Correlates of Pre-Exposure Prophylaxis (PrEP) use among Black women

Purpose of reviewThis review summarizes interventions to promote HIV pre-exposure prophylaxis (PrEP) use among adolescent girls and young women (AGYW) in HIV endemic settings, while also highlighting gaps in our current measures of PrEP intervention success.Recent findingsAGYW report challenges with PrEP use, although the field is currently grappling with defining metrics of optimal PrEP use applicable for AGYW with dynamic HIV prevention needs. Ongoing studies are exploring multilevel interventions to address barriers to PrEP use for AGYW. At the individual and interpersonal levels, mHealth, drug-level feedback, adherence counseling, peer groups, and PrEP decision-support interventions are acceptable and feasible for AGYW although limited effectiveness data are available. At the health facility and community levels, PrEP demand creation, modified PrEP refill schedules, and integrated PrEP and reproductive health services are also promising options to support PrEP use for AGYW.SummaryAs PrEP delivery continues to expand, improved metrics of success and evidence on the effectiveness of multi-level adherence support interventions are needed to maximize the impact of PrEP for AGYW in HIV endemic settings. We present case studies of these intervention approaches but limited data are currently available on the effectiveness of these approaches. We will look toward forthcoming study results on the impact of PrEP interventions, including mHealth, drug-level feedback and other enhanced counseling, peer support, decision-support tools, PrEP demand creation, modified refills, and integrated service delivery, to determine the ideal package of PrEP support approaches for AGYW.

Between one to two-thirds of HIV infections among gay, bisexual, and other men who have sex with men are from primary partners, and there has been increased research attention focused on strategies to increase PrEP adoption among male couples. While there is evidence that partner support is a strong correlate of pre-exposure prophylaxis (PrEP) adoption, there has been a lack of attention on PrEP communication dynamics among male couples. In this paper, we build upon this literature through analysis of dyadic data from a large cross-sectional survey of 543 concordant sero-negative and serodiscordant male couples to examine individual and relationship factors associated with reports of partner communication around PrEP, comfort in discussing PrEP, and perceived partner-level support for PrEP use. PrEP use was relatively low (16.2%), and although 87.5% of men reported their partners would support their PrEP use, only 26.3% had talked to their partner recently about PrEP. PrEP communication and perceived support for PrEP were significantly negatively associated with PrEP stigma and stigma based on sexuality (i.e., internalized homophobia and enacted external stigma based on sexuality), while men with sexual agreements were more comfortable talking about PrEP with their partner. There is a need to adapt current interventions, or develop new dyadic interventions, that provide opportunities for male couples to talk and learn about PrEP together, as a potential pathway to engage them toward PrEP use.

Having condomless anal sex while relying on the HIV pre-exposure prophylaxis (PrEP) use of one's sex partner is referred to as PrEP surfing. We aimed to estimate the proportion of MSM practicing PrEP surfing, their intention to practice it, and determinants of both. Open prospective cohort study. We included MSM participating in the Amsterdam Cohort Studies in 2021-2023. Biannually, participants completed questionnaires on recent (=preceding 6 months) sexual behaviour, including PrEP use, PrEP surfing, and intention for both in the coming 6 months (7-point Likert scale). We assessed determinants of PrEP surfing with logistic regression and determinants of intention with linear regression. We included 2,187 visits from 636 participants to analyse intention for PrEP surfing. Median age was 45 (IQR = 34-52) years, median number of recent sex partners 4 (IQR = 1-11), and 264 (41%) participants reported recent PrEP use. For recent PrEP surfing, 1,779 visits from 562/636 (88%) participants with event-driven/no PrEP use were analysed. Recent PrEP surfing was reported in 449/1,779 (25%) visits. Median intention for PrEP surfing was 4 (IQR = 1-6); in 588/2,187 (27%) visits, intention for PrEP surfing was high (=score 6-7). Recent PrEP use and high perceived probability of acquiring HIV were associated with recent PrEP surfing and higher intention, while age ≥45 and having a steady partner were inversely associated. Having ≥3 recent partners was associated with recent PrEP surfing. PrEP surfing is a common HIV prevention strategy among MSM in Amsterdam. Its effectiveness needs to be determined to optimize HIV prevention care.

