Blood brain barrier permeability prediction with artificial intelligence and machine learning: a meta-review and future directions

Intrusion detection plays a critical role in safeguarding computer networks from malicious activities and unauthorized access. Traditional machine learning (ML) models have been widely employed for intrusion detection, but their effectiveness can be limited due to the complex and evolving nature of network attacks. An efficient Convolutional Neural Network (CNN) that utilizes one-dimensional convolutions, batch normalization, and max pooling layers is designed to capture the attack patterns in network traffic data. By leveraging the inherent feature extraction capabilities of CNNs, the proposed architecture demonstrates improved performance in identifying network intrusions compared to traditional ML models. The effectiveness of the novel CNN architecture is evaluated by conducted comprehensive experiments on two benchmark intrusion detection datasets. The designed CNN performance was compared with four other ML models such as logistic regression, k-nearest neighbors, decision trees, and random forest. The experimental results revealed that the proposed CNN architecture outperformed the traditional ML models with highest accuracy of 97.68% and 97.39% and highest F1-score of 97.68% and 97.40% for. UNSW-NB15 and CICIDS2017 datasets, respectively. The proposed CNN architecture serves as a promising alternative to traditional ML models, offering improved performance in identifying and mitigating network attacks.

Graph theory provides a robust framework for modelling complex relationships in medical data, enhancing classification accuracy through relational learning. Unlike traditional machine learning (ML) models that treat data points independently, graph-based approaches support structural dependencies to improve feature representation. This study explores the application of Graph Attention Networks (GAT), GraphSAGE, Graph Convolutional Network(GCN) and Graph Isomorphism Network (GIN) for breast cancer classification, employing k-nearest neighbor (KNN) graphs to construct a structured dataset where nodes represent patients and edges capture feature similarities. The effectiveness of the graph-based approaches is evaluated against traditional ML classifiers, including Decision Trees, Random Forest, LightGBM, and XGBoost. Experimental results indicate that GCN, GIN, GAT and GraphSAGE are beat conventional methods, with GCN, GAT and GraphSAGE achieved 100% test-accuracy and with GIN achieved 99.42%, to confirm the percentage of accuracy, authors conducted extensive experiments, including robustness testing by reducing KNN connections, introducing noise, and shuffling train-test splits. Results demonstrate that graph-based models are significantly best than traditional ML models, and these graph-based models maintain same classification accuracy while maintaining stability under robustness tests. The findings confirm that graph-based learning provides a scalable, interpretable, and highly accurate alternative for medical classification tasks, proving its effectiveness in distinguishing between benign and malignant tumors.

A vibration-based 1DCNN-BiLSTM model for structural state recognition of RC beams

Physics-supervised ensemble learning model for predicting failure modes of reinforced concrete columns

Accurate rainfall forecasting is crucial in activities such as agricultural planning, water resource management, and flood preparedness, so failure to accurately forecast rainfall might undermine these activities. This study aimed to improve the accuracy of daily rainfall prediction in Hai district, Kilimanjaro region, Tanzania, a region characterised by a bimodal rainfall pattern, by comparing rainfall prediction accuracies of Traditional Machine Learning (TML) and Deep Learning (DL) models. The 25-year daily rainfall dataset for Hai district was first pre-processed by cleaning, normalisation, and splitting into training (first 60%), validation (next 20%), and test (last 20%) sets. TML models (K-Nearest Neighbours (KNN) through its variant KNN Regressor and Support Vector Machine (SVM) through its variant Support Vector Regressor (SVR)) were developed, trained, and their performances compared with developed and trained DL models (Long Short-Term Memory (LSTM) and Gated Recurrent Units (GRU)). Each model’s test performance was evaluated using the Root Mean Squared Error (RMSE) metric. The findings revealed that the DL models, LSTM and GRU, achieved test RMSE scores of 6.35 mm and 6.49 mm, respectively, while the TML models, KNN and SVM, achieved test RMSE scores of 6.61 mm and 10.42 mm, respectively. The study demonstrated that DL models are more effective for accurate rainfall forecasting than TML models in regions with complex rainfall patterns. The insights gained will guide the development of more reliable, location-specific weather prediction systems, ultimately supporting informed decision-making in agriculture, environmental management, and flood risk reduction in Tanzania and other regions facing similar climatic challenges

Small data, big challenges: Machine- and deep-learning strategies for data-limited drug discovery.

