An Improved Convolutional Neural Network Model for DNA Classification

Understanding the learning mechanism of convolutional neural networks in spectral analysis

Developing a treatment strategy that effectively prolongs the lives of people with brain tumors requires an accurate diagnosis of the condition. Therefore, improving the preoperative classification of meningiomas is a priority. Machine learning (ML) has made great strides thanks to the development of convolutional neural networks (CNNs) and computer-aided tumor detection systems. The deep convolutional layers automatically extract important and dependable information from the input space, in contrast to more traditional neural network layers. One recent and promising advancement in this field is ML. Still, there is a dearth of studies being carried out in this area. Therefore, starting with the analysis of magnetic resonance images, we have suggested in this research work a tried-and-tested and methodical strategy for real-time meningioma diagnosis by image segmentation using a very deep transfer learning CNN model or DNN model (VGG-16) with CUDA. Since the VGGNet CNN model has a greater level of accuracy than other deep CNN models like AlexNet, GoogleNet, etc., we have chosen to employ it. The VGG network that we have constructed with very small convolutional filters consists of 13 convolutional layers and 3 fully connected layers. Our VGGNet model takes in an sMRI FLAIR image input. The VGG's convolutional layers leverage a minimal receptive field, i.e., 3 × 3, the smallest possible size that still captures up/down and left/right. Moreover, there are also 1 × 1 convolution filters acting as a linear transformation of the input. This is followed by a ReLU unit. The convolution stride is fixed at 1 pixel to keep the spatial resolution preserved after convolution. All the hidden layers in our VGG network also use ReLU. A dataset consisting of 264 3D FLAIR sMRI image segments from three different classes (meningioma, tuberculoma, and normal) was employed. The number of epochs in the Sequential Model was set to 10. The Keras layers that we used were Dense, Dropout, Flatten, Batch Normalization, and ReLU. According to the simulation findings, our suggested model successfully classified all of the data in the dataset used, with a 99.0% overall accuracy. The performance metrics of the implemented model and confusion matrix for tumor classification indicate the model's high accuracy in brain tumor classification. The good outcomes demonstrate the possibility of our suggested method as a useful diagnostic tool, promoting better understanding, a prognostic tool for clinical outcomes, and an efficient brain tumor treatment planning tool. It was demonstrated that several performance metrics we computed using the confusion matrix of the previously used model were very good. Consequently, we think that the approach we have suggested is an important way to identify brain tumors.

Machine Learning can be used to process a lot of data and learn patterns from that data to predict the future. One of the most widely used parts of machine learning is Deep Learning. The Deep Learning method that currently provides the most significant results in image recognition is Convolutional Neural Network (CNN). Convolutional Neural Network (CNN) is one of the deep learning algorithms used for computer vision use cases such as image or video classification and detecting objects within images or even image areas. Some research related to the CNN model states that this model has a very good accuracy of 92% but with a fairly small amount of data and the use of epochs, namely 100, resulting in a higher validation error value than the error value in the training process, so that over fitting will occur. Based on several problems in the related research literature, this article aims to identify the weaknesses and shortcomings of Deep Learning algorithms using CNN models that refer to the state of the art, so that they can be used as a reference for further research. The state of the art related to research in the last five years, the Deep Learning algorithm using the CNN model found that (1) The number of epochs can affect the accuracy of the CNN model, (2) 2. The application of architecture can affect the accuracy of the CNN model, (3) the application of the type of layer can affect the accuracy of the CNN model. Based on several problems in the research literature related to the identification of weaknesses and shortcomings of Deep Learning using the CNN model which refers to Table 1. State of the Art summary of literature review research for the last five years, it can be concluded that to increase the accuracy of the CNN model, it is necessary to increase the number of epochs, apply the right architecture according to the problems in the research conducted, and use the type of layer. The hypothesis of this article can be used as a reference for further research related to Deep Learning using the CNN model.