The most at-risk population among women for human immunodeficiency virus (HIV) diagnosis in the United States are Black women, accounting for 61% of all new HIV cases. Pre-exposure prophylaxis (PrEP) is a safe and effective HIV prevention method for people at risk of HIV acquisition. Although disproportionately affected by HIV, Black women's knowledge, perceived benefits, and uptake of PrEP remain low. The socioecological model (SEM) may be useful for understanding why there is a low uptake of PrEP among Black women. The current study used the SEM to explore provider perspectives on the barriers and facilitators of PrEP uptake among Black women in Eastern Virginia. Semistructured interviews were conducted with a total sample of 15 community health care providers. Barriers of PrEP uptake at the societal (e.g., PrEP advertisements focus on gay men), community/organizational (e.g., time constraints in the workplace), interpersonal (e.g., perceived monogamy), and individual (e.g., unmet basic needs) levels were identified. Providers also identified facilitators of PrEP uptake at the societal (e.g., PrEP advertisements that target women), community/organizational (e.g., PrEP education), interpersonal (e.g., HIV-positive partner), and individual (e.g., PrEP awareness and perceived susceptibility to HIV) levels. These findings highlight unique barriers to accessing and taking PrEP for Black women in the United States, and potential factors that could facilitate PrEP use. Both barriers and facilitators may be important targets for interventions to improve PrEP uptake. Future research focused on improving PrEP uptake among Black women in the United States should consider multi-level interventions that target barriers and facilitators to reduce rates of HIV infections.

Pre-exposure prophylaxis (PrEP) is an effective tool to prevent HIV and has recently been approved in Taiwan. However, more research regarding PrEP acceptability and effective PrEP implementation is needed in Taiwan. Little is known about the intention to use PrEP and salient psychosocial factors among men who have sex with men (MSM). The purpose of this study was to examine health beliefs linked to PrEP use intention among young MSM (YMSM) in Taiwan. Using the Health Belief Model (HBM) as a guiding framework, an anonymous online survey was used to collect data from participants who were recruited using multiple channels to ensure diversity. Multivariate logistic regression was performed to examine the health beliefs linked to high PrEP use intention. Data from 1329 HIV-negative YMSM were analyzed; 488 (36.7%) were classified as having high PrEP use intention, which was found to be associated with having high perceived susceptibility to HIV infection [adjusted odds ratio (AOR) = 2.11], high perceived benefits of PrEP use (AOR = 2.14), high self-efficacy in PrEP use (AOR = 4.19), and many cues to action concerning PrEP use (AOR = 1.49). YMSM with high perceived barriers to PrEP use (AOR = 0.64) had lower PrEP use intention. In addition, the effects of HBM constructs and specific health beliefs on PrEP use intention varied by preferred penile-anal sexual role. The study findings may inform efforts aimed at improving PrEP acceptability and optimizing PrEP implementation programs tailored for YMSM of different sexual roles.

Strong evidence exists that daily pre-exposure prophylaxis (PrEP) is effective as an HIV preventive tool provided that there is good individual adherence 1. In 2014, the World Health Organization (WHO) issued new guidelines recommending PrEP use 2. In France, as a consequence of HIV/AIDS organizations' advocacy and the Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS) Intervention Préventive de l'Exposition aux Risques avec et pour les Gays (IPERGAY) trial results proving high efficacy of on-demand tenofovir (TDF)/emtricitabine (FTC) use in men who have sex with men (MSM) 3, health authorities have approved PrEP use for most-at-risk populations. Literature on awareness and acceptability of PrEP, and willingness to use it, mainly among MSM, 4 shows that, in countries where it is not officially accessible, some people are informally using antiretroviral (ARV) medication obtained in several ways outside of biomedical trials as a prevention tool 5, but data on this are still insufficient. In this context, AIDES, a French community-based organization (CBO), conducted the cross-sectional national “Flash PrEP” survey to characterize informal PrEP use in France. All people benefitting from AIDES' on-site and outreach activities filled in paper or online questionnaires, from March to May 2014, collecting data on: sociodemographic characteristics; awareness of PrEP authorization in the USA; willingness and intention to use PrEP when authorized; sexual behaviour; drug injection; risk perception and sexually transmitted infection (STI) awareness; HIV testing; post-exposure prophylaxis (PEP). Informal PrEP use at least once during one's lifetime was explored using the statement: “I have used ARV treatment at least once in my lifetime (received from a friend or partner, for example) before sexual intercourse to avoid HIV infection” (yes/no). The sampling bias introduced by collecting data with online and paper questionnaires was corrected by implementing the inverse propensity score weighting technique. Groups of respondents to paper (treatment group) and online (control group) questionnaires were balanced in terms of sociodemographic and socioeconomic characteristics, ensuring their comparability. Statistical analysis was performed using spss statistical software (version 17). A total of 2668 people filled in the questionnaire (71% online survey), of whom 4.6% (n = 123) declared informal PrEP use. Informal PrEP users were 74% MSM and 14.6% women; 91.9% were born in France, 61.8% had a university degree, and their median age was 31 [interquartile range (IQR) 25–41] years. More than one-third (38.2%) of the PrEP users self-perceived themselves to be at high or very high risk of HIV infection compared with 10.1% of those not using PrEP (P < 0.001). Seventy informal PrEP users had a main partner (56.9%), and this partner was serodiscordant for 14 MSM and one woman (21.4%). Factors associated with informal PrEP use, estimated using multivariate logistic regression adjusting for participants' sexual orientation (women, MSM, or heterosexual men), were as follows (Table 1): MSM; younger age; being aware of PrEP authorization in the USA; high or very high HIV risk self-perception; having, in the previous 12 months, injected drugs, used PEP or had at least two HIV tests; and never having used condoms with one's main partner. In contrast, being aware of having had (or not) an STI in the previous 12 months was inversely associated with informal PrEP use. These results show that informal PrEP use exists in France. Associated factors indicate that users are well informed about prevention tools, are highly exposed to HIV and monitor their risks, as they use both PEP and frequent HIV testing, suggesting that these people are linked with the health system and HIV/AIDS CBOs. The experiences reported by informal PrEP users in this study may be helpful in the design of future PrEP services, now that PrEP is authorized in France. We thank all the people who completed the “Flash PrEP” survey and all those who participated in the data collection. We would also like to thank our colleague Thomas Gonçalvez for his valuable help with the first steps of the database work.

