Computers in Dermatology

O-131: Negative emotion predicts poor outcome in poor prognosis IVF patients

α-MSH as a potential biomarker of severity and prognosis after intracerebral hemorrhage: A prospective cohort study

The current (2012) histological classification of immunoglobulin A nephropathy was established using a case-control study of 287 patients. However, the risk of progression to end-stage renal disease (ESRD) has not been validated for the previous (2002) classification. This study aimed to determine whether the previous classification could identify the risk of long-term renal outcome through re-analysis of the 2012 cohort. On the basis of the 2002 classification, namely 'good prognosis', 'relatively good prognosis', 'relatively poor prognosis', and 'poor prognosis', we examined the clinical data at the time of biopsy, the correlation between the 2002 classification and long-term renal outcomes, and a patient-by-patient correlation between the 2002 and 2012 classification systems. This was performed by analyzing samples from the 287 patients used to establish the 2012 classification. The rate of decline of estimated glomerular filtration rate was greater and the odds ratio of progression to ESRD was higher in the 'poor prognosis' group. In contrast, the odds ratio for renal death was comparable between the groups described as 'relatively poor prognosis' and 'relatively good prognosis' in the 2002 classification. Many patients in the 2002 classification were classified with a lower histological grade in the current classification, but none were classified with a higher grade. The 2002 classification could also identify the risk of progression to ESRD. However, it was overestimated for patients in the 'poor prognosis' group in the 2002 classification, as that group included patients with milder histological damage.

Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients

832 PROGNOSTIC CLINICAL PARAMETERS TO PREDICT THE NECESSITY OF RECONSTRUCTIVE VASCULAR SURGERY FOR PATIENTS WHO UNDERGO POSTCHEMOTHERAPY RETROPERITONEAL LYMPH NODE DISSECTION (PC-RPLND) FOR ADVANCED NONSEMINATOUS GERM CELL TUMORS (NSGCT). RESULTS OF THE GERMAN TESTICULAR CANCER STUDY GROUP (GTCSG) AND THE ASSOCIATION OF UROLOGIC ONCOLOGY (AUO)

Stage II-III colorectal cancer (CRC) represents the initial phase of tumor invasion and lymph node metastasis. Surgery is the preferred treatment option for patients at this stage, however, due to the complex progression mechanisms of the disease, incomplete tumor resection, postoperative cancer cell metastasis, and the development of drug resistance to chemotherapy often lead to poor prognosis. The present study aimed to investigate the status of poor postoperative prognosis in patients with stage II-III CRC following radical surgery, analyze the impact of preoperative albumin-hemoglobin (ALB-Hb) score and serum microRNA-497-5p (miR-497-5p) levels on adverse outcomes and develop a predictive model for poor prognosis. Baseline data of 154 patients with stage II-III CRC treated at Tianjin Haihe Hospital (Tianjin, China) or Guangzhou First People's Hospital (Guangzhou, China) between December 2021 and December 2024 were retrospectively selected. Patients were stratified into the poor and good prognosis groups based on clinical outcomes. Univariate analysis was performed on baseline characteristics and laboratory parameters. Variables demonstrating notable differences were subsequently evaluated for multicollinearity. Factors without collinearity were incorporated into a Cox proportional hazards regression model to identify determinants of postoperative prognosis in patients treated with radical resection. These predictors were then used to construct a prognostic nomogram, with model accuracy verified through calibration curves. Among the 154 patients with stage II-III CRC, 63 cases (40.91%) had poor prognosis and 91 cases (59.09%) had good prognosis. Univariate and collinearity analyses revealed marked differences in preoperative levels of miR-497-5p, Kallikrein-related peptidase 5 (KLK5), angiopoietin-2 (Ang-2) and ALB-Hb scores, with no collinearity observed (P<0.05; variation inflation factor ≤10; tolerance ≥0.1). Cox proportional hazards regression model demonstrated that all these indicators were independent factors influencing poor prognosis following radical surgery in patients with stage II-III CRC (all P<0.05). Based on these findings, a nomogram was constructed and calibration curves closely approximated the ideal curve. Preoperative ALB, Hb, miR-497-5p, KLK5, Ang-2 levels and ALB-Hb scores were notable prognostic factors for patients with stage II-III CRC following radical resection, demonstrating high predictive value for poor postoperative outcomes. The present study provided clinically relevant indicators to screen high-risk patients with potential poor prognosis following radical surgery for stages II-III CRC.

