DeepR2OM: Accurate Recognition for RNA 2'-O-Methylation Sites in Human Genome Using Deep Learning.

Deep learning (also known as deep structured learning, hierarchical learning, or deep machine learning) is a branch of machine learning based on a set of algorithms that attempt to model high-level abstractions in data by using a deep graph with multiple processing layers, composed of multiple linear and nonlinear transformations. Deep learning has been characterized as a class of machine learning algorithms with the following characteristics [257]: • They use a cascade of many layers of nonlinear processing units for feature extraction and transformation. Each successive layer uses the output from the previous layer as input. The algorithms may be supervised or unsupervised and applications include pattern analysis (unsupervised) and classification (supervised). • They are based on the (unsupervised) learning of multiple levels of features or representations of the data. Higher-level features are derived from lower-level features to form a hierarchical representation. • They are part of the broader machine learning field of learning representations of data. • They learn multiple levels of representations that correspond to different levels of abstraction; the levels form a hierarchy of concepts. These definitions have in common: multiple layers of nonlinear processing units and the supervised or unsupervised learning of feature representations in each layer, with the layers forming a hierarchy from low-level to high-level features. Various deep learning architectures such as deep neural networks, convolutional deep neural networks, deep belief networks (DBN), and recurrent neural networks have been applied to fields like computer vision, automatic speech recognition, natural language processing, audio recognition, and bioinformatics where they have been shown to produce state-of-the-art results on various tasks. In this chapter we start in Section 7.1 with an introduction, giving a brief history of this field, the relevant literature, and its applications. Then we study some basic concepts of deep learning such as convolutional neural networks, recurrent neural networks, backpropagation algorithm, restricted Boltzmann machines, and deep learning networks in Section 7.2. Then we illustrate three examples for Apache Spark implementation for mobile big data (MBD), user moving pattern extraction, and combination with nonparametric Bayesian learning, respectively, in Sections 7.3 through 7.5. Finally, we have summary in Section 7.6.

The leather industry plays a crucial role in the production of high-quality leather products to remain competitive in the market. Due to various reasons such as material handling and turning, leather defects can appear at different stages of the production process. This paper proposed deep learning techniques, specifically transfer learning, deep convolutional neural networks (D-CNN), and ensemble learning for automating leather defect detection and classification. The dataset was taken from the open source Kaggle. The dataset was preprocessed from the beginning. However, we performed Error Level Analysis (ELA) to detect possible changes or fraud in the image. We also used data augmentation techniques (resizing, rescaling, flipping, rotation, zooming, and contrasting) on the dataset to improve the model performance. This study investigated deep learning architectures for automatic leather defect detection, comparing them with seven deep convolutional neural networks (D-CNN) models and transfer learning architectures. Furthermore, we introduce and evaluate two novel ensemble models: MER built on transfer learning architecture (MobileNetV2, EfficientNetB0, and ResNet50) and AZL built on D-CNN architecture (AlexNet, ZfNet, and LeNet). A key contribution of this study is the demonstration of significant performance improvements achieved by strategically integrating squeeze and excitation and label smoothing techniques into transfer learning, D-CNN, and ensemble frameworks. Our proposed MER ensemble method achieves a state-of-the-art of 96.39% for leather defect detection. The proposed model was evaluated using performance metrics including precision, recall, F1-score, AUC, ROC, and Matthews Correlation Coefficient (MCC). Additionally, Grad-CAM was employed for explainable AI to visualize and interpret the model’s decision-making process. Comparative analysis against separate transfer learning and D-CNN models fails to establish the superior performance of our MER ensemble, which highlights the potential to significantly advance automated quality inspection in leather production. This study provides insights into evaluating the best deep learning techniques for leather defect classification, paving the way for more accurate, efficient, and reliable industrial applications. Proposes a robust deep learning-based framework for automated leather defect detection using transfer learning, deep CNNs, and two novel ensemble models (MER and AZL), enhanced with squeeze-and-excitation and label smoothing techniques. Achieves state-of-the-art performance with the proposed MER ensemble model, achieve 96.39% accuracy, and demonstrates superior results across precision, recall, F1-score, AUC–ROC, and MCC. Integrates Error Level Analysis (ELA), extensive data augmentation, and Grad-CAM–based explainable AI to ensure data reliability, improve generalization, and provide transparent visual interpretation of defect regions for industrial quality inspection.

