Breast Cancer Detection in Mammography Images Using Deep Convolutional Neural Networks and Fuzzy Ensemble Modeling Techniques.

e18052 {\rtf1\ansi\ansicpg936\cocoartf1347\cocoasubrtf570 {\fonttbl\f0\froman\fcharset0 Times-Roman;\f1\fnil\fcharset0 Calibri;\f2\fswiss\fcharset0 Helvetica; \f3\fnil\fcharset134 STHeitiSC-Light;\f4\froman\fcharset0 TimesNewRomanPSMT;} {\colortbl;\red255\green255\blue255;\red0\green0\blue0;} \paperw11900\paperh16840\margl1440\margr1440\vieww25400\viewh13600\viewkind0 \deftab720 \pard\pardeftab720 \f0\fs24 \cf2 \expnd0\expndtw0\kerning0 \outl0\strokewidth0 \strokec2 AI platform in mammagraphy to screening breast cancer: a sole center experence. \f1\fs21 \cf0 \kerning1\expnd0\expndtw0 \outl0\strokewidth0 \ \pard\pardeftab720\ri714\qj \cf0 Background: The aim of this study was to use deep convolutional neural network (DCNN) to relieve radiologists ' burden and to minimize misses and interpretation errors of suspicious lesions at digital mammography. Methods: We developed and trained the DCNN model on the training set, then validated it in an internal validation set. The labeled data were used for training the DCNN model, and the mass detection, calcification detection and benign and malignant diagnosis were interpreted respectively. After verifying the feasibility of the DCNN model in the diagnosis of breast cancer, we gradually increased the number of cases in the training set and established the verification set to test the training results. The latest training sets include 21100 atlas of our hospital between April 2010 and October 2017, among which the malignant case atlas is 1774. Each atlas contains 2 ipsilateral mammography images. The verification set includes 1307 atlas, among which the malignant case atlas is 248. Results: The DCNN model achieved high performance in identifying breast cancer patients in the validation sets tested, with sensitivity of 98.02%, specificity of 91.86% \f3 \'a3\'ac \f2 and area under the curve values of 0.9813. As for mass detection, we reached a recall rate of 89.6% on the premise of lowing the false positive to 0.168%. For the latest clinical data between October 2018 and November 2018 including 1043 atlas from 576 patients, the sensitivity was 78.6% (95%CI 62.8-89.1) versus 90.5% (95%CI 76.5 \f4 - \f2 96.9; p=0.021) and specificity was 93.4% (95%CI 91.6 \f4 - \f2 94.8) versus 82.7% (95%CI 80.2 \f4 - \f2 85 \f4 . \f2 0; p<0.0001). Conclusions: The DCNN model showed improved specificity in diagnosis breast cancer compared with a group of skilled radiologists. As the number of cases in the training set increases, the capacity of DCNN model will be further improved.

Background: Breast cancer is one of the leading causes of death in women, making early detection through mammography crucial for improving survival rates. However, human interpretation of mammograms is often prone to diagnostic errors. This study addresses the challenge of improving the accuracy of breast cancer detection by leveraging advanced machine learning techniques. Methods: We propose an extended ensemble deep learning model that integrates three state-of-the-art convolutional neural network (CNN) architectures: VGG16, DenseNet121, and InceptionV3. The model utilizes multi-scale feature extraction to enhance the detection of both benign and malignant masses in mammograms. This ensemble approach is evaluated on two benchmark datasets: INbreast and CBIS-DDSM. Results: The proposed ensemble model achieved significant performance improvements. On the INbreast dataset, the ensemble model attained an accuracy of 90.1%, recall of 88.3%, and an F1-score of 89.1%. For the CBIS-DDSM dataset, the model reached 89.5% accuracy and 90.2% specificity. The ensemble method outperformed each individual CNN model, reducing both false positives and false negatives, thereby providing more reliable diagnostic results. Conclusions: The ensemble deep learning model demonstrated strong potential as a decision support tool for radiologists, offering more accurate and earlier detection of breast cancer. By leveraging the complementary strengths of multiple CNN architectures, this approach can improve clinical decision making and enhance the accessibility of high-quality breast cancer screening.

