Computational approach for chronic wound tissue characterization

Machine learning (ML) models are cost-effective tools that can establish a prognosis by considering clinical, genomic, and histological data from breast cancer patients. In this study, we evaluate the performance of 12 ML models in predicting the overall survival of breast cancer patients from “The Cancer Genome Atlas-Breast Cancer” database at 60 months of follow-up. The models evaluated were Logistic Regression (LR), Ridge Classifier (RC), Least Absolute Shrinkage and Selection Operator (LASSO), K-Nearest Neighbors (KNN), Naive Bayes (NB), Linear Discriminant Analysis (LDA), Decision Tree (DT), Multilayer Perceptron (MP), Stochastic Gradient Descent (SGD), Support Vector Machine (SVM), Random Forest (RF), and XGBoost (XGB). The most accurate models were NB (86.76%) and SGD (85.29%). The models with the highest sensitivity were SGD (93.75%), MP (91.67%), and NB (89.89%), while the models with the highest specificity were KNN (95.0%), DT (90.0%), and LASSO (85.0%). The models with the highest area under the ROC curve were LDA (90.83%), LASSO (90.1%), and LR (89.79%). The most relevant variables were “Previous Diagnosis of Cancer,” “Presence of Tumor,” “Ancillary Therapy,” and “Histology.” Our findings demonstrate that AI tools for predicting patient outcomes are a viable option when expensive prognostic genomic tools are not available. According to our results, NB and LASSO show promising performance in predicting the prognosis of breast cancer patients. Further studies with data from developing countries are needed to improve the performance of these tools.

Advancement in technology has helped people to live a long and better life. But the increased life expectancy has also elevated the risk of age related disorders, especially the neurodegenerative disorders. Alzheimer’s is one such neurodegenerative disorder, which is also the leading contributor towards dementia in elderly people. Despite of extensive research in this field, scientists have failed to find a cure for the disease till date. This makes early diagnosis of Alzheimer’s very crucial so as to delay its progression and improve the condition of the patient. Various techniques are being employed for diagnosing Alzheimer’s which include neuropsychological tests, medical imaging, blood based biomarkers, etc. Apart from this, various machine learning algorithms have been employed so far to diagnose Alzheimer’s in its early stages. In the current research, authors compared the performance of various machine learning techniques i.e., Linear Discriminant Analysis (LDA), K-Nearest Neighbour (KNN), Naïve Bayes (NB), Support Vector Machines (SVM), Decision Trees (DT), Random Forests (RF) and Multi Layer Perceptron (MLP) on Alzheimer’s dataset. This paper experimentally demonstrated that normalization exhibits a predominant role in enhancing the efficiency of some machine learning algorithms. Therefore it becomes imperative to choose the algorithms as per the available data. In this paper, the efficiency of the given machine learning methods was compared in terms of accuracy and f1-score. Naïve Bayes gave a better overall performance for both accuracy and f1-score and it also remained unaffected with the normalization of data along with LDA, DT and RF. Whereas KNN, SVM and MLP showed a drastic (17% to 86%) improvement in the performance when they are given normalized data as compared to un-normalized data from Alzheimer’s dataset.

Handwritten signature identification is a process that determines an individual’s true identity by analyzing their signature. This is an important task in various applications such as financial transactions, legal document verification, and biometric systems. Various techniques have been developed for signature identification, including feature-based methods and machine learning-based methods. However, verifying handwritten signatures in digital transactions and remote document authentication is still challenging. The inherent variety in people’s signatures, which may occur due to factors such as mood, exhaustion, or even the writing tool used, contributes to the problem. Furthermore, the proliferation of sophisticated forgery methods, such as freehand mimicking and sophisticated picture manipulation, necessitates the development of reliable and precise tools for identifying authentic signatures from fake ones.The present paper suggests a method for identifying signatures based on integrating static (off-line) handwritten signature data. This is done by fusing three types of signature features: Linear Discriminant Analysis (LDA) as appearance-based features, Fast Fourier Transform (FFT) as frequency-features, and Gray-Level Co-occurrence Matrix (GLCM) as texture-features. Then, these fused features are inputted into four types of machine learning algorithms: Naive Bayes, K-Nearest Neighbor, Decision Tree, and AdaBoost classifiers, to identify each person and to find the most robust algorithm in terms of accuracy and precision and recall. For experiments, we have used two famous datasets: SigComp2011 and CEDAR. After training datasets, the highest accuracy achieved was 100% on the CEDAR dataset and 94.43% on the SigComp2011 dataset using a Naive Bayes classifier. Index Terms— Fast Fourier Transform, Gray-Level Co-occurrence Matrix, Handwritten Signature, Linear Discriminant Analysis, Machine Learning.