In recent decades, deep learning (DL) has become a rapidly growing research direction, redefining the state-of-the-art performances in a wide range of techniques, such as object detection and speech recognition. In the aircraft design, dynamics, and control field, many works hinge on the information-rich data-driven approach, which includes the fusion-based prognostic and health management, the airliner's flight safety monitoring, intelligent sensing, and flight control systems development. While DL provides great potentials to solve these data-driven problems, a systematic review and discussion as to how the DL has been/can be used for these problems are still missing in relation to the rapidly developing and widely used DL techniques. In this article, we aim to address this urgent issue to provide a timely overview of the state-of-the-art for applying DL to the aircraft design, dynamics, and control field. In particular, we briefly introduce five representative DL methods, i.e., deep neural network, deep autoencoder, deep belief network, convolutional neural network, and recurrent neural network. Mathematical definitions for each method are presented, and illustrative applications are also discussed. We then review the existing DL-based works that have appeared in the aircraft design, dynamics, and control field. The review efforts are divided into two major groups, i.e., the own-ship aircraft modeling, wherein the works have been/can be implemented online for the aircraft design/dynamics/control, and other airplanes research works, wherein DL-based schemes provide offline monitoring of the aircraft operation. We then summarize the data sources and DL architectures. Referring to the experiences of DL research works/techniques development in other related fields, future opportunities, challenges, and potential solutions for implementing DL in the aircraft design, dynamics, and control field are also discussed.

ABSTRACTIn recent years, there has been a significant surge in the utilisation of deep learning and machine learning techniques for addressing complex and time‐intensive problems. The significance of employing deep learning becomes increasingly evident as the complexity of the problem increases. In the field of electromagnetics, the utilisation of deep learning techniques has exhibited exceptional efficacy across many applications, especially in wireless communications. In wireless communications, providing a structure that can simultaneously generate multiple beams and beamform them involves complexity and specific constraints. In this article, the time modulation technique is utilised to generate harmonics in the sidebands alongside the fundamental beam in various planar antenna arrays. By demonstrating the nonlinear shaping of the harmonic beams relative to each other, a novel approach is proposed that leverages deep learning techniques for the beamforming of both the fundamental beam and harmonic beams. In this regard, two models are proposed: a deep neural network (DNN) and a convolutional neural network (CNN). The input of CNN is comprised of two‐dimensional patterns of the main beam and harmonics. The input to DNN, on the other hand, includes useful details about the main beam and harmonics, such as their scanning angles, side lobe levels and directivities. The output of the models consists of the time modulation parameters of the array elements, including the pulse width and the pulse delay. The results demonstrate that DNN has achieved better accuracy and a shorter processing time in comprehending the relationship between the time modulation of array elements with different array dimensions and the radiation pattern of the fundamental beam and harmonic beams. Additionally, several samples are presented to evaluate the proposed model. The results demonstrate a high level of accuracy in fundamental beamforming, as well as in harmonic beamforming and beam steering.

Algorithms based on deep learning are taking off as solutions to several problems in numerous fields. Numerous deep learning architectures like convolutional neural networks, recurrent neural networks, deep belief networks, artificial neural networks and deep neural networks have been used in fields such as audio recognition, machine vision, processing of natural language, recognition of speech, social network filtering, computer vision, translating languages and bioinformatics. One such application of deep learning architectures is object detection. Object detection in satellite and aerial imagery undertakes an important role in a long list of applications and has allured a lot of attention which resulted in exceptional progress in recent years. It has abundant uses in various fields such as surveillance, military, national security, urban planning, environmental applications, traffic control and forestry. Several issues like varying size, background and orientation of the target object make the automatic detection of target in satellite imagery a challenging issue. Recent research in this field has given better speed and accuracy to the detection of the target object. With the rise in the data being generated by the Earth Observation programs, it is becoming much more imperative to find better and efficient ways to exploit this data by improving upon the existing Deep Learning research. In this paper, we bring forth a wide-ranging analysis of the recent advancements in methods of object detection based on deep learning to recognize the objects in satellite imagery.KeywordsDeep learningObject detectionSatellite imageryRemote sensingYou Only Look Once (YOLO)You Only Look Twice (YOLT)Single Shot Detector (SSD)Convolutional Neural Networks (CNN)Faster Region-based Convolutional Neural Networks (Faster RCNN)Hybrid Deep Convolutional Neural Network (HDNN)Satellite Imagery Multiscale Rapid Detection with Windowed Networks (SIMRDWN)

