Deep Learning Algorithms in the Development of Generative AI Models for Automated Content Creation

Artificial Intelligence (AI) and Machine Learning (ML) have come up as transformative technologies in the pharmaceutical sciences, particularly in synthetic route planning and early-stage drug discovery.ML models can predict retrosynthetic pathways, optimize reaction conditions, and reduce trial-and-error in laboratory synthesis. Beyond their role in synthesis, AI-driven tools are now widely used to analyze complex biological and chemical data, helping researchers identify viable drug candidates at much earlier stages. Techniques such as virtual screening, predictive modeling, and structure–activity analysis allow scientists to make informed decisions before entering costly experimental phases. These methods also support the evaluation of safety, efficacy, and pharmacokinetic behavior, improving the overall quality of candidate selection. At the same time, Generative AI (GAI) is revolutionizing drug discovery by designing novel molecular structures with desired biological properties using deep learning algorithms such as generative adversarial networks (GANs) and transformer-based models. These intelligent systems not only accelerate the drug development timeline but also enhance decision-making in lead optimization and target validation. This integrated AI-driven approach significantly reduces cost, time and resources, enabling the way for faster and more efficient drug innovation.

Generative Artificial Intelligence (AI) has shown significant promise in healthcare, particularly in medical imaging, by improving data augmentation, diagnostic accuracy, and model generalization. However, existing models such as Generative Adversarial Networks (GANs) and Diffusion Models face challenges in balancing image realism, structural fidelity, and computational efficiency. GANs often suffer from mode collapse and limited diversity, while diffusion models, though high in fidelity, are computationally intensive and slow to sample. To address these limitations, we propose a Hybrid GAN–Diffusion approach that synergistically combines the strengths of both architectures. Our pipeline first pretrains a StyleGAN2-ADA model to capture coarse-to-fine radiographic structure efficiently, then refines the generated samples using a Denoising Diffusion Probabilistic Model (DDPM) to enhance anatomical plausibility and diversity. This sequential design fuses the sharpness and speed of GANs with the coverage and robustness of diffusion models, yielding synthetic images of superior quality and clinical utility. We evaluate the framework on the Kaggle Chest X-Ray Pneumonia dataset for training and perform external validation on NIH ChestXray14 to assess cross-dataset generalization. Experimental results demonstrate that the hybrid model achieves an ROC-AUC of 0.984 in-distribution and 0.892 on the external dataset, outperforming classical augmentation, GAN-only, and diffusion-only baselines. The synthetic data quality is further validated by a simulated Fréchet Inception Distance (FID) of 16.2, indicating high realism and diversity. The proposed method establishes a new state-of-the-art in medical image augmentation, demonstrating that hybrid generative pipelines can effectively overcome data scarcity while improving model robustness and generalization.

Generative artificial intelligence (GAI), a specialized branch of artificial intelligence, has developed as a dynamic discipline that drives innovation and creativity across several domains. It is concerned with creating models that can autonomously produce novel text, images, videos, music, 3D, code, and more. GAI is distinguished by its capacity to acquire knowledge from extensive datasets, identify recurring patterns, capture distributions, and produce novel content demonstrating similar features. This review presents a comprehensive historical overview of the development and progression of GAI techniques over the years. Various essential methodologies employed in developing GAI are also discussed, including Generative Adversarial Networks (GANs), Variational AutoEncoders (VAEs), transformers, and diffusion models. Moreover, a detailed overview of the technologies used in GAI is provided for generating images, videos, music, code, and text, such as ChatGPT, DALL-E, Midjourney, Claude, Bard, GitHub Copilot, and others. The research subsequently introduces the different datasets used to train the GAI models and the evaluation metrics for evaluating their performances. Ultimately, the research investigates the diverse applications of GAI across various domains, challenges, and ethical implications.

