Artificial intelligence techniques in inherited retinal diseases: a review

Artificial Intelligence (AI) has emerged as one of the most transformative technological developments of the modern era, offering a profound impact on various sectors, including education. The integration of AI into education presents a complex interplay of opportunities, challenges, and risks that require comprehensive exploration. This study adopts a mixed-methods approach, utilizing bibliometric, conceptual, and hermeneutic analyses to examine the role of AI in educational contexts. Bibliometric analysis quantitatively and visually maps research trends, employing tools to analyze 8,288 documents retrieved from the Scopus database using the keywords "Artificial Intelligence" OR "AI" AND "Education." Over the past two decades, the field has seen exponential growth, with contributions from 28,740 authors worldwide. The mapping highlights key areas of AI application, such as machine learning, deep learning, educational engineering, and computer-aided instruction, alongside technologies like ChatGPT, virtual reality, big data, and data mining. Conceptual analysis dissects critical ideas such as posthumanism, transhumanism, and their intersection with AI in education. These paradigms are reshaping education by challenging its traditional roles as a vehicle for human development and societal progress. AI's role in facilitating personalized learning experiences underscores its potential for enhancing efficiency and adaptability. However, it also raises pressing questions about its alignment with broader educational objectives. Beyond knowledge transfer, education fosters character development, critical thinking, and social skills areas potentially undermined by overreliance on AI technologies. The hermeneutic method provides a deeper interpretation of philosophical texts and literature, emphasizing the ethical and societal implications of integrating AI into education. Posthumanism and transhumanism, which advocate for merging human capabilities with technological advancements, pose existential challenges to education's foundational values. Tools like ChatGPT, while powerful, risk eroding academic integrity and critical skill development. For instance, reliance on AI for solving exam problems or answering complex queries undermines the principles of effort and intellectual growth, essential components of education. The research underscores the dual-edged nature of AI in education. On one hand, it enables adaptive and efficient learning systems. On the other hand, it disrupts traditional educational practices, raising ethical dilemmas and questions about the future of human-centric learning. Philosophical perspectives are crucial in navigating these disruptions, advocating for an education system that balances technological integration with the preservation of core academic values. This involves addressing the ethical considerations surrounding AI applications, particularly the potential misuse of tools like ChatGPT, which are byproducts of posthumanist and transhumanist ideologies. Education, as a transformative process, must evolve to integrate AI responsibly, ensuring that it complements rather than replaces human intellectual efforts. This requires reconstructing educational systems to mitigate the unintended consequences of AI technologies. Philosophical inquiry into the purpose of education must guide the realignment of its goals, emphasizing how knowledge is acquired and skills are nurtured in a rapidly evolving digital landscape. By fostering awareness of the ethical and practical implications of AI, educational institutions can reclaim their role in cultivating well-rounded individuals capable of critical thought and ethical decision-making. In conclusion, this study highlights the need for a balanced approach to integrating AI into education. While technological advancements offer unprecedented opportunities for innovation, they must not overshadow the humanistic values at the core of education. By addressing the challenges posed by posthumanism and transhumanism, the educational sector can harness AI's potential while safeguarding its mission to develop responsible, ethical, and capable individuals for the 21st century.

Background: The field of sports science has been fundamentally transformed by the integration of artificial intelligence (AI) technologies. AI has enabled advances in areas such as performance optimization, training personalization, injury risk assessment and prevention, talent recognition, rehabilitation, athlete monitoring, and wellness optimization. Objective: This review aims to explore the diverse impact of AI in sports science, highlighting advances in AI techniques, the challenges and limitations of integrating AI tools, and the emerging role of AI chatbots in shaping the future of sports research and applications. Methods: The review examines the existing literature on the application of machine learning, deep learning and other AI techniques in various aspects of sports science research and practice. It provides an overview of how these technologies have been used to improve personalized training programs, video analysis, injury risk prediction, talent identification, and rehabilitation. Results: The article describes how AI-powered tools and techniques have revolutionized sports science, enabling personalized, data-driven and efficient approaches to performance optimization. Sophisticated machine learning algorithms such as artificial neural networks, decision trees and support vector machines have been used to develop predictive models for injury risk assessment and prevention, leading to improvements in athletes' wellbeing and long-term performance. AI-driven talent identification and selection processes have also shown promise in recognizing exceptional athletes with greater accuracy. In addition, the integration of AI into athlete monitoring and rehabilitation has led to greater personalization, better decision making and faster return to play. Conclusion: The integration of AI and machine learning techniques into sports science has the potential to transform the field and lead to improved athlete performance, reduced risk of injury, improved well-being, and more personalized and effective interventions. The emergence of AI chatbots expands the applications of these technologies in sports science and offers new opportunities to streamline research processes, provide personalized advice to athletes and support sports medicine and rehabilitation