Prediction of the stage of cancer plays an important role in planning the course of treatment and has been largely reliant on imaging tools which do not capture molecular events that cause cancer progression. Gene-expression data-based analyses are able to identify these events, allowing RNA-sequence and microarray cancer data to be used for cancer analyses. Breast cancer is the most common cancer worldwide, and is classified into four stages - stages 1, 2, 3, and 4 [2]. While machine learning models have previously been explored to perform stage classification with limited success, multi-class stage classification has not had significant progress. There is a need for improved multi-class classification models, such as by investigating deep learning models. Gene-expression-based cancer data is characterised by the small size of available datasets, class imbalance, and high dimensionality. Class balancing methods must be applied to the dataset. Since all the genes are not necessary for stage prediction, retaining only the necessary genes can improve classification accuracy. The breast cancer samples are to be classified into 4 classes of stages 1 to 4. Invasive ductal carcinoma breast cancer samples are obtained from The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) datasets and combined. Two class balancing techniques are explored, synthetic minority oversampling technique (SMOTE) and SMOTE followed by random undersampling. A hybrid feature selection pipeline is proposed, with three pipelines explored involving combinations of filter and embedded feature selection methods: Pipeline 1 - minimum-redundancy maximum-relevancy (mRMR) and correlation feature selection (CFS), Pipeline 2 - mRMR, mutual information (MI) and CFS, and Pipeline 3 - mRMR and support vector machine-recursive feature elimination (SVM-RFE). The classification is done using deep learning models, namely deep neural network, convolutional neural network, recurrent neural network, a modified deep neural network, and an AutoKeras generated model. Classification performance post class-balancing and various feature selection techniques show marked improvement over classification prior to feature selection. The best multiclass classification was found to be by a deep neural network post SMOTE and random undersampling, and feature selection using mRMR and recursive feature elimination, with a Cohen-Kappa score of 0.303 and a classification accuracy of 53.1%. For binary classification into early and late-stage cancer, the best performance is obtained by a modified deep neural network (DNN) post SMOTE and random undersampling, and feature selection using mRMR and recursive feature elimination, with an accuracy of 81.0% and a Cohen-Kappa score (CKS) of 0.280. This pipeline also showed improved multiclass classification performance on neuroblastoma cancer data, with a best area under the receiver operating characteristic (auROC) curve score of 0.872, as compared to 0.71 obtained in previous work, an improvement of 22.81%. The results and analysis reveal that feature selection techniques play a vital role in gene-expression data-based classification, and the proposed hybrid feature selection pipeline improves classification performance. Multi-class classification is possible using deep learning models, though further improvement particularly in late-stage classification is necessary and should be explored further.

