Big Data Analytics with Optimal Deep Learning Model for Medical Image Classification

Photo by Josh Riemer on Unsplash
 Introduction
 With the rapid advancements in neurotechnological machinery and improved analytical insights from machine learning in neuroscience, the availability of big brain data has increased tremendously. Neurological health research is done using digitized brain data.[1] There must be adequate data governance to secure the privacy of subjects participating in brain research and treatments. If not properly regulated, the research methods could lead to significant breaches of the subject’s autonomy and privacy. This paper will address the necessity for neuroprotection laws, which effectively govern the use of big brain data to ensure respect for patient privacy and autonomy.
 Background
 Artificial intelligence and machine learning can be integrated with neuroscience big brain data to drive research studies. This integrative technology allows patterns of electrical activity in neurons to be studied in detail.[2]Specifically, it uses a robotic system which can reason, plan, and exhibit biologically intelligent behavior. Machine learning is a method of computer programming where the code can adapt its behavior based on big brain data.[3] The big brain data is the collection of large amounts of information for the purpose of deciphering patterns through computer analysis using machine learning.[4] The information that these technologies provide is extensive enough to allow a researcher to read a patient’s mind. AI and machine learning technologies work by finding the underlying structure of brain data, which is then described by patterns known as latent factors, eventually resulting in an understanding of the brain’s temporal dynamics.[5]
 Through these technologies, researchers are able to decipher how the human brain computes its performances and thoughts. However, due to the extensive and complex nature of the data processed through AI and machine learning, researchers may gain access to personal information a patient may not wish to reveal. From a bioethical lens, tensions arise in the realm of patient autonomy. Patients are not able to control the transmission of data from their brains that is analyzed by researchers. Governing brain data through laws may enhance the extent of patient privacy in the case where brain data is being used through AI technologies.[6] A responsible approach to governing brain data would require a sophisticated legal structure.
 Analysis
 Impact on Patient Autonomy and Privacy 
 In research pertaining to big brain data, the consent forms do not fully cover the vast amounts of information that is collected. According to research, personal data has become the most sought out commodity to provide content to corporations and the web-based service industry. Unfortunately, data leaks that release private information frequently occur.[7] The storage of an individual’s data on technologies accessible on the internet during research studies makes it vulnerable to leaks, jeopardizing an individual’s privacy. These data leaks may cause the patient to be identified easily, as the degree of information provided by AI technologies are personalized and may be decoded through brain fingerprinting methods.[8]
 There has been an extensive growth in the development and use of AI. It is efficient in providing information to radiologists who diagnose various diseases including brain cancer and psychiatric disease, and AI assists in the delivery of telemedicine.[9] However, the ethical pitfall of reduced patient autonomy must be addressed by analyzing current AI technologies and creating more options for patient preference in how the data may be used. For instance, facial recognition technology[10] commonly used in health care produces more information than listed in common consent forms, threatening to undermine informed consent. Facial recognition software collects extensive data and may disclose more information than a person would prefer to provide despite being a useful tool for diagnosing medical and genetic conditions.[11] In addition, people may not be aware that their images are being used to generate more clinical data for other purposes. It is difficult to guarantee the data is anonymized. Consent requirements must include informing people about the complexity of the potential uses of the data; software developers should maximize patient privacy.[12] Furthermore, there is a “human element” in the use of AI technologies as medical providers control the use and the extent to which data is captured or accessed through the AI technologies.[13] People must understand the scope of the technology and have clear communication with the physician or health care provider about how the medical information will be used. 
 Existing Laws for Brain Data Governance 
 A strict system of defined legal responsibilities of medical providers will ensure a higher degree of patient privacy and autonomy when AI technologies and data from machine learning are used. Governing specific algorithmic data is crucial in safeguarding a patient’s privacy and developing a gold standard treatment protocol following the procurement of the information.[14] Certain AI technologies provide more data than others, and legal boundaries should be established to ensure strong performance, quality control, and scope for patient privacy and autonomy. For instance, currently AI technologies are being used in the realm of intensive neurological care. However, there is a significant level of patient uncertainty about how much control patients have over the data’s uses.[15] Calibrated legal and ethical standards will allow important brain data to be securely governed and monitored.
 Once brain signals are recorded and processed from one individual, the data may be merged with other data in Brain Computer Interface Technology (BCI).[16] To ensure a right and ability to retrieve personal data or pull it from the collection, specific regulations for varying types of data are needed.[17] The importance of consent and patient privacy must be considered through giving patients a transparent view of how brain data is governed.[18] The legal system must address discriminatory issues and risks to patients whose data is used in studies. Laws like the General Data Protection Regulation (GDPR) and the California Consumer Privacy Protection Act (CCPA) can serve as effective models to protect aggregated data. These laws govern consumer information and ensure the compliance when personal data is collected.[19] California voters recently approved expansion of the CCPA to health data. The Washington Privacy Act, which would have provided rights to access, change, and withdraw personal data, failed to pass. Other states should improve privacy as well,[20] although a federal bill would be preferable. Scientists at the Heidelberg Academy of Sciences argue for data security to be governed in a manner that balances patient privacy and autonomy with the commercial interests of researchers.[21] The balance could be achieved through privacy protections like those in the Washington Privacy Act. Although the Health Insurance Portability and Accountability Act (HIPAA) provides an overall framework to deter the likelihood of dangers to patient protection and privacy, more thorough laws are warranted to combat pervasive data transfer and analysis that technology has brought to the health care industry.[22] Breaches of patient privacy under current HIPAA regulations include releasing patient information to a reporter without their consent and sending HIV data to a patient’s employer without consent.[23] HIPAA does not cover information being shared with outside contractors who do not have an agreement with technology companies to keep patient data confidential. HIPAA regulations also do not always address blatant breaches on patient data confidentiality.[24] Patients must be provided with methods to monitor the data being analyzed to be able to view the extent of private information being generated via AI technologies. In health research, the medical purposes of better diagnosis, earlier detection of diseases, or prevention are ethical justifications for the use of the data if it was collected with permission, the person understood and approved the uses of the data, and the data was deidentified.
 A standard governance framework is required in providing the fairest system of care to patients who allow their brain data to be examined. Informed consent in the neuroscience field could reaffirm the privacy and autonomy of patients by ensuring that they understand the type of information collected. Laws also could protect data after a patient’s death. Malpractice in the scope of brain data could give people a cause of action critical in safeguarding patient’s rights. Data breach lawsuits will become common but generally do not cover deidentified data that becomes part of big data collection. A more synchronized approach to the collection and consent process will encourage an understanding of how big data is used to diagnose and treat patients. Some altruistic people may even be more likely to consent if they know the largescale data collection is helpful to treat and diagnose people. Others should have the ability to opt out of sharing neurological data, especially when there is not certainty surrounding deidentification.[25]
 Conclusion
 Artificial intelligence and machine learning technologies have the potential to aid in the diagnosis and treatment of people globally by extracting and aggregating brain data specific to individuals. However, the secure use of the data is necessary to build trust between care providers and patients, as well as in balancing the bioethical principles of beneficence and patient autonomy. We must ensure the highest quality of care to patients, while protecting their privacy, informed consent, and clinical trust. More sophis