Pressure ulcer is a clinical pathology of localized damage to the skin and underlying tissue caused by pressure, shear o friction. Diagnosis, treatment and care of pressure ulcers involve high costs for sanitary systems. Accurate wound evaluation is a critical task for optimizing the effectiveness of treatments and care. Clinicians usually evaluate each pressure ulcer by visual inspection of the damaged tissues, which is an imprecise manner of assessing the wound state. Current computer vision approaches do not offer a global solution to this particular problem. In this article, a hybrid approach based on neural networks and Bayesian classifiers is used in the designing of a computational system for automatic tissue identification on wound images. A mean shift procedure and a region-growing strategy are implemented for effective region segmentation. Color and texture features are extracted from the segmented regions. A set of k multi-layer perceptrons are trained with inputs consisting of color and texture patterns, and outputs consisting of categorical tissue classes which are determined by clinical experts. This training procedure is driven by a k-fold cross-validation method. Finally, a Bayesian committee machine is formed by training a Bayesian classifier to combine the classifications of the k neural networks. Our outcomes show high performance scores of a two-stage cascade approach for tissue identification.

The problems of adulteration and mislabeling are very common in the food industry. Laser-induced breakdown spectroscopy (LIBS) coupled with chemometric methods has many intrinsic advantages on adulteration analysis of various materials. In this work, several chemometric algorithms, i.e., principal component analysis (PCA), decision tree (DT), random forest (RF), partial least squares discriminant analysis (PLS-DA), linear discriminant analysis (LDA), and support vector machine (SVM), were carried out assisted by LIBS technology to study the classification performances on rice geographic origins. A series of samples, including 20 kinds of rice samples from different geographic origins, was detected using LIBS with no pretreatment processes. For data analysis, PCA was employed to reduce the input variables, and to reduce the collinearity of LIBS spectral results as well. The results showed the classification accuracies of the mentioned chemometric algorithms of DT, RF, PLS-DA, LDA, and SVM with 89 input variables of 86.80%, 96.30%, 96.80%, 98.60%, and 99.20%, respectively. At the same time, the operation times of these algorithms were 3.81 s, 54.64 s, 3.63 s, 2.09 s, and 531.01 s, respectively. On the other hand, 30 principal components of input variables were also tested under the same conditions. The classification accuracies for the above algorithms were 81.60%, 98.00%, 95.70%, 98.40%, and 99.20%, respectively. The operation times were 2.01 s, 4.88 s, 3.67 s, 0.36 s, and 308.55 s, respectively. In addition, the five-fold cross-validation classification accuracies with 30 input variables for DT, RF, PLS-DA, LDA, and SVM were 83.75%, 97.95%, 94.75%, 98.35%, and 99.25%, respectively. As a result, LDA was demonstrated to be the best and most efficient tool for rice geographic origin classification assisted by LIBS with high accuracy and analytical speed, which has great potential for rapid identification of adulterated products in agriculture without use of any chemical reagent.

