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Serum metabolic markers for α-synucleinopathies conversion in isolated REM sleep behavior disorder: a prospective cohort study.

Objective: To explore the risk factors of early enteral nutrition intolerance in extremely severe burn patients. Methods: A retrospective case-control study was performed. From January 2018 to December 2020, seventy-six adult patients with extremely severe burns who met the inclusion criteria were admitted to Hwa Mei Hospital of University of Chinese Academy of Sciences, including 55 males and 21 females, aged (45±11) years with burns of 62% (52%, 82%) total body surface area. Depending on the patient's tolerance to early enteral nutrition, they were divided into tolerance group (47 patients) and intolerance group (29 patients), and their clinical data were statistically analyzed, including age, sex, body mass index (BMI), underlying disease, total burn area, full-thickness burn area, abbreviated burn severity index (ABSI) score, implementation of mechanical ventilation on the day of admission, stable shock state, vomiting before feeding. The following data were recorded including the onset time, duration length, and frequency of enteral nutrition intolerance of patients in intolerance group, and the number of operations, the length of hospitalization, the occurrence of sepsis within 2 weeks after injury, the outcome, as well as the serum hypersensitive C-reactive protein (hs-CRP), albumin, fasting blood glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transpeptidase (γ-GT) on post burn day (PBD) 1, 5, 9, and 13 of patients in the two groups. Data were statistically analyzed with independent sample t test, Mann-Whitney U test, and chi-square test to screen the related factors of early enteral nutrition intolerance of the patients. Binary univariate and multivariate logistic regression analysis were used to analyze the independent risk factors of early enteral nutrition intolerance of the patients. Results: There were no statistically significant differences in age, sex, BMI, and percentage of underlying disease of patients between the two groups (P>0.05). The total burn area, full-thickness burn area, ABSI score, mechanical ventilation percentage on the day of admission, percentage of unstable shock period, percentage of vomiting before feeding of patients in intolerance group were significantly higher than those in tolerance group (Z=-4.559, -3.378, -4.067, χ2=18.375, 23.319, 8.339, P<0.01). In intolerance group, the onset time of intolerance was (9±4) d after injury, and the duration length was 4 (2, 6) d, with a total of 46 times occurred. Compared with tolerance group, the percentage of sepsis and mortality of patients in intolerance group were significantly higher within 2 weeks after injury (χ2=16.571, 12.665, P<0.01). The number of operation and length of hospitalization of patients in the two groups were similar (P>0.05); however the length of hospitalization of patients in the intolerance group was significantly more than that in tolerance group after excluding the death cases (Z=-2.266, P<0.05). On PBD 1, the level of fasting blood glucose and AST of patients in intolerance group were significantly higher than those in tolerance group (t=3.070, Z=-3.070, P<0.01). On PBD 5, the levels of hs-CRP, albumin, fasting blood-glucose, ALT, AST, and γ-GT of patients in the two groups were similar (P>0.05). On PBD 9, the level of hs-CRP of patients in intolerance group was significantly higher than that in tolerance group (t=2.836, P<0.01), and the levels of ALT and γ-GT of patients in intolerance group were significantly lower than those in tolerance group (Z=-3.932, -2.052, P<0.05 or P<0.01). On PBD 13, the level of hs-CRP of patients in intolerance group was significantly higher than that in tolerance group (t=3.794, P<0.01), and the levels of fasting blood glucose, ALT, and γ-GT of patients in intolerance group were significantly lower than those in tolerance group (t=-2.176, Z=-2.945, -2.250, P<0.05 or P<0.01). Binary univariate logistic regression analysis showed that total burn area, full-thickness burn area, ABSI score, implementation of mechanical ventilation on the day of admission, unstable shock period, vomiting before feeding, and fasting blood-glucose on PBD 1 of patients were related to early enteral nutrition intolerance (odds ratio=1.086, 1.052, 1.775, 9.167, 12.797, 10.125, 1.249, 95% confidence interval=1.045-1.129, 1.019-1.085, 1.320-2.387, 3.132-26.829, 4.199-39.000, 2.003-51.172, 1.066-1.464, P<0.01). Multivariate logistic regression analysis showed that the large total burn area, unstable shock period, vomiting before feeding, and high fasting blood-glucose on PBD 1 of patients were the independent risk factors of early enteral nutrition intolerance in patients (odds ratio=1.073, 6.390, 9.004, 1.246, 95% confidence interval=1.021-1.128, 1.527-26.734, 1.134-71.496, 1.007-1.540, P<0.05 or P<0.01). Conclusions: The percentage of early enteral nutrition intolerance is very high in extremely severe burn patients, which is closely related to poor prognosis. Large total burn area, vomiting before feeding, unstable shock phase, high fasting glucose on PBD 1 of patients are the independent risk factors for early enteral nutrition intolerance in extremely severe burn patients. The benefits and risks should be carefully evaluated before starting enteral nutrition in such patients, and early enteral nutrition should not be blindly pursued.

