For a multiplier pair ( X , Y ) \left ( X,Y\right ) we study the closed densely defined operators T T on X X that commute with all of the multiplications by right multipliers in X X . We apply our general results to special cases involving H p H^{p} , completions of L ∞ [ 0 , 1 ] L^{\infty }\left [ 0,1\right ] with respect to certain norms, and the completion of a I I 1 II_{1} factor von Neumann algebra with respect to a unitarily invariant norm, where we show that each such T T is a “left multiplication”. However, we give an example of a closed densely defined operator on the Bergman space that commutes with all multiplications by H ∞ H^{\infty } -functions but is not a multiplication operator.