Breast cancer is an important topic in medical image analysis because it is a high-risk disease and the leading cause of death in women. Early detection of breast cancer improves treatment outcomes, which can be achieved by identifying it using mammography images. Computer-aided diagnostic systems detect and classify medical images of breast lesions, allowing radiologists to make accurate diagnoses. Deep learning algorithms improved the performance of these diagnoses systems. We utilized efficient deep learning approaches to propose a system that can detect breast cancer in mammograms. The proposed approach adopted relies on two main elements: improving image contrast to enhance marginal information and extracting discriminatory features sufficient to improve overall classification quality, these improvements achieved based on a new model from scratch to focus on enhancing the accuracy and reliability of breast cancer detection. The model trained on the digital database for screening mammography (DDSM) dataset and compared with different convolutional neural network (CNN) models, namely EfficientNetB1, EfficientNetB5, ResNet-50, and ResNet101. Moreover, to enhance the feature selection process, we have integrated adam optimizer in our methodology. In evaluation, the proposed method achieved 96.5% accuracy across the dataset. These results show the effectiveness of this method in identifying breast cancer through images.

Breast cancer (BC) is the most common cause of women’s deaths worldwide. The mammography technique is the most important modality for the detection of BC. To detect abnormalities in mammographic images, the Breast Imaging Reporting and Data System (BI-RADs) is used as a baseline. The correct allocation of BI-RADs categories for mammographic images is always an interesting task, even for specialists. In this work, to detect and classify the mammogram images in BI-RADs, a novel hybrid model is presented using a convolutional neural network (CNN) with the integration of a support vector machine (SVM). The dataset used in this research was collected from different hospitals in the Qassim health cluster of Saudi Arabia. The collection of all categories of BI-RADs is one of the major contributions of this paper. Another significant contribution is the development of a hybrid approach through the integration of CNN and SVM. The proposed hybrid approach uses three CNN models to obtain ensemble CNN model results. This ensemble model saves the values to integrate them with SVM. The proposed system achieved a classification accuracy, sensitivity, specificity, precision, and F1-score of 93.6%, 94.8%, 96.9%, 96.6%, and 95.7%, respectively. The proposed model achieved better performance compared to previously available methods.

World’s second most occurring cancer is breast cancer. Prediction of disease is one of the most challenging tasks and there are many factors that effect this type of diagnosis like the ability of visual perception. This paper proposed a Convolutional Neural Network (CNN) based proper method for analyzing the earliest signs of breast cancer with the help of mammogram images. The main goal of proposed system is to identify the disease of breast cancer at early stages. Due to this reason, Mammographic image analysis society (MIAS) dataset is used. There are three hundred & twenty two (322) mammograms in the dataset, with 209 images of normal breasts and 133 images of abnormal breasts. While abnormal breasts are further classified as benign (62 images) and malignant (51 images). To implement this system, python library Keras and Tensor Flow libraries are used along with deep learning model CNN. Convolutional Neural Network (CNN) has been shown to be effective in detecting breast cancer in mammography images with 70% accuracy rate, according to promising testing data. The proposed system will enable the radiologist in detecting breast cancer in early stages.

Breast cancer is one of the most common cancers occurring in women and is the main cause of mortality among women aged 20 to 59. Detection of breast cancer in the early stage increases survival rate to 80%, and the rate decreases to around 40% if diagnosed in its later stage. There exists significant need to diagnose breast cancer in its early stage itself among women suspected with the disease. The hematoxylin and eosin (H&E)–stained histopathology tissue samples taken by pathologists from suspected breast areas are viewed with whole slide imaging (WSI) and can be stored as digital histopathology images. Manual analysis of histopathology images is time-consuming and leads to inter- and intraobserver variability. Hence, automated classification methods are in research focus. Breast tumors are classified as benign and malignant tumors, which are non-cancerous and cancerous tumors, respectively. Currently, deep learning through convolutional neural networks is an emerging technology and has proven to be successful for image segmentation and classification applications. These deep CNNs require large labeled datasets, which are lacking in the field of medicine, especially for breast cancer images. Also, high computational power, time, and memory are required if CNN is to be trained from scratch. To overcome this, transfer learning from natural images like ImageNet, comprising of 1.2 million natural images belonging to 1,000 classes, is used. Pretrained models like VGG16, ResNet50, Inception, AlexNet, and DenseNet are employed for transfer learning, and fine-tuning is to be performed for refinement. In the proposed method, four different network architectures, namely, AlexNet, VGG16, Inception v3, and DenseNet121, are used for classification of histopathological images using transfer learning. The top dense layers of these architectures are removed, and custom dense layers are added for classification. Also, the weights of the last two layers are fine-tuned with the histopathology input images dataset. The publicly available breast cancer hisopathology images dataset BreakHis is used for validation of the proposed method. The experimental results prove that transfer learning–based CNN gives better classification accuracy compared to networks learned from scratch. Also, it is inferred from the experimental results that the pretrained model of DenseNet121 gives the highest classification accuracy of 0.9520 compared to the other models and state-of-the-art methods.