IntroductionThe worldwide prevalence of diabetes has been increasing for decades; diabetes can lead to serious health problems and even death, but the effects of maintaining low fasting blood glucose (FBG) remain controversial. The purpose of this study was to investigate the relationship between FBG levels and all-cause mortality in a long-term follow-up cohort and to find a relatively safe range of FBG levels.MethodsThis study included 17,902 adults from a community-based cohort study in rural China who were prospectively followed from 2003 to 2018. Generalized estimating equations were used to evaluate the association between FBG and all-cause mortality, adjusting for pertinent covariates and auto-correlations among siblings.ResultsA total of 1053 (5.9%) deaths occurred during 15 years of follow-up. There was a significant U-shaped association between all-cause mortality and FBG. Compared with the reference group (FBG of 5.6 – < 6.1 mmol/l), the risk of death among individuals with FBG levels < 5.6 mmol/l significantly increased by 38% (OR 1.34; 95% CI 1.13–1.59), while the risk of death among individuals with FBG ≥ 6.1 mmol/l or participants with a self-reported history of diabetes significantly increased by 51% (OR 1.49; 95% CI 1.20–1.85). Additionally, the U-shaped association remained steady in any stratification of risk factors.ConclusionOur study showed a significant U-shaped relationship between FBG levels and risk of all-cause mortality in this rural Chinese population. When FBG was within the range of 5.6 – < 6.1 mmol/l, the risk of all-cause mortality was the lowest.Electronic supplementary materialThe online version of this article (doi:10.1007/s13300-020-00927-6) contains supplementary material, which is available to authorized users.

The aim of the present study is to investigate the relationship between obesity and fertility in Iraqidiabetic men whose body mass index (BMI) more than 25Kg/m2, and compare the results with controlgroup corresponding age and BMI. Forty samples of men semen's were divided into two groups with andwithout diabetes and each group subdivided into two subgroups according to BMI. The parameters thatmeasured in this study are( glucose, insulin and lipid profile in fasting state) also (testosterone, prolactin,alkaline phosphatase) were measured for each of four subgroups [controls(I, II) and diabetes(III, IV)].Semen's analysis included (sperm concentration in ml, total count per ejaculate and viability). In diabeticsubgroup (III) the mean levels of fasting blood glucose, insulin, cholesterol and triglycerides weresignificantly elevated, while significantly decrease in testosterone, prolactin, high density lipoproteinscholesterol, alkaline phosphatase and total sperm count but there were no significant difference in totalcholesterol, the sperm concentration and viability as compared with control subgroup(I). In diabeticsubgroup (IV) the mean levels of fasting blood (glucose, insulin, cholesterol and triglycerides) weresignificantly elevated, while significantly decrease in (testosterone, prolactin, high density lipoproteinscholesterol, alkaline phosphatase, sperm concentration, viability and total sperm count) but there were nosignificant difference in fasting (insulin and high density lipoproteins- cholesterol) as compared withcontrol subgroup(II). In diabetic subgroup(III) the mean of BMI and the mean levels of fasting blood(glucose, total cholesterol and triglycerides) significantly elevated, while there were significantly decreasein(testosterone, alkaline phosphatase, sperm concentration, viability and total sperm count but there wereno significant difference in fasting (insulin, high density lipoproteins- cholesterol) and prolactin, ascompared with diabetic subgroup(IV). For all the above biochemical parameters investigated we canconclude that there is inverse- relationship between obesity and fertility which increase in the presence ofdiabetes.