Background and aimsThe birth weight of a newborn is a crucial factor that affects their overall health and future well-being. Low birth weight (LBW) is a widespread global issue, which the World Health Organization defines as weighing less than 2,500 g. LBW can have severe negative consequences on an individual’s health, including neonatal mortality and various health concerns throughout their life. To address this problem, this study has been conducted using BDHS 2017–2018 data to uncover important aspects of LBW using a variety of machine learning (ML) approaches and to determine the best feature selection technique and best predictive ML model.MethodsTo pick out the key features, the Boruta algorithm and wrapper method were used. Logistic Regression (LR) used as traditional method and several machine learning classifiers were then used, including, DT (Decision Tree), SVM (Support Vector Machine), NB (Naïve Bayes), RF (Random Forest), XGBoost (eXtreme Gradient Boosting), and AdaBoost (Adaptive Boosting), to determine the best model for predicting LBW. The model’s performance was evaluated based on the specificity, sensitivity, accuracy, F1 score and AUC value.ResultsResult shows, Boruta algorithm identifies eleven significant features including respondent’s age, highest education level, educational attainment, wealth index, age at first birth, weight, height, BMI, age at first sexual intercourse, birth order number, and whether the child is a twin. Incorporating Boruta algorithm’s significant features, the performance of traditional LR and ML methods including DT, SVM, NB, RF, XGBoost, and AB were evaluated where LR, had a specificity, sensitivity, accuracy and F1 score of 0.85, 0.5, 85.15% and 0.915. While the ML methods DT, SVM, NB, RF, XGBoost, and AB model’s respective accuracy values were 85.35%, 85.15%, 84.54%, 81.18%, and 84.41%. Based on the specificity, sensitivity, accuracy, F1 score and AUC, RF (specificity = 0.99, sensitivity = 0.58, accuracy = 85.86%, F1 score = 0.9243, AUC = 0.549) outperformed the other methods. Both the classical (LR) and machine learning (ML) models’ performance has improved dramatically when important characteristics are extracted using the wrapper method. The LR method identified five significant features with a specificity, sensitivity, accuracy and F1 score of 0.87, 0.33, 87.12% and 0.9309. The region, whether the infant is a twin, and cesarean delivery were the three key features discovered by the DT and RF models, which were implemented using the wrapper technique. All three models had the identical F1 score of 0.9318. However, “child is twin” was recognized as a significant feature by the SVM, NB, and AB models, with an F1 score of 0.9315. Ultimately, with an F1 score of 0.9315, the XGBoost model recognized “child is twin” and “age at first sex” as relevant features. Random Forest again beat the other approaches in this instance.ConclusionsThe study reveals Wrapper method as the optimal feature selection technique. The ML method outperforms traditional methods, with Random Forest (RF) being the most effective predictive model for Low-Birth-Weight prediction. The study suggests that policymakers in Bangladesh can mitigate low birth weight newborns by considering identified risk factors.

The aim of this paper was to develop a computer assisted tissue classification (granulation, necrotic, and slough) scheme for chronic wound (CW) evaluation using medical image processing and statistical machine learning techniques. The red-green-blue (RGB) wound images grabbed by normal digital camera were first transformed into HSI (hue, saturation, and intensity) color space and subsequently the “S” component of HSI color channels was selected as it provided higher contrast. Wound areas from 6 different types of CW were segmented from whole images using fuzzy divergence based thresholding by minimizing edge ambiguity. A set of color and textural features describing granulation, necrotic, and slough tissues in the segmented wound area were extracted using various mathematical techniques. Finally, statistical learning algorithms, namely, Bayesian classification and support vector machine (SVM), were trained and tested for wound tissue classification in different CW images. The performance of the wound area segmentation protocol was further validated by ground truth images labeled by clinical experts. It was observed that SVM with 3rd order polynomial kernel provided the highest accuracies, that is, 86.94%, 90.47%, and 75.53%, for classifying granulation, slough, and necrotic tissues, respectively. The proposed automated tissue classification technique achieved the highest overall accuracy, that is, 87.61%, with highest kappa statistic value (0.793).

The flow of traffic analysis can be helpful for to improving the traffic quality and protect it from the conditions to cause danger, risk, or injury. Our goal is about reducing the accidents risk which involves designing the roads and principles. The previous road designing patterns of highly accidental risk. Especially some of the circumstances of accidents may be related to the driver such as driver fault, health problems, or also vehicles such as brake failure, steering, or the road itself such as poor sidewalks, and lack of road equipment, and safety measures. In this paper, we talk about some of the best road designing techniques in the world. ‘Double crossover diamond interchange (DCD)’, is a true way to go more people reduce the vehicle striking violently against another. One more design is that a ‘roundabout’, is a circular common intersection where the vehicles can travel anticlockwise around that center part. In This Modern roundabout, there is no need for traffic signals or speed breakers. When the vehicles enter the roundabout zone, if traffic is there in the roundabout, then go to the circulating roadway area and go to their desired street. Find the exact models to predict the deaths and severe injuries caused by road accidents. This analysis needs to classify the various models of machine learning and data science algorithms for instance Linear Regression, Decision Tree, Random Forest (RF), and Naive Bayes Classification and Support Vector Machine (SVM). The decision tree algorithm has a root node and contain child nodes. But Random Forest is having multiple decision trees. Random Forest has the best performance with 79% accuracy then decision tree with 70% accuracy, SVM with 75%, Logic Regression with 72%, and Naive Bayes with 73% accuracy.