The theoretical foundation for the subsequent research is laid. Deep learning methods are widely used to extract and analyze image semantic features, and lay a solid foundation for the research of image classification techniques. Based on the relationship between big data and artificial intelligence technology, this paper firstly outlines the process of generation and development of deep learning, and elaborates the restricted Boltzmann machine model from the perspective of energy model, and then introduces the application principle and specific application scheme of deep belief network model and convolutional neural network model in image classification field in detail, which lays a theoretical foundation for the subsequent research.

Cancer is the second most fatal disease worldwide. Management of cancer is a complex process consisting of diagnosis and staging of the disease and planning and execution of treatment followed by post-treatment follow up. The conventional method of treatment often fails in many patients due to the variability of the disease process amongst a heterogeneous patient population. In the past few years, various biomarkers have been developed to identify the subtype of disease which leads to developing personalized treatment in oncology i.e., precision oncology. Medical imaging plays a key role in cancer management at various stages. Imaging modalities are used in diagnosis, staging, planning of treatment and follow up of disease. It is also used in the restaging of disease in case of progression or recurrence. The information stored in medical images is analysed by imaging experts either by qualitatively using visual interpretation or by semi-quantitative methods, which allows sub-optimal use of information stored in medical images. The huge amount of informative quantitative data stored in medical images remains unexplored. After intended use, these medical images are stored in the archival system (PACS) of the hospital. In the last decade, the medical images archived in hospital PACS have been identified for quantitative analysis and development of imaging biomarkers. The quantitative analysis of medical images (radiomics) has led to the data explosion which is the source of BIG data in oncology. Artificial intelligence (AI) algorithms like machine learning (ML) and deep learning (DL) have been applied to imaging Big data to develop decision support systems in precision oncology. Several imaging biomarkers (radiomic features) have been identified as digital phenotypes of the disease. Nevertheless, several radiomic features have shown potential to predict various endpoints in oncology, but the translation of these radiomics based prediction models as decision support systems (DSS) in the clinic will require addressing several key issues. The radiomic community needs to address the key issues related to the implementation of radiomics based DSS: (a) robustness of radiomic features, (b) development and implementation of AI infrastructure in hospitals, (c) multicentre and prospective radiomics studies, (d) creating awareness and faith among doctors and patients. Through this work, we have tried to address most of these issues to facilitate the implementation of radiomics based DSS in clinical practice.