Inherited retinal diseases (IRDs) are genetic disorders affecting photoreceptors and the retinal pigment epithelium, leading to progressive vision loss. Retinitis pigmentosa (RP), the most common IRD, manifests as night blindness, peripheral vision loss, and eventually central vision decline. RP is genetically diverse and can be categorized into non-syndromic and syndromic. Advanced imaging technologies such as fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT) facilitate diagnosing and managing these conditions. The integration of artificial intelligence in analyzing retinal images has shown promise in identifying genes associated with RP. This study used a dataset from Portuguese public hospitals, comprising 2798 FAF images labeled for syndromic and non-syndromic RP across 66 genes. Three pre-trained models, Inception-v3, ResNet-50, and VGG-19, were used to classify these images, obtaining an accuracy of over 80% in the training data and 54%, 56%, and 54% in the test data for all models. Data preprocessing included class balancing and boosting to address variability in gene representation. Model performance was evaluated using some main metrics. The findings demonstrate the effectiveness of deep learning in automatically classifying retinal images for different RP-associated genes, marking a significant advancement in the diagnostic capabilities of artificial intelligence and advanced imaging techniques in IRD.

Evaluating the ability of artificial intelligence to predict suicide: A systematic review of reviews.

This primer provides an overview of artificial intelligence (AI) for the oncologist and technologist, delineating its relevance, methodologies, and applications. AI, encompassing machine learning (ML) and deep learning (DL), utilizes algorithms to analyze data and make predictions, facilitating early cancer detection and personalized treatment strategies. ML, characterized by supervised and unsupervised learning, allows for pattern recognition and prediction, whereas DL, particularly through convolutional neural networks and transformers, excels in complex data analysis. AI applications span various oncology data types, including electronic health records, medical imaging (radiology and digital pathology), biomarkers (genomics, proteomics, and metabolomics), and digital health sensors. Leveraging AI in oncology enhances diagnostic accuracy, improves treatment selection, and enables early detection through innovative approaches such as wearable devices and mobile health applications. This primer underscores AI's transformative potential in advancing cancer care, exemplified by Food and Drug Administration-approved AI systems and prominent DL architectures. This overview serves as a guide for researchers, clinicians, and policymakers navigating the evolving landscape of AI-driven oncology, emphasizing its pivotal role in augmenting patient outcomes and shaping the future of cancer care.

Artificial intelligence (AI) has transformed pharmacological research through machine learning, deep learning, and natural language processing. These advancements have greatly influenced drug discovery, development, and precision medicine. AI algorithms analyze vast biomedical data identifying potential drug targets, predicting efficacy, and optimizing lead compounds. AI has diverse applications in pharmacological research, including target identification, drug repurposing, virtual screening, de novo drug design, toxicity prediction, and personalized medicine. AI improves patient selection, trial design, and real-time data analysis in clinical trials, leading to enhanced safety and efficacy outcomes. Post-marketing surveillance utilizes AI-based systems to monitor adverse events, detect drug interactions, and support pharmacovigilance efforts.Machine learning models extract patterns from complex datasets, enabling accurate predictions and informed decision-making, thus accelerating drug discovery. Deep learning, specifically convolutional neural networks (CNN), excels in image analysis, aiding biomarker identification and optimizing drug formulation. Natural language processing facilitates the mining and analysis of scientific literature, unlocking valuable insights and information.However, the adoption of AI in pharmacological research raises ethical considerations. Ensuring data privacy and security, addressing algorithm bias and transparency, obtaining informed consent, and maintaining human oversight in decision-making are crucial ethical concerns. The responsible deployment of AI necessitates robust frameworks and regulations.The future of AI in pharmacological research is promising, with integration with emerging technologies like genomics, proteomics, and metabolomics offering the potential for personalized medicine and targeted therapies. Collaboration among academia, industry, and regulatory bodies is essential for the ethical implementation of AI in drug discovery and development. Continuous research and development in AI techniques and comprehensive training programs will empower scientists and healthcare professionals to fully exploit AI's potential, leading to improved patient outcomes and innovative pharmacological interventions.