The growing rate of breast cancer necessitates immediate global attention. Mammography images are used to determine the stage of malignancy. Breast cancer stages must be identified in order to save a person's life. This article's main goal is to identify different techniques to obtain the difference between two breast cancer mammography images taken of the same individual at different times. This is the first effort to identify breast cancer in mammography images using change detection techniques. The Mammogram Image Change Detection (ICD) technique is also a recent advancement to prevent breast cancer in the early stage and precancerous level in medical images. The main purpose of this work is to observe the changes between breast cancer images in different screening periods using different techniques. Mammogram Breast Cancer Image Change Detection (MBCICD) methods usually start with a Difference Image (DI) and classify the pixels in the DI into changed and unaffected classes using unsupervised fuzzy c means (FCM) clustering methods based on texture features taken from the log and mean ratio difference pictures. Two operators, mean ratio and log ratio, were used to check the changes in the images. The Gabor wavelet is utilized as a feature extraction technique among several standards. Using the Gabor wavelet ratio operators is a useful method for altering the detection of breast cancer in mammography images. Currently, it is challenging to obtain real malignant images of the same person for testing or training. In this study, two images are utilized. To clearly see the changes, one is an image from the MIAS breast cancer mammography images dataset, and the other is a self-generated change image. The research aims to examine the image results and other quantitative analysis results of proposed change detection methods on cancer images. The Mean Ratio Accuracy result is 0.9738, and the Log ratio PCC is 0.9737. The classification results are the Log Ratio + Gabor Filter + FCM is 0.9737, and Mean Ratio +Gabor Filter + FCM is 0.9719. The mean Ratio Accuracy result is 0.9738, Log ratio is 0.9737. Log Ratio + Gabor Filter + FCM is 0.9737, Mean Ratio +Gabor Filter + FCM is 0.9719. Comparing the PCC of proposed change detection methods with the FDA-RMG method on the same dataset, the accuracy is 0.9481 only. The study concludes that variations in mammography breast cancer images could be successfully identified using the ratio operators with Gabor wavelet features.