Development in Computer vision applications, most prominently in Artificial Intelligence (AI) over the past decade, has encouraged researchers to use computational algorithms. Machine Learning (ML) and Deep Learning (DL) algorithms are getting attention in the biomedical area to early diagnosis and prognosis of lethiferous diseases with higher accuracy using statistical analysis. Cervical cancer is one of the predominant gynecological infectious forms of cancer in females ecumenically, generally transpiring in less-developed nations. DL algorithms are more optimized and convenient due to the automatic feature extraction in Cervical lesion detection at an early phase. Here we analyze the convolutional neural network (CNN) models' performance using variation in channels depth comprises in the convolution layers to classify multi-class liquid-based cytology (LBC) Whole slide images (WSI). We propose three CNN models having two convolution layers with the number of channels (4,8), (8,16), and (32,64) and two pooling layers. CNN model with the highest number of channels in the convolution layers gives the leading performance with an accuracy of 96.89%, precision of 93.38%, the sensitivity of 93.75%, and F-score of 94.15%.

Sentiment Analysis was a process for identifying whether a source of text contains certain opinions, emotions, and polarity. Twitter Sentiment Analysis was a process for identifying sentiment and polarity on tweet. Twitter Sentiment Analysis provided a way for did survey about public sentiment to product, or particular even through collections of tweet. Main problem in sentiment identifying was how to determine classification model that gave high accuracy to classifying sentiment of tweet. One of the method for classifying sentiment of tweet was Deep Learning. Convolutional Neural Network (CNN) was special type of architecture from Deep Learning that its architecture had convolution layer. Convolution layer was important for extract relevant feature from text for classifying sentiment. The objective of this research was for found out the best CNN model for classifying sentiment of tweet. By using a dataset of tweets about public opinion on the Smartfren 4G network service, we searched the best CNN model using 6 combination parameters, that is the computational eficiency method, window size, and dimension of word embedding for parameters in Word2Vec Skip-gram model, then activation function in convolution layer, dropout rate, and pool size in pooling layer for parameters in CNN. The test is done using 10-fold cross validation for each search for the best parameter value and produced the best CNN model with an accuracy value of 88,21%.

One of the diseases that attacks the lungs is pneumonia. Pneumonia is inflammation and fluid in the lungs making it difficult to breathe. This disease is diagnosed using X-Ray. Against the darker background of the lungs, infected tissue shows denser areas, which causes them to appear as white spots called infiltrates. In the image processing approach, pneumonia-infected X-rays can be detected using machine learning as well as deep learning. The convolutional neural network model is able to recognize images well and focus on points that are invisible to the human eye. Previous research using a convolutional neural network model with 10 convolution layers and 6 convolution layers has not achieved optimal accuracy. The aim of this research is to develop a convolutional neural network with a simpler architecture, namely two convolution layers and three convolution layers to solve the same problem, as well as examining the combination of various hyperparameter sizes and regularization techniques. We need to know which convolutional neural network architecture is better. As a result, the convolutional neural network classification model can recognize chest x-rays infected with pneumonia very well. The best classification model obtained an average accuracy of 89.743% with a three-layer convolution architecture, batch size 32, L2 regularization 0.0001, and dropout 0.2. The precision reached 94.091%, recall 86.456%, f1-score 89.601%, specificity 85.491, and error rate 10.257%. Based on the results obtained, convolutional neural network models have the potential to diagnose pneumonia and other diseases.

