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Clarifying tetrapod embryogenesis, a physicist's point of view

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Abstract

\n The origin of tetrapods is a complex question that webs together genetic, \npaleontological, developmental and physical facts. Basically, the \ndevelopment of embryos is described by a complex mix of mechanical movements \nand biochemical inductions of genetic origin. It is difficult to sort out in \nthis scientific question what are the fundamental features imposed by \nconservation laws of physics, and by force equilibria, and what can be \nascribed to successive, very specific, stop-and-go inductions of genetic \nnature. A posteriori, evolution selects the parameters of this process as found in the \nobserved species. Whether there is a general law to animal formation seems \nout of the question. However, several concepts developed in biology, like \nthe concept of “organizer” seem questionable from a physics point of view, \nsince the entire deformation and force field should be the “organizer” of \ndevelopment, and one can hardly ascribe such a role to a single small area \nof the embryo body. In the same spirit, the concept of “positional \ninformation” encapsulated in concentration of chemicals seems questionable \nsince the deformation and force fields in embryonic tissues are tensors. \nFinally, the concept of a development organized in space along three \northogonal (“Cartesian”) axes associated to chemical gradients seems also \nquestionable, since early embryo development is driven by complex vortex \nfields, with hyperbolic trajectories which span the entire embryo. Such \nhyperbolic trajectories are best understood by a description in terms of \ndipolar components of the morphogenetic forces, whose projections along \northogonal axe have no specific meaning except as a mathematical tool. I \nreview here the present state of description of several aspects of tetrapods \nmorphogenesis and evolution, from the point of view of physics. It is \ngetting clear that several basic features of tetrapods body are a direct \nconsequences of fundamental laws of physics. Several lines of work reviewed \nhere show that the topology of the tetrapods may be directly related to the \nstructure of the earliest movements in embryos. The bio-mechanical approach \nleads to important consequences for the constraints on evolution of the \ncraniates. Such consequences have received a controversial welcome in the \nlast decade, although they may encapsulate the true origin of craniates, \nesp. simians, and eventually homo.\n\n \n

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