In recent years, successful applications of deep learning (DL) have inspired scientists to explore the possibilities of applying DL approaches to modeling scientific problems. Existing studies have revealed that to bake the physics into the DL makes a good supplement to the traditional numerical methods (e.g., finite element, finite volume method) which primarily rely on partial differential equations (PDEs). While DL models are ordinarily trained in a purely data-driven manner, integrating physics into them for simulating scientific problems has several benefits such as (i) physics constraints could regularize the over-parameterized model and hence mitigate the overfitting issue commonly seen in DL; (ii) physics information could also effectively reduce the amount of data needed for training the model; (iii) the resultant physics-informed DL models feature better interpretability and generalizability compared with the conventional black-box model. Furthermore, the powerful expressiveness of the deep network, guaranteed by the universal approximation theorem, makes it a suitable approximator for the solution to a physical system. In this dissertation, we develop two different DL architectures (or approaches), one being continuous scheme-based while the other discrete scheme-based, that leverage physics knowledge for modeling scientific problems. Through comprehensive numerical experiments, we demonstrate the proposed models can be used in solving general PDEs, establishing predictive data-driven models for dynamical systems, identifying the parameters in governing PDEs or even discovering the entire governing PDEs of dynamical systems from scarce and noisy measurements. The continuous model roots on the physics-informed neural network (PINN) which uses a fully connected neural network (FCNN) to approximate the physical fields of a system globally. This model is mesh-free as the residual of the physics (e.g., PDEs, initial/boundary values) is evaluated on a set of collocation points within the physical domain. Several applications including the forward simulations, data-driven simulations and solving inverse problems are presented to exemplify the advantages of PINN over traditional numerical methods. However, the original PINN suffers from inaccurate initial/boundary values due to the weak enforcement of the initial/boundary conditions (I/BCs). To overcome this issue, we propose an improved PINN model by utilizing multiple deep neural networks (DNNs) to construct the solution. Through a DNN pre-trained to represent the initial/boundary values, the approximated solution would obey the given I/BCs forcibly. With several numerical examples, we show that the improved PINN is characterized with much better accuracy on the I/BCs. Though the PINN shows great promise in data-driven modeling and solving inverse problems, some inherent limitations of PINN still exist, such as (i) the solution might lacks fine-scale details due to the global approximation of FCNN; (ii) high computational expense caused by the FCNN it roots on; (iii) incapability to incorporate existing PDE terms (e.g., $\Delta u$) into the network architecture. To overcome these drawbacks, this dissertation also proposes a discrete model - Physics-encoded Recurrent Convolutional Neural Network (PeRCNN) which recurrently updates the solution (or state variable) for time marching. Specifically, it utilizes convolutional neural network (CNN) to capture the spatial patterns of the solution while the recurrent network mimics the forward Euler scheme (or Runge-Kutta scheme) in numerical methods. PeRCNN is a mesh-based and discrete model due to the discretization in time and spatial dimension. The local connectivity of CNN makes PeRCNN more computationally efficient. In addition, the coercive encoding mechanism of physics in PeRCNN, fundamentally different from the PINN relying on soft penalty, ensures the network to rigorously obey given physics. The proposed PeRCNN is successfully applied to solving general PDEs, the data-driven modeling of dynamical systems and the data-driven discovery of governing PDEs from scarce and noisy measurements. Comparisons with the state-of-the-art DL models demonstrate that the proposed PeRCNN possesses excellent computational efficiency, accuracy and generalizability. --Author's abstract

This review examines the recent developments in deep learning (DL) techniques applied to multimodal fusion image segmentation for liver cancer. Hepatocellular carcinoma is a highly dangerous malignant tumor that requires accurate image segmentation for effective treatment and disease monitoring. Multimodal image fusion has the potential to offer more comprehensive information and more precise segmentation, and DL techniques have achieved remarkable progress in this domain. This paper starts with an introduction to liver cancer, then explains the preprocessing and fusion methods for multimodal images, then explores the application of DL methods in this area. Various DL architectures such as convolutional neural networks (CNN) and U-Net are discussed and their benefits in multimodal image fusion segmentation. Furthermore, various evaluation metrics and datasets currently used to measure the performance of segmentation models are reviewed. While reviewing the progress, the challenges of current research, such as data imbalance, model generalization, and model interpretability, are emphasized and future research directions are suggested. The application of DL in multimodal image segmentation for liver cancer is transforming the field of medical imaging and is expected to further enhance the accuracy and efficiency of clinical decision making. This review provides useful insights and guidance for medical practitioners.

A survey of deep learning-driven architecture for predictive maintenance

To classify the texts accurately, many machine learning techniques have been utilized in the field of Natural Language Processing (NLP). For many pattern classification applications, great success has been obtained when implemented with deep learning models rather than using ordinary machine learning techniques. Understanding the complex models and their respective relationships within the data determines the success of such deep learning techniques. But analyzing the suitable deep learning methods, techniques, and architectures for text classification is a huge challenge for researchers. In this work, a Contiguous Convolutional Neural Network (CCNN) based on Differential Evolution (DE) is initially proposed and named as Evolutionary Contiguous Convolutional Neural Network (ECCNN) where the data instances of the input point are considered along with the contiguous data points in the dataset so that a deeper understanding is provided for the classification of the respective input, thereby boosting the performance of the deep learning model. Secondly, a swarm-based Deep Neural Network (DNN) utilizing Particle Swarm Optimization (PSO) with DNN is proposed for the classification of text, and it is named Swarm DNN. This model is validated on two datasets and the best results are obtained when implemented with the Swarm DNN model as it produced a high classification accuracy of 97.32% when tested on the BBC newsgroup text dataset and 87.99% when tested on 20 newsgroup text datasets. Similarly, when implemented with the ECCNN model, it produced a high classification accuracy of 97.11% when tested on the BBC newsgroup text dataset and 88.76% when tested on 20 newsgroup text datasets.