BackgroundMany gay and bisexual men (GBM) experience anxiety about HIV, particularly in relation to sex. Use of HIV pre-exposure prophylaxis (PrEP) as an HIV prevention strategy may affect levels of...

Barriers and facilitators in pre-exposure prophylaxis (PrEP) use intention among Chinese homosexual men

ObjectivesTo describe the experiences of oral HIV pre-exposure prophylaxis (PrEP) use, preferences comparing oral PrEP to future long-acting PrEP products (the dapivirine vaginal ring (PrEP ring) and injectable cabotegravir (CAB...

ObjectivesTo examine changes in the occurrence of physical sex with non-steady partners among men who have sex with men (MSM) in Belgium during the first weeks of the COVID-19 lockdown...

BackgroundAwareness of pre-exposure prophylaxis (PrEP) for HIV prevention is increasing, but little is known about the functional knowledge of PrEP and its impact on willingness to use PrEP.ObjectiveThe objective of this study was to assess the functional knowledge of PrEP among a sample of gay, bisexual, and other men who have sex with men (MSM) participating in a Web-based survey of sexually active MSM.MethodsMen at least 18 years old, residing in the United States, and reporting sex with a man in the previous 6 months were recruited through social networking websites. PrEP functional knowledge included the following 4 questions (1) efficacy of consistent PrEP use, (2) inconsistent PrEP use and effectiveness, (3) PrEP and condom use, and (4) effectiveness at reducing sexually transmitted infections (STIs). Ordinal logistic regression was used to identify respondent characteristics associated with PrEP functional knowledge. In a subsample of participants responding to HIV prevention questions, we compared willingness to use PrEP by response to PrEP functional knowledge using logistic regression analysis adjusted for age, race and ethnicity, and education level.ResultsAmong 573 respondents, PrEP knowledge was high regarding adherence (488/573, 85.2%), condom use (532/573, 92.8%), and STIs (480/573, 83.8%), but only 252/573 (44.0%) identified the correct efficacy. Lower functional PrEP knowledge was associated with minority race/ethnicity (P=.005), lower education (P=.01), and not having an HIV test in the past year (P=.02). Higher PrEP knowledge was associated with willingness to use PrEP (P=.009). Younger age was not associated with higher PrEP functional knowledge or willingness to use PrEP.ConclusionsPrEP knowledge was generally high in our study, including condom use and consistent use but may be lacking in higher risk MSM. The majority of respondents did not correctly identify PrEP efficacy with consistent use, which could impact motivation to seek out PrEP for HIV prevention. Targeted messaging to increase PrEP knowledge may increase PrEP use.