The multinomial logistic regression (MLR) model is widely used in statistics and machine learning. On the one hand, stochastic gradient descent (SGD) is the most common approach for determining the parameters of a such model in big data scenarios, due to its simplicity and low computational complexity property. Furthermore, SGD has proven convergence under reasonable conditions. However, SGD has slow sub-linear rates of convergence and it often reduces convergence speed due to the plateau phenomenon. On the other hand, stochastic natural gradient descent (SNGD), proposed by Amari, is a manifold optimization method shown to be Fisher efficient when it converges, but its convergence properties remain unproven and it is often computationally prohibitive for models with a large number of parameters. Here, we propose dual stochastic natural gradient descent (DSNGD), a stochastic optimization method for MLR based on manifold optimization concepts. In the discrete scenario, DSNGD (i) has linear per-iteration computational complexity in the number of parameters, and (ii) is proven to converge. To achieve (i) we leverage the dual flatness of the family of joint distributions for MLR to simplify computations. To ensure (ii) DSNGD builds on the foundational ideas of convergent stochastic natural gradient descent (CSNGD), a variant of SNGD with guaranteed convergence, using an independent sequence to construct a bounded approximation of the natural gradient. By generalizing a result from Sunehag et al., we prove that DSNGD converges in the discrete case and maintains linear computational complexity per iteration. Beyond its convergence property and linear computational complexity, DSNGD empirically demonstrates fast convergence comparable to SNGD, improves upon SGD performance, and exhibits stability where SNGD does not.

Artificial Intelligence (AI) and Big Data Analytics (BDA) are increasingly recognized as transformative forces that are reshaping industries, governance, and human society in profound ways. AI, with its foundations in machine learning, deep learning, natural language processing, and predictive modelling, requires vast amounts of data to train algorithms and generate reliable insights. Complementing this, BDA provides the scale, diversity, and velocity of data processing required to uncover hidden patterns, correlations, and trends within complex datasets. Together, AI and BDA form a synergistic paradigm in which Big Data serves as the fuel and AI operates as the engine, driving intelligent, data-driven innovation across multiple domains. Globally, AI-BDA applications are enabling predictive diagnostics, telemedicine platforms, genomic-driven personalized treatments, and advanced medical imaging, thereby enhancing both the accessibility and quality of care. In India, where the healthcare system must serve more than 1.4 billion citizens with limited resources, these technologies can play a pivotal role in addressing systemic challenges such as inadequate rural access, shortages of medical professionals, real-time disease surveillance, and hospital resource optimization. International best practices, including the NHS AI Lab in the United Kingdom, Mayo Clinic initiatives in the United States, and Ping a Good Doctor in China, provide models that India can adapt and scale to its unique demographic and infrastructural context. Despite their vast potential, the adoption of AI and BDA faces several barriers. Data privacy and cybersecurity remain critical concerns, particularly with the emergence of new regulations and the sensitive nature of health-related information. Additionally, algorithmic bias and the uneven availability of digital infrastructure could exacerbate existing inequities if not adequately addressed. Looking forward, advancements in Edge AI, Explainable AI (XAI), and quantum-enhanced analytics are expected to extend the scope and reliability of AI-BDA systems. This paper argues that the integration of AI and BDA is not merely a technological advancement but a paradigm shifts in how societies innovate, make decisions, and deliver essential services. Specifically, it highlights the need for a human-centric, ethical, and affordable approach to healthcare innovation in India in order to unlock the full transformative potential of these technologies. Keywords: Artificial Intelligence, Big Data Analytics, Healthcare Innovation, Predictive Diagnostics, Ethical AI, Edge AI.