A well-known vegetable crop farmed all throughout the world is the potato. The possibility of a large number of diseases, however, could also impair the harvest. In order to quickly deal with the crop, it is vital for the planter to recognise the type of contamination. It had been determined that the leaves were a simple indicator of many diseases. Many Machine Learning (ML) techniques as well as Convolution Neural Network (CNN) models are superior in the literature for the detection of tomato crop diseases. CNN models rely on deep learning and neural networks, which are superior than traditional machine learning methods like decision trees and kNN. Although well before CNN creates beautiful artwork, the wide range of subjects they cover renders them operationally intensive. This painting suggests a less complex CNN model with eight convolution layer At the publicly accessible dataset PlantVillage, the recommended compact model performs better than the standard machine learning techniques and pre-trained fashions with an accuracy of 98.4%. The PlantVillage dataset includes 39 classes of different crops, including tomato diseases. These crops include apple, potato, maize, grapes, and more. In comparison to VGG16, which has an amazing accuracy of 93% 5% in pretrained patterns, k-NN has the absolute best accuracy of 94% in conventional ML approaches. After image augmentation, picture pre-processing was used to improve the suggested CNN's overall performance by having the ability to modify the brightness of the image using the knowledge of a prospective variable involving a randomized width of the image. The suggested model, which has a 98% accuracy rate, is also incredibly effective with datasets other than PlantVillage.

Excessive withdrawal of groundwater for agricultural irrigation can cause seawater intrusion into coastal aquifers. Such a case will in turn results in deterioration of irrigation water quality. Determination of irrigation water quality with traditional methods is a time-consuming and costly process. However, machine learning algorithms can be useful tools for modeling and estimating groundwater quality used for irrigation water purposes. In this study, TDS, PS, SAR, and Cl parameters of groundwater were estimated with models based on EC and pH variables. For this purpose, prediction performances of two different deep learning methods (convolutional neural network (CNN) and deep neural network (DNN)) and two different classical machine learning (Random Forest (RF) and extreme gradient boosting (XGBoost)) methods were compared. In addition, predictive uncertainty of the models was determined by quantile regression (QR) analysis. Performance criteria and results of uncertainty analysis revealed that CNN (in testing phase, NSE = 0.95 for TDS, NSE = 0.96 for PS, NSE = 0.67 for SAR and NSE = 0.93 for CI) and DNN (in testing phase, NSE = 0.91 for TDS, NSE = 0.91 for PS, NSE = 0.57 for SAR and NSE = 0.94 for Cl) models had quite a close performance in estimation of TDS, PS, SAR, and Cl parameters and higher than the other two classical machine learning methods. As a result, the CNN model can be considered the best performing model in estimating all quality parameters due to the highest NSE and lowest RMSE values. In addition, the Taylor diagram showed that the values estimated using the CNN model had the highest correlation with the measured data. It was determined that the model with the lowest uncertainty based on the PICP statistics was DNN, followed by the CNN model. However, the CNN model has predicted outliers more accurately. Present findings proved that deep learning models could offer efficient tools for predicting irrigation water quality parameters.

BACKGROUND AND AIM: Outdoor ultrafine particles (UFP; 100 nm) and black carbon (BC) vary greatly within cities and may have adverse impacts on human health such as cardiovascular mortality and brain tumour incidence. Traditional regression methods for estimating spatial distributions of ambient air pollution depend on extensive, curated geospatial information system databases. This has resulted in a disparity wherein little is known about local air pollution in the data-sparse settings of low- and middle- income countries. We used a hybrid approach to develop new models to estimate within-city spatial variations in outdoor UFP and BC concentrations across Bucaramanga, Colombia. METHODS: We conducted a large-scale mobile monitoring campaign over twenty days in 2019. Land use regression (LUR) models were developed using land use parameters from curated and open-source databases. Convolutional Neural Network (CNN) models were developed using Google Maps satellite view and street view images. Combined models were developed by combining predictions from the LUR and CNN models. After training in the training and validation sets, predictions were generated in the test set and compared to measured values. RESULTS:The combined UFP model (R2=0.54) outperformed the CNN (R2=0.47) and land use regression (LUR) models (R2=0.47) on their own. Similarly, the combined BC model also outperformed the CNN and LUR BC models (R2 = 0.51 vs 0.43 and 0.45 respectively). Spatial variations in model performance were more stable for the CNN and combined models compared to the LUR models suggesting that the combined approach may be less likely to contribute to differential exposure measurement error in epidemiological studies. CONCLUSIONS:Estimates from these models can then be applied to population-based cohorts in order to evaluate population health risks. Additionally, our findings demonstrated that satellite and street-level images can be combined with a traditional LUR modelling approach to improve predictions of within-city spatial variations in outdoor UFP and BC concentrations. KEYWORDS: Ultrafine particles, Black Carbon, Deep learning, Images, Land use regression