ABSTRACTObjectiveIn spinal surgery, precise identification of high‐speed bur milling states is crucial for patient safety. This study investigates whether integrating tactile and auditory perception can enhance the accuracy of milling state detection in robot‐assisted cervical laminectomy.MethodsBased on the mathematical and physical model of vibration and sound in high‐speed bur milling bone, the feasibility of employing vibration and sound characteristics to identify the milling states of high‐speed bur is studied systematically. Cervical laminectomy was performed on the cervical spine of the sheep. During the signal acquisition process, acceleration sensors and microphones were installed to collect vibration and sound signals, respectively. Seven milling states were set up in the experiment: (1) Milling depths of cortical bone (CTB): 0.5, 1.0, and 1.5 mm; (2) Milling depths of milling of cancellous bone (CCB): 0.5, 1.0, and 1.5 mm; (3) Boundary conditions: high‐speed bur idling or complete penetration of bone (PT). The milling speed was set at 0.5 mm/s, the milling angle was 45°, and the bur diameter was 4 mm. The vibration or sound was extracted by Fast Fourier Transform (FFT) in the frequency domain of the first nine harmonics to generate the feature vector in 9 dimensions (9‐D) space. These vibration and sound features were combined to form an 18‐D multi‐perception spatial vector for subsequent analysis, including five machine learning algorithms: Support Vector Machine (SVM), K Nearest Neighbors (KNN), Naive Bayes (NB), Linear Discriminant Analysis (LDA), and Decision Tree (DT), and deep learning models: Long Short‐Term Memory networks (LSTM).ResultsBased on the 18‐D features of tactile and auditory multisensory fusion, the LSTM model is trained using 6600 sets of high‐speed bur milling data. In order to achieve the best performance, a layer‐by‐layer parameter optimization strategy was used to determine the optimal parameter configuration, and finally, a single‐layer LSTM with 12 memory units was constructed. In terms of accuracy and stability, the model is significantly superior to the machine learning algorithms (SVM, KNN, NB, LDA, and DT), and the accuracy of LSTM is 99.32% in the milling states identification of cervical lamina milling with high‐speed bur.ConclusionThrough theoretical analysis and experimental verification, the study built a multi‐perception fusion framework based on tactile and auditory perception and accurately identified the cervical vertebra milling states through the LSTM model, which can provide perception means for operational spinal surgery robots in the future.

Objective: Using methylation characteristics of human genes to construct machine learning predictive models for screening cervical cancer and precancerous lesions. Methods: Human DNA methylation detection was performed on 224 cervical exfoliated cell specimens from the Cancer Hospital of the Chinese Academy of Medical Sciences, Tianjin Central Hospital of Gynecology Obstetrics, Xinmi Maternal and Child Health Hospital of Henan Province, West China Second Affiliated Hospital of Sichuan University, and Heping Hospital Affiliated to Changzhi Medical College collected during April 2014 and March 2015. The hypermethylated gene fragments related to cervical cancer were selected by high-density, high-association, and hypermethylated gene fragment screening and the LASSO regression algorithm. Taking cervical intraepithelial neoplasia grade 2 (CIN2) or more severe lesions as the research outcome, machine learning predictive models based on the random forest (RF), naive Bayes (NB), and support vector machine (SVM) algorithm, respectively, were constructed. A total of 144 outpatient specimens were used as the training set and 80 cervical exfoliated cell specimens from women participating in the cervical cancer screening program were used as the test set to verify the predictive models. Using histological diagnosis results as the gold standard, the detection efficacy for CIN2 or more severe lesions of the three machine learning predictive models were compared with that of the human papilloma virus (HPV) detection and cytological diagnosis. Results: In the training set of 144 cases, there were 34 cases of HPV positivity, with a positive rate of 23.61%. Cytologically, there were 37 cases diagnosed as no intraepithelial lesion or malignancy (NILM), and 107 cases diagnosed as atypical squamous cells of undetermined significance (ASC-US) or above. Histologically, there were 28 cases without cervical intraepithelial neoplasia or benign cervical lesions, 31 cases of CIN1, 18 cases of CIN2, 31 cases of CIN3, and 36 cases of squamous cell carcinoma. Seven hypermethylated gene fragments were selected from 45 genes, and three machine learning prediction models based on the RF, NB, and SVM algorithm, respectively, were constructed. In the validation set of 80 cases, there were 28 cases of HPV positivity, with a positive rate of 35.00%. Cytologically, there were 65 cases diagnosed as NILM and 15 cases as ASC-US or above. Histologically, there were 39 cases without cervical intraepithelial neoplasia or benign cervical lesions, 10 cases of CIN1, 10 cases of CIN2, 11 cases of CIN3, and 10 cases of squamous cell carcinoma. In the validation set, the area under the curve (AUC) values of the RF model, NB model, SVM model, HPV detection, and cytological diagnosis of CIN2 or above were 0.90, 0.88, 0.82, 0.68, and 0.45, respectively. The DeLong test showed that there was no statistically significant difference in the AUC values between the RF, NB, and SVM models (all P＞0.05), and the AUC values of the RF and NB models were higher than that of HPV detection (both P＜0.01), and the AUC values of the RF, NB, and SVM models were higher than that of cytological diagnosis (all P＜0.01). Compared with the NB model, the sensitivity of the RF model was similar (80.65% vs. 77.42%), but the specificity of the NB model was much higher than that of the RF model (93.88% vs. 73.47%). Conclusion: Among the machine learning prediction models for cervical cancer and precancerous lesions constructed based on human DNA methylation, the NB model has good predictive performance for CIN2 and above lesions, and may be used for screening of cervical cancer and precancerous lesions.