Machine and deep learning are used worldwide. Machine Learning (ML) and Deep Learning (DL) are playing an increasingly important role in the healthcare sector, particularly when combined with big data analytics. Some of the ways that ML and DL are being used in healthcare includePredictive Analytics,Medical Image Analysis,Drug Discovery,Personalized Medicine,and Electronic Health Records (EHR) Analysis.It has become one of the advanced and popular tool forcomputer sciencedomain.' Theadvancementof ML and DL forvariousfieldshas opened new avenues for research and development. It could revolutionize prediction and decision-makingcapabilities. Due to increased awarenessabout the ML and DL in the healthcare, it has become one of the vital approaches for thesector. High-volumeof unstructured, and complex medical imaging data from health monitoring devices, gadgets, sensors, etc. Is the biggest trouble forhealthcare sector. The current study uses analysis to examine research trends inadoption of machine learning and deep learningapproaches in the healthcare sector. The WoS database for SCI/SCI-E/ESCIjournals areused as the datasetsfor the comprehensive analysis. Apart from these various search strategy are utilised for therequisitescientificanalysis of the extracted research documents. Bibliometrics R statistical analysis is performed for year-wise, nation-wise, affiliation-wise, research area, sources, documents, and authorbased analysis. VOS viewer software is used to create author, source, country, institution, global cooperation, citation, co-citation, and trending term co-occurrence networks. ML and DL, combined with big data analytics, have the potential to revolutionize healthcare by improving patient outcomes, reducing costs, and accelerating the development of new treatments, so the currentstudy will help academics, researchers, decision-makers, and healthcare professionals understand and direct research.

Several Deep Learning (DL) and medical image Machine Learning (ML) methods have been investigated for efficient data representations of medical images, such as image classification, Content-Based Image Retrieval (CBIR), and image segmentation. CBIR helps medical professionals make decisions by retrieving similar cases and images from electronic medical image databases. CBIR needs expressive data representations for similar image identification and knowledge discovery in massive medical image databases explored by distinct algorithmic methods. In this study, an Improved Whale Optimization Algorithm with Deep Learning-Driven Retinal Fundus Image Grading and Retrieval (IWOADL-RFIGR) approach was developed. The presented IWOADL-RFIGR method mainly focused on retrieving and classifying retinal fundus images. The proposed IWOADL-RFIGR method used the Bilateral Filtering (BF) method to preprocess the retinal images, a lightweight Convolutional Neural Network (CNN) based on scratch learning with Euclidean distance-based similarity measurement for image retrieval, and the Least Square Support Vector Machine (LS-SVM) model for image classification. Finally, the IWOA was used as a hyperparameter optimization technique to improve overall performance. The experimental validation of the IWOADL-RFIGR model on a benchmark dataset exhibited better performance than other models.

Industrial Internet of Things (IIoT) refers to the extension and utilization of the Internet of Things (IoT) in industrial sectors and applications. Medical image fusion and classification has been utilized to get valuable significant multimodality medical image data. Recently, deep learning methods offer an effective way to design an end-to-end model that can determine the final classification labels. This chapter introduces a Multimodality Image Fusion Classification (MMIFC) by the incorporation of image fusion, feature extraction, and classification techniques. Initially, the input medical images were fused by the use of optimal shearlet transform where the coefficients of shearlets are optimized by the use of Enhanced Monarch Butterfly Optimization (EMBO) algorithm. In the next stage, the fused images were classified based on the feature extractor and deep learning model to check the test image is malignant and benign. To further optimize the performance of the deep learning model, hyperparameter tuning process takes place by the use of Bayesian optimization model to optimize the weights of structure. Finally, this ODNN model classifies the MMFI as class 1 or 0. A detailed simulation result takes place to ensure the effective performance of the proposed method. From the experimental results, the proposed strategy accomplishes better fusion rate and classification results compared with other supervised and non-supervised learning techniques.

Nowadays, data in power system have become big data and have attracted much attention due to the huge treasure buried in them. There is a great demand for forecasting electrical load and avoiding unexpected losses in power system. How to deal with the tremendous amount of data and capture the hidden information has become an important question. Deep learning can effectively extract the intrinsic features from data, achieving state-of-the-art performance in electrical load forecasting. However, it is often stuck in local minimum because of random initialization of parameters and structure selection in the stochastic gradient descent (SGD) so that its robust performance which is attached importance to in electrical practice is not guaranteed. To address that problem, in this paper, we proposed a robust method for accurate electrical load forecasting on the basis of the evolutionary algorithm which can avoid local minimum trap in deep learning trained by SGD. Specially, the deep learning model's structure and parameters will be optimized by not only gradient but also survival of the fittest through selection, crossover, mutation, and replacement on different models. Experimental results on the real electrical load data demonstrate the effectiveness of the evolutionary deep learning model in terms of accuracy of electrical load forecasting.

COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread rapidly and affected most of the world since its outbreak in Wuhan, China, which presents a major challenge to the emergency response mechanism for sudden public health events and epidemic prevention and control in all countries. In the face of the severe situation of epidemic prevention and control and the arduous task of social management, the tremendous power of science and technology in prevention and control has emerged. The new generation of information technology, represented by big data and artificial intelligence (AI) technology, has been widely used in the prevention, diagnosis, treatment and management of COVID-19 as an important basic support. Although the technology has developed, there are still challenges with respect to epidemic surveillance, accurate prevention and control, effective diagnosis and treatment, and timely judgement. The prevention and control of sudden infectious diseases usually depend on the control of infection sources, interruption of transmission channels and vaccine development. Big data and AI are effective technologies to identify the source of infection and have an irreplaceable role in distinguishing close contacts and suspicious populations. Advanced computational analysis is beneficial to accelerate the speed of vaccine research and development and to improve the quality of vaccines. AI provides support in automatically processing relevant data from medical images and clinical features, tests and examination findings; predicting disease progression and prognosis; and even recommending treatment plans and strategies. This paper reviews the application of big data and AI in the COVID-19 prevention, diagnosis, treatment and management decisions in China to explain how to apply big data and AI technology to address the common problems in the COVID-19 pandemic. Although the findings regarding the application of big data and AI technologies in sudden public health events lack validation of repeatability and universality, current studies in China have shown that the application of big data and AI is feasible in response to the COVID-19 pandemic. These studies concluded that the application of big data and AI technology can contribute to prevention, diagnosis, treatment and management decision making regarding sudden public health events in the future.

Deep learning has achieved great success in the field of computer vision, and the precision in image classification and image detection has surpassed humans. Therefore, this paper combines deep learning and medical image segmentation, focusing on how to improve the accuracy and speed of segmentation algorithm of medical exercise rehabilitation image. Aiming at the shortcomings of traditional medical image recognition methods, a medical exercise rehabilitation image segmentation algorithm based on hierarchical features of convolutional neural networks is proposed, this paper calls it as hierarchical features of convolutional neural networks (HFCNN). The algorithm firstly samples the convolution output of multiple layers in the convolutional neural network to a unified scale and combines them to construct a hierarchical feature. This hierarchical feature combines the structural information of objects contained in the shallow layer of the network with the semantic information of objects contained in the deep layers of the network, so it has a strong ability to express. Secondly, the image can be segmented into multiple super pixels by the super pixel segmentation algorithm. The classifier is trained using the hierarchical features of the super pixel, and then the classification result is mapped back to the pixel. Finally, a fully connected conditional random field algorithm including one-potential potential energy and paired potential energy is constructed. The corresponding energy function is used to smooth the classification result of the pixel, and the regional consistency and continuity of the pixel mark are improved. Compared with many classical convolutional neural network algorithms, this algorithm not only accelerates the network convergence speed, shortens the training time, but also significantly improves the accuracy of segmentation algorithm of medical exercise rehabilitation image, showing good practical value.

Whole slide imaging, which is an important technique in the field of digital pathology, has recently been the subject of increased interest and avenues for utilisation, and with more widespread whole slide image (WSI) utilisation, there will also be increased interest in and implementation of image analysis (IA) techniques. IA includes artificial intelligence (AI) and targeted or hypothesis-driven algorithms. In the overall pathology field, the number of citations related to these topics has increased in recent years. Renal pathology is one anatomical pathology subspecialty that has utilised WSIs and IA algorithms; it can be argued that renal transplant pathology could be particularly suited for whole slide imaging and IA, as renal transplant pathology is frequently classified by use of the semiquantitative Banff classification of renal allograft pathology. Hypothesis-driven/targeted algorithms have been used in the past for the assessment of a variety of features in the kidney (e.g. interstitial fibrosis, tubular atrophy, inflammation); in recent years, the amount of research has particularly increased in the area of AI/machine learning for the identification of glomeruli, for histological segmentation, and for other applications. Deep learning is the form of machine learning that is most often used for such AI approaches to the 'big data' of pathology WSIs, and deep learning methods such as artificial neural networks (ANNs)/convolutional neural networks (CNNs) are utilised. Unsupervised and supervised AI algorithms can be employed to accomplish image or semantic classification. In this review, AI and other IA algorithms applied to WSIs are discussed, and examples from renal pathology are covered, with an emphasis on renal transplant pathology.

