Characterization of a Bioprinted Anticancer Cell Therapy System Generated with Continuous Liquid Interface Production

Current state and future scope of additive manufacturing technologies via vat photopolymerization

Marginal and internal discrepancies associated with carbon digital light synthesis additively manufactured interim crowns

Electroactive hydrogels (EAH) have gained prominence for their unique ability to change shape or size under an electric field, finding applications in biosensors and soft actuators. This study focuses on a tunnelable EAH tailored for high-resolution 3D printing via the micro continuous liquid interface production (µCLIP) process. The resin formulations mainly involve acrylic acid (AA) and 4-hydroxybutyl acrylate (4-HBA). AA, with its carboxyl groups, introduces electroactuation, generating osmotic pressure in the hydrogel matrix. This results in swelling, inducing bending towards the cathode, accentuating the material’s responsiveness. In contrast, 4-HBA offers mechanical resilience, providing an elastic backbone, and ensuring the hydrogel’s applicability. Our results illustrate the hydrogel’s strength, flexibility, and bending capabilities across varied compositions and electric field strengths. Notably, the µCLIP process enabled the 3D printing of our EAH into sophisticated structures, like the lattice. The combination of AA’s electro-responsive traits with 4-HBA’s durability has birthed a material with vast practical implications. This study provides extended potential breakthroughs in soft robotics, wearable electronics, and medical devices, marking a significant stride in the realm of electroactive materials.

Dynamic topology optimization of 3D-Printed transtibial orthopedic implant using tunable isotropic porous metamaterials

Vat photopolymerization (VP) 3D printing, a subset of additive manufacturing, is renowned for its capability to create intricate structures with high precision, particularly useful in optical applications. The process involves using photosensitive resins cured layer by layer through various light-curing technologies like Stereolithography (SLA), Digital Light Processing (DLP), Two-Photon Polymerization (TPP), Continuous Liquid Interface Production (CLIP), and Liquid Crystal Display (LCD). Each technique offers unique advantages in terms of speed, resolution, and material compatibility, with TPP providing the highest resolution. This review explores the diverse applications of VP 3D-printed optical components, including lenses, waveguides, optical gratings, resonators, metamaterials, sensors, and actuators, demonstrating their significant role in advancing optical technology and innovation. Challenges in material selection, post-processing requirements, size limitations, and support structures are discussed, alongside potential future research directions. These include developing advanced photopolymer materials with enhanced optical properties, hardware improvements for higher resolution and multi-material printing, and quality assurance measures for ensuring optical precision. Despite some limitations, VP 3D printing presents a promising avenue for the rapid prototyping and production of complex, multifunctional optical devices, marking a significant stride in optical manufacturing and technological development.

Continuous Liquid Interface Production

Additive manufacturing, also known as 3D printing, enables production of complex customized shapes without requiring specialized tooling and fixture, and mass customization can then be realized with larger adoption. The slicing procedure is one of the fundamental tasks for 3D printing, and the slicing resolution has to be very high for fine fabrication, especially in the recent developed Continuous Liquid Interface Production (CLIP) process. The slicing procedure is then becoming the bottleneck in the pre-fabrication process, which could take hours for one model. This becomes even more significant in mass customization, where hundreds or thousands of models have to be fabricated. We observe that the customized products are generally in a same homogeneous class of shape with small variation. Our study finds that the slicing information of one model can be reused for other models in the same homogeneous group under a properly defined parameterization. Experimental results show that the reuse of slicing information have a maximum of 50 times speedup, and its utilization is dropped from more than 90% to less than 50% in the pre-fabrication process.

Correction: Multiphysics Simulation of Continuous Liquid Interface Production (CLIP) 3D Printing Technology

Think outside the box: 3D bioprinting concepts for biotechnological applications – recent developments and future perspectives

3D bioprinting is a disruptive, computer-aided, and additive manufacturing technology that allows the obtention, layer-by-layer, of 3D complex structures. This technology is believed to offer tremendous opportunities in several fields including biomedical, pharmaceutical, and food industries. Several bioprinting processes and bio-ink materials have emerged recently. However, there is still a pressing need to develop low-cost sustainable bio-ink materials with superior qualities (excellent mechanical, viscoelastic and thermal properties, biocompatibility, and biodegradability). Marine-derived biomaterials, including polysaccharides and proteins, represent a viable and renewable source for bio-ink formulations. Therefore, the focus of this review centers around the use of marine-derived biomaterials in the formulations of bio-ink. It starts with a general overview of 3D bioprinting processes followed by a description of the most commonly used marine-derived biomaterials for 3D bioprinting, with a special attention paid to chitosan, glycosaminoglycans, alginate, carrageenan, collagen, and gelatin. The challenges facing the application of marine-derived biomaterials in 3D bioprinting within the biomedical and pharmaceutical fields along with future directions are also discussed.

Review for "Development of a biocompatible 3D hydrogel scaffold using continuous liquid interface production for the delivery of cell therapies to treat recurrent glioblastoma"

Review for "Development of a biocompatible 3D hydrogel scaffold using continuous liquid interface production for the delivery of cell therapies to treat recurrent glioblastoma"

Decision letter for "Development of a biocompatible 3D hydrogel scaffold using continuous liquid interface production for the delivery of cell therapies to treat recurrent glioblastoma"

3D bioprinting bone/cartilage organoids: construction, applications, and challenges

Inhibited astrocytic differentiation in neural stem cell-laden 3D bioprinted conductive composite hydrogel scaffolds for repair of spinal cord injury