Deep learning and its application in geochemical mapping

Artificial intelligence and enabled technologies for neurological disorders: a narrative review and critical analysis

Malware detection plays a significant role in the realm of cybersecurity, yet traditional methods frequently struggle to identify novel and polymorphic threats. It investigates the growing role of Generative Artificial Intelligence (GenAI), including Generative Adversarial Networks (GANs), Variational Autoencoders (VAEs), and Transformer-based models, in enhancing malware detection. We systematically reviewed and analyzed over 25 peer-reviewed studies and technical reports published between 2017 and 2024, including recent surveys and case studies on GenAI-based cybersecurity solutions. Four benchmark datasets-Malimg, UNSW-NB15, CIC-IoT23, and EMBER-were evaluated across the literature for their suitability in GenAI-based malware detection. The techniques are compared based on performance metrics such as classification accuracy, anomaly detection precision, F1-score, adversarial robustness, and computational efficiency. The paper also identifies key limitations, including mode collapse, low interpretability, and vulnerability to evasion and poisoning attacks. Finally, we identify various possibilities for future research, including real-time AI defenses, hybrid GenAI-discriminative approaches, and explainable AI integration. This study serves as a foundational reference for advancing GenAI-powered malware detection frameworks in cybersecurity. To provide a more reliable and precise malware detection pipeline, the suggested hybrid framework combines Transformer-based sequence modeling, VAE-driven latent feature encoding, and GAN-based data augmentation. Furthermore, the proposed hybrid model combining GAN-based augmentation, VAE-driven latent representation learning, and Transformerbased sequence modeling demonstrates improved robustness and detection accuracy, offering a unified approach to address malware diversity, imbalance, and evolving threat behaviors. The proposed hybrid model delivers the highest accuracy <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(96.4 \%)$</tex>.

Generative artificial intelligence, especially with regard to the generative adversarial network (GAN), is an important research area in radiology as evidenced by a number of literature reviews on the role of GAN in radiology published in the last few years. However, no review article about GAN in pediatric radiology has been published yet. The purpose of this paper is to systematically review applications of GAN in pediatric radiology, their performances, and methods for their performance evaluation. Electronic databases were used for a literature search on 6 April 2023. Thirty-seven papers met the selection criteria and were included. This review reveals that the GAN can be applied to magnetic resonance imaging, X-ray, computed tomography, ultrasound and positron emission tomography for image translation, segmentation, reconstruction, quality assessment, synthesis and data augmentation, and disease diagnosis. About 80% of the included studies compared their GAN model performances with those of other approaches and indicated that their GAN models outperformed the others by 0.1–158.6%. However, these study findings should be used with caution because of a number of methodological weaknesses. For future GAN studies, more robust methods will be essential for addressing these issues. Otherwise, this would affect the clinical adoption of the GAN-based applications in pediatric radiology and the potential advantages of GAN could not be realized widely.

Deepfake technology, leveraging advanced artificial intelligence (AI) algorithms, has emerged as a powerful tool for generating hyper‐realistic synthetic human faces, presenting both innovative opportunities and significant challenges. Meanwhile, the development of Deepfake detectors represents another branch of models striving to recognize AI‐generated fake faces and protect people from the misinformation of Deepfake. This ongoing cat‐and‐mouse game between generation and detection has spurred a dynamic evolution in the landscape of Deepfake. This survey comprehensively studies recent advancements in Deepfake generation and detection techniques, focusing particularly on the utilization of generative adversarial networks (GANs) and diffusion models (DMs). For both GAN‐based and DM‐based Deepfake generators, we categorize them based on whether they synthesize new content or manipulate existing content. Correspondingly, we examine various strategies employed to identify synthetic and manipulated Deepfake, respectively. Finally, we summarize our findings by discussing the unique capabilities and limitations of GANs and DM in the context of Deepfake. We also identify promising future directions for research, including the development of hybrid approaches that leverage the strengths of both GANs and DM, the exploration of novel detection strategies utilizing advanced AI techniques, and the ethical considerations surrounding the development of Deepfake. This survey paper serves as a valuable resource for researchers, practitioners, and policymakers seeking to understand the state‐of‐the‐art in Deepfake technology, its implications, and potential avenues for future research and development.

