Associations between cerebellar development and autistic traits during adolescence: a population-based cohort study

The aim of this study was to identify phenotypes in mothers and fathers that are specifically associated with disturbances in reciprocal social interactions and communication in their young children with autism spectrum disorder (ASD) in a Japanese sample. Autistic traits in parents were evaluated using the Autism-spectrum Quotient (AQ), the Empathy Quotient (EQ) and the Systemizing Quotient (SQ) in 88 parents (44 mothers and corresponding fathers) of children with ASD and in 60 parents (30 mothers and corresponding fathers) of typically developing (TD) children. For the measurement of autistic traits in children, we employed the Social Responsiveness Scale (SRS). In two of the five AQ subscales (social skills and communication), the parents of ASD children scored significantly higher than did the parents of TD children, regardless of whether the parent was a mother or a father. In addition, in mothers of ASD children, there were significant positive correlations between two of the five AQ subscales (attention-switching and communication) and the SRS T-score in their children. This is the first study to demonstrate that the social skills and communication subscales in the AQ are more sensitive as autism traits in a Japanese sample and to demonstrate that some autistic traits in mothers are specifically associated with disturbances in the social ability of their young children with ASD, as measured by the SRS score. Further study is necessary to determine whether these results were caused by genetic or environmental factors.

Somatosensory abnormalities are commonly recognized as diagnostic criteria in autism spectrum disorder (ASD), and may also exist in individuals with autistic traits. The present research included two studies to explore the painful and non-painful sensation and their cognitive-neurological mechanisms of individuals with autistic traits. Study 1 included 358 participants to assess the relationship between autistic traits and pain/non-pain sensitivities using questionnaires: the Autism Spectrum Quotient (AQ), the Pain Sensitivity Questionnaire, and the Highly Sensitive Person Scale, respectively. Study 1 found that autistic traits were positively correlated with non-pain sensitivity, but not associated with pain sensitivity. Study 2 recruited 1,167 participants whose autistic traits were assessed using the AQ. Subsequently, thirty-three participants who scored within the top 10% and bottom 10% on the AQ were selected into High-AQ and Low-AQ groups, respectively, to explore the cognitive-neural responses of individuals with autistic traits to both painful and non-painful stimuli with event-related potential (ERP) technology. Results of Study 2 showed that the High-AQ group showed higher intensity ratings, more negative emotional reactions, and larger N1 amplitudes than the Low-AQ group to the non-painful stimuli, but no difference of response to the painful stimuli was found between High-AQ and Low-AQ groups. These findings suggest that individuals with autistic traits may experience enhanced non-painful sensation but intact painful sensation.

Background: subthreshold autistic traits can be found in students with normal cognitive abilities and may be associated with reduced empathy and impaired communication skills. The aim of this study was to assess the prevalence of subthreshold autistic traits in a sample of undergraduate medical students recruited from the Pavia University School of Medicine. We also determined the potential association between autistic traits and the students’ preferences on their future specialty choice. Methods: 135 undergraduate Italian medical students were asked to fill the Autism Spectrum Quotient (AQ), a short self-administered scale which measures autistic traits in individuals with normal cognitive abilities. Participants were divided into 7 groups according to their specialty. Intergroup differences were analyzed using one-way ANOVA and analysis of covariance (ANCOVA). Results: the sample showed low-to-mild autistic traits (mean AQ score 17.09±5.05, cut-off for high levels of autistic traits 32). There was a statistically significant difference (p=0.013) between surgery and psychiatry on the “Imagination” subscale of the AQ. Conclusions: to our knowledge, our study is the first to assess Italian students using the AQ. Our findings of a significant relation between AQ scores and the future choice of a particular medical specialty confirm that the professional attitudes may be interrelated with specific interpersonal skills as well as autistic traits.