The management of diabetes mellitus (DM) involves education, nutritional intervention, and physical exercise, in addition to pharmacological interventions, with the long-term goal of preventing complications through the control of blood glucose levels. Several studies have shown that acupuncture, both conventional acupuncture and electroacupuncture, is useful for lowering blood glucose levels in patients with DM. This study aimed to determine the additional effect of electroacupuncture at the MA-IC 3 Endocrine ear acupoint on fasting blood glucose levels in patients with Type 2 DM who were receiving oral hypoglycemic agents at Banjar General Hospital. In this randomized controlled study, fifty-four study participants who were being treated with oral antidiabetics were allocated into two groups, receiving either electroacupuncture (EA) at the MA-IC 3 ear acupoint with dense disperse wave for 30 minutes or acupuncture at the same point and for the same duration but without EA (No EA). Fasting blood glucose levels were measured before and after the intervention. In Group A (EA), the mean fasting blood glucose (FBG) level decreased from 157.26±24.485 to 142.59±26.771 (p < 0.05), whereas in Group B (No EA), the mean FBG decreased from 149.67±21.485 to 148.74±21.326 (p < 0.05). The difference in the amount of FBG decrease between Group A (EA) and Group B (No EA) was statistically significant (p < 0.05). EA at the MA-IC 3 Endocrine lowers FBG levels to a greater degree than acupuncture with no EA in patients with type 2 DM.

Purpose: To present thyroid hormones (THs) cutoff values to assess the association of THs and glucose metabolism in obese patients with euthyroid function. Methods: This study investigated 445 obese patients (235 females and 210 males) with euthyroid function received treatment in the department of endocrinology of shanghai 10th people’s hospital from 2011 to 2019, with the median age of 29 years (interquartile range 22-35 years). The cut-offs for thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) were 2mIU/L, 16mIU/L, and 5mIU/L, respectively. Results: Fasting blood glucose (FBG) and 2h-glucose (BG120) were significantly higher in low FT3 (P&amp;lt;0.05) and high FT4 patients (P&amp;lt;0.05). In patients with TSH under 2mIU/L, a low FT3 group was robustly associated with higher FBG and BG120 levels (P&amp;lt;0.05). In patients with TSH under 1.5mIU/L, additional association with lower fasting and 2h-insulin (P&amp;lt;0.05) could be found. FT3 had no predictive value in high TSH patients. In patients TSH over 1.5 or 2mIU/L, a high FT4 group was robustly associated with higher FBG and BG120 levels (P&amp;lt;0.05). FT4 had no predictive value in low TSH patients. Patients with TSH over 2mIU/L, high FT4 group had a crude odds ratio of 2.65(95% Confidence interval 1.40-5.03, P=0.003) for FBG compared with low FT4 and remained significant after adjustments for age, gender and body mass index. Similar results could be obtained in patients with TSH over 1.5mIU/L. Conclusions: A combination of TSH and FT4/FT3 instead of only one thyroid hormone indicator had predictive value of glucose metabolism in obese patients with euthyroid function. Disclosure J. Zhang: None. G. Li: None. X. Cheng: None. X. Wang: None. M. Jayachandran: None. Y. Huang: None. S. Qu: None. Funding National Key Research and Development Program of China (2018YFC1314100); National Natural Science Foundation of China (81970677); Shanghai Pujiang Program (2019PJD040); Effect of ApoC3 High Expression on Islet Cells and Related Molecular Mechanism (03.05.18.002)