The Evolving Role of Artificial Intelligence in Radiotherapy Treatment Planning—A Literature Review

Artificial Intelligence (AI) is increasingly transforming healthcare by enhancing diagnostic accuracy, personalizing treatment, and improving operational efficiencies. This review explores AI's impact across several key areas: cancer medicine, fraud detection, and lessons from the petroleum industry. In cancer medicine, AI-driven advancements are leading to more accurate diagnostics, personalized treatment plans, and predictive models for patient outcomes. In fraud detection, AI techniques such as anomaly detection and natural language processing are effectively identifying and mitigating fraudulent activities, safeguarding financial and operational integrity. Insights from the petroleum industry reveal how AI applications, such as predictive maintenance and operational optimization, can be adapted to healthcare settings to enhance equipment reliability and resource management. Emerging trends include the integration of AI with genomics, telemedicine, and cross-disciplinary innovations, which promise further advancements in personalized care and operational efficiency. However, ethical considerations such as data privacy, bias, and transparency must be addressed to ensure responsible AI deployment. The review concludes by highlighting the need for continued innovation, collaboration, and patient-centric approaches to fully realize AI's potential in transforming healthcare and improving patient outcomes.

Artificial intelligence (AI) is transforming ophthalmology by leveraging machine learning (ML) and deep learning (DL) techniques, particularly artificial neural networks (ANN) and convolutional neural networks (CNN) to mimic human brain functions and enhance accuracy through data exposure. These AI systems are particularly effective in analyzing ophthalmic images for early disease detection, improving diagnostic precision, streamlining clinical workflows, and ultimately enhancing patient outcomes. This study aims to explore the specific applications and impact of AI in the fields of glaucoma, corneal diseases, and oculoplastics. This study reviews current AI technologies in ophthalmology, examining the implementation of ML and DL techniques. It evaluates AI's role in early disease detection, diagnostic accuracy, clinical workflow enhancement, and patient outcomes. AI has significantly advanced the early detection and management of various ocular conditions. In glaucoma, AI systems provide standardized, rapid identification of disease characteristics, reducing intra- and interobserver bias and workload. For corneal diseases, AI tools enhance diagnostic methods for conditions such as keratitis and keratoconus, improving early detection and treatment planning. In oculoplastics, AI assists in the diagnosis and monitoring of eyelid and orbital diseases, facilitating precise surgical planning and postoperative management. The integration of AI in ophthalmology has revolutionized eye care by enhancing diagnostic precision, streamlining clinical workflows, and improving patient outcomes. As AI technologies continue to evolve, their applications in ophthalmology are expected to expand, offering innovative solutions for the diagnosis, monitoring, treatment, and surgical outcomes of various eye conditions.

The integration of artificial intelligence (AI) in education has the potential to revolutionize teaching and learning, particularly in the development of students’ critical thinking skills. This study explores science instructors' familiarity, perceptions, and experiences with using AI to enhance students' critical thinking skills, as well as the level of institutional support for AI integration in teaching. A quantitative survey was conducted among 20 science instructors from higher education institutions in Isabela, Philippines. The findings reveal that while instructors acknowledge AI's potential to improve educational outcomes, there is a significant gap in formal AI training and literacy among educators. Positive correlations were found between AI literacy, AI integration, and critical thinking development, suggesting that as AI literacy increases, AI integration and enhancement of critical thinking skills also increase. Regression analysis identified AI integration as a significant predictor of critical thinking development. Challenges remain in the effective implementation of AI, including concerns about overreliance on AI-generated responses and the need for clear assessment guidelines. Interestingly, years of teaching experience did not significantly influence participants’ AI literacy, perceptions, or integration. This study highlights the importance of developing comprehensive AI literacy programs for educators and integrating AI into curriculum structures to balance AI-enhanced learning with human-centered pedagogy. These findings emphasize the need for thoughtful implementation and ongoing research to effectively leverage AI in promoting critical thinking skills in science education.

Nowadays, Artificial Intelligence (AI) and its subfields, Machine Learning (ML) and Deep Learning (DL), are used for a variety of medical applications. It can help clinicians track the patient’s illness cycle, assist with diagnosis, and offer appropriate therapy alternatives. Each approach employed may address one or more AI problems, such as segmentation, prediction, recognition, classification, and regression. However, the amount of AI-featured research on Inherited Retinal Diseases (IRDs) is currently limited. Thus, this study aims to examine artificial intelligence approaches used in managing Inherited Retinal Disorders, from diagnosis to treatment. A total of 20,906 articles were identified using the Natural Language Processing (NLP) method from the IEEE Xplore, Springer, Elsevier, MDPI, and PubMed databases, and papers submitted from 2010 to 30 October 2021 are included in this systematic review. The resultant study demonstrates the AI approaches utilized on images from different IRD patient categories and the most utilized AI architectures and models with their imaging modalities, identifying the main benefits and challenges of using such methods.

Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of Mendelian disorders that plays a crucial role in the etiology of blindness across the world. Molecular genetic diagnosis of IRD remains extremely complex and challenging because mutations are only detected in 40% to 60% of cases. In this study, we aimed to dissect the contributions of copy number variations (CNVs) in IRD patients. A total of 50 patients were diagnosed with IRD, all of whom previously tested negative for pathogenic mutations in known disease genes. Single-nucleotide polymorphism array analysis was performed by using the HumanCoreExome BeadChip. Analyses of CNVs were carried out by using GenomeStudio, KaryoStudio, and cnvPartition. The putative pathogenic CNVs were further confirmed by real-time quantitative PCR. We identified four novel CNVs in three different genes (one duplication in USH2A gene, two duplications in CEP290 gene, and one duplication in RIMS2 gene) in total four families, at a detection rate of 8% (4/50). All of these CNVs are currently absent in all databases. Three variations are located in genes that are already known to cause inherited retinal disease: USH2A and CEP290, while the association between mutation in the RIMS2 gene and IRD is reported for the first time. We performed whole-genome-wide CNV analyses in a large cohort as an alternative approach to molecular diagnosis of IRDs. This study dissected the contributions of CNVs of IRDs, not only increasing the yield in genetic testing but also suggesting the CNVs should be analyzed in the patients with IRDs.

The integration of Artificial Intelligence (AI) in higher education has sparked a transformative shift in pedagogical methodologies, student engagement, and academic integrity across the UK and Ireland (Dogru, et.al, 2023). This qualitative study delves into the multifaceted implications of utilising AI in academic assignments from the perspective of higher education students, drawing on semi-structured interviews carried out with higher education students. The findings reveal a variety of perceived benefits, including enhanced study efficiency, personalised learning support (Hanaba et al., 2020; Yang, 2021), and the potential of AI to level the academic playing field for students with diverse needs. However, these advantages are in contrast with students’ perceptions of a wide range of significant concerns and challenges, notably the ethical dilemmas surrounding academic honesty, the potential for student dependency on AI leading to diminished knowledge and skill development, as well as the issue of equity in relation to students’ access to AI resources. Moreover, the study stresses a critical gap in institutional guidance regarding AI use, with students voicing a need for clear, consistent guidance from universities. This paper highlights the complex landscape of AI in academia, advocating for a balanced approach that harnesses AI's potential while addressing ethical, educational, and equity challenges. The study emphasises a need for immediate and more in-depth research into the use of AI in higher education from the perspective of both students and university staff in Ireland/UK.

Background: Artificial intelligence (AI) is transforming healthcare systems by improving operational efficiency, simplifying patient care procedures, and improving diagnostic accuracy. Artificial intelligence (AI) technologies, like machine learning and natural language processing, present previously unheard-of chances to quickly and accurately evaluate enormous volumes of healthcare data, assisting with clinical decision-making and enhancing patient outcomes. Aim thorough examination and analysis of artificial intelligence's impact on healthcare leadership, with a particular emphasis on present nursing trends and their implications for the future. The study tries to uncover the advantages, difficulties, and consequences of AI integration by looking at how AI technologies including clinical decision support systems, predictive analytics, robots, natural language processing, and telehealth are being used in nursing practice. Method: A comprehensive analysis including research articles published between 2015 and 2024 was carried out. To give a thorough overview of AI's present and future uses in healthcare, major themes and trends were found and summarized. Results: By stressing AI's role in improving diagnostic accuracy and patient outcomes, the study highlights the technology's major contributions to drug discovery, virtual patient care, and medical imaging. Human-centered design concerns, the necessity of educational changes, and ethical challenges surrounding the application of AI surfaced as crucial topics needing attention. Conclusion: AI has enormous potential to transform healthcare by enhancing operational effectiveness, optimizing the delivery of care, and increasing diagnostic precision. Still, ethical issues must be resolved, interdisciplinary cooperation must be promoted, and educational frameworks must be improved in order to provide healthcare workers with the necessary AI skills.

The integration of artificial intelligence (AI), including the recent appearance of revolutionary large language models (LLMs), marks a transformative era in the field of negotiations, reshaping traditional practices and presenting a range of opportunities and challenges. This article delves into the evolving interplay between negotiation and various AI technologies, as they now combine massive computational power with user-friendly interfaces capable of fluent, multi-topic conversations. The article categorizes AI's role in negotiation into assistance, semi-automation, and automation, each offering unique advantages and addressing different negotiation needs. While AI's ability to compensate for human limitations in rationality, emotion, and computational capacity is promising, it also raises concerns regarding biases, ethical considerations, and the reliability of automated decision-making. The burgeoning AI and negotiation collaboration necessitates a balanced approach, harnessing AI's potential to enhance negotiation outcomes while conscientiously navigating its challenges. This article aims to foster understanding of and influence the future trajectory of negotiation and AI, highlighting the need for ongoing research and development to ensure ethical, effective, and equitable negotiation practices in an AI-augmented future.