Recently, the deep learning methods have achieved great success in pattern recognition tasks. Especially for character recognition, most of the state-of-the-art results belong to the deep learning models. Among those models, the convolutional neural network (CNN) becomes the most popular due to its outstanding performance. Therefore, many trials were made in order to make improvements on CNN. However, most of the trials only focused on the network structure or training skills, the inter-class information is usually ignored. In this paper, we have proposed a novel CNN model with two training feedbacks: the reconstruction feedback and the classification feedback. By using the reconstruction feedback, the inter-class information (for example, shape similarity) of the characters is taken into account. Consequently, without enlarging the network structure, our model can outperform those state-of-the-art improved CNN models, which is proved by the experimental results.

Handwritten digit recognition, a task in computer vision, is critical for applications such as postal automation, banking, and digitization of forms. Traditional approaches have leveraged statistical models, but the rise of deep learning, particularly Convolutional Neural Networks (CNN) and Long-Short Term Memory (LSTM), has revolutionized the field. However, a comprehensive performance comparison of CNN and LSTM architectures in the context of handwritten digit classification remains underexplored. This study aimed to address this gap by evaluating and comparing CNN and LSTM models for the classification of handwritten digits. Two machine learning models – Convolutional Neural Network (CNN) and Long-Short Term Memory (LSTM) were trained with the preprocessed handwritten digit dataset. The CNN model was designed with multiple convolutional and pooling layers, along with dropout for regularization. The LSTM model was designed with LSTM layers to capture sequential patterns in the data, followed by a dense layer for classification. The models were implemented in python, evaluated and compared based on accuracy, precision, recall and F1-score. The evaluation and comparison results indicate that CNN achieved 99.31% accuracy, 99.0% precision, 99.0% recall, and a 99.0% F1-score, while LSTM achieved 98.90% accuracy, 99.0% precision, 99.0% recall, and a 99.0% F1-score. The results demonstrated that CNN outperformed LSTM in terms of accuracy and misclassification errors, making it the optimal choice for image-based handwritten digit recognition. This finding underscores the efficiency of CNN in addressing challenges related to digit recognition, contributing to the advancement of automated digit classification systems and improving the accuracy of image-based classification tasks.

Among the many deep learning methods, the convolutional neural network (CNN) model has an excellent performance in image recognition. Research on identifying and classifying image datasets using CNN is ongoing. Animal species recognition and classification with CNN is expected to be helpful for various applications. However, sophisticated feature recognition is essential to classify quasi-species with similar features, such as the quasi-species of parrots that have a high color similarity. The purpose of this study is to develop a vision-based mobile application to classify endangered parrot species using an advanced CNN model based on transfer learning (some parrots have quite similar colors and shapes). We acquired the images in two ways: collecting them directly from the Seoul Grand Park Zoo and crawling them using the Google search. Subsequently, we have built advanced CNN models with transfer learning and trained them using the data. Next, we converted one of the fully trained models into a file for execution on mobile devices and created the Android package files. The accuracy was measured for each of the eight CNN models. The overall accuracy for the camera of the mobile device was 94.125%. For certain species, the accuracy of recognition was 100%, with the required time of only 455 ms. Our approach helps to recognize the species in real time using the camera of the mobile device. Applications will be helpful for the prevention of smuggling of endangered species in the customs clearance area.

