• Cite Icon25
  • https://doi.org/10.1007/978-1-4757-3419-5_19Copy DOI Icon

An Optimizing Up-and-Down Design

  • Jan 1, 2001
  • Euloge E Kpamegan +1 more
Show More
  • Abstract
  • Literature Map
  • References
  • Citations
  • Similar Papers
Abstract

Assume that the probability of success is unimodal as a function of dose. Take the response to be binary and the possible treatment space to be a lattice. The Optimizing Up-and-Down Design allocates treatments to pairs of subjects in a way that causes the treatment distribution to cluster around the treatment with maximum success probability. This procedure is constructed to use accruing information to limit the number of patients that are exposed to doses with high probabilities of failure. The Optimizing Up-and-Down Design is motivated by Kiefer and Wolfowitz’s stochastic approximation procedure. In this paper, we compare its performance to stochastic approximation. As an estimator of the best dose, simulation studies demonstrate that the mode of the empirical treatment distribution using the Optimizing Up-and-Down Design converges faster than does the usual estimator using stochastic approximation.Keywordsconstant gain stochastic algorithmMarkov chainsphase I/II clinical trialrandom walk designsstationary treatment distributionstochastic approximation

Similar Papers
  • Research Article
  • Citations22

Algorithmic Aspects of Optimal Channel Coding

  • Feb 01, 2018
  • IEEE Transactions on Information Theory
  • Siddharth Barman +1
  • Book Chapter
  • Citations84

New Collision Attacks on SHA-1 Based on Optimal Joint Local-Collision Analysis

  • Jan 01, 2013
  • Marc Stevens
  • Research Article

Asymptotic behavior of truncated stochastic approximation procedures

  • Jan 01, 2017
  • Mathematical Methods of Statistics
  • T Sharia +1
  • Research Article
  • Citations2

Probabilistic channel simulation using coherence

  • Dec 26, 2024
  • Physical Review Research
  • Benchi Zhao +2
  • Book Chapter
  • Citations8

Convergence of Stochastic Approximation Algorithms with Non-Additive Dependent Disturbances and Applications

  • Jan 01, 1983
  • David Ruppert
  • Research Article
  • Citations1

Generation of nonclassical states in a large detuning cavity

  • Mar 01, 2008
  • Chinese Physics B
  • Zhang Ying-Jie +2
  • Research Article
  • Citations1

On Stochastic Approximation Procedures with Averaging

  • Jan 01, 2000
  • Theory of Probability & Its Applications
  • A Le Breton +1
  • Research Article

Discrete variable stochastic approximation procedures and recursive autoregressive model identification

  • Oct 01, 1990
  • International Journal of Systems Science
  • Katsuji Uosaki +1
  • Research Article
  • Citations94

Probabilistic Distillation of Quantum Coherence.

  • Aug 17, 2018
  • Physical Review Letters
  • Kun Fang +4
  • Research Article
  • Citations5

Finite-Time Error Bounds of Biased Stochastic Approximation With Application to TD-Learning

  • Jan 01, 2022
  • IEEE Transactions on Signal Processing
  • Gang Wang
  • Book Chapter

Pricing American Put Options Using Stochastic Optimization Methods

  • Jan 01, 2006
  • G Yin +4
  • Book Chapter
  • Citations2

CONVERGENCE PROPERTIES FOR A FAMILY OF BOUNDED FIXED STEP-SIZE ALGORITHMS

  • Jan 01, 1984
  • Adaptive Systems in Control and Signal Processing 1983
  • D.C Farden
  • Research Article
  • Citations20

Maximum Likelihood State Estimation of Semi-Markovian Switching System in Non-Gaussian Measurement Noise

  • Jan 01, 2010
  • IEEE Transactions on Aerospace and Electronic Systems
  • Dongliang Huang +1
  • Conference Article
  • Citations4

Recursive EM algorithm for stochastic ML DOA estimation

  • May 01, 2002
  • Pei Jung Chung +1
  • Research Article

Learning undirected graphical models using persistent sequential Monte Carlo

  • Apr 01, 2016
  • Machine Learning
  • Hanchen Xiong +2
Cactus Communications logo

Copyright 2026 Cactus Communications. All rights reserved.