Developmental dyslexia and specific language impairment: distinct syntactic profiles?

Associations Between Key Language-Related Measures in Typically Developing School-Age Children

Here we use two filtered speech tasks to investigate children’s processing of slow (<4 Hz) versus faster (∼33 Hz) temporal modulations in speech. We compare groups of children with either developmental dyslexia (Experiment 1) or speech and language impairments (SLIs, Experiment 2) to groups of typically-developing (TD) children age-matched to each disorder group. Ten nursery rhymes were filtered so that their modulation frequencies were either low-pass filtered (<4 Hz) or band-pass filtered (22 – 40 Hz). Recognition of the filtered nursery rhymes was tested in a picture recognition multiple choice paradigm. Children with dyslexia aged 10 years showed equivalent recognition overall to TD controls for both the low-pass and band-pass filtered stimuli, but showed significantly impaired acoustic learning during the experiment from low-pass filtered targets. Children with oral SLIs aged 9 years showed significantly poorer recognition of band pass filtered targets compared to their TD controls, and showed comparable acoustic learning effects to TD children during the experiment. The SLI samples were also divided into children with and without phonological difficulties. The children with both SLI and phonological difficulties were impaired in recognizing both kinds of filtered speech. These data are suggestive of impaired temporal sampling of the speech signal at different modulation rates by children with different kinds of developmental language disorder. Both SLI and dyslexic samples showed impaired discrimination of amplitude rise times. Implications of these findings for a temporal sampling framework for understanding developmental language disorders are discussed.

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Discriminating autism and language impairment and specific language impairment through acuity of musical imagery

In many languages a weakness in non-word repetition serves as a useful clinical marker of specific language impairment (SLI) in children. However, recent work in Italian has shown that the repetition of real words may also have clinical utility. For young typically developing Italian children, real word repetition is more predictive of particular grammatical abilities than is non-word repetition. This finding is important because these particular grammatical abilities--the production of present-tense third-person plural inflections and