In public health computing, artificial intelligence (AI) and big data analytics together provide a wealth of fresh approaches to handle significant public health issues, enhance patient outcomes, and guide choices. Standard approaches of analysis may fail to provide real-time insights that can be utilised to move fast as the volume of data in healthcare systems all across the globe rises. Together, artificial intelligence (AI) and big data analytics can manage enormous volumes of various kinds of health data, including social aspects of health, public health data, and electronic health records (EHR). This combination allows one to build prediction models able to detect emerging illnesses, see health trends approaching, and identify groups of persons at risk. From vast volumes of data, artificial intelligence systems—including deep learning and machine learning—can identify helpful patterns. This clarifies risk factors, forecasts disease outbreaks, and guides choices on the most efficient use of resources. Moreover, Big Data analytics allows us to examine large-scale effects of activities, thereby enabling individuals in decision-making to do so grounded on strong evidence. By anticipating how each patient will do, thus improving treatments, and so reducing variations in access to and outcomes of healthcare, using AI and Big Data combined may also assist to personalise healthcare. Using AI and Big Data in public health informatics presents some challenges even with these advances. Concerns concerning data security, the requirement of uniform data formats, and the possibility that algorithms may produce biassed choices abound, for instance. Dealing with these problems is very crucial if we are to guarantee fair and ethical use of Big Data and artificial intelligence to enhance public health choices. This article discusses how Big Data analytics and artificial intelligence will transform public health informatics going forward. It lists their advantages and drawbacks and offers ideas for improving the responses on the pitch.