Deep learning has revolutionized the modern-day world starting with its application in computer vision such as image classification, face recognition, autonomous vehicle etc. it has been explored in various areas where human beings find it difficult to come up with solutions to the challenges at hand.By the word deep, it implies they are trained with millions, billions of parameters to achieve outstanding results.In this review paper, the fundamentals of deep learning have been discussed extensively starting with the classification, types of activation functions, different deep learning algorithms as well as their applications were also discussed.Recurrent neural network (RNNs) and its variant, convolution neural networks (CNNs) and various architectures, recursive neural networks (RvNNs), restricted Boltzmann machines (RBMs), deep belief networks (DBNs), generative adversarial networks (GANs) and other deep learning were discussed extensively.Some of the findings of researchers for some of these algorithms were highlighted.Based on various paper reviewed and thorough analysis carried out, it was observed that the exploration of deep learnings in this modern-day world has found applications in virtually all fields of life from medicine, academy, transportation, entertainments, particularly the exploration of CNNs, RNNs, and GANs.

The World Health Organization (WHO) grading system of pancreatic neuroendocrine tumor (PNET) plays an important role in the clinical decision. The rarity of PNET often negatively affects the radiological application of deep learning algorithms due to the low availability of radiological images. We tried to investigate the feasibility of predicting WHO grades of PNET on contrast-enhanced magnetic resonance (MR) images by deep learning algorithms. Ninety-six patients with PNET underwent preoperative contrast-enhanced MR imaging. Fivefold cross-validation was used in which five iterations of training and validation were performed. Within every iteration, on the training set augmented by synthetic images generated from generative adversarial network (GAN), a convolutional neural network (CNN) was trained and its performance was evaluated on the paired internal validation set. Finally, the trained CNNs from cross-validation and their averaged counterpart were separately assessed on another ten patients from a different external validation set. Averaging the results across the five iterations in the cross-validation, for the CNN model, the average accuracy was 85.13% ± 0.44% and micro-average AUC was 0.9117 ± 0.0053. Evaluated on the external validation set, the average accuracy of the five trained CNNs ranges between 79.08 and 82.35%, and the range of micro-average AUC was between 0.8825 and 0.8932. The average accuracy and micro-average AUC of the averaged CNN were 81.05% and 0.8847, respectively. Synthetic images generated from GAN could be used to alleviate the difficulty of radiological image collection for uncommon disease like PNET. With the help of GAN, the CNN showed the potential to predict the WHO grades of PNET on contrast-enhanced MR images.

The application of the Generative Adversarial Networks (GANs) model has increased rapidly in the past few years. This paper will demonstrate the training results of different GANs models in different epochs. Since GANs is a structure, they can be applied to different neural network layers such as Convolutional Neural Network (CNN) and multilayer perceptron (MLP). Different neural network layers are constructed and trained separately to compare their performance and efficiency in this experiment. To achieve this goal, all models perform the same task, generating handwritten numbers. In the experiment, three GANs models are tested. Two of them are based on MLP. They use the same structure and the same number of units. The only difference is the activation function. One uses the sigmoid function, and the other uses the LeakyRelu function. The last model is based on CNN. Specifically, the GANs model using Convolutional layers is called DCGAN. All models are constructed using TensorFlow, each of them was trained for 10, 20, 40, 80, 120, and 160 epochs. The generated images and loss value are recorded in all cases of the previously mentioned epochs of training. The experimental results demonstrated that Compared with the GANs model based on MLP, DCGAN has higher training efficiency and better image quality. Different activation functions can also affect the efficiency of the GANs model.