Bmi, Fasting Blood-glucose and Total-cholesterol Levels in Adults with Intellectual Disabilities or Autism Spectrum Disorder with or Without Epilepsy and Valproic Acid Treatment

Objective To explore the effect of the health management service in patients with metabolic syndrome (MS) by family doctors. Methods A total of 417 patients with MS were screened during a health examination and divided into the intervention and control groups (206 and 211 cases, respectively), using a random digital table. Based on routine health follow-up, the intervention group received increased health management intervention by the family doctor, while the control group was only had followed-up with routine health check-ups. After 1 year, the changes in body mass index (BMI), blood pressure, triglyceride (TG) levels, fasting blood glucose (FBG) levels, and high-density lipoprotein cholesterol (HDL-C) in the two groups of patients were observed. The effect of intervention was analyzed using the paired design t-test and chi-square test. Results In the intervention group, the BMI (25.04±2.92) kg/m2, systolic blood pressure (121.5±15.6) mmHg (1 mmHg=0.133 kPa), TG levels (2.02±1.24) mmol/L, and FBGlevels(5.92±1.75) mmol/L after the intervention, were lower than those before the intervention (25.66±2.64) kg/m2, (128.4±16.5) mmHg, (2.43±1.06) mmol/L, (6.34±1.62) mmol/L; respectively, and these differenceswerestatistically significant (t=2.437, 3.598, 3.536, 2.983, respectively; P<0.05). HDL-C levels after the intervention (1.32±0.26) mmol/L were higher than thosebefore the intervention (1.26±0.32) mmol/L, and the difference was statistically significant (t=-2.218, P<0.05). In the intervention group, blood pressure, BMI, FBGlevels, and HDL-C levels after the intervention were higher than the normal reference values.The proportion of patients with normal reference valuesafter the intervention were 62.6%, 75.2%, 14.6%, and 52.9%, respectively, which were lower than those before the intervention(92.7%, 85.4% 23.3%, and 63.6%, respectively); thesedifferenceswerestatistically significant (χ2=53.795, 6.777, 5.124, and 4.832, respectively;P<0.05). After 1 year, the control group had lower BMI (24.52±2.69) kg/m2 than that before the intervention (25.79±2.85) kg/m2; thisdifference was statistically significant (t=2.421, P<0.05).There were no significant differences in the systolic and diastolic blood pressure, TG levels, HDL-C levels, and FBG levels. Conclusion Health management byfamily doctors can effectively reduce weight, blood pressure, blood lipids, and blood sugar by interfering with the lifestyle of patients with MS. Key words: Metabolic syndrome X; Family; Health management

Objective To explore the fasting blood glucose (FBG) variation trends and the prevalence of impaired fasting blood glucose (IFG) among medical staff in Beijing, 2009−2015. Methods A prospective cohort study, using seven years of follow-up data, was conducted in a large-scale tertiary hospital in Beijing. A total of 1 284 medical staff aged 35 to 60 years were recruited. We divided them into 4 groups according to age and occupational categories, and the level of FBG was tested at the same time each year. Results The number of medical staff who completed all 7 annual FBG tests was 403. There was a stepwise increase in the levels of FBG (4.92 mmol/L, 5.26 mmol/L, and 5.60 mmol/L in the years 2009, 2012, and 2015, respectively; F=100.643, P<0.001). An increasing trend in the prevalence of IFG was also evident (3.7%, 7.7%, and 13.4% in the years 2009, 2012, and 2015, respectively; χ2=39.099, P<0.001). Compared with baseline levels (in 2009), the average levels of FBG and the prevalence of IFG in men and women, as well as in all occupational classes (doctors, nurses, technicians, and other medical employees), were significantly elevated by the year 2015 (all P<0.05). The levels of FBG in male medical staff were higher than that in female medical staff, in both 2009 and 2015 (both P<0.001). Conclusion The trend of increasing FBG levels and IFG cases in medical staff, especially in men, has been a problem for hospitals. Health policy action is urgently needed to deflate the IFG bubbles. Key words: Blood glucose; Attitude to Health; Impaired fasting blood glucose; Health checkup; Health management