Computer-aided diagnosis of ocular disorders like glaucoma can be effectively performed with retinal fundus images. Since the advent of machine learning and later deep learning techniques in medical image analysis, research focusing on automated and early detection of glaucoma has gained prominence. In this paper, we show how a deep Convolutional Neural Network model can be used in visualising the features related to Glaucoma that are consistent with (a subset of) those used by ophthalmologists for diagnosis. However, since the doctors do not necessarily depend entirely on these features but back them up with other important measurements such as visual field testing (HVF), any deep neural network such as CNN may not necessarily be expected to yield 100% accuracy. Further, other important parameters such as Intraocular Pressure (IOP), which may be built into a deep learning model, may not necessarily correlate well with the presence of Glaucoma. In this work, a deep CNN model has been trained and tested on a large number of high-quality fundus images, both normal and glaucomatous. We compare the results with transfer learning models such as VGG16, ResNet50, and MobileNetV2. On an average, we obtained an accuracy of 93.75% in identifying glaucoma, focusing only on the features of the fundus image.

Recently, deep neural networks (DNNs) have been widely studied and achieved tremendous success in a variety of real-world applications, such as computer vision, natural language processing, medical diagnosis, and machine translation. Deep reinforcement learning (DRL), as an emerging powerful deep learning technique, combines DNNs with reinforcement learning into an interactive system that enables the agent to learn the best policy from the environment to optimize their rewards. DRL opens up many new applications in domains such as healthcare, robotics, and smart grids. With the rapid evolution of IT infrastructures, cloud computing has been witnessed as the most common computing paradigm. The underlying infrastructure of cloud computing relies on a large amount of data centers. Nowadays, with the fast development of communication technologies, such as 5G, cloud computing is now evolving into yet another new paradigm called edge computing, providing for emerging applications, especially in the Internet-of-Things. The energy efficiency issue from both "cloud" and "edge" are becoming more crucial and calls for more attention. To solve the real-world energy efficiency problems, we take advantage of the deep learning and deep reinforcement learning techniques for efficient modeling of both "edge" and "cloud" applications. On the "edge" side, wearable technologies and the Internet of Things (IoT) are becoming increasingly popular in both personal and commercial applications with the employment of the embedded system technologies. Non-Volatile Processors (NVPs) have been proposed for the intermittent power supply problem, to ensure the instant on/off for embedded systems under the unstable power supply. We proposed neural network-based prediction techniques to derive the best power extraction policy and converter parameters optimization technique for NVPs. In cloud computing, we formulated a novel optimal power management problem of data centers to minimize the total cost by proposing the long short term memory (LSTM) neural network-based method for the prediction of future data center power consumption, and further we presented a novel DRL-based hierarchical framework for solving the overall resource allocation and power management problem in cloud computing systems. Furthermore, we explored the effectiveness of the DRL-based framework for high dimensional action and state spaces problem-dynamic treatment regimes, to model real-life complexity in heterogeneous disease progression and treatment choices, to provide doctors and patients the data-driven personalized decision recommendations. Last but not least, we explored the efficiency of deep neural networks. Structured weight pruning is a representative model compression technique of DNNs to reduce both the storage and computation requirements and meanwhile accelerate inference. An automatic hyperparameter determination process is necessary due to a large number of flexible hyperparameters. We propose an automatic structured pruning framework to compress the DNNs. Our framework outperforms the prior works on automatic model compression by up to 33× in pruning rate (120× reduction in the actual parameter count) under the same accuracy. Significant inference speedup has been observed from the proposed framework on actual measurements on the smartphone.