Background Incidence rate of thyroid cancer is steadily increasing due to overdiagnosis and overtreatment. Thyroid ultrasound is commonly used to diagnose thyroid cancer. The aim of this study is to examine the accuracy of using deep convolutional neural network (DCNN) models to improve diagnosis of thyroid cancer by analyzing sonographic imaging data from clinical thyroid ultrasound. Methods A total of 131,731 sonographic images from 17,627 thyroid cancer patients and 180,668 sonographic images from 25,325 controls used as training set were obtained from Tianjin Cancer Hospital. Images from anatomical sites that did not have cancer according to location sign on the image were not included. All thyroid cancer patients and 13·2% of controls (51,255 images) were confirmed by pathological reports. DCNN is a specific type of neural network optimized for image recognition. We trained two DCNN models on the training set and subsequently evaluated the performance on one independent internal (Tianjin, 1,118 individuals) and two external (Jilin,154 individuals; Weihai, 1,420 individuals) validation sets. Individuals in the validation sets all have pathological examinations. We compared the specificity/sensitivity of DCNN models with the performance of six thyroid ultrasound radiologists on these three validation sets. Findings DCNN model achieved high performance in identifying thyroid cancer patients versus six experience radiologists: for Tianjin validation set, sensitivity was 92·2% versus 96·9% (95% CI 89·7% - 94·3% vs. 93·9% - 98·6%; p = 0·003), and specificity was 85·6% versus 59·4% (95% CI 82·4% - 88·4% vs. 53% - 65·6%; p < 0·0001); for Jilin validation set, sensitivity was 84·3% versus 92·9% (95% CI 73·6% - 91·9% vs. 84·1% - 97·6%; p = 0·05), and specificity was 86·9% versus 57·1% (95% CI 77·8% - 93·3% vs. 45·9% - 67·9%; p < 0·0001); for Weihai validation set, sensitivity was 84·5% versus 89% (95% CI 81·2% - 87·4% vs. 81·9% - 94%; p = 0·2), and specificity was 87·5% versus 68·6% (95% CI 85·1% - 89·6% vs. 60·7% - 75·8%; p < 0·0001). Interpretation DCNN models exhibited high accuracy, sensitivity, and specificity in identifying thyroid cancer patients at levels comparable to or higher than six experienced radiologists. Conferred by the high specificity of DCNN models, the rate of overdiagnosis and overtreatment of patients with thyroid cancer is expected to decrease. This supports future application of the deep learning models to clinical practice for thyroid cancer diagnosis. However, further validation of these DCNN models in prospective clinical trials is warranted. Funding The Program for Changjiang Scholars and Innovative Research Team in University in China (IRT_14R40), National Natural Science Foundation of China (31801117). Citation Format: Xiangchun Li, Sheng Zhang, Qiang Zhang, Xi Wei, Yi Pan, Jing Zhao, Xiaojie Xin, Xiaoqing Wang, Fan Yang, Jianxin Li, Meng Yang, Qinghua Wang, Xiangqian Zheng, Yanhui Zhao, Lun Zhang, Xudong Wang, Zhimin Zheng, Christopher T. Whitlow, Metin N. Gurcan, Boris Pasche, Ming Gao, Wei Zhang, Kexin Chen. Diagnosis of thyroid cancer using deep convolutional neural network models applied to sonographic images from clinical ultrasound exams [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1394.

The early and precise diagnosis of breast cancer is one of the most important factors in enhancing survival rates. Despite considerable improvements in screening methods, medical imaging, and treatment approaches, the issue of reliable early detection remains a significant problem due to instability in clinical interpretation and the complexity of diagnostic information. Conventional methods of diagnosis emphasize the analysis of clinical and histopathological information, which are prone to inter-observer error and do not necessarily reveal subtle patterns related to disease progression. Artificial Intelligence has demonstrated enormous potential in alleviating these weaknesses. Ensemble methods, as well as support vector machines and gradient boosting-based algorithms such as XGBoost and LightGBM, have shown excellent results in the analysis of structured clinical data. Simultaneously, deep learning (DL) systems, specifically convolutional neural networks (CNNs), have been demonstrated to be exceptionally successful in medical image analysis such as mammography and histopathology. However, the interpretability of such models remains a major obstacle to their usage in clinical practice. To address this problem, Explainable Artificial Intelligence (XAI) methods, including SHAP, LIME, and Grad-CAM, have been proposed to improve model transparency and contribute significantly to understanding how decisions are made. This paper reviews recent developments in ML, DL, and XAI in relation to breast cancer diagnosis. It examines commonly used datasets, evaluation metrics, and trends, and also reports the most significant issues, including data constraints, lack of interpretability, and challenges in multimodal integration. Moreover, this paper identifies knowledge gaps in existing research and highlights the necessity of developing robust, explainable, and actionable AI-based diagnostic systems.

Posing a threat to a large portion of the population on a worldwide scale, breast cancer is now a deleterious pandemic. Chances of survival greatly improve if detected early, giving us impetus to contribute to various methods of detection from a technical perspective. A tool used to detect and diagnose breast-related diseases is a digital mammogram. The main purpose of this paper is to detect the probability of early stage breast cancer detection using mammography images. These mammograms were pre-processed using CLAHE technique. In order to detect masses from the aforementioned mammograms, a hybrid approach has been employed: combining a neural network with a linear classifier. Deep Learning model VGG16, based on convolutional neural networks which are efficient for image processing, was used for feature extraction, which were then fed into linear classifiers. Linear classifiers are also efficient, especially for rich data in terms of training and testing. Using this approach, the results of the mammogram were classified as normal or abnormal, with normal indicating that no tumour was present, abnormal indicating that a tumour (benign or malignant), calcifications, circumscribed, spiculated or other masses, distortions, or asymmetry may be present. This method was fairly successful in classifying mammograms as normal or abnormal correctly.