BackgroundResearch has indicated that there may be a positive association between increased proportions of monounsaturated fatty acid (MUFA) intake and improved blood glucose levels. There has also been literature indicating there may be a link between intake of micronutrients such as iron, selenium, magnesium, vitamin E, and zinc and blood glucose levels. Using the validated Vioscreen food frequency questionnaire (FFQ), the current study aims to outline the relationship between various micronutrients and fasting blood glucose (FBG) levels as a marker of insulin resistance in individuals with pre‐diabetes.ObjectiveTo outline the effect of dietary micronutrients on FBG in individuals with pre‐diabetes using the Vioscreen FFQ.MethodsAll participants completed the Vioscreen FFQ. Participants were required to be fasting for at least 8 hours before blood glucose test was performed. Fasting blood glucose was compared with dietary intake of iron, selenium, magnesium, vitamin E, zinc, MUFAs, polyunsaturated fatty acids (PUFAs), and saturated fatty acids (SFAs).ResultsA univariate regression analysis of FBG compared with intake of different micronutrients gathered via Vioscreen FFQ showed a number of correlations.There was a statically significant negative correlation between fasting blood glucose (FBG) and dietary intake of total cholesterol (r=−0.12, p=0.02), iron (r=−0.48, p=0.04), selenium (r=−0.56, p=0.01), magnesium (r=−0.5, p=0.02), zinc (r=−0.45, p=0.04), MUFAs (r=−0.61, p=0.01), saturated fatty acids (SFA) (r=−0.58, p=0.01), and polyunsaturated fatty acids (PUFA) (r=−0.41, p=0.04).A negative correlation was present between FBG and vitamin E, however the finding did not reach significance (r=−0.282, p=0.17).ConclusionsData gathered from the Vioscreen FFQ suggests that there are significant correlations present between certain micronutrients and FBG levels for individuals with pre‐diabetes. These results indicate that increasing the amount of dietary iron, selenium, magnesium, zinc, MUFAs, SFAs, and PUFAs may be a valid dietary intervention for the treatment and maintenance of pre‐diabetes. A noteworthy finding of this study was the negative relationship between PUFAs (r=−0.41, p=0.04), MUFAs (r=−0.61, p=0.01), and SFAs (r=−0.58, p=0.01). This finding supports the theory of a high fat, low carbohydrate diet as an intervention for the maintenance of blood glucose levels in those with insulin resistance. It is particularly interesting that increased proportions of dietary SFA were associated with lower FBG levels, considering current 2015 U.S. Dietary Guidelines suggest limiting saturated fat in the diet. It must be noted however, that the sample size used was fairly small with 10 participants. This limitation indicates more research must be done to clarify the specific relationship, and mechanism in which the micronutrients tested affect FBG levels.Support or Funding InformationViterbo University Summer Undergraduate Research FellowshipTexas Pecan Growers Association

