In most major cities, air pollution is still a severe problem, and there are frequent exceedances of air quality standards for many primary and secondary pollutants. In particular, the high emissions from vehicles can lead to high concentrations within the urban canopy, where the atmospheric flow and turbulence is disturbed by buildings or other obstacles. The high emissions of vehicle NOx from urban centers serves to lower O3 levels within major cities. Nevertheless, NO2 levels may be extremely high in such urban environments, and questions arise about the role of urban street canyons as “pre-reaction chambers” that may further enhance NO2 formation. To understand the ramifications of proposed emission reduction strategies on the street canyon level, photochemical models for high resolution simulation of urban core air quality are needed. Previous modeling on the urban street canyon scale has either focussed on non-reactive pollutants or has invoked simple approximations for dealing with simplified NO-NO2-O3 chemistry (Yamartino and Wiegand, 1986; Berkowicz et al., 1997). While such simplifications may be appropriate within a single canyon for receptors nearby the emission sources, they are not reasonable for addressing questions associated with the series of canyons or quarters as are found in the urban core. This paper summarizes the development of a full photochemical model for high resolution simulation of urban core air and reports the results of the initial applications of this model, MICRO-CALGRID, to multiple and single street canyons. The model development was funded by the German Federal Environmental Agency (Umweltbundesamt).