This study proposes an automatic method for identifying Huntington’s disease using features extracted from gait signals derived from force-sensitive resistors. Features were extracted using metrics of fluctuation magnitude and fluctuation dynamics, obtained from a detrended Fluctuation Analysis (DFA). In the classification, five machine learning algorithms (Support Vector Machines (SVM), K-Nearest Neighbor (KNN), Naive Bayes (NB), Linear Discriminant Analysis (LDA) and Decision Tree (DT)) were compared by the leave-one-out cross-validation method. Our experiments showed that SVM and DT provided the best results, achieving an average accuracy of 100.0%, representing an improvement compared to other results in the literature, and proving the effectiveness of the proposed method.

BackgroundPredictive models for delayed graft function (DGF) after kidney transplantation are usually developed using logistic regression. We want to evaluate the value of machine learning methods in the prediction of DGF.Methods497 kidney transplantations from deceased donors at the Ghent University Hospital between 2005 and 2011 are included. A feature elimination procedure is applied to determine the optimal number of features, resulting in 20 selected parameters (24 parameters after conversion to indicator parameters) out of 55 retrospectively collected parameters. Subsequently, 9 distinct types of predictive models are fitted using the reduced data set: logistic regression (LR), linear discriminant analysis (LDA), quadratic discriminant analysis (QDA), support vector machines (SVMs; using linear, radial basis function and polynomial kernels), decision tree (DT), random forest (RF), and stochastic gradient boosting (SGB). Performance of the models is assessed by computing sensitivity, positive predictive values and area under the receiver operating characteristic curve (AUROC) after 10-fold stratified cross-validation. AUROCs of the models are pairwise compared using Wilcoxon signed-rank test.ResultsThe observed incidence of DGF is 12.5 %. DT is not able to discriminate between recipients with and without DGF (AUROC of 52.5 %) and is inferior to the other methods. SGB, RF and polynomial SVM are mainly able to identify recipients without DGF (AUROC of 77.2, 73.9 and 79.8 %, respectively) and only outperform DT. LDA, QDA, radial SVM and LR also have the ability to identify recipients with DGF, resulting in higher discriminative capacity (AUROC of 82.2, 79.6, 83.3 and 81.7 %, respectively), which outperforms DT and RF. Linear SVM has the highest discriminative capacity (AUROC of 84.3 %), outperforming each method, except for radial SVM, polynomial SVM and LDA. However, it is the only method superior to LR.ConclusionsThe discriminative capacities of LDA, linear SVM, radial SVM and LR are the only ones above 80 %. None of the pairwise AUROC comparisons between these models is statistically significant, except linear SVM outperforming LR. Additionally, the sensitivity of linear SVM to identify recipients with DGF is amongst the three highest of all models. Due to both reasons, the authors believe that linear SVM is most appropriate to predict DGF.

This study uses the MQTT-IoT-IDS2020 dataset, which contains normal traffic and attack traffic such as scan_A, scan_sU, Sparta, and mqtt_bruteforce attacks. This dataset is statistically extracted based on the unidirectional-based features packet header flow feature and has 19 features. This study used 10 best algorithms, namely ADABOST, eXtreme gradient boosting classifier (XGBC), stochastic gradient descent classifier (SGDC), random forest (RF), Naïve Bayes (NB), multi-layer perceptron classifier (MLPC), decision tree (DT), logistic regression (LR), linear discriminant analysis (LDA), and K-Nearest Neighbor (KNN) using binary class and multi-class. Using this classification algorithm, researchers measure the value of accuracy, precision, recall, F1 score, classification time, and receiver operating characteristic (ROC) curve to obtain the best classification algorithm. Measurement of accuracy value is done by dividing the dataset into 80:20 for training data and testing data, then validating the measurement of accuracy value with k-fold.