With the development of information and technology, especially with the boom in big data, healthcare support systems are becoming much better. Patient data can be collected, retrieved, and stored in real time. These data are valuable and meaningful for monitoring, diagnosing, and further applications in data analysis and decision-making. Essentially, the data can be divided into three types, namely, statistical, image-based, and sequential data. Each type has a different method of retrieval, processing, and deployment. Additionally, the application of machine learning (ML) and deep learning (DL) in healthcare support systems is growing more rapidly than ever. Numerous high-performance architectures are proposed to optimize decision-making. As reliability and stability are the most important factors in the healthcare support system, enhancing the predicted performance and maintaining the stability of the model are always the top priority. The main idea of our study comes from ensemble techniques. Numerous studies and data science competitions show that by combining several weak models into one, ensemble models can attain outstanding performance and reliability. We propose three deep ensemble learning (DEL) approaches, each with stable and reliable performance, that are workable on the above-mentioned data types. These are deep-stacked generalization ensemble learning, gradient deep learning boosting, and deep aggregation learning. The experiment results show that our proposed approaches achieve more vigorous and reliable performance than traditional ML and DL techniques on statistical, image-based, and sequential benchmark datasets. In particular, on the Heart Disease UCI dataset, representing the statistical type, the gradient deep learning boosting approach dominates the others with accuracy, recall, F1-score, Matthews correlation coefficient, and area under the curve values of 0.87, 0.81, 0.83, 0.73, and 0.91, respectively. On the X-ray dataset, representing the image-based type, the deep aggregation learning approach shows the highest performance with values of 0.91, 0.97, 0.93, 0.80, and 0.94, respectively. On the Depresjon dataset, representing the sequence type, the deep-stacked generalization ensemble learning approach outperforms the others with values of 0.91, 0.84, 0.86, 0.8, and 0.94, respectively. Overall, we conclude that applying DL models using our proposed approaches is a promising method for the healthcare support system to enhance prediction and diagnosis performance. Furthermore, our study reveals that these approaches are flexible and easy to apply to achieve optimal performance.

Feature selection (FS) plays a crucial role in medical imaging by reducing dimensionality, improving computational efficiency, and enhancing diagnostic accuracy. Traditional FS techniques, including filter, wrapper, and embedded methods, have been widely used but often struggle with high-dimensional and heterogeneous medical imaging data. Deep learning-based FS methods, particularly Convolutional Neural Networks (CNNs) and autoencoders, have demonstrated superior performance but lack interpretability. Hybrid approaches that combine classical and deep learning techniques have emerged as a promising solution, offering improved accuracy and explainability. Furthermore, integrating multi-modal imaging data (e.g., Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Positron Emission Tomography (PET), and Ultrasound (US)) poses additional challenges in FS, necessitating advanced feature fusion strategies. Multi-modal feature fusion combines information from different imaging modalities to improve diagnostic accuracy. Recently, quantum computing has gained attention as a revolutionary approach for FS, providing the potential to handle high-dimensional medical data more efficiently. This systematic literature review comprehensively examines classical, Deep Learning (DL), hybrid, and quantum-based FS techniques in medical imaging. Key outcomes include a structured taxonomy of FS methods, a critical evaluation of their performance across modalities, and identification of core challenges such as computational burden, interpretability, and ethical considerations. Future research directions—such as explainable AI (XAI), federated learning, and quantum-enhanced FS—are also emphasized to bridge the current gaps. This review provides actionable insights for developing scalable, interpretable, and clinically applicable FS methods in the evolving landscape of medical imaging.

Alzheimer's Disease (AD) is a serious neurological illness that causes memory loss gradually by destroying brain cells. This deadly brain illness primarily strikes the elderly, impairing their cognitive and bodily abilities until brain shrinkage occurs. Modern techniques are required for an accurate diagnosis of AD. Machine learning has gained attraction in the medical field as a means of determining a person's risk of developing AD in its early stages. One of the most advanced soft computing neural network-based Deep Learning (DL) methodologies has garnered significant interest among researchers in automating early-stage AD diagnosis. Hence, a comprehensive review is necessary to gain insights into DL techniques for the advancement of more effective methods for diagnosing AD. This review explores multiple biomarkers associated with Alzheimer's Disease (AD) and various DL methodologies, including Deep Neural Networks (DNN), Convolutional Neural Networks (CNN), Recurrent Neural Networks (RNN), The k-nearest-neighbor (k-NN), Deep Boltzmann Machines (DBM), and Deep Belief Networks (DBN), which have been employed for automating the early diagnosis of AD. Moreover, the unique contributions of this review include the classification of ATN biomarkers for Alzheimer's Disease (AD), systemic description of diverse DL algorithms for early AD assessment, along with a discussion of widely utilized online datasets such as ADNI, OASIS, etc. Additionally, this review provides perspectives on future trends derived from critical evaluation of each variant of DL techniques across different modalities, dataset sources, AUC values, and accuracies.