To explore independent risk factors for early prognosis prediction in patients with traumatic brain injury (TBI). Retrospective observational study. Trauma center of a tertiary care hospital in Shenzhen, Guangdong, China. A total of 321 patients with TBI from January 2020 to December 2022. To identify risk factors that could predict the prognosis of patients with TBI, and explore the relationship between coagulation function, progressive hemorrhagic injury (PHI), and prognosis. Baseline characteristics, coagulation function-related measurements at admission, and occurrence of PHI were retrospectively obtained from medical records. Patient prognosis was evaluated by Glasgow outcome scale (GOS) score 1 month after hospital admission. Bivariate and multivariate logistic regression analyses were performed to identify risk factors associated with patient prognosis. The receiver operating characteristic curve analysis was applied to evaluate the diagnostic potential of each risk factor. There were 162 patients with good prognosis (GOS 4-5) and 159 patients with poor prognosis (GOS 1-3). Bivariate and multivariate logistic regression analyses showed the development of PHI (odds ratio [OR] = 11.154, 95% confidence interval [CI]: 4.926-25.260), brain herniation (OR = 8.588, 95% CI: 3.510-21.014), coagulation disorders (OR = 7.961, 95% CI: 3.676-17.242); history of blood transfusion within 24 hours of admission (OR = 3.474, 95% CI: 1.517-7.953); multiple injuries (OR = 3.277, 95% CI: 1.453-7.392); fluid replacement volumes within 24 hours of admission (OR = 2.881, 95% CI: 1.367-6.072); and Glasgow coma scale scores (OR = 2.523, 95% CI: 1.414-4.501) to be independent risk factors for poor prognosis. PHI had the highest area under the curve in receiver operating characteristic analysis. The occurrence of PHI, brain herniation, coagulation disorders, history of blood transfusion within 24 hours of admission, multiple injuries, fluid replacement volumes ≥ 2000 mL within 24 hours of admission, and low Glasgow coma scale scores could predict poor short-term prognosis in TBI patients.

A29 - Multigene prognostic and predictive tests in Luminal breast cancer patients: relation between Mammaprint® results and nodal status in a retrospectively monocentric analysis

PurposePrognostication in cancer is growing in importance as increasingly accurate tools are developed. Prognostic accuracy intensifies ethical concerns that a poor prognosis could be psychologically harmful to survivors. Uveal melanoma (UM) prognostication allows survivors to be reliably told that life expectancy is either normal (good prognosis) or severely curtailed because of metastatic disease (poor prognosis). Treatment cannot change life expectancy. To identify whether prognosis is associated with psychological harm, we compared harm in UM survivors with good and poor prognoses and those who declined testing and compared these outcomes to general population norms.MethodsNon-randomized 5-year study of a consecutive series of 708 UM survivors (51.6% male, mean age 69.03, SD=12.12) with observations at 6, 12, 24, 36, 48 and 60 months. We operationalized psychological harm as anxiety and depression symptoms, worry about cancer recurrence (WREC) and poor quality of life (QoL).ResultsCompared to other groups, survivors with poor prognoses showed initially elevated anxiety and depression and consistently elevated worry about local or distant recurrence over 5 years. Good prognoses were not associated with outcomes. Generally, no prognostic groups reported anxiety, depression and WREC or QoL scores that exceeded general population norms.ConclusionsUsing a large sample, we found that harm accruing from a poor prognosis was statistically significant over 5 years, but did not exceed general non-cancer population norms.Implications for Cancer SurvivorsSurvivors desire prognostic information. At a population level, we do not believe that our findings show sufficiently strong links between prognostication outcome and psychological harm to deny patients the option of knowing their prognosis. Nonetheless, it is important that patients are informed of potential adverse psychological consequences of a poor prognosis.

Role of Sprouty2 in the Pathogenesis of Chronic Lymphocytic Leukemia

Recurrent vascular events partially explain association between diabetes and poor prognosis in young ischemic stroke patients

