Assessment of a novel mass detection algorithm in mammograms

Breast cancer is the second most common type of cancer in the world. Several computer-aided detection and diagnosis systems have been used to assist health experts and to indicate suspect areas that would be difficult to perceive by the human eye; this approach has aided in the detection and diagnosis of cancer. The present work proposes a method for the automatic detection of masses in digital mammograms by using quality threshold (QT), a correlogram function, and the support vector machine (SVM). This methodology comprises the following steps: The first step is to perform preprocessing with a low-pass filter, which increases the scale of the contrast, and the next step is to use an enhancement to the wavelet transform with a linear function. After the preprocessing is segmentation using QT; then, we perform post-processing, which involves the selection of the best mass candidates. This step is performed by analyzing the shape descriptors through the SVM. For the stage that involves the extraction of texture features, we used Haralick descriptors and a correlogram function. In the classification stage, the SVM was again used for training, validation, and final test. The results were as follows: sensitivity 92.31 %, specificity 82.2 %, accuracy 83.53 %, mean rate of false positives per image 1.12, and area under the receiver operating characteristic (ROC) curve 0.8033. Breast cancer is notable for presenting the highest mortality rate in addition to one of the smallest survival rates after diagnosis. An early diagnosis means a considerable increase in the survival chance of the patients. The methodology proposed herein contributes to the early diagnosis and survival rate and, thus, proves to be a useful tool for specialists who attempt to anticipate the detection of masses.

For the purpose of accurate and efficient mass detection in full-field digital mammograms, weproposeamethodfor automated mass detection that consists oftwostages: suspicious region localization and false-positive (FP) reduction, by classifying these regions into mass and non-mass regions (normal tissues). In the first stage, the density of the wavelet coefficients based on Quincunx Lifting Scheme (DWC-QLS) is used to find suspicious regions (regions of interest, ROIs) in full mammograms. In the second stage, a patch-based CNN classifier is developed as an FP reduction to classify the suspicious regions. The main aim of this stage is to reduce the false-positive suspicious regions while keeping the true-positive suspicious regions. To further improve the performance of the FP reduction, the effectiveness of different transfer learning strategies is further explored and the best fine-tuning strategy in training InceptionV3 model is determined experimentally. The experimental results show that the proposed method can achieve an overall performance of 0.98 TPR @1.43 FPI on the INbreast database. In addition, the suggested segmentation method detects the mass location with 100% sensitivity and average of 5.4 false positives per image. Based on the obtained results,the introduced method was able to successfully detectand classify suspicious regions in digital mammograms and provide better TPR and FPI results in comparison with other state-of-the-art method.

The computer-aided detection (CAD) system plays a vital role in early cancer diagnosis and thus aids in reducing the mortality rate of breast cancer. In this study, a hierarchical template matching method is proposed to detect the breast mass in mammograms. First, three types of templates are designed and compared, and the sech template is selected to match the mass. Then, a hierarchical matching method, which makes full use of the high sensitivity of the local part-based template and the low false positive rate of the complete template, is used to detect the mass. At last, to eliminate some of flase positives, a set of rules are set based on various features. The performance of this proposed method is evaluated by 368 mammograms selected from the digital database of screening mammography. The sensitivity and the false positive rate are 96.2% and 5.2 per image, respectively. This preliminary study indicates that the proposed method is a promising strategy, and it has great potential in improving the accuracy of CAD systems in interpreting mammograms.

Computer-aided diagnosis (CAD) system is helpful for lesion detection. In this study, we proposed a new mass detection method with analysis of bilateral mammograms. First of all, the mass candidates were detected in single view. To utilize the information in dual view, we match corresponding regions in mediolateral oblique (MLO) and craniocaudally (CC) views of the breast. In this paper, we introduced twin support vector machines (TWSVM) as classifier for mass detection, and proposed a new method for feature selection called multiple twin support vector machines (MTWSVM-RFE) to improve the accuracy of detection.

Detection of suspicious masses in mammograms play a vital role in early diagnosis of breast cancer, to reduce the death rate among women. The presence of masses and calcification’s in mammograms is distinguishing signs for breast cancer diagnosis. But in some cases, due to contrast variation, fuzzy boundaries and presence of noise in mammograms, segmentation and detection of masses is challenging assignment. This paper presents a new segmentation approach to detect masses in mammographic images. The proposed approach consist of artifacts elimination and pectoral region extraction, suspicious mass enhancement using dual morphological operation technique and finally, extraction of Regions of Interest (ROIs) from background using scaled Reyni entropy. The proposed system has been tested on two data-sets i.e. mini- Mammographic Image Analysis Society (mini-MIAS) and Digital Database for Screening Mammography (DDSM), over 50 and 90 mammograms respectively. Performance achieved with proposed system in terms of True Positive Fraction (TPF) yields 93.2% and 93.9% respectively, at the rate of 1.48 and 0.74 average False Positive per Image (FP/I), tested on both Cranio-Caudal (CC) and Medio-Lateral Oblique (MLO) views. The obtained experimental results demonstrates that proposed method gives improved results for mass detection and can be useful for radiologists in diagnosis of breast cancer at early stage.