Accurately identifying epileptogenic zone (EZ) using high-frequency oscillations (HFOs) is a challenge that must be mastered to transfer HFOs into clinical use. We analyzed the ability of a convolutional neural network (CNN) model to distinguish EZ and non-EZ HFOs. Nineteen medically intractable epilepsy patients with good surgical outcomes 2 years after surgery were studied. Five-minute interictal intracranial electroencephalogram epochs of slow-wave sleep were selected randomly. Then 5 s segments of ripples (80–200 Hz) and fast ripples (FRs, 200–500 Hz) were detected automatically. The EZs and non-EZs were identified using the surgery resection range. We innovatively converted all epochs into four types of images using two scales: original waveforms, filtered waveforms, wavelet spectrum images, and smoothed pseudo Wigner–Ville distribution (SPWVD) spectrum images. Two scales were fixed and fitted scales. We then used a CNN model to classify the HFOs into EZ and non-EZ categories. As a result, 7,000 epochs of ripples and 2,000 epochs of FRs were randomly selected from the EZ and non-EZ data for analysis. Our CNN model can distinguish EZ and non-EZ HFOs successfully. Except for original ripple waveforms, the results from CNN models that are trained using fixed-scale images are significantly better than those from models trained using fitted-scale images (p < 0.05). Of the four fixed-scale transformations, the CNN based on the adjusted SPWVD (ASPWVD) produced the best accuracies (80.89 ± 1.43% and 77.85 ± 1.61% for ripples and FRs, respectively, p < 0.05). The CNN using ASPWVD transformation images is an effective deep learning method that can be used to classify EZ and non-EZ HFOs.

Deep learning methods have been developed and widely used in land use classification with remote sensing images. In addition, due to the different datasets used in different studies, there is a lack of direct comparison between different deep learning model applications in land use classification. The open source dataset DeepSat was used to build and test a convolutional neural network (CNN) model. The convolution kernels in the model were extracted to further study the specific features learned by the deep learning model. In addition, different CNN-based models were compared to explore the impacts of model structures on model accuracy. The major conclusions from the research are: (1) CNN model is effective in land use classification, with an accuracy of 0.9998 and 0.9991 for the SAT-4 and SAT-6 data, respectively; (2) CNN does have a “learning” ability that can extract the most critical and effective information from training datasets; and (3) for remote sensing land use classification, increasing the number of convolution kernels is better than adding more convolutional layers. Max pooling is better than average pooling. In addition, a localized response normalized layer can also improve model accuracy.

Bone cancer is a significant health issue that leads to severe complications and deaths worldwide. Early detection can significantly improve patient outcomes, often resulting in a complete cure. Traditional approaches to managing bone cancer can be augmented with technology-driven methods, particularly those enabled by artificial intelligence. Convolutional Neural Networks (CNNs) and their variants have proven effective in medical data analysis. However, deep learning techniques require enhancements to improve performance in cancer detection across various medical imaging modalities. In this paper, we propose a deep-learning framework that utilizes advanced CNN models for the automatic screening of bone cancer. We have enhanced both the CNN model and the ResNet-50 model, which are integral components of the proposed framework. Additionally, we introduced an algorithm called Learning-based Bone Cancer Detection (LbBCD), designed to optimize the utilization of these enhanced deep learning models to improve bone cancer detection efficiency. Our research emphasizes a Region of Interest (ROI) based approach to enhance the screening process for bone cancer. Using a benchmark dataset known as the Bone CT Scan dataset, our empirical study demonstrated that the proposed deep learning framework, integrated with enhanced CNN and ResNet-50 models, achieved remarkable performance. Specifically, the enhanced CNN model reached an accuracy of 90.90%, while the enhanced ResNet-50 model achieved an accuracy of 92.20%, outperforming state-of-the-art deep learning models. Therefore, this proposed system can be integrated into healthcare applications for automatically screening bone cancer, contributing to a clinical decision support system for healthcare professionals.