CLINICAL FEATURE VS ARTIFICIAL INTELLIGENCE FEATURE: RISK FACTOR ANALYSIS BASED ON DEEP LEARNING

PurposeTo differentiate complicated appendicitis (CA) from uncomplicated appendicitis (UA) in children, we developed and validated an artificial intelligence (AI) model using a multimodal approach integrating ultrasound images and clinical data.MethodsA retrospective analysis was performed on 372 pathologically confirmed pediatric appendicitis cases (230 male, 142 female) from three centers, all with preoperative abdominal ultrasound. Deep learning (DL) features and radiomic features were extracted from appendiceal ultrasound images using deep transfer learning (DTL) and conventional radiomic methods, respectively. We selected 12 radiomic features, 9 DL features, and 3 clinical features—namely, white blood cell count (WBC), neutrophil count (NEU), and C-reactive protein (CRP)—for building the machine learning classification model. Based on these features, four distinct models were constructed: the Rad model (radiomic features only), the DL model (DL features only), the DTL model (combined radiomic and DL features), and the Combine model (integrating all three feature types: radiomic, DL, and clinical features). Model performance was evaluated using receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and the DeLong test. Finally, the combined model was compared to the performance of clinicians with varying levels of experience.ResultsThe combined model demonstrated consistently favorable performance across all cohorts (AUC: 0.940, 0.895, 0.866, and 0.783 for training and validation sets, respectively). The model's accuracy (0.862) and positive predictive value (0.896) were comparable to senior surgeons (0.741, 0.970) and superior to junior surgeons (0.672, 0.865) in the internal validation cohort. DCA confirmed the clinical utility of the combined model over conventional strategies.ConclusionOur ultrasound-based AI model provides reliable differentiation between CA and UA in children, offering potential value as a diagnostic support tool for clinical decision making.

The benefit of virtual rehabilitation is that it helps the patient increase their engagement and motivation. Another advantage is that it allows patient specific. A third utility is that the therapist can make the sessions more efficient and productive. A feature of virtual reality (VR) rehabilitation is that it is possible to create virtual environments which are more realistic than those in a video game and in which the patients can perform exercises. As a result, the patients are more immersed and motivated to avoid the boredom from which patients in standard therapy usually suffer. The features of artificial intelligence (AI) in biomedicine are the optimisation of diagnostics, treatment, and patient monitoring. AI allows for the analysis to have the potential to detect subtle deviations. In this chapter, the application of virtual reality and artificial intelligence in healthcare was discussed.

Diabetic retinopathy (DR) is a late microvascular complication of Diabetes Mellitus (DM) that could lead to permanent blindness in patients, without early detection. Although adequate management of DM via regular eye examination can preserve vision in in 98% of the DR cases, DR screening and diagnoses based on clinical lesion features devised by expert clinicians; are costly, time-consuming and not sufficiently accurate. This raises the requirements for Artificial Intelligent (AI) systems which can accurately detect DR automatically and thus preventing DR before affecting vision. Hence, such systems can help clinician experts in certain cases and aid ophthalmologists in rapid diagnoses. To address such requirements, several approaches have been proposed in the literature that use Machine Learning (ML) and Deep Learning (DL) techniques to develop such systems. However, these approaches ignore the highly valuable clinical lesion features that could contribute significantly to the accurate detection of DR. Therefore, in this study we introduce a framework called DR-detector that employs the Extreme Gradient Boosting (XGBoost) ML model trained via the combination of the features extracted by the pretrained convolutional neural networks commonly known as transfer learning (TL) models and the clinical retinal lesion features for accurate detection of DR. The retinal lesion features are extracted via image segmentation technique using the UNET DL model and captures exudates (EXs), microaneurysms (MAs), and hemorrhages (HEMs) that are relevant lesions for DR detection. The feature combination approach implemented in DR-detector has been applied to two common TL models in the literature namely VGG-16 and ResNet-50. We trained the DR-detector model using a training dataset comprising of 1,840 color fundus images collected from e-ophtha, retinal lesions and APTOS 2019 Kaggle datasets of which 920 images are healthy. To validate the DR-detector model, we test the model on external dataset that consists of 81 healthy images collected from High-Resolution Fundus (HRF) dataset and MESSIDOR-2 datasets and 81 images with DR signs collected from Indian Diabetic Retinopathy Image Dataset (IDRID) dataset annotated for DR by expert. The experimental results show that the DR-detector model achieves a testing accuracy of 100% in detecting DR after training it with the combination of ResNet-50 and lesion features and 99.38% accuracy after training it with the combination of VGG-16 and lesion features. More importantly, the results also show a higher contribution of specific lesion features toward the performance of the DR-detector model. For instance, using only the hemorrhages feature to train the model, our model achieves an accuracy of 99.38 in detecting DR, which is higher than the accuracy when training the model with the combination of all lesion features (89%) and equal to the accuracy when training the model with the combination of all lesions and VGG-16 features together. This highlights the possibility of using only the clinical features, such as lesions that are clinically interpretable, to build the next generation of robust artificial intelligence (AI) systems with great clinical interpretability for DR detection. The code of the DR-detector framework is available on GitHub at https://github.com/Janga-Lab/DR-detector and can be readily employed for detecting DR from retinal image datasets.