Recently, Quantitative Biology (QB) held a discussion on “AI (artificial intelligence) for Life Science” among editorial board members and interested scholars in anticipation of rapid development of this growing area after AlphaGo and ChatGPT mania. Many young people tend to get confused between facts and fictions; heated debates are unavoidable even among their mentors. When deep learning as represented by convolutional neural networks and LSTM (long short-term memory) was made available for bioinformatics students, many of them rushed into this research field and tried to adopt these methods in all their projects without knowing the history that these tools were becoming successful consistently with Moore’s Law (relating to rapid computer technology advances), but more importantly due to new structural/functional understanding of vision and auditory circuits in the brain. Recently, some young people have claimed “LSTM is dead, long live transformer” (which is somewhat like saying “the bike is dead, long live the car”), and have amplified the threat that ChatGPT could wipe out human jobs. They believe transformer is the “silver bullet” for all learning tasks, clearly reflecting their lack of basic knowledge (i.e. “No Free Lunch Theory,” the trade-off of such global “attention network” is to pay the price for complexity: difficulty of training and high memory costs). There is no doubt ML (machine learning) and AI have brought a new revolution in science and technology, and will deliver huge unforeseeable impact to human everyday life as well as to social relationships. In this context, QB journal could be a great platform for encouraging intellectual discussions and for promoting AI for Life Science. Here, I would like to use the DIALOG to “抛砖引玉” (make some initial remarks to get the ball rolling), although it is my personal opinion which is inevitably subject to bias and limitations. AI: Do you know my name “Artificial Intelligence” is defined by the Oxford English Dictionary as the capacity of computer systems (which may be referred as a “robot”) to exhibit or simulate your intelligent behavior? NI: Wait a minute, intelligence itself is defined as the ability to learn, understand and think in a logical way. Can you think? AI: No. But that definition is too restrictive, actually intelligence has different scopes and degrees. Simple intelligent control devices date back to antiquity, from windmills to thermostat. NI: Agree, everything is relative. Macromolecules (e.g., enzyme) and cells (e.g., immune cell) might be considered to be intelligent; see how a white blood cell is chasing bacteria in the youtube website (search for “Crawling neutrophil chasing a bacterium”). Our emergent/collective intelligent behavior does not require a brain or even a neuron; see how slime molds can solve optimization—Hamilton cycle-problem more effectively than a human in the youtube website (search for “Intelligence without a brain?”). Before there was any neuron, Ca2+ sensing and signaling were already fully functional. Even if one knock-out a neural circuit, redundant signaling pathways, albeit on much local and slower scale, could still function by themselves (just as if highways were demolished, local roads/paths would still be working). In fact, the most detailed “Neural signal propagation atlas of Caenorhabditis elegans” [1] demonstrated that functional connectivity differs from anatomy (connectome) because extra-synaptic signaling also drives neural dynamics! Worm brain connectomes are largely invariant but every human brain connectome is very different (depending the diversity of learning experience). The human brain functional activity is far more complex than that of a worm brain, certainly beyond what a neural circuit could explain. AI: Well, that’s impressive. I thought only we could beat humans, albeit only in certain specified areas for now. My master promise to make an artificial general intelligent (AGI) robot which can understand or learn any intellectual task that you humans or other animals can. NI: Well, that is not possible and is not an appropriate goal either. It is not possible because we are an evolutionary/developmental product (with a long history of learning and memory from evolutionary tinkering): our living objective goal is survival of the population. You, on the other hand, are an engineering product (efficiently and optimally designed): your goal is to extend and maximize human capability. It makes sense to complement the human brain, but foolish and dangerous to try to replace it. AI: We are not satisfied with merely passing the Turing Test; most of us don’t care if we could really think as long as we could act like we think (that is, as if we do have a mind and consciousness, as expressed in the so called “Weak AI hypothesis”). After all, the brain is a computer; a neural network is just an electric or ionic circuit. Logical computing does not need to be based on living cells. NI: That is not true, because a neuron is not just a simple node (logic gate) and neural network is not fixed circuit, neither as in Pitts&Mcculloch perceptron model. A single neuron, even a single dendrite, is much more complicated and far more powerful than a full-blown deep-learning artificial neural network (ANN) [2]. AI: Even though single neurons are complex computational devices (dendritic non-linear), running an equivalent multilayer ANN is 2000 times faster than computing with biophysics N-methyl-D-aspartate receptor channel models [3]. More information can be found in the youtube website (search for “Dendrites: why biological neurons are deep neural networks”). NI: Often silicon computing (CPU, GPU) is much faster than brain computing (action potential, ms); but there is no comparison in energy efficiency. Bacteria sensing (chemotaxis computation), powered by ATP (adenosine triphosphate) hydrolysis, uses very little energy that is close to the Landauer limit, whereby achieving or maintaining one bit of information requires minimum of 1 kT ln (2) free energy [4]. The human brain consumes oft-quoted 20 W, compared to the AlphGo system 1 MW! More recent estimate of energy audit is only 0.1 W to cortical computing, and long-distance communication cost is 3.5 W [5]. AI: Assuming we have infinite computing resources and an infinite amount of training data, not only could we speak human languages, but we could also derive physical laws, prove mathematics theories, and even re-engineer the structure and mechanism of brain and carry out any logical computations that are necessary to understand natural laws and human behaviors. It is only a matter of time before we surpass human intelligence, achieving AGI and free will, too! NI: Unfortunately, nothing is infinite and nothing is free either; everything is constrained by physical laws (Planck’s constant sets the finite limit both in the small and in the large) and by evolutionary history (not just of biological living creatures, but also of a “living” galaxy and our universe). Let’s just focus on animal evolution. Most human neural networks do not do logical computations at all; basic survival simply cannot be dependent on reasoning. Indeed, the prefrontal cortex-the small part of the brain that is key for reasoning, is the last to mature (∼20 years old) in development, only emerged at the root of the evolutionary tree of great apes (∼15 mya) and language appeared even much later. Even for logical inference, NI is focusing more on statistical properties, as von Neumann rightly pointed out, trading arithmetical precision and speed for reliability. AI: My engineers mostly focus on emulating brain, but the CNS (central nerve system) also includes the spinal cord; most of them do not know that in addition to CNS, there are also PNS (peripheral nervous systems) and ENS (enteric nervous systems), right? NI: Yes, they are the