In medical image analysis, multi-view modeling is crucial for pathology detection when the target lesion is presented in different views, e.g. mass lesions in breasts. Currently mammogram is the most effective imaging modality for mass lesion detection of breast cancer at the early stage. The pathological information from the two paired views (i.e., medio-Iateral oblique and cranio-caudal) are highly relational and complementary, which is crucial for diagnosis in clinical practice. Existing mass detection methods do not consider learning synergistic features from the two relational views. For the first time, we propose a novel mass detection framework to capture the latent relation information from the two paired views of a same mass in mammogram. We evaluate our model on a public mammogram dataset and a large-scale private dataset, demonstrating that the proposed method outperforms existing feature fusion approaches and state-of-the-art mass detection methods. We further analyze the performance gains from the relation modeling. Our quantitative and qualitative results suggest that jointly learning cross- view features boosts the detection performance of existing models, which is a promising avenue for mass detection task in mammogram.

Background: Automatic detection and classification of breast masses in mammograms are still challenging tasks. Today, computer-aided diagnosis (CAD) systems are being developed to assist radiologists in interpreting mammograms. Objectives: This study aimed to provide a novel method for automatic segmentation and classification of masses in mammograms to help radiologists make an accurate diagnosis. Materials and Methods: For an efficient mass diagnosis in mammograms, we proposed an automatic scheme to perform both mass detection and classification. First, a combination of several image enhancement algorithms, including contrast-limited adaptive histogram equalization (CLAHE), guided imaging, and median filtering, was investigated to enhance the visual features of breast area and increase the accuracy of segmentation outcomes. Second, the density of discrete wavelet coefficient density (DDWCs), based on the quincunx lifting scheme (QLS), was proposed to find suspicious mass regions or regions of interest (ROIs). Finally, mass lesions that appeared in the mammogram were classified into four categories of benign, probably benign, malignant, and probably malignant, based on the morphological shape. The proposed method was evaluated among 1593 images from the Curated Breast Imaging Subset-Digital Database for Screening Mammography (CBIS-DDSM) dataset. Results: The experimental results revealed that the suspected region localization had 100% sensitivity, with a mean of 6.4 ± 4.5 false positive (FP) detections per image. Moreover, the results showed an overall accuracy of 85.9% and an area under the curve (AUC) of 0.901 for the mass classification algorithm. Conclusion: The present results showed the comparable performance of our proposed method to that of the state-of-the-art methods.

This paper presents an efficient technique for the detection of spiculated massesin the digitized mammogram to assist the attending radiologist in making his decisions. The presented technique consists of two stages, enhancement of spiculation masses followed by the segmentation process. Fuzzy Histogram Hyperbolization (FHH) algorithm is first used to improve the quality of the digitized mammogram images. The Fuzzy C-Mean (FCM) algorithm is then applied to the preprocessed image to initialize the segmentation. Four measures of quantifying enhancement have been developed in this work. Each measure is based on the statistical information obtained from the labelled region of interest and a border area surrounding it. The methodology is based on the assumption that target and background areas are accurately specified. We have tested the algorithms on digitized mammograms obtained from the Digital Databases for Mammographic Image Analysis Society (MIAS).KeywordsGrey ScaleDigital MammographyEnhancement TechniqueBackground AreaFuzzy EntropyThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Mammography is a gold standard imaging modality and is widely used for breast cancer screening. With recent advances in the field of deep learning, the use of deep convolution neural networks (CNNs) in medical image analysis has become very encouraging. The aim of this study is to exploit CNNs for mass detection in mammograms using pre-trained networks. We use the resnet-50 CNN architecture pre-trained with the ImageNet database to perform mass detection on two publicly available image datasets: CBIS-DDSM and INbreast. We demonstrate that the CNN model pretrained using natural image database (ImageNet) can be effectively finetuned to yield better results, compared to randomly initialized models. Further, the benefit of applying transfer learning on a smaller dataset is demonstrated by using the best model obtained from CBIS-DDSM training to finetune on the INbreast database. We analyzed the adaptability of the CNN’s last fully connected (FC) layer and the all convolutional layers to detect masses. The results showed a testing accuracy of 0.92 and an area under the receiver operating characteristic curve (AUC) of 0.98 for the model finetuned on all convolutional layers, while testing accuracy of 0.86 and AUC=0.93 when the model is trained only on the last FC layer.