This article examines the essence and characteristics of artificial intelligence (AI) and its applications in various agriculture segments. Special attention is paid to the challenges of implementing AI in crop production, animal husbandry, resource management, and analytical processes. The role of robotics is examined as a key factor in the digital transformation of the agricultural sector, facilitating the adoption of new production approaches. The article highlights the main advantages of AI in the agricultural sector, such as the automation of routine tasks, reduction of manual labor costs, increased production efficiency, and the creation of new products. The use of intelligent technologies optimizes resources and boosts productivity, contributing to the competitiveness of agricultural enterprises. The article also reviews global experiences in the implementation of AI and robotics in agriculture. Examples of successful use of these technologies by leading companies are provided, along with an analysis of the experience of Ukrainian agricultural enterprises. Positive aspects of AI implementation, such as increased efficiency and crop yields, are studied, while drawbacks and risks associated with adapting new technologies to the specific conditions of Ukrainian agriculture are also highlighted. The conclusions of the article emphasize that the use of AI is a promising direction for the development of the agricultural sector. AI technologies help address key challenges related to food security and sustainable development. Despite the challenges and risks, AI's potential to enhance agricultural production efficiency is significant, and the future of agriculture largely depends on the further development and implementation of these technologies. The widespread introduction of intelligent technologies can not only transform agricultural processes, but also make them more environmentally sustainable and economically profitable in the long term. Key words: artificial intelligence, agricultural sector, innovative technologies, agriculture, crop production, animal husbandry, robotics, machine intelligence.

In combination with the characteristics of artificial intelligence and separate subject course as well as the actual needs of teaching, this paper introduces the construction circumstance of the separate subject curriculum resource library based on artificial intelligence in respects of the construction of the separate subject curriculum resource library, the optimization of teaching resources and conditions, and analyzes the construction of the relevance resource database of the interdiscipline resource library in detail. By making use of the concrete application of machine learning algorithms in data mining, establishes the machine learning module and the expert system module to simulate the knowledge and experience of the human experts, and the decision-making support is provided for the solution steps and ways of problems.