This study aimed to assess the frequency of autistic traits in patients with migraine and to examine the effect of autistic traits on migraine-related disability, as well as anxiety and depressive symptoms, through the mediating factors of anxiety sensitivity and sensory sensitivity. Autism spectrum disorder (ASD) and migraine are two distinct clinical conditions marked by impaired sensory processing. Both conditions induce widespread alterations in the brain and exhibit symptoms associated with sensory sensitivity. Research examining the relationship between migraine and autistic traits is sparse. Moreover, the occurrence of autistic traits in patients with migraine and their effect on headache-related disability and psychiatric comorbidities has not been thoroughly investigated. This cross-sectional study included 169 patients with migraine and 112 healthy controls. Data collection for the study was conducted from November 2022 to May 2023. The Autism Spectrum Quotient (AQ), Hospital Anxiety and Depression Scale, Anxiety Sensitivity Index, and Dunn Adolescent/Adult Sensory Profile were given to participants. The Headache Impact Test-6 and the Visual Analogue Scale were used to evaluate quality of life and headache intensity for patients with migraine. Analyses examined how autism affects migraine-related disability, anxiety, and depressive symptoms through anxiety and sensory sensitivity. While 35% of patients with migraine were found to have autistic traits (AQ ≥ 23), this rate was found to be 17% in healthy controls. In the migraine group, autistic traits were positively correlated with sensory sensitivity, anxiety sensitivity, and depressive symptoms. Although autistic traits did not have a direct effect on headache-related disability and anxiety symptoms, indirect effects through anxiety sensitivity and sensory sensitivity were found to be significant (total indirect effect = 0.16, 95% confidence interval [CI] = [0.08, 0.25], total indirect effect = 0.24, 95% CI = [0.14, 0.33]). In addition, autistic traits had a direct effect on depressive symptoms. Indirect effects through anxiety sensitivity and sensory sensitivity were also significant (total indirect effect = 0.14, 95% CI = [0.08, 0.21]). This study shows that autistic traits are more frequent among patients with migraine and that these traits exhibit indirect effects on headache-related disability and psychiatric comorbidities. Recognizing autistic traits in patients with migraine may be crucial for formulating methods to mitigate comorbidities and enhance the quality of life in this population. Autism and migraine are two different conditions that affect the brain and sensory traits. We do not know much about how these two conditions affect each other, so we compared autism traits in people with migraine and healthy controls. We found that people with migraine are more likely to have autism traits, which can make migraine disability, anxiety, and depression worse; understanding and treating these traits could improve life quality for migraine patients.

Event Abstract Back to Event Autistic traits and adaptive coding of face identity Gillian Rhodes1*, Linda Jeffery1, Libby Taylor1 and Louise Ewing1 1 ARC Centre of Excellence in Cognition and its Disorders, School of Psychology, University of Western Australia, Australia Background Our ability to discriminate and recognize thousands of faces despite their similarity as visual patterns relies on adaptive, norm-based, coding mechanisms that are continuously updated by experience. Reduced adaptive coding of face identity has been proposed as a neurocognitive endophenotype for autism, because it is found in autism and in relatives of individuals with autism. Autistic traits can also extend continuously into the general population, raising the possibility that reduced adaptive coding of face identity may be more generally associated with autistic traits. In the present study, we investigated whether adaptive coding of face identity decreases as autistic traits increase in an undergraduate population. Methods Adaptive coding was measured using face identity aftereffects, and autistic traits were measured using the Autism-Spectrum Quotient (AQ) and its subscales. We also measured face and car recognition ability to determine whether autistic traits are selectively related to face recognition difficulties. Results We found that men who scored higher on levels of autistic traits related to social interaction had reduced adaptive coding of face identity. This result is consistent with the idea that atypical adaptive face-coding mechanisms are an endophenotype for autism. Autistic traits were also linked with face-selective recognition difficulties in men. However, there were some unexpected sex differences. In women, autistic traits were linked positively, rather than negatively, with adaptive coding of identity, and were unrelated to face-selective recognition difficulties. Discussion The sex differences observed here indicate that autistic traits can have different neurocognitive correlates in men and women and raise the intriguing possibility that endophenotypes of autism can differ in men and women. However, our results suggest that, at least for men, atypical adaptive coding of faces may be an endophenotype for autism. Acknowledgements This research was supported by the Australian Research Council Centre of Excellence in Cognition and its Disorders (CE110001021), an ARC Professorial Fellowship to Rhodes (DP0877379) and an ARC Discovery Outstanding Researcher Award to Rhodes (DP130102300). We thank Mayu Nishimura and Daphne Maurer for co-creating the Robbers Game used in the Identity Aftereffects task and Ainsley Read for assistance with testing. Ethical approval was granted by the Human Research Ethics Committee of the Univer Keywords: autistic traits, broader autism phenotype, face recognition, face identity aftereffects, adaptive coding, Endophenotypes Conference: ACNS-2013 Australasian Cognitive Neuroscience Society Conference, Clayton, Melbourne, Australia, 28 Nov - 1 Dec, 2013. Presentation Type: Oral Topic: Other Citation: Rhodes G, Jeffery L, Taylor L and Ewing L (2013). Autistic traits and adaptive coding of face identity. Conference Abstract: ACNS-2013 Australasian Cognitive Neuroscience Society Conference. doi: 10.3389/conf.fnhum.2013.212.00193 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 Oct 2013; Published Online: 25 Nov 2013. * Correspondence: Prof. Gillian Rhodes, ARC Centre of Excellence in Cognition and its Disorders, School of Psychology, University of Western Australia, perth, Australia, gillian.rhodes@uwa.edu.au Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Gillian Rhodes Linda Jeffery Libby Taylor Louise Ewing Google Gillian Rhodes Linda Jeffery Libby Taylor Louise Ewing Google Scholar Gillian Rhodes Linda Jeffery Libby Taylor Louise Ewing PubMed Gillian Rhodes Linda Jeffery Libby Taylor Louise Ewing Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