Generative AI has revolutionized computer vision by enabling machines to synthesize and enhance visual data. Advances in deep learning, such as Generative Adversarial Networks (GANs), Variational Autoencoders (VAEs), and diffusion models, have led to high-quality image generation with applications in medical imaging, data augmentation, and autonomous systems. Despite its potential, challenges like ethical concerns, dataset biases, and computational costs remain critical for future research and implementation. This paper explores the evolution of generative AI, its methodologies, applications, and the ethical and computational challenges it presents.

<sec><title>Objective</title> As urban design faces increasing demands for contextual responsiveness, iterative optimization, and data-informed reasoning, integrating artificial intelligence into the design process has gained renewed relevance. Among emerging technologies, generative artificial intelligence (GAI) shows strong potential for automating content creation and simulating spatial configurations. This research provides a comprehensive review of recent developments in the application of GAI to urban design. The research identifies representative technical pathways, their respective intervention stages, and the functional mechanisms by which generative models are reshaping the design workflow. This research presents a structured, theory-informed synthesis of how different generative models contribute to tasks such as intention modeling, spatial reasoning, and performance-driven design. Building on design thinking and a descriptive lens informed by the technology acceptance model (TAM), the research examines how model type, data modality, and task characteristics affect GAI’s functional role, usability, and acceptance. Particular attention is given to mapping deployment forms, from isolated tools to coordinated multi-model workflows, and to characterizing cross-cutting challenges of controllability, transparency, and contextual adaptability in urban design settings. </sec><sec><title>Methods</title> Following the PRISMA protocol, the research conducts a multi-stage literature review combining automated search and expert screening. A total of 125 peer-reviewed articles and high-impact preprints are selected from Web of Science, CNKI, arXiv, and selected industry sources, covering the period from 2014 to July 2025. Search terms such as “generative AI”, “AIGC”, “GAN”, “diffusion model”, “variational autoencoder”, “autoregressive model”, “large language model”, and urban-related keywords are used in various combinations. Based on the collected literature, four types of generative models are summarized as image-driven, language-driven, structure-driven, and feedback-optimized models, according to their application characteristics in urban design tasks. These types are aligned with four stages of the design process: preliminary analysis, scheme generation, evaluation and decision-making, and outcome expression. On this basis, a two-dimensional framework to examine how different GAI pathways intervene across tasks is formed. To refine the mapping, each design stage is further broken down into three representative sub-tasks. Preliminary analysis includes public demand analysis, urban data enhancement, case/task framing, and spatial element recognition. Scheme generation covers design intention modeling, spatial layout generation, and 3D form construction. The evaluation and decision-making stage includes multi-objective optimization, scheme evaluation, and scenario prediction. The final expression stage involves textual documentation, 2D representation, and visual rendering. A quantitative analysis is also conducted to show the distribution of model types over design stages, identify common combinations, and trace the evolution of research focus over time. TAM informs a descriptive synthesis of perceived usefulness (PU) and perceived ease of use (PEU) across model types to illuminate adoption patterns. </sec><sec><title>Results</title> The findings reveal that GAI models are increasingly integrated into urban design workflows but exhibit uneven adoption across task types and modalities. Image-driven models dominate in both early-stage analysis and final visual representation due to their high interpretability, usability, and compatibility with existing design practices. Language-driven models are commonly used in public demand analysis, participatory planning, and scenario scripting, enabled by the rise of large language models (LLMs) such as ChatGPT and DeepSeek. Structure-driven models, though less prevalent, show promise in generating street networks, land-parcel layouts, and spatial typologies using graph-based logic. Feedback-optimized models, which rely on reinforcement learning, evolutionary algorithms, and performance simulation are the least adopted, but demonstrate strong potential in multi-objective optimization and iterative decision-making. Recent research indicates an increasing use of multi-model workflows, such as text-to-image pipelines integrated with urban simulation or feedback loops. While GAI applications increasingly support design iteration, their adoption is heavily influenced by the controllability, explainability, and contextual adaptability of models. PU and PEU vary significantly by model type, with image-driven models rated highest and structure-driven and feedback-optimized models facing usability challenges due to complexity and low transparency. </sec><sec><title>Conclusion</title> Although GAI has demonstrated broad applicability across the urban design process, current implementations are largely procedural and auxiliary in nature. Most models recombine existing inputs rather than construct original logic, and few possess autonomous reasoning or normative awareness. This limits their role to content augmentation rather than conceptual guidance in design development. Moreover, issues such as opaque decision logic, lack of domain-specific knowledge embedding, and poor adaptability to local planning norms hinder practical adoption. Addressing these challenges requires multi-level efforts: 1) Construct structured, regionally grounded urban design datasets; 2) improve model interpretability, controllability, and responsiveness to professional input; and 3) develop modular, multi-model systems that support seamless interaction across design stages. Human – AI collaboration mechanisms — especially those based on iterative prompts and semantic feedback-must be enhanced to enable AI not just as a tool, but as an active design partner. This review offers a comprehensive reference for scholars and practitioners seeking to understand how GAI is reshaping the logic, structure, and agency of urban design. </sec>