BackgroundLung cancer (LC) is a leading cause of cancer-related mortality, and immunotherapy (IO) has shown promise in treating advanced-stage LC. However, identifying patients likely to benefit from IO and monitoring treatment response remains challenging. This study aims to develop a predictive model for progression-free survival (PFS) in LC patients with IO based on clinical features and advanced imaging biomarkers.Materials and methodsA retrospective analysis was conducted on a cohort of 206 LC patients receiving IO treatment. Pre-treatment computed tomography images were used to extract advanced imaging biomarkers, including intratumoral and peritumoral-vasculature radiomics. Clinical features, including age, gene status, hematology, and staging, were also collected. Key radiomic and clinical features for predicting IO outcomes were identified using a two-step feature selection process, including univariate Cox regression and chi-squared test, followed by sequential forward selection. The DeepSurv model was constructed to predict PFS based on clinical and radiomic features. Model performance was evaluated using the area under the time-dependent receiver operating characteristic curve (AUC) and concordance index (C-index).ResultsCombining radiomics of intratumoral heterogeneity and peritumoral-vasculature with clinical features demonstrated a significant enhancement (p < 0.001) in predicting IO response. The proposed DeepSurv model exhibited a prediction performance with AUCs ranging from 0.76 to 0.80 and a C-index of 0.83. Furthermore, the predicted personalized PFS curves revealed a significant difference (p < 0.05) between patients with favorable and unfavorable prognoses.ConclusionsIntegrating intratumoral and peritumoral-vasculature radiomics with clinical features enabled the development of a predictive model for PFS in LC patients with IO. The proposed model’s capability to estimate individualized PFS probability and differentiate the prognosis status held promise to facilitate personalized medicine and improve patient outcomes in LC.

Aim: Machine learning (ML) and deep learning (DL) predictive models have been employed widely in clinical settings. Their potential support and aid to the clinician of providing an objective measure that can be shared among different centers enables the possibility of building more robust multicentric studies. This study aimed to propose a user-friendly and low-cost tool for COVID-19 mortality prediction using both an ML and a DL approach. Method: We enrolled 2348 patients from several hospitals in the Province of Reggio Emilia. Overall, 19 clinical features were provided by the Radiology Units of Azienda USL-IRCCS of Reggio Emilia, and 5892 radiomic features were extracted from each COVID-19 patient’s high-resolution computed tomography. We built and trained two classifiers to predict COVID-19 mortality: a machine learning algorithm, or support vector machine (SVM), and a deep learning model, or feedforward neural network (FNN). In order to evaluate the impact of the different feature sets on the final performance of the classifiers, we repeated the training session three times, first using only clinical features, then employing only radiomic features, and finally combining both information. Results: We obtained similar performances for both the machine learning and deep learning algorithms, with the best area under the receiver operating characteristic (ROC) curve, or AUC, obtained exploiting both clinical and radiomic information: 0.803 for the machine learning model and 0.864 for the deep learning model. Conclusions: Our work, performed on large and heterogeneous datasets (i.e., data from different CT scanners), confirms the results obtained in the recent literature. Such algorithms have the potential to be included in a clinical practice framework since they can not only be applied to COVID-19 mortality prediction but also to other classification problems such as diabetic prediction, asthma prediction, and cancer metastases prediction. Our study proves that the lesion’s inhomogeneity depicted by radiomic features combined with clinical information is relevant for COVID-19 mortality prediction.

With advancements in mobile technology and artificial intelligence (AI) methods, there has been a substantial surge in the availability of direct-to-consumer mobile applications (apps) claiming to aid in the assessment and management of diverse skin conditions. Despite widespread patient downloads, these apps exhibit limited evidence supporting their efficacy. To identify and characterize current English-language AI dermatology mobile apps available for download, focusing on aspects such as purpose, supporting evidence, regulatory status, clinician input, data privacy measures, and use of image data. In this cross-sectional study, both Apple and Android mobile app stores were systematically searched for dermatology-related apps that use AI algorithms. Each app's purpose, target audience, evidence-based claims, algorithm details, data availability, clinician input during development, and data usage privacy policies were evaluated. A total of 909 apps were initially identified. Following the removal of 518 duplicates, 391 apps remained. Subsequent review excluded 350 apps due to nonmedical nature, non-English languages, absence of AI features, or unavailability, ultimately leaving 41 apps for detailed analysis. The findings revealed several concerning aspects of the current landscape of AI apps in dermatology. Notably, none of the apps were approved by the US Food and Drug Administration, and only 2 of the apps included disclaimers for the lack of regulatory approval. Overall, the study found that these apps lack supporting evidence, input from clinicians and/or dermatologists, and transparency in algorithm development, data usage, and user privacy. This cross-sectional study determined that although AI dermatology mobile apps hold promise for improving access to care and patient outcomes, in their current state, they may pose harm due to potential risks, lack of consistent validation, and misleading user communication. Addressing challenges in efficacy, safety, and transparency through effective regulation, validation, and standardized evaluation criteria is essential to harness the benefits of these apps while minimizing risks.