ObjectiveTo explore the association between the Oxidative Balance Score (OBS), which represents the balance of multiple oxidative stress-related dietary and lifestyle exposures, and the risk of metabolic syndrome (MetS).MethodsA population-based cross-sectional study design was adopted and 16,850 participants in NHANES database were included in the statistics analysis stage. The OBS was constructed by combining information from 20 a priori selected pro- and antioxidant factors. Weighted logistic regression and restricted cubic splines (RCS) were used to estimate the association between OBS and MetS.ResultsParticipants in the highest OBS quartile, indicating low oxidative stress (OS) levels, exhibited a significantly lower risk of MetS (odds Ratio [OR] = 0.55, 95% confidence Interval [CI]: 0.47–0.64) compared to the lowest quartile. Specifically, higher OBS was inversely associated with abdominal obesity (OR = 0.61, 95% CI: 0.54–0.69), hypertension (OR = 0.69, 95% CI: 0.58–0.83), elevated triglycerides (OR = 0.68, 95% CI: 0.57–0.82), low high-density lipoprotein cholesterol (HDL-C) levels (OR = 0.60, 95% CI: 0.50–0.70) and fasting blood glucose (FBG) levels (OR = 0.74, 95% CI: 0.62–0.88). The observed inverse association between OBS and hypertension or FBG levels appeared to primarily influenced by BMI. The association between dietary OBS intervals and elevated FBG levels was not statistically significant in men, whereas the risk was lower by 25% in women.ConclusionsA higher OBS, representing a balance of multiple oxidative stress-related dietary and lifestyle exposures, is associated with a lower risk of MetS. Therefore, adhering to an antioxidant diet and lifestyle may help prevent the occurrence of metabolic disorders.

BackgroundThis study aimed to assess the associations of serum uric acid (SUA) levels and hyperuricemia with cardiometabolic risk factors in a Chinese community-dwelling population.MethodsA large cohort of 4706 residents was enrolled in this study. Physical examinations and laboratory tests were performed following a standardized protocol. Multiple linear and logistic regression analyses were conducted with adjustment of cardiometabolic risk factors including age, sex, body mass index (BMI), blood pressure (BP), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c) and fasting blood glucose (FBG) levels using SPSS version 17 software.ResultsThe prevalence of hyperuricemia was 7.6 %. There were significant differences in age, BMI, BP, TG, HDL-c, LDL-c and FBG levels and the proportion of men between participants with and without hyperuricemia. Multiple linear regression analysis showed that SUA levels were positively associated with age, sex, BMI, BP, TG and LDL-c levels, but negatively associated with HDL-c and FBG levels. Multiple logistic regression analysis showed that per unit increase in age was associated with a 1.014 times higher odds of the presence of hyperuricemia. Men had a 1.858 times higher odds of the presence of hyperuricemia compared with women. Per unit increases in BMI, BP, TG and LDL-c levels were associated with 1.103, 1.016, 1.173 and 1.200 times higher odds of the presence of hyperuricemia, respectively. Per unit increases in HDL-c and FBG levels were associated with 0.616 and 0.900 times lower odds of the presence of hyperuricemia, respectively.ConclusionsIn a Chinese community-dwelling population, age, sex, BMI, BP, TG, HDL-c, LDL-c and FBG levels are cardiometabolic risk factors that are significantly associated with SUA levels, as well as the presence of hyperuricemia.

This research was designed to investigate antihyperglycaemic impact of aqueous extract of Moringa oleifera leaf on alloxan-induced diabetic male wistar rats. Diabetes is a metabolic disease linked to weakened sugar metabolism. Managing diabetes devoid of any adverse effect remains an issue to health system. Therefore, there is an increase in the search for better anti-diabetic medicine. M. oleifera leaves were air-dried, grinded, sieved and the aqueous extract was prepared. Twenty male wistar rats were used and these rats were grouped into four groups, five rats in each group. Group 1 and group 2 rats were diabetes induced groups treated with 100 and 400 mg/kg of aqueous extract of M. oleifera leaf respectively, group 3-diabetic untreated group, group 4-control group. Fasting blood glucose level, uric acid level and C-reactive protein level were measured by oxidase method, Uricase-PAP method and turbilatex method respectively. Results of this research work showed a significant increase in the fasting blood glucose level, uric acid level and C-reactive protein level in rats that were diabetic when compared with the control rats. However, treatment with 100 and 400 mg/kg of aqueous extract of M. oleifera leaf for a period of four weeks brought the fasting blood glucose level, uric acid level and C-reactive protein level toward the basal level significantly (P<0.05). The study showed that the aqueous extract of M. oleifera leaf has the potential to lower the elevated fasting blood glucose, uric acid and C-reactive protein levels toward the basal level in alloxan-induced diabetic male Wistar rats. Key words: Hyperglycaemia, Moringa oleifera leaf, fasting blood glucose, uric acid, C-reactive protein, health system, metabolic disease.