Background Earlier detection of breast cancer through mammography screening has reduced disease-specific mortality; however, confounding issues such as technical challenges, breast density, and tumor size can result in false negatives and ultimately later stage diagnosis. Next generation liquid biopsy has the potential to complement mammography and enable earlier detection for more women. We have previously demonstrated high sensitivity and specificity for early detection of invasive breast cancer (IBC) by utilizing a novel category of cancer-associated small RNAs, termed orphan noncoding RNAs (oncRNAs), through a liquid biopsy platform. Here, we further improve the ability to detect breast cancer in a larger, multi-source cohort through an AI-driven approach and demonstrate potential for detection of ductal carcinoma in-situ (DCIS). Methods We utilized The Cancer Genome Atlas (TCGA) small RNA-seq database to discover a library of 20,538 oncRNAs, through a female-specific analysis, that were significantly enriched among 1,103 breast tumors compared to 349 normal tissue samples spanning multiple tissue sites. The diagnostic performance of these oncRNAs were assessed in an independent cohort of archived serum samples from 663 female individuals, sourced from Indivumed (Hamburg, Germany), Proteogenex (Inglewood, CA), and MT Group (Los Angeles, CA), including 279 breast cancer patients of various stages (221 IBC and 58 DCIS; mean age: 57.0 ± 13.8 years; ever-smoker: 25.8%) and 304 age-matched controls (mean age: 58.5 ± 13.9 years; ever-smoker: 23.4%) without breast cancer. All samples were collected between 2010–2022 at time of diagnosis for breast cancer patients. We sequenced the small RNA content of these samples at an average depth of 25.28 ± 9.37 million 50-bp single-end reads. We detected 18,025 (87.8%) unique breast cancer-specific oncRNA species within at least one sample from the study cohort. We then trained a generative AI model using 5-fold cross-validation to predict cancer status for all samples. Results Our oncRNA-based model achieved an overall AUC of 0.95 (95% CI, 0.93–0.97) for prediction of IBC versus cancer-free controls with a sensitivity of 0.87 (0.82–0.91) at 90% specificity. We observed high sensitivities, also at 90% specificity, across all tumor stages and tumor sizes (Table 1). Sensitivities for the earliest stage and smallest tumor size were 0.87 (0.78–0.93) and 0.81 (0.61–0.93) for Stage I (n=83) and T1a–b ( >1mm to ≤10mm; n=26), respectively. Additionally, in a small single-source cohort, we also saw high model accuracy and sensitivity for DCIS, which we aim to confirm in additional cohorts. While our overall cancer cohort primarily consisted of individuals with luminal breast cancer, our model had high sensitivities across all breast cancer subtypes at 0.90 (0.84–0.94), 0.73 (0.59–0.85), and 0.86 (0.42–1.0) for luminal (n=181), HER2 positive (n=49), and triple negative (n=7), respectively. Conclusions We further demonstrate the potential utility of oncRNAs as a blood-based biomarker using an AI algorithm for sensitive and accurate early detection of breast cancer in a large cohort. Additionally, we have shown that this oncRNA-based assay performs well in detecting small, early-stage invasive breast tumors, with potential to detect precursors of breast cancer. Table 1: Model sensitivity in breast cancer by tumor stage and size For each tumor stage and size, as defined by the AJCC 7th Edition breast cancer staging system, sensitivity and 95% Pearson-Clopper confidence intervals (CI) are reported at 90% specificity for the number of samples (N). Citation Format: Noura Tbeileh, Taylor Cavazos, Mehran Karimzadeh, Jeffrey Wang, Alice Huang, Dung Ngoc Lam, Seda Kilinc, Jieyang Wang, Xuan Zhao, Andy Pohl, Helen Li, Lisa Fish, Kimberly Chau, Marra Francis, Lee Schwartzberg, Patrick Arensdorf, Hani Goodarzi, Fereydoun Hormozdiari, Babak Alipanahi. Cell-free orphan noncoding RNAs and AI enable early detection of invasive breast cancer and ductal carcinoma in-situ [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO2-13-08.