With the permeation of artificial intelligence (AI) through the tourism and hospitality industry, a comprehensive understanding of its features and service outcomes is important for both academia and practice. In this study, a meta-analytic framework with 23 constructs from 91 research papers was developed. This analysis indicated that AI features can be categorized as sensory, social or functional; and the relationships among these features were revealed. Additionally, these features lead to positive service outcomes via a process involving customers’ cognition, affect and relationships with service providers. The research method, AI type and participants’ gender moderate the influence of AI features on service outcomes, but stimulants and prior experience do not. These findings enhance the understanding of AI applications and consequences and have managerial implications.

Forecasting the behavior of the stock market is a classic but difficult topic, one that has attracted the interest of both economists and computer scientists. Over the course of the last couple of decades, researchers have investigated linear models as well as models that are based on machine learning (ML), deep learning (DL), reinforcement learning (RL), and deep reinforcement learning (DRL) in order to create an accurate predictive model. Machine learning algorithms can now extract high-level financial market data patterns. Investors are using deep learning models to anticipate and evaluate stock and foreign exchange markets due to the advantage of artificial intelligence. Recent years have seen a proliferation of the deep reinforcement learning algorithm’s application in algorithmic trading. DRL agents, which combine price prediction and trading signal production, have been used to construct several completely automated trading systems or strategies. Our objective is to enable interested researchers to stay current and easily imitate earlier findings. In this paper, we have worked to explain the utility of Machine Learning, Deep Learning, Reinforcement Learning, and Deep Reinforcement Learning in Quantitative Finance (QF) and the Stock Market. We also outline potential future study paths in this area based on the overview that was presented before.

This study aims to develop and validate an interpretable deep learning (DL) model and a nomogram based on endoscopic ultrasound (EUS) images for the prediction of pathological grading in pancreatic neuroendocrine tumors (PNETs). This multicenter retrospective study included 108 patients with PNETs, who were divided into train (n = 81, internal center) and test cohorts (n = 27, external centers). Univariate and multivariate logistic regression were used for screening demographic characteristics and EUS semantic features. Deep transfer learning was employed using a pre-trained ResNet18 model to extract features from EUS images. Feature selection was conducted using the least absolute shrinkage and selection operator (LASSO), and various machine learning algorithms were utilized to construct DL models. The optimal model was then integrated with clinical features to develop a nomogram. The performance of the model was assessed using the area under the curve (AUC), calibration curves, decision curve analysis (DCA), and clinical impact curves (CIC). The nomogram, which integrates the optimal DL model (Naive Bayes) with clinical features, achieved AUC values of 0.928 (95% CI 0.849–0.981) in the train cohort and 0.882 (95% CI 0.778–0.954) in the test cohort. Calibration curves revealed minimal discrepancies between predicted and actual probabilities, with mean absolute errors of 4.5% and 6.6% in the train and test cohorts, respectively. DCA and CIC demonstrated substantial net benefit and clinical utility. The SHapley Additive exPlanations (SHAP) method provided insights into the contribution of each DL feature to the model’s predictions. This study developed and validated a novel interpretable DL model and nomogram using EUS images and machine learning, which holds promise for enhancing the clinical application of EUS in identifying PNETs’ pathological grading.