The perceptions, motivations, and beliefs of HIV-uninfected women about pre-exposure prophylaxis (PrEP) use during pregnancy can influence its uptake and adherence. This study elicited the views of HIV-uninfected women with personal experience taking PrEP during pregnancy. Qualitative interviews were conducted with HIV-uninfected women who had personal experience taking PrEP while pregnant. Semistructured interviews were conducted with 21 HIV-uninfected Kenyan women in HIV-serodiscordant couples enrolled in an open-label PrEP demonstration project who became pregnant while using PrEP and continued PrEP through their pregnancy. Interviews were audio-recorded and transcribed into English. A qualitative descriptive analysis was performed, using a constant comparison approach to identify key themes related to PrEP use in pregnancy. Desire to remain HIV uninfected and have an HIV-free infant were strong motivators influencing continued use of PrEP during pregnancy. Supporting HIV-infected partners and childbearing within an HIV-serodiscordant relationship were also motivators. Women had challenges distinguishing normal pregnancy symptoms from PrEP side effects and were concerned that observed side effects could be signs of danger for the infant related to PrEP exposure. Health care providers were important conduits of knowledge about PrEP, and continuity of PrEP providers throughout pregnancy facilitated adherence. HIV-uninfected women in HIV-serodiscordant couples were motivated to use PrEP during pregnancy to remain HIV uninfected and to have an HIV-free child but had concerns about side effects. Health care providers will be important for PrEP messaging and adherence support in this unique population.

BackgroundYoung women account for a disproportionate fraction of new HIV infections in Africa and are a priority population for HIV prevention, including implementation of preexposure prophylaxis (PrEP). The overarching goal of this project was to demonstrate the feasibility of integrating PrEP delivery within routine family planning (FP) clinics to serve as a platform to efficiently reach at-risk adolescent girls and young women (AGYW) for PrEP in HIV high-burden settings.Methods and findingsThe PrEP Implementation in Young Women and Adolescents (PrIYA) program is a real-world implementation program to demonstrate integration of PrEP delivery for at-risk AGYW in FP clinics in Kisumu, Kenya. Between November 2017 and June 2018, women aged 15 to 45 from the general population seeking FP services at 8 public health clinics were universally screened for HIV behavioral risk factors and offered PrEP following national PrEP guidelines. We evaluated PrEP uptake and continuation, and robust Poisson regression methods were used to identify correlates of uptake and early continuation of PrEP, with age included as a one-knot linear spline. Overall, 1,271 HIV-uninfected women accessing routine FP clinics were screened for PrEP; the median age was 25 years (interquartile range [IQR]: 22–29), 627 (49%) were <24 years old, 1,026 (82%) were married, more than one-third (34%) had partners of unknown HIV status, and the vast majority (n = 1,200 [94%]) reported recent condom-less sex. Of 1,271 women screened, 278 (22%) initiated PrEP, and 114 (41%) returned for at least one refill visit after initiation. PrEP uptake was independently associated with reported male-partner HIV status (HIV-positive 94%, unknown 35%, HIV-negative 8%; p < 0.001) and marital status (28% unmarried versus married 21%; p = 0.04), and a higher proportion of women ≥24 years (26%; 191/740) initiated PrEP compared to 16% (87/531) of young women <24 years (p < 0.001). There was a moderate and statistically non-significant unadjusted increase in PrEP uptake among women using oral contraception pills (OCPs) compared to women using injectable or long-acting reversible contraception methods (OCP 28% versus injectable/implants/intrauterine devices [IUDs] 18%; p = 0.06). Among women with at least one post-PrEP initiation follow-up visit (n = 278), no HIV infection was documented during the project period. Overall, continuation of PrEP use at 1, 3, and 6 months post initiation was 41%, 24%, and 15%, respectively. The likelihood for early continuation of PrEP use (i.e., return for at least one PrEP refill within 45 days post initiation) was strongly associated with reported male-partner HIV status (HIV-positive 67%, -negative 39%, unknown 31%; overall effect p = 0.001), and a higher proportion of women ≥24 years old continued PrEP at 1 month compared with young women <24 years old (47% versus 29%; p = 0.002). For women ≥24 years old, the likelihood to continue PrEP use at 1 month post initiation increased by 3% for each additional year of a woman’s age (adjusted prevalence ratio [PR]: 1.03; 95% confidence interval [CI]: 1.01–1.05; p = 0.01). In contrast, for women <24 years old, the likelihood of continuing PrEP for each additional year of a woman’s age was high in magnitude (approximately 6%) but statistically non-significant (adjusted PR: 1.06; 95% CI: 0.97–1.16; p = 0.18). Frequently reported reasons for discontinuing PrEP were low perceived risk of HIV (25%), knowledge that partner was HIV negative (24%), experiencing side effects (20%), and pill burden (17%). Study limitations include lack of qualitative work to provide insights into women’s decision-making on PrEP uptake and continuation, the small number of measured covariates imposed by the program data, and a nonrandomized design limiting definitive ascertainment of the robustness of a PrEP-dedicated nurse-led implementation strategy.ConclusionsIn this real-world PrEP implementation program in Kenya, integration of universal screening and counseling for PrEP in FP clinics was feasible, making this platform a potential “one-stop” location for FP and PrEP. There was a high drop-off in PrEP continuation, but a subset of women continued PrEP use at least through 1 month, possibly indicating further reflection or decision-making on PrEP use. Greater efforts to support PrEP normalization and persistence for African women are needed to help women navigate their decisions about HIV prevention preferences as their reproductive goals and HIV vulnerability evolve.

