing early diagnosis and precise treatment options. Machine learning (ML) techniques applied to genomic datasets have a lot of potentials to deliver PM. DL has the power to accurately analyze tumor data and recommend the best possible treatment for cancer patients with a personalized approach. The capacity to anticipate how a patient will respond to a medication using DL techniques will aid in the reevaluation of treatment decisions, as well as the reduction of errors and disease-related financial burden. This chapter discusses the overall characteristics of DL and PM, as well as the importance of DL in precision oncology drug discovery and development, genomics, and biomarker datasets. It also outlines the potential of different technologies of DL in cancer diagnosis, detection, and prediction. It also highlights the applications of DL in translational oncology and its clinical benefits. Various challenges and limitations associated with DL techniques, such as like unique genomic patterns, small sample size, multidisciplinary expertise, and clinical trials, are also addressed.
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