The Smart Home designed to extend older adults independence is emerging as a clinical solution to the growing ageing population. Nurses will and should play a key role in the development and application of Smart Home technology. Accordingly, conceptual frameworks are needed for nurse scientists who are collaborating with multidisciplinary research teams in developing an intelligent Smart Home that assists with managing older adults' health. We present a conceptual framework that is grounded in critical realism and pragmatism, informing a unique mixed methodological approach to generating, analyzing, and contextualizing sensor data for clinician-based machine learning. This framework can guide nurse scientists in knowledge construction as they participate in multidisciplinary health-assistive Smart Home and artificial intelligence research. In this paper, we review philosophical underpinnings and explicate how this framework can guide nurse scientists collaborating with engineers to develop intelligent health-assistive Smart Homes. It is critical that clinical nursing knowledge is integrated into Smart Home and artificial intelligence features. A conceptual framework and practical method will provide needed structure for knowledge construction by nurse scientists.

Cooperative robots became a very important research topic due to their capability to accomplish tasks fast and more efficiently. In order for cooperative robots to accomplish their tasks, they need to be able to plan their paths in the environment without any collision. Path planning for cooperative robots with deep reinforcement learning is a new research topic in robotics and artificial intelligence. Path planning via deep reinforcement learning is an end to end method. The robot directly receives the data from the sensor (usually high dimensional images) and generates an optimal policy that plans a safe path to the target. In this paper, we first present an overview of reinforcement learning, deep learning, and deep reinforcement learning. Then, we introduce methods used for path planning. Finally, we discuss the challenges of deep reinforcement learning path planning for cooperative robots.

This study aims to construct and validate a predictable deep learning model associated with clinical data and multi-sequence magnetic resonance imaging (MRI) for short-term postoperative facial nerve function in patients with acoustic neuroma. A total of 110 patients with acoustic neuroma who underwent surgery through the retrosigmoid sinus approach were included. Clinical data and raw features from four MRI sequences (T1-weighted, T2-weighted, T1-weighted contrast enhancement, and T2-weighted-Flair images) were analyzed. Spearman correlation analysis along with least absolute shrinkage and selection operator regression were used to screen combined clinical and radiomic features. Nomogram, machine learning, and convolutional neural network (CNN) models were constructed to predict the prognosis of facial nerve function on the seventh day after surgery. Receiver operating characteristic (ROC) curve and decision curve analysis (DCA) were used to evaluate model performance. A total of 1050 radiomic parameters were extracted, from which 13 radiomic and 3 clinical features were selected. The CNN model performed best among all prediction models in the test set with an area under the curve (AUC) of 0.89 (95% CI, 0.84-0.91). CNN modeling that combines clinical and multi-sequence MRI radiomic features provides excellent performance for predicting short-term facial nerve function after surgery in patients with acoustic neuroma. As such, CNN modeling may serve as a potential decision-making tool for neurosurgery.

Banking operations have changed due to technological advancement. On one hand, modernization in technology has facilitated the daily operation of banks; on the other hand, this has also resulted in an increase in the number of cyber-attacks. Artificial Intelligence has introduced new models to detect and prevent cybercrimes. Some fraud has also occurred due to the involvement of employees inside particular organizations. So, this study has focused on both sides: the machine as well as the human. Firstly, the research has focused on fraud diamond theory and has analyzed factors such as rationalization, capabilities, perceived pressure, and perceived opportunities to understand the psychology of the fraudster. Secondly, Artificial Intelligence characteristics, threat exposure, big data management, explainability, cost effectiveness, and risk prediction are evaluated to explore their use in fraud reduction in banks. The research data have been collected from 15 Banks in Pakistan with the help of a questionnaire using five-item Likert scales. The data have been analyzed using IBM SPSS Software. The results gained after correlation and regression analysis proved that Fraud diamond theory and AI characteristics have positive and significant effects on cybercrimes. This study is a great contribution to the banking industry of Pakistan as it provides a complete analysis to control fraud inside organizations by understanding the mindset of fraudsters with the help of fraud diamond theory. At the same time, outside fraud will be handled with the help of Artificial Intelligence. This will result in banks growth, which ultimately boosts the economy of a country.