Drug resistance may be acquired in people starting human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) during undiagnosed infection. Population-based estimates of PrEP-related resistance are lacking. We used New York City surveillance and partner services data to measure the effect of PrEP use (tenofovir disoproxil fumarate/tenofivir alafenamide fumarate with emtricitabine) history on the baseline prevalence of M184I/V mutations in people with HIV diagnosed in 2015-2022. PrEP use was categorized as "recent" (defined as PrEP stopped ≤90 days before diagnosis), "past" (PrEP stopped >90 days before diagnosis), or "no known use." Resistance-associated mutations were determined using the Stanford algorithm. We used log binomial regression to generate the adjusted relative risk (aRR) of M184I/V by PrEP use history in people with or without acute HIV infection (AHI). Of 4246 people with newly diagnosed HIV and a genotype obtained within ≤30 days of diagnosis, 560 (13%) had AHI; 136 (3%) reported recent and 124 (35%) past PrEP use; and 98 (2%) harbored M184I/V. In people with AHI, recent PrEP use was associated with a 6 times greater risk of M184I/V than no known use (aRR, 5.86 [95% confidence interval, 2.49-13.77]). Among people without AHI, the risk of M184I/V in recent users was 7 times that in people with no known use (aRR, 7.26 [95% confidence interval, 3.98-13.24]), and in past users, it was 4 times that in those with no known use (4.46 [2.15-9.24]). PrEP use was strongly associated with baseline M184I/V in New York City, regardless of AHI status. Ordering a nucleic acid test when indicated after assessment of exposure, antiretroviral history, and AHI symptoms can decrease PrEP initiation in people with undetected infection.

Men who have sex with men (MSM) are disproportionately affected by HIV and represent the primary target population for pre-exposure prophylaxis (PrEP) use. However, PrEP adoption in China remains limited, partly due to its late regulatory approval. This study aims to investigate the awareness and willingness of PrEP use and associated factors among MSM in Maanshan city, so as to promote the popularization of PrEP. This cross-sectional study was conducted in Maanshan City, China, between June 2016 and December 2019. Participants completed the questionnaire through respondent-driven sampling (RDS). The questionnaire information was organized and analyzed using SPSS 23.0 software. Both univariate and multivariate logistic regression models were employed to investigate the determinants of PrEP willingness and awareness among HIV-negative MSM. A total of 879 participants were enrolled, with 837 providing analyzable data. The majority (62.25%) were aged <30 years old, with 97.49% self-identified as homosexual. Among participants, 50.18% reported regular male sexual partners. Regarding sexual behaviors, 71.80% of MSM engaged in casual sex and 36.56% unprotected anal sex (UAI) within the last six months. HIV awareness was reported by 92.83% of respondents, while PrEP awareness was substantially lower (22.70%). Willingness to use PrEP was high (89.49%), with 16.49% preferring to take PrEP daily and 84.59% preferring to take PrEP on demand. Multivariate logistic regression revealed that vocational school (vs. high school or below), recent casual sex engagement, PrEP awareness, and recent UAI history were significant predictors of PrEP willingness. Higher education (university or above vs. high school or below), versatile sexual role (vs. op/insertive ones), recent casual sex and prior HIV testing were positively associated with PrEP awareness. Maanshan's MSM population demonstrated high PrEP acceptance but limited awareness. The findings suggest that expanding access to HIV testing could enhance PrEP awareness. Simultaneously, PrEP dissemination combined with targeted HIV prevention may effectively reduce HIV transmission in the MSM population.