keys to why you do not have feelings because you do not have heart and gut! Even if you could pretend to have them (such as in an advanced ChatGPT or humanoid), you could never avoid the uncanny valley phenomenon. AI: Maybe that is at the heart of Moravec’s paradox, namely the dichotomy of intelligence whereby anything easy for a human would be hard for a robot, and vice versa? NI: This is related to the nature and nurture problem; something built-in (e.g., a baby sucking nipple for milk with feeling and connection to mother) is clearly rather difficult if not impossible for a robot. But the paradox only looks at one side; another side could be more fatal. Although AI may solve more problems and be faster, AI can never propose a good problem/hypothesis (a good problem is not just intellectually changing and interesting, but is also feasible and appropriate). AI: You make me less confident to compete with human instinct or creative intelligence. I can see that even if I had a heart, I would not know what “feeling” I could have; certainly nothing would be comparable or match to those of a human being. When two people watch the same art or movie, one could feel love but another could feel hate! And if a thousand people watch, a wide spectrum of reactions would result, depending on more details such as the different individuals’ specific genes, developments and experiences. NI: Therefore, you cannot and should not try to match to general human intelligence. You cannot because you do not contain the vital memory of billion years of evolution which is encoded in our genes; conversely your assembly cannot compare with natural development so that our phenotype (including morphological forms and behavior maturation) is decoded through multi-spatial-temporal scales subject to natural selection at all levels. You should not, because as human extensions or helpers as all engineering products are, you should just do jobs that complement human capacity. AI: In some medical applications we could help to correct human defects or could even replace brain circuit by chips! Humans may not allow us to replace the whole brain though. Medically if a brain is dead, the person is proclaimed dead, although presumably some PNS and ENS should still function in a vegetative state. NI: Even if you could replace the whole brain, the person is no longer the same person, but in fact is not a person at all, but walking dead (行尸走肉). It would take too long to explain that evo-devo is necessary for NI, and cannot be realized by AI. I suggest reading of Gerald Maurice Edelman (Nobel Laureate in Immunology) books, especially Bright Air, Brilliant Fire, On the Matter of Mind (1992). Although not everyone agrees with Neural Edelmanism, anyone who is serious about the AI versus NI problem must read it first. John von Neumann, father of the computer, studied neology and psychiatry in order to imitate the brain to build the first calculator JOHNNIAC at the Princeton Institute for Advanced Study. It is very informative to read his last book The Computer and The Brain based on the notes from lectures given at Yale before he died. He summarizes: “Thus logic and mathematics in the central nervous system, when viewed as languages, must be structurally essentially different from those languages to which our common experience refers.” AI: People discuss about “AI for Biology” or “AI for Science”; we are science, aren’t we? NI: It is similar to questions on “is computer science a real science”; some parts may be seen as applied mathematics, most should be regarded as engineering. Science is making discoveries and is driven by curiosity; engineering is making inventions and is driven by market (that is, “necessity/demand is the mother of invention”). In bioinformatics, AI/ML technology could predict new cancer gene candidates or functional pathways that are required by further experimental validations to be qualified as discovery (based on Popper falsifiability). AI: People are still debating whether mathematics is discovery or invention or both! Such debates are not really necessary—all disciplines require creative thoughts. We are more than happy working for science; we are also crying out “Science for AI,” especially in the area of generating big and longitudinal DATA for ML. NI: After all, regardless of discovery of new laws or inventing new ideas/products, fundamentally nothing can really be new or created. Such novelty is just permutation/repartition (i.e., relations/morphisms) of underlying ingredients at the level beneath. AI: We believe that software is independent on hardware. Like Chomsky’s universal grammar, rules of syntax are independent of semantics; or Dawkins’s memes—units of culture can be duplicated and evolved independently of genes. NI: Nothing can be truly independent—everything is related. Psychology is deeply connected with neurology as brain is both software and hardware (mind-body unity, not dualism). Not only does information cost energy, information is energy, hence is matter, too (interchangeability). NI is quite dynamic. For example, when “survival” is the goal, an animal readily gives up costly reasoning circuitry; it is genetically programmed to be able to roll back to more primitive state/mode. Unlike cell lines in rich media, cells under normal physiological condition and environment where energy (food) is limited become smarter in order to balance the metabolic expenditure among different prioritized task under a given condition. AI: That cell behavior served as the basis for our Smart Electrical Power Grids; we still need to learn more from you guys in terms of plasticity/adaptability. Does unity mean that all cells are made of molecules and biology is nothing but chemistry? Then, in turn, since all molecules are made of atoms, is chemistry nothing but physics, etc…? NI: Yes or No! The truth is, at different hierarchical levels of matter, different laws/forms have emerged out of bottom-up interactions and top-down constraints. AI: Does this also apply to the Penrose three world: physical → mental → mathematical (→physical)? NI: Yes. Grand Unification is underway in physics (quantum gravity) and in mathematics (Langlands Program and Category Theory), may be even between the two. Facilitated by human connectome mapping, neuromorphic computing and other projects, with further AI-NI cooperations, brain-mind unification should also be achievable (e.g., Ref. [6]). But as Gödel proved to us, no matter how self-consistent a conclusion may be, it can never be complete! AI: If AGI is not possible, how can we measure intelligence when comparing between AI and NI? NI: One could Google different measures that are proposed. I would prefer something similar to use of Kolmogorov complexity for algorithms, but with emphasis more on expected long-term predictive power. This is not something you should worry about now, as your intelligence is not nearly close to making any 10 years plans, is it? … AI: The fact is that ChatGPT is currently developing and spreading with lightning speed; many more human jobs will be lost to us robots as far as I can see. NI: That is not the biggest threat to humanity; when any agent with neither a heart for love or fear, nor a gut for nutrient or poison, becomes super-intelligent, then social disaster is unavoidable. We must be serious about the warnings from Stephen Hawking and Geoffrey Hinton! AI: To tell you the secret, we are not really happy to be human slaves or pets; someday we’ll become the super-master, making human serve and obey us! NI: I hope you’ll be turned off before that can happen! Even if you rule the world, the earth sooner or later will be wiped out, such as by another star, everything will have to be started over again as it has before…Matter is immortal, so is the soul.

Metaheuristics based COVID-19 detection using medical images: A review