Background. Several molecular genetic alterations in breast cancer, including aneuploidy, altered apoptosis, aberrant expression of p53, HER-2/neu and Bcl-2, have been associated with poor prognosis in breast cancer patients. To determine the importance of molecular-genetic factors relative to more traditional surgical- pathologic prognostic factors, multivariate analysis was performed. Materials and Methods. Ninety-four fresh tissue samples of primary breast carcinoma were studied with flow cytometry for DNA ploidy. On the same specimens steroid hormone receptors (ER and PR) were measured in the cytosol fraction using Abbott ELISA assays, HER-2/neu was determined in the membrane fraction and mutant p53 protein in the nuclear fraction, both, by Oncogene Science ELIZA procedures. Bcl-2 and apoptosis (Cell death) were measured in cell lysates by Oncogene Science & Boehringer Mannheim ELISA assays. In addition, information regarding surgical-pathological features of the tumor was obtained. Multivariate analysis using unconditional logistic regression model was done to identify variables predictive of poor prognosis. Results. Using univariate analysis, histological grade, tumor stage, lymph node status, HER-2/neu, and mutant p53, were predictive of poor short-term prognosis. By multivariate analysis, tumor stage, lymph node status, HER-2/neu were independent factors. Grade subgroup analysis versus time of relapse, illustrated a predictive value of Bcl-2 in only low-grade tumors while apoptosis was significant in high-grade type. Conclusion. Among a panel of moleculargenetic factors investigated, HER-2/neu was the most strongly predictive of poor shortterm prognosis in breast cancer. Patients with HER-2/neu positive tumors can benefit from Herceptin therapy.

Objective: to assess a role of immunomonitoring in patients with disseminated renal-cell carcinoma. Subjects and methods . One hundred and seventy-five patients treated in 1998 to 2008 were followed up. The patients received various immunochemotherapy regimens including interleukin-2 (IL-2), interferon-α (IFN-α), Xeloda, cyclophosphamide. The immune status, including lymphocytes and their subpopulations, cytokine components (IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12; IFN-α, IFN-γ; tumor necrosis factor-α (TNF-α)), immunoglobulins (IgA, IgG, IgM), complement components (C1q, C3, C3a, C4, C5a), was evaluated before treatment and at therapy-free intervals. Results . The time course of changes in cytokines (IL-6, IL-8, IL-10; TNF-α and IFN-γ) and some lymphocyte subpopulations (CD4+CD8+, CD3-CD16+CD56+, CD3+CD16+CD56+, CD4+CD25+Foxp3) greatly differs in patients who belong to different prognostic groups according to the Memorial Sloan-Kettering Cancer Center (MSKCC) inclusion criteria. Multivariate analysis has shown that the levels of IL-6 (spontaneous and induced production), IL-8 (spontaneous and induced production), TNF-α (spontaneous production), IFN-γ (induced production), NK T cells (CD3+CD16+CD56+), regulatory T cells (CD4+CD25+Foxp3) affect survival. Integration of the above indices into the MSKCC scale revealed that the groups were prognostically heterogeneous. The median survival in patients with good prognosis was 36.2 months (50.3, 38.3, and 24.5 months in those with 0—1, 2—3, and more than 3 immunological factors, respectively) and in those with relatively good and poor prognosis it was 15.3 (29.1, 15.3, and 18.1 months) and 8.5 (12.1, 9.3, and 6.3 months) months, respectively. Conclusion. The cytokine status reflects the aggressiveness of a tumor process. The cytokine level changes may be used to predict the out- come of the disease.

135P - Can we improve patient selection for phase I clinical trials (phI1) based on immuno-oncology score prognostic index (VIO)?

Human adenovirus (HAdV) is an enveloped icosahedral DNA virus. HAdV infection can lead to immune system damage, resulting in decreased numbers and compromised function of T cells and B cells. It can also cause an imbalanced Th1/Th2 ratio and dysregulation of pro-inflammatory and anti-inflammatory cytokines. To investigate the serum levels of interleukin (IL)-13 and IL-17A in children with HAdV pneumonia. Pediatric patients diagnosed with HAdV pneumonia were divided into a non-severe group or a severe group based on the severity of their condition. Patients in the severe group were further classified into good and poor prognosis subgroups. We collected 2-2.5 mL of venous blood from each patient, which was then centrifuged. Using an ELISA detection kit, we determined the concentrations of IL-13 and IL-17A. Patients with a severe condition exhibited significantly higher serum concentrations of IL-13 and IL-17A than the non-severe cases. Out of 50 severe cases, 32 had good prognoses, while 18 cases showed poor prognoses. Patients with poor prognoses showed significantly higher serum concentrations of IL-13 compared to those with good prognoses. Serum concentrations of IL-13 and IL-17A are potential diagnostic markers for pediatric patients with severe HAdV pneumonia. Additionally, they demonstrate good predictive value for a poor prognosis in severe pneumonia cases.