he rapid progress in implementing Artificial Intelligence (AI) across various domains such as healthcare decision-making, medical diagnosis, and others has raised significant concerns regarding the fairness and bias embedded within AI systems. This is particularly crucial in sectors like healthcare, employment, criminal justice, credit scoring, and the emerging field of generative AI models (GenAI) producing synthetic media. Such systems can lead to unfair outcomes and perpetuate existing inequalities, including biases ingrained in the synthetic data representation of individuals.This survey paper provides a concise yet comprehensive examination of fairness and bias in AI, encompassing their origins, ramifications, and potential mitigation strategies. We scrutinize sources of bias, including data, algorithmic, and human decision biases, shedding light on the emergent issue of generative AI bias where models may replicate and amplify societal stereotypes. Assessing the societal impact of biased AI systems, we spotlight the perpetuation of inequalities and the reinforcement of harmful stereotypes, especially as generative AI gains traction in shaping public perception through generated content.Various proposed mitigation strategies are explored, with an emphasis on the ethical considerations surrounding their implementation. We stress the necessity of interdisciplinary collaboration to ensure the effectiveness of these strategies. Through a systematic literature review spanning multiple academic disciplines, we define AI bias and its various types, delving into the nuances of generative AI bias. We discuss the adverse effects of AI bias on individuals and society, providing an overview of current approaches to mitigate bias, including data preprocessing, model selection, and post-processing. Unique challenges posed by generative AI models are highlighted, underscoring the importance of tailored strategies to address them effectively.Addressing bias in AI necessitates a holistic approach, involving diverse and representative datasets, enhanced transparency, and accountability in AI systems, and exploration of alternative AI paradigms prioritizing fairness and ethical considerations. This survey contributes to the ongoing discourse on developing fair and unbiased AI systems by outlining the sources, impacts, and mitigation strategies related to AI bias, with a particular focus on the burgeoning field of generative AI.

Imputation of missing images via source-to-target modality translation can improve diversity in medical imaging protocols. A pervasive approach for synthesizing target images involves one-shot mapping through generative adversarial networks (GAN). Yet, GAN models that implicitly characterize the image distribution can suffer from limited sample fidelity. Here, we propose a novel method based on adversarial diffusion modeling, SynDiff, for improved performance in medical image translation. To capture a direct correlate of the image distribution, SynDiff leverages a conditional diffusion process that progressively maps noise and source images onto the target image. For fast and accurate image sampling during inference, large diffusion steps are taken with adversarial projections in the reverse diffusion direction. To enable training on unpaired datasets, a cycle-consistent architecture is devised with coupled diffusive and non-diffusive modules that bilaterally translate between two modalities. Extensive assessments are reported on the utility of SynDiff against competing GAN and diffusion models in multi-contrast MRI and MRI-CT translation. Our demonstrations indicate that SynDiff offers quantitatively and qualitatively superior performance against competing baselines.