Since temperament affects the development of social behaviours and interpersonal relations, the possible links between autistic traits and temperament are of particular interest. The purpose of the study was to explore the relationships between autistic traits and temperamental characteristics in the framework of the Regulative Temperament Theory by Strelau, and the Emotionality, Activity and Sociability theory by Buss and Plomin, with particular emphasis on gender differences. The Autism Spectrum Quotient (AQ), Formal Characteristics of Behaviour – Temperament Inventory and Temperament Survey for Adults were administered. The participants were 593 university students, including 364 females and 229 males. Results showed positive correlations between autistic traits and Emotional Reactivity, Perseveration, Distress, Fear and Anger, and negative correlations with Activity, Briskness, Endurance and Sociability. The results of multiple regression analyses involving the Autism Spectrum Quotient score as a dependent measure were different for females and males. Results of exploratory PCA analysis showed that AQ score, Sociability and Activity loaded one factor (with AQ loading being opposite to two others). High AQ scorers demonstrated higher Emotional Reactivity, Perseveration, Distress and Anger, and lower Briskness, Endurance, Activity and Sociability as compared to norms for the general population. In this study we showed that temperament measures were able to identify items that correlated in parts with autistic traits, while other items were obverse. The relationships between temperament and autistic traits differ slightly between genders. We assume that with regard to the broader autism phenotype, temperaments might be helpful in characterizing healthy control samples.

IntroductionChildhood trauma (CT) and bullying have been shown to be associated with autistic traits (AT) and to mediate the relationship between AT and psychotic experiences (PEs). Understanding how different childhood adversity subtypes influence distinct domains of PEs can provide important insights for preventing PEs in individuals with high AT.ObjectivesThis study aimed to investigate the impacts of childhood adversity subtypes on the relationship between AT and PEs in a general population twin sample.MethodsWe analyzed data on 792 twins and siblings from the first wave of the TwinssCan Project, a longitudinal general population twin cohort. AT were measured using the Autism-Spectrum Quotient (AQ), and PEs using the Community Assessment of Psychic Experiences (CAPE) which consists of three subscales (positive, negative and depressive). CT subtypes were assessed using the Childhood Trauma Questionnaire (CTQ), evaluating emotional, physical, and sexual abuse, as well as emotional and physical neglect. Bullying was assessed using the Retrospective Bullying Questionnaire (RBQ). Multilevel linear regression analyses were conducted. Positive, negative, and depressive PEs were regarded as the dependent variables, interactions of CT subtypes and bullying with total AQ were regarded as independent variables in separate models. All models were adjusted for age and sex. Bonferroni correction (p<0.008) was applied for multiple comparisons.ResultsThe mean of the age of the participants was 17.5 ± 3.6 years and 60.2% of the sample was female. Emotional abuse (B = 0.12, 95% CI: 0.08 to 0.15), physical abuse (B = 0.15, 95% CI: 0.07 to 0.22), sexual abuse (B = 0.10, 95% CI: 0.03 to 0.16), emotional neglect (B = 0.05, 95% CI: 0.02 to 0.09) and physical neglect (B = 0.07, 95% CI: 0.03 to 0.11) significantly moderated the positive relationship between AT and positive PEs. However, only emotional abuse uniquely moderated the relationship between AT and both negative and depressive PEs (B = 0.09, 95% CI: 0.04 to 0.13; B = 0.09, 95% CI: 0.04 to 0.14) with physical neglect showing a trend toward significance for depressive PEs (B = 0.08, 95% CI: 0.02 to 0.13). Bullying did not moderate any domain of PEs.ConclusionsEmotional abuse may play a unique role in moderating the relationship between AT and PEs, affecting all domains of psychosis expression. Conversely, other forms of CT predominantly influence positive PEs. Further research is needed to clarify the distinct pathways through which distinct types of childhood adversity impact the association between AT and PEs.Disclosure of InterestM. Karaçam Doğan: None Declared, T. Prachason: None Declared, B. Lin: None Declared, L.-K. Pries: None Declared, A. Arias-Magnasco: None Declared, R. Bortoletto: None Declared, C. Menne-Lothmann: None Declared, J. Decoster: None Declared, R. van Winkel: None Declared, D. Collip: None Declared, P. Delespaul: None Declared, M. De Hert: None Declared, C. Derom: None Declared, E. Thiery: None Declared, N. Jacobs: None Declared, J. van Os: None Declared, B. Rutten: None Declared, N. Brondino : None Declared, M. Colizzi Consultant of: GW Pharma Limited, GW Pharma Italy SRL and F. Hoffmann-La Roche Limited, outside of this work. , L. Fusar-Poli: None Declared, S. Guloksuz: None Declared