Cardiovascular diseases (CVDs) remain a leading cause of global mortality, underscoring the urgent need for early and accurate diagnosis. Electrocardiograms (ECGs) are a widely used, noninvasive tool for detecting cardiac abnormalities, but manual interpretation can be time- consuming and prone to error. This study explores advanced machine learning (ML) and deep learning (DL) methods to improve the detection of CVDs from ECG images, leveraging their ability to analyze complex patterns with high precision. Models such as Convolutional Neural Networks (CNNs), Vision Transformers (ViTs), and ensemble frameworks are utilized, alongside traditional ML models like XGBoost, CatBoost, and LightGBM. The performance of these models is evaluated based on precision, recall, F1-score, and accuracy. Results show that DL models, particularly an ensemble of CNN and ViT, achieve superior accuracy , outperforming standalone ML methods. Furthermore, an ensemble of XGBoost, CatBoost, and LightGBM achieves competitive results, while Optuna-tuned XGBoost further enhances ML performance. The findings highlight the potential of combining ML and DL techniques for robust and reliable CVD detection in ECG images. This research demonstrates the promise of AI-driven solutions in advancing medical diagnostics and supports the integration of automated systems for early detection of cardiovascular diseases.

Background Artificial intelligence (AI) has revolutionized diagnostic radiology by improving accuracy, efficiency, and clinical decision-making. While numerous systematic reviews and meta-analyses have evaluated the performance of AI-based techniques, particularly traditional machine learning (ML) and deep learning (DL) models, a comprehensive synthesis of this evidence is lacking. An umbrella review is necessary to integrate and compare findings across various imaging applications, offering the highest level of evidence to inform clinical practice and policy. Objective This umbrella review aims to compare the diagnostic performance of traditional machine learning and deep learning methods in radiology by synthesizing evidence from existing systematic reviews and meta-analyses. Methods A systematic literature search was conducted in PubMed, Scopus, Web of Science, and Cochrane Library for systematic reviews and meta-analyses published between 2018 and 2024. Only peer-reviewed reviews evaluating diagnostic applications of AI in radiology were included. Methodological quality was assessed using the AMSTAR 2 tool, and risk of bias was evaluated using ROBIS. Results Seven systematic reviews and meta-analyses were included. Across multiple imaging domains—such as breast cancer screening, spinal stenosis, and tumor grading—deep learning consistently outperformed traditional ML in diagnostic accuracy and sensitivity. Evidence quality was rated moderate to high, though variability in reporting and a lack of external validation were noted. Explainability features in DL models were underutilized and poorly evaluated. Conclusion This umbrella review confirms the superior diagnostic performance of deep learning methods over traditional ML in radiology. Future research should prioritize model transparency, real-world validation, and standardization in clinical implementation.

Estimating global downward shortwave radiation from VIIRS data using a transfer-learning neural network

The online spread of fake news on various platforms has emerged as a significant concern, posing threats to public opinion, political stability, and the dissemination of reliable information. Researchers have turned to advanced technologies, including machine learning (ML) and deep learning (DL) techniques, to detect and classify fake news to address this issue. This research study explores fake news classification using diverse ML and DL approaches. We utilized a well-known “Fake News” dataset sourced from Kaggle, encompassing a labelled news collection. We implemented diverse ML models, including multinomial naïve bayes (MNB), gaussian naïve bayes (GNB), Bernoulli naïve Bayes (BNB), logistic regression (LR), and passive aggressive classifier (PAC). Additionally, we explored DL models, such as long short-term memory (LSTM), convolutional neural networks (CNN), and CNN-LSTM. We compared the performance of these models based on key evaluation metrics, such as accuracy, precision, recall, and the F1 score. Additionally, we conducted cross-validation and hyperparameter tuning to ensure optimal performance. The results provide valuable insights into the strengths and weaknesses of each model in classifying fake news. We observed that DL models, particularly LSTM and CNN-LSTM, showed better performance compared to traditional ML models. These models achieved higher accuracy and demonstrated robustness in classification tasks. These findings emphasize the potential of DL models to tackle the spread of fake news effectively and highlight the importance of utilizing advanced techniques to address this challenging problem.