Deep learning-based computed tomography applied to the diagnosis of rib fractures

Breast cancer (BC) remains a leading cause of cancer-related mortality among women globally, with early detection playing a crucial role in improving patient outcomes. While deep learning models—particularly Convolutional Neural Networks (CNNs)—have demonstrated exceptional performance in breast cancer detection, their high computational demands limit deployment in low-resource environments such as mobile devices and rural clinics. To bridge this gap, we propose a lightweight CNN model for breast cancer detection using Knowledge Distillation (KD), a technique that transfers knowledge from a complex, high-capacity "teacher" model to a compact and efficient "student" model. In this study, we develop and evaluate both teacher and student models using the Wisconsin Diagnostic Breast Cancer (WDBC), Breast Cancer Diagnosis (BCD), and Primary Breast Cancer vs Normal Breast Tissue (PBCT) datasets. The student model is designed to operate with only 0.06% of the parameters used by the teacher model, significantly reducing memory and computational overhead. Despite its lightweight architecture, the student model achieves up to 100% classification accuracy and demonstrates robust generalization across multiple datasets. Our approach enables high-accuracy breast cancer detection while ensuring fast inference and low resource consumption, making it well-suited for deployment in real-world, resource-constrained environments such as mobile health platforms and embedded medical devices. The findings highlight the transformative potential of knowledge distillation in democratizing access to advanced AI-driven diagnostics.

As one of the most common malignant tumors among women worldwide, breast cancer requires early diagnosis and accurate classification to significantly improve patient survival rates. Conventional imaging techniques like mammography, ultrasound, and magnetic resonance imaging (MRI) play a pivotal role in breast cancer screening. Nonetheless, they are constrained by relatively low specificity and a significant dependence on the expertise of medical professionals. In recent years, machine learning and deep learning techniques have provided new approaches for the intelligent diagnosis of breast cancer by extracting high-dimensional features from medical images. This study delves into the pathological aspects, imaging technologies, and the implementation of machine learning algorithms in the context of breast cancer. It conducts a comprehensive review of the diagnostic criteria for non-invasive, early-stage invasive, and fully invasive breast cancers, while also evaluating the strengths and weaknesses of various imaging modalities, including mammography, ultrasound, MRI, and nuclear medicine imaging. The limitations of conventional imaging methods in subtype differentiation are also discussed. Furthermore, by integrating radiomics and deep learning models such as convolutional neural networks (CNN) and random forests, the study evaluates the performance of intelligent diagnostic systems in breast cancer classification. Clinical cases and publicly available datasets were used as data sources. The results show that combining multimodal imaging features with machine learning algorithms significantly improves diagnostic accuracy, achieving an area under the curve (AUC) of 0.922. This research provides theoretical support and technical references for the precise diagnosis and treatment of breast cancer. Future work should focus on enhancing model generalizability and conducting multi-center clinical validation.

Assess the efficacy of deep convolutional neural networks (DCNNs) in detection of critical enteric feeding tube malpositions on radiographs. 5475 de-identified HIPAA compliant frontal view chest and abdominal radiographs were obtained, consisting of 174 x-rays of bronchial insertions and 5301 non-critical radiographs, including normal course, normal chest, and normal abdominal x-rays. The ground-truth classification for enteric feeding tube placement was performed by two board-certified radiologists. Untrained and pretrained deep convolutional neural network models for Inception V3, ResNet50, and DenseNet 121 were each employed. The radiographs were fed into each deep convolutional neural network, which included untrained and pretrained models. The Tensorflow framework was used for Inception V3, ResNet50, and DenseNet. Images were split into training (4745), validation (630), and test (100). Both real-time and preprocessing image augmentation strategies were performed. Receiver operating characteristic (ROC) and area under the curve (AUC) on the test data were used to assess the models. Statistical differences among the AUCs were obtained. p < 0.05 was considered statistically significant. The pretrained Inception V3, which had an AUC of 0.87 (95 CI; 0.80–0.94), performed statistically significantly better (p < .001) than the untrained Inception V3, with an AUC of 0.60 (95 CI; 0.52–0.68). The pretrained Inception V3 also had the highest AUC overall, as compared with ResNet50 and DenseNet121, with AUC values ranging from 0.82 to 0.85. Each pretrained network outperformed its untrained counterpart. (p < 0.05). Deep learning demonstrates promise in differentiating critical vs. non-critical placement with an AUC of 0.87. Pretrained networks outperformed untrained ones in all cases. DCNNs may allow for more rapid identification and communication of critical feeding tube malpositions.