In this paper, we present an efficient fractal method for detection and diagnosis of mass lesion in mammogram which is one of the abnormalities in mammographic images. We used 110 images that were carefully selected by a radiologist, and their abnormalities were also confirmed by biopsy. These images included circumscribed benign, ill-defined, and spiculated malignant masses. Firstly, we discriminated lesions automatically using new fractal dimensions. The results which were examined by different types of breast density showed that the proposed method was able to yield quite satisfactory detection results. Secondly, noting that contours of masses playing the most important role in diagnosis of different mass types, we defined new fractal features based on information extraction from the contours. This information is able to identify the roughness in mass contours and determines the extent of spiculation or smoothness of the masses. In this manner, in classification of the spiculated malignant masses from the circumscribed benign tumors, we achieved highly satisfactory results, i.e., 0.98 measured in terms of area under ROC curve (AUC). In this paper, it is also shown that the roughness in contours is a suitable characteristic feature for diagnosis of ill-defined malignant tumors with AUC equal to 0.94 in their classification. The extracted information was also found to be useful in the classification of early malignancies whereas in the classification of spiculated and ill-defined malignant masses in their early stage from those of benign tumors, we achieved high accuracy of 0.99 and 0.90 for AUC, respectively.

The screening of mammograms is a difficult task for the radiologist, due to variation in contrast and homogeneous structure of the masses and surrounding breast tissues. Therefore, an adaptive threshold-based contrast enhancement method is proposed in this paper for enhancement of suspicious masses in mammograms. Homomorphic filtering and wavelet-based denosing has been used prior to enhancement in the describe method. The approach contains, artefact suppression using pre-processing. Then wavelet transform is applied on the preprocessed mammogram, homomorphic filter is used to filter the approximate coefficient and wavelet shrinkage operator is applied on detail coefficients for denoising. Finally, contrast enhancement approach is used to enhance the suspicious region based on adaptive threshold technique. Two databases, namely Digital Database for Screening Mammography (DDSM) and Mammographic Image Analysis Society (MIAS), were used to test proposed method. The obtain results using proposed method gives better visibility for suspicious masses for all types of mammograms.

Breast cancer continues to be a significant public health problem in the world. Early detection is the key for improving breast cancer prognosis. Mammography has been one of the most reliable methods for early detection of breast carcinomas. However, it is difficult for radiologists to provide both accurate and uniform evaluation for the enormous mammograms generated in widespread screening. The main objective of this paper is to enhance, detect and classify masses in digital mammogram. We develop a performance based case-based reasoning classification algorithm for mammographic findings to provide support for the clinical decision to perform biopsy of the breast. The developed classifier will be used for training and testing the images which is cancerous and noncancerous and improve the performance of the system.

Simultaneous detection and classification of breast masses in digital mammograms via a deep learning YOLO-based CAD system

For the radiologists, it is difficult to identify the mass on a mammogram since the masses are surrounded by the mammary gland and blood vessel. In current breast cancer screening, about 10 by radiologists owing to the ambiguous margins of lesions and the visual fatigue of radiologists resulting from the long-time diagnosis. For these reasons, many computer-aided detection (CADe) systems have been developed to aid radiologists in detecting mammographic lesions that may indicate the presence of breast cancer. The purpose of this study is to construct an automated CADe system using a new feature extraction method for mammographic mass detection. In this system, some adaptive square regions of interest (ROIs) are segmented according to the size of suspicious areas. Then a new feature extraction method adopting grey level co-occurrence matrix and optical density features called GLCM-OD features is applied to each ROI. The GLCM-OD features describe local grey level texture characteristics and the whole photometric distribution of the ROI. Finally, the stepwise linear discriminant analysis is applied to classify abnormal regions by selecting and rating individual performance of each feature. This system is trained and tested by 358 mammographic cases from the digital database of screening mammography (DDSM). The proposed system averagely provides sensitivity of 97.3% with 4.9 false positives per image and the Az is 0.981. The results prove that the proposed system achieves satisfactory detection performance.Keywordscomputer-aided detection systemgrey level co-occurrence matrixoptical densityGLCM-OD features

Breast cancer is one of the most leading causes of cancer deaths among women. Early detection of cancer increases the survival rate of the affected women. Machine learning approaches that are used for classification of breast cancer usually takes a lot of processing time during the training process. This paper attempts to propose a Machine Learning approach for breast cancer detection in mammograms, which does not depend on the number of training samples. The paper aims to develop a core vector machine-based diagnosis system for breast cancer detection using the date from MIAS. The main motivation behind using this system is to reduce the computational and memory requirement for large training data and to improve the classification accuracy. The proposed method has four stages: 1) Pre-processing is done to extract the breast region using global thresholding and enhancement using histogram equalization; 2) identification of potential mass using Otsu thresholding; 3) feature extraction using Laws Texture energy measures; and 4) mass detection is done using Core vector machine (CVM) classifier. Comparative analysis was done with different existing algorithms: Artificial Neural Network (ANN), Support Vector Machine (SVM), and Fuzzy Support Vector Machines (FSVM). The results illustrate that the proposed Core Vector Machine (CVM) classifier produced a promising result in terms of sensitivity (96.9%), misclassification rate (0.0443) and accuracy (95.89%). The time taken for training process is 0.0443, which is less when compared with other machine learning algorithms. Performance analysis shows that CVM classifier is superior to other classifiers like ANN, SVM and FSVM. The computational time of the CVM classifier during the training process was also analysed and found to be better than other discussed algorithms. The results achieved show that CVM classifier is the best algorithm for breast mass detection in mammograms.