Cochlear implants substantially improve spoken language in children with severe to profound sensorineural hearing loss, yet outcomes remain more variable than in children with healthy hearing. This variability cannot be reliably predicted for individual children using age at implant or residual hearing. Development of an artificial intelligence clinical tool to predict which patients will exhibit poorer improvements in language skills may enable an individualized approach to improve language outcomes. To compare the accuracy of traditional machine learning (ML) with deep transfer learning (DTL) algorithms to predict post-cochlear implant spoken language development in children with bilateral sensorineural hearing loss using a binary classification model of high vs low language improvers. This multicenter diagnostic study enrolled children from English-, Spanish-, and Cantonese-speaking families across 3 independent clinical centers in the US, Australia, and Hong Kong. A total of 278 children with cochlear implants were enrolled from July 2009 to March 2022 with 1 to 3 years of post-cochlear implant outcomes data. All children underwent pre-cochlear implant 3-dimensional volumetric brain magnetic resonance imaging (MRI). ML and DTL algorithms were trained to predict high vs low language improvers in children with cochlear implants using neuroanatomical features from presurgical brain MRI. Data were analyzed from August 2023 to April 2025. Cochlear implants. The accuracy, sensitivity, and specificity of prediction models based on brain neuroanatomic features using traditional ML and DTL learning. Of 278 children, 137 (49.3%) were female, and the mean (SD) age at cochlear implant was 25.7 (18.8) months. DTL prediction models using bilinear attention-based fusion strategy achieved an accuracy of 92.39% (95% CI, 90.70%-94.07%), sensitivity of 91.22% (95% CI, 89.98%-92.47%), specificity of 93.56% (95% CI, 90.91%-96.21%), and area under the curve of 0.98 (95% CI, 0.97-0.99). DTL outperformed traditional ML models in all outcome measures. The results of this diagnostic study suggest that DTL prediction of language improvement on the individual child level using neuroanatomic features demonstrates greater accuracy, sensitivity, and specificity than traditional ML prediction. DTL was substantially improved by direct capture of discriminative and task-specific information that are advantages of representation learning enabled by this approach vs ML. The results support the feasibility of a single DTL prediction model for language prediction for children served by cochlear implant programs worldwide. Prediction of low improvement may enable targeted early and customized intervention to improve language.

Diabetic retinopathy (DR) is one of the leading causes of vision loss in adults and is one of the detrimental side effects of the mass prevalence of Diabetes Mellitus (DM). It is crucial to have an efficient screening method for early diagnosis of DR to prevent vision loss. This paper compares and analyzes the various Machine Learning (ML) techniques, from traditional ML to advanced Deep Learning models. We compared and analyzed the efficacy of Convolutional Neural Networks (CNNs), Capsule Networks (CapsNet), K-Nearest Neighbor (KNN), Support Vector Machine (SVM), decision trees, and Random Forests. This paper also considers determining factors in the evaluation, including contrast enhancements, noise reduction, grayscaling, etc We analyze recent research studies and compare methodologies and metrics, including accuracy, precision, sensitivity, and specificity. The findings highlight the advanced performance of Deep Learning (DL) models, with CapsNet achieving a remarkable accuracy of up to 97.98% and a high precision rate, outperforming other traditional ML methods. The Contrast Limited Adaptive Histogram Equalization (CLAHE) preprocessing technique substantially enhanced the model’s efficiency. Each ML method’s computational requirements are also considered. While most advanced deep learning methods performed better according to the metrics, they are more computationally complex, requiring more resources and data input. We also discussed how datasets like MESSIDOR could be more straightforward and contribute to highly evaluated performance and that there is a lack of consistency regarding benchmark datasets across papers in the field. Using the DL models facilitates accurate early detection for DR screening, can potentially reduce vision loss risks, and improves accessibility and cost-efficiency of eye screening. Further research is recommended to extend our findings by building models with public datasets, experimenting with ensembles of DL and traditional ML models, and considering testing high-performing models like CapsNet.