Controlling blood glucose is paramount in diabetes management, yet medication non-adherence often hinders optimal outcomes. This study investigated the impact of pharmacist counseling on Fasting Blood Glucose (FBG) levels and medication adherence in Type 2 Diabetes Mellitus (T2DM) patients within a rural primary healthcare setting. A quasi-experimental pre- and post-test design was employed with 112 T2DM outpatients from Puskemas Simpang Mamplam, Bireuen City, Aceh, Indonesia, from March to April 2024. Medication adherence was assessed using the MARS-10 Questionnaire, and FBG levels were measured via finger prick. The majority of participants were female (79.5%), aged 41-60 (45.5%, mean age 55.70 ± 10.07 years), with secondary education (43.8%), predominantly sedentary/inactive workers (60.7%), and reported low-income (38.4%). Data analysis was performed using the Wilcoxon Signed rank Test. Following counseling, which was provided every two weeks over the two-months period, the mean medication adherence score significantly increased (p &lt; 0.001) from 3.150 ± 0.942 to 8.790 ± 1.297. FBG levels also significantly decreased (p&lt;0.05), from an initial mean of 308.98 ± 72.995 to 220.42 ± 68.547 at two weeks, 162.36 ± 50.191 at four weeks, and 130.00 ± 27.774 at six weeks. These findings suggest that pharmacist counseling significantly improves both medication adherence (p &lt; 0.001) and glycemic control (FBG decrease, p &lt; 0,05) in T2DM patients.

Introduction: Type 2 diabetes mellitus (T2DM) known as Mathumegam is a significant health concern in the twenty-first century. Despite great advances in contemporary science, there is a lack of moderately safe and effective drugs for treatment. The purpose of this study was to evaluate the efficacy of a poly herbal traditional decoction containing 10 herbs such as Senna auriculata (root &amp; bark), Cissampelos pareira (root), Ficus racemosa (bark), Terminalia arjuna (bark), Acacia arabica (bark), Syzygium cumini (bark), Curcuma longa (rhizome), Terminalia chebula (fruit pulp), Phyllanthus emblica (dry fruit), and Terminalia bellirica (fruit pulp) in the management of T2DM. Materials and Methods: It was a double-blind, randomized controlled trial involving 100 T2DM patients who were not well managed by diet or exercise. For a period of 12 weeks, 50 patients in group A were administered 5g of the test medication mixed with 100ml (one tumbler) of hot water for 10 to 15 min, as well as standard Western therapy. Group B patients (n=50) received a placebo in addition to normal Western therapy. The main focus of the study was to achieve a 3-month decrease in glycosylated hemoglobin (HbA1c) levels from the starting point, with additional objectives including lowering fasting blood glucose (FBG) levels and observing changes in diabetic symptoms. Results: At the end of the trial, mean fasting blood glucose levels decreased to 119.04 ± 11.52 and 176.90 ± 13.91 mg/dL in the test and control groups, respectively. Group A showed a more significant decrease in mean fasting blood glucose levels compared to group B. This indicates that the daily use of poly herbal traditional decoction along with standard allopathic medical therapy for 3 months led to notable reductions in FBG levels. Similarly, group A showed greater improvement in the measured signs and symptoms of diabetes, such as polydipsia, polyuria, polyphagia, weariness, and burning sensation in the hands and feet compared to group B throughout the trial. At baseline, the mean HbA1c (%) in group A and group B was 7.47 ± 0.70 and 7.39 ± 0.66, respectively. After 12 weeks of investigation, the levels of glycated hemoglobin were lowered to 5.03 ± 0.53 and 6.79 ± 0.51 respectively. There were no adverse events reported during the trial period. Conclusion: This study found that the experimental medication was beneficial in T2DM, radically lowering FBG and HbA1c levels in diabetic individuals after 12 weeks of treatment.