This paper disseminates an extra dimension of substantial analysis demonstrating the trade-offs between the performance of Parametric (P) and Non-Parametric (NP) classification algorithms when applied to classify faults occurring in pneumatic actuators. Owing to the criticality of the actuator failures, classifying faults accurately may lead to robust fault tolerant models. In most cases, when applying machine learning, the choice of existing classifier algorithms for an application is random. This work, addresses the issue and quantitatively supports the selection of appropriate algorithm for non-parametric datasets. For the case study, popular parametric classification algorithms namely: Naïve Bayes (NB), Logistic Regression (LR), Linear Discriminant Analysis (LDA), Perceptron (PER) and non-parametric algorithms namely: Multi-Layer Perceptron (MLP), k Nearest Neighbor (kNN), Support Vector Machine (SVM), Decision Tree (DT) and Random Forest (RF) are implemented over a non-parametric, imbalanced synthetic dataset of a benchmark actuator process. Upon using parametric classifiers, severe adultery in results is witnessed which misleads the interpretation towards the accuracy of the model. Experimentally, about 20% improvement in accuracy is obtained on using non-parametric classifiers over the parametric ones. The robustness of the models is evaluated by inducing label noise varying between 5% to 20%. Triptych analysis is applied to discuss the interpretability of each machine learning model. The trade-offs in choice and performance of algorithms and the evaluating metrics for each estimator are analyzed both quantitatively and qualitatively. For a more cogent reasoning through validation, the results obtained for the synthetic dataset are compared against the industrial dataset of the pneumatic actuator of the sugar refinery, Development and Application of Methods for Actuator Diagnosis in Industrial Control Systems (DAMADICS). The efficiency of non-parametric classifiers for the pneumatic actuator dataset is well proved.

Objectives Neuropsychological tests (NPTs) are standard tools for assessing cognitive function. These tools can evaluate the cognitive status of a subject, which can be time-consuming and expensive for interpretation. Therefore, this paper aimed to optimize the systematic NPTs by machine learning and develop new classification models for differentiating healthy controls (HC), mild cognitive impairment, and Alzheimer’s disease dementia (ADD) among groups of subjects. Patients and methods A total dataset of 14,926 subjects was obtained from the formal 46 NPTs based on the Seoul Neuropsychological Screening Battery (SNSB). The statistical values of the dataset included an age of 70.18 ± 7.13 with an education level of 8.18 ± 5.50 and a diagnosis group of three; HC, MCI, and ADD. The dataset was preprocessed and classified in two- and three-way machine-learning classification from scikit-learn (www.scikit-learn.org) to differentiate between HC versus MCI, HC versus ADD, HC versus Cognitive Impairment (CI) (MCI + ADD), and HC versus MCI versus ADD. We compared the performance of seven machine learning algorithms, including Naïve Bayes (NB), random forest (RF), decision tree (DT), k-nearest neighbors (KNN), support vector machine (SVM), AdaBoost, and linear discriminant analysis (LDA). The accuracy, sensitivity, specificity, positive predicted value (PPV), negative predictive value (NPV), area under the curve (AUC), confusion matrixes, and receiver operating characteristic (ROC) were obtained from each model based on the test dataset. Results The trained models based on 29 best-selected NPT features were evaluated, the model with the RF algorithm yielded the best accuracy, sensitivity, specificity, PPV, NPV, and AUC in all four models: HC versus MCI was 98%, 98%, 97%, 98%, 97%, and 99%; HC versus ADD was 98%, 99%, 96%, 97%, 98%, and 99%; HC versus CI was 97%, 99%, 92%, 97%, 97%, and 99% and HC versus MCI versus ADD was 97%, 96%, 98%, 97%, 98%, and 99%, respectively, in predicting of cognitive impairment among subjects. Conclusion According to the results, the RF algorithm was the best classification model for both two- and three-way classification among the seven algorithms trained on an imbalanced NPTs SNSB dataset. The trained models proved useful for diagnosing MCI and ADD in patients with normal NPTs. These models can optimize cognitive evaluation, enhance diagnostic accuracy, and reduce missed diagnoses.