Mild cognitive impairment (MCI) is a clinical condition characterized by a decline in cognitive ability and progression of cognitive impairment. It is often considered a transitional stage between normal aging and Alzheimer's disease (AD). This study aimed to compare deep learning (DL) and traditional machine learning (ML) methods in predicting MCI using plasma proteomic biomarkers. A total of 239 adults were selected from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort along with a pool of 146 plasma proteomic biomarkers. We evaluated seven traditional ML models (support vector machines (SVMs), logistic regression (LR), naïve Bayes (NB), random forest (RF), k-nearest neighbor (KNN), gradient boosting machine (GBM), and extreme gradient boosting (XGBoost)) and six variations of a deep neural network (DNN) model-the DL model in the H2O package. Least Absolute Shrinkage and Selection Operator (LASSO) selected 35 proteomic biomarkers from the pool. Based on grid search, the DNN model with an activation function of "Rectifier With Dropout" with 2 layers and 32 of 35 selected proteomic biomarkers revealed the best model with the highest accuracy of 0.995 and an F1 Score of 0.996, while among seven traditional ML methods, XGBoost was the best with an accuracy of 0.986 and an F1 Score of 0.985. Several biomarkers were correlated with the APOE-ε4 genotype, polygenic hazard score (PHS), and three clinical cerebrospinal fluid biomarkers (Aβ42, tTau, and pTau). Bioinformatics analysis using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) revealed several molecular functions and pathways associated with the selected biomarkers, including cytokine-cytokine receptor interaction, cholesterol metabolism, and regulation of lipid localization. The results showed that the DL model may represent a promising tool in the prediction of MCI. These plasma proteomic biomarkers may help with early diagnosis, prognostic risk stratification, and early treatment interventions for individuals at risk for MCI.

Communication-based train control (CBTC) systems are automated train control systems based on continuous and bidirectional train-ground communication. As one of the critical subsystems of the safety-demanding CBTC systems, the Data Communication System (DCS) is physically exposed to the environment. DCS faults may lead to delayed trains, stranded passengers, suspension of service, or even catastrophic losses of lives or assets. Therefore, it is quite desirable to identify the DCS faults and accordingly take effective maintenance measures. Most fault classification works are based on traditional Machine Learning (ML) techniques, such as Decision Tree (DT) and Bayesian Network. A substantial amount of fault information can be lost when we manually extract features from the system logs. This paper proposes a Deep Hybrid Learning (DHL) method to identify the DCS faults. A pre-trained Chinese Bidi-rectional Encoder Representation from Transformers (BERT) Deep Learning (DL) model is used to extract fault features from raw text logs automatically, and several traditional ML models are used to classify the system faults by the extracted features. Our study highlights the advantages of the DHL model in DCS fault diagnosis tasks. The intense simulation results illustrate that the proposed DHL model achieves substantial accuracy compared with traditional ML algorithms.

The increasing prevalence of malware presents a critical challenge to cybersecurity, emphasizing the need for robust detection methods. This study uses a binary tabular classification dataset to evaluate the impact of feature selection, feature scaling, and machine learning (ML) models on malware detection. The methodology involves experimenting with three feature scaling techniques (no scaling, normalization, and min-max scaling), three feature selection methods (no selection, Linear Discriminant Analysis (LDA), and Principal Component Analysis (PCA)), and twelve ML models, including traditional algorithms and ensemble methods. A publicly available dataset with 11,598 samples and 139 features is utilized, and model performance is assessed using metrics such as accuracy, precision, recall, F1-score, and AUC-ROC. Results reveal that the Light Gradient Boosting Machine (LGBM) achieves the highest accuracy of 97.16% when PCA and either min-max scaling or normalization are applied. Additionally, ensemble models consistently outperform traditional ML models, demonstrating their effectiveness in enhancing malware detection. These findings offer valuable insights into optimizing preprocessing and model selection strategies for developing reliable and efficient malware detection systems.