Little is known about the relationship between autistic traits and addictive behaviors such as problem gambling. Thus, the present study examined clinical characteristics and multiple facets of cognition in young adults who gamble and have autistic traits. A total of 102 young adults who gamble were recruited from two Mid-Western university communities in the United States using media advertisements. Autistic traits were examined using the brief Autism-Spectrum Quotient (AQ-10). Clinician rating scales, questionnaires, and cognitive tests were completed. Relationships between AQ10 scores and demographic, gambling symptom, and neurocognitive measures were evaluated. Autistic traits were correlated with disordered gambling symptoms, attention-deficit/hyperactivity disorder (ADHD) symptoms, trait impulsivity, and some types of obsessive-compulsive symptoms. In regression, ADHD no longer significantly related to autistic traits once disordered gambling symptoms were accounted for; whereas the link between autistic traits and disordered gambling symptoms was robust even controlling for ADHD. These data suggest a particularly strong relationship between autistic traits and problem gambling symptoms, as well as certain aspects of impulsivity and compulsivity. The link between ADHD and autistic traits in some prior studies may have been attributable to disordered gambling symptoms, which was likely not screened for, and since individuals may endorse ADHD instruments due to other impulsive/compulsive symptom types (eg, gambling). The contribution of autistic traits to the emergence and chronicity of disordered gambling now requires further scrutiny, not only in community samples (such as this) but also in clinical settings.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that influences an individual's cognitive functions and social interaction. While most studies have focused on children and adolescents diagnosed with ASD, elevated levels of autistic traits in subclinical populations may also influence individuals' daily functioning. Autistic traits are also linked to the Big Five personality. In particular, neuroticism (emotion instability) has been shown to be positively associated with autistic traits, which may contribute to behavioral symptoms of autistic traits. The present study aimed to investigate the association between autistic symptoms and sensorimotor processing among a subclinical population. One hundred young adults (Mage = 20.32 years; SD = 3.69 years; 69 female) completed a choice reaction time (RT) task, and their behavioral performance was analyzed using the ex-Gaussian modeling. The Autism Quotient (AQ) and the Ten-Item Personality Inventory (TIPI) were used to assess autistic traits and neuroticism, respectively. The mediation analysis was conducted to examine the behavioral mechanism through which autistic traits influence sensorimotor processing. The results showed that the AQ score was negatively correlated with RT and positively correlated with neuroticism score. Importantly, the mediation analysis indicated an indirect effect, suggesting that neuroticism mediates the association between the AQ score and RT. The findings indicated a possible mechanism of the association between autistic traits and sensorimotor responses and suggested that neuroticism should be included as an intervention target for ASD. The present study contributes to the research on autistic traits and has practical implications for future intervention programs to improve daily functioning among individuals with ASD.

In recent years, referrals of youth to specialised gender services have risen sharply, with ~11% of these youth diagnosed as autistic compared with a general population rate of ~1%. In two preregistered studies, we addressed this insufficiently understood intersection. In Study 1, we examined the number and developmental trajectory of autism traits in autistic and nonautistic gender clinic-referred and cisgender youth (aged 7–16 years) using both screening measures (Autism-Spectrum Quotient Children’s Version and Autism-Spectrum Quotient Adolescent Version, Social Communication Questionnaire–Lifetime) and diagnostic tools (Autism Diagnostic Interview–Revised, Brief Observation of Symptoms of Autism). In Study 2, we examined autism traits among the caregivers of participants from each group using the Autism-Spectrum Quotient Adolescent Version. Study 1 results showed the autism phenotype in autistic gender clinic-referred youth closely resembled that of their cisgender autistic peers. In addition, after addressing methodological limitations in previous research, we found no evidence of elevated autism traits in nonautistic gender clinic-referred youth, challenging findings of some earlier studies. Study 2 provided evidence of familial aggregation of both autism traits and diagnoses among caregivers of both autistic gender clinic-referred and cisgender participants. Taken together, these findings challenge the hypothesis that autism in gender-diverse youth is merely a ‘phenomimic’ of autism and provide valuable clinical insights into the presentation of autism in this population.Lay abstractIn recent years, more young people have been referred to specialised gender clinics for support with their gender identity. Interestingly, about 11% of these young people are also diagnosed with autism–much higher than the general population rate of only around 1%. This overlap has raised important questions about how autism and gender diversity are related, and even whether autism traits in gender-diverse people with an autism diagnosis really reflect autism. In this research, we carried out two studies to understand this link better. In the first study, we looked at autism traits in gender-diverse children and adolescents aged 7–16 years who were referred to a gender clinic for issues with their gender identity. We compared them with both autistic and nonautistic children who were not referred to gender services. We used several standard tools to assess autism-related traits, including both questionnaires and clinical interviews. We found that gender-diverse youth who were also autistic showed similar patterns of autism traits as cisgender autistic children who were not exploring their gender. Importantly, nonautistic gender-diverse youth did not show unusually high levels of autism traits, which challenges some earlier studies that suggested they might. In the second study, we explored autism traits in the caregivers (mostly mothers) of the young people in our first study. We found that caregivers of autistic children–whether the children were gender-diverse or not–were more likely to be autistic than the caregivers of nonautistic children. Moreover, even nonautistic caregivers of autistic children displayed more autism traits than caregivers of nonautistic children, irrespective of whether their child was gender-diverse or not. Overall, our findings challenge the idea that autism in gender-diverse youth is just a mimic of ‘true’ autism caused by gender-related stress or experiences. Instead, the results point to genuine autism that presents in a typical way. This research provides important insights for clinicians and families, and highlights the need to take the gender-related concerns of autistic children as seriously as of nonautistic children.

The literature examining the co-occurrence of gender dysphoria (GD) and autistic traits has so far been limited to a series of small case studies and two systematic studies, one looking at autistic traits in gender dysphoric children and the other set within the context of the extreme male brain hypothesis and looking at adults. The current study examined this co-occurrence of GD and autistic traits in an adult population, to see whether this heightened prevalence persisted from childhood as well as to provide further comparison of MtF versus FtM transsexuals and homosexual versus nonhomosexual individuals. Using the Autistic Spectrum Quotient (AQ), 91 GD adults (63 male-to-female [MtF] and 28 female-to-male [FtM]) undertaking treatment at a gender clinic completed the AQ. The prevalence of autistic traits consistent with a clinical diagnosis for an autism spectrum disorder (ASD) was 5.5 % (n = 3 MtF and n = 2 FtM) compared to reports of clinical diagnoses of 0.5-2.0 % in the general population. In contrast to the single previous report in adults, there was no significant difference between MtF and FtM on AQ scores; however, all of those who scored above the clinical cut-off were classified as nonhomosexual with respect to natal sex. Results were considered in the context of emerging theories for the observed co-occurrence of GD and autistic traits.

Individuals with autistic traits are those who present in the normal population with characteristics of social, communication, personality, and cognitive impairments but do not meet the clinical threshold for autism spectrum disorder (ASD). Most studies have focused on the abnormalities in ASD patients rather than on individuals with autistic traits. In this study, we focused on the behaviors of a large sample (N = 401) of Chinese individuals with different levels of autistic traits, measured using the Autism Spectrum Quotient, and applied voxel-based morphometry (VBM) to determine their association to differences in brain structure. The results mainly showed that the correlation between gray matter volume (GMV) and gray matter density of the brain and the Autism Spectrum Quotient was significant in these regions: the right middle frontal gyrus, which are involved in social processing and social reasoning; the left parahippocampal gyrus, which is involved in socioemotional behaviors and unconscious relational memory encoding; and the right superior parietal lobule, which are involved in cognitive control and the ability to show attention to detail. These findings reveal that people with autistic traits in the normal population have atypical development in GMV and gray matter density, which may affect their social functioning and communication ability.

Anecdotal reports and empirical evidence suggest that sensory processing issues are a key feature of autism spectrum conditions. This study set out to investigate whether adults with autism spectrum conditions report more sensory over-responsivity than adults without autism spectrum conditions. Another goal of the study was to identify whether autistic traits in adults with and without autism spectrum conditions were associated with sensory over-responsivity. Adults with (n = 221) and without (n = 181) autism spectrum conditions participated in an online survey. The Autism Spectrum Quotient, the Raven Matrices and the Sensory Processing Scale were used to characterize the sample. Adults with autism spectrum conditions reported more sensory over-responsivity than control participants across various sensory domains (visual, auditory, tactile, olfactory, gustatory and proprioceptive). Sensory over-responsivity correlated positively with autistic traits (Autism Spectrum Quotient) at a significant level across groups and within groups. Adults with autism spectrum conditions experience sensory over-responsivity to daily sensory stimuli to a high degree. A positive relationship exists between sensory over-responsivity and autistic traits. Understanding sensory over-responsivity and ways of measuring it in adults with autism spectrum conditions has implications for research and clinical settings.

Individuals with autistic traits display impaired social interaction and communication in everyday life, but the underlying cognitive neural mechanisms remain very unclear and still remain controversial. The mind-blindness hypothesis suggests that social difficulties in individuals with autistic traits are caused by empathy impairment in individuals; however, the intense world theory suggests that these social difficulties are caused by sensory hyper-reactivity and sensory overload, rather than empathy impairment. To further test these two theories, this study investigated event-related potentials (ERPs) to explore the cognitive neural processing of repetitive expressions in individuals with autistic traits. This study employed the Mandarin version of the autism-spectrum quotient (AQ) to assess autistic traits in 2,502 healthy adults. Two subset groups were used, e.g., the participants of a high-AQ group were randomly selected among the 10% of individuals with the highest AQ scores; similarly, the participants in the low-AQ group were randomly selected from the 10% of participants with the lowest AQ scores. In an experiment, three different facial expressions (positive, neutral, or negative) of the same person were presented successively and pseudo-randomly in each trial. Participants needed to define the expression of the face that was presented last. The results showed that compared with the low-AQ group, the high-AQ group exhibited higher P1 amplitudes induced by the second and third presented expressions, as well as higher P3 amplitudes induced by the third presented negative expressions. This indicates that individuals with autistic traits may experience overly strong perception, attention, and cognitive evaluation to repetitive expressions, particularly negative expressions. This result supports the intense world theory more strongly than the mind-blindness hypothesis.

The relationships of spirituality with human social cognition, as exemplified in autism spectrum and schizophrenia spectrum cognitive variation, remain largely unstudied. We quantified non-clinical levels of autism spectrum and schizotypal spectrum traits (using the Autism Quotient and the Schizotypal Personality Questionnaire-Brief Revised) and dimensions of spirituality (using the Hardt Spirituality Questionnaire) in a large sample of undergraduate students. We tested in particular the hypothesis, based on the diametrical model of autism and psychosis, that autism should be negatively associated, and positive schizotypal traits should be positively associated, with spirituality. Our primary findings were threefold. First, in support of the diametric model, total Spirituality score was significantly negatively correlated with total Autism Quotient score, and significantly positively correlated with Positive Schizotypal traits (the Schizotypal Personality Cognitive-Perceptual subscale), as predicted. Second, these associations were driven mainly by opposite patterns regarding the Search for Meaning Spirituality subscale, which was the only subscale that was significantly negatively associated with autism, and significantly positively associated with Positive Schizotypal traits. Third, Belief in God was positively correlated with Positive Schizotypal traits, but was uncorrelated with autism traits. The opposite findings for Search for Meaning can be interpreted in the contexts of well-supported cognitive models for understanding autism in terms of weak central coherence, and understanding Positive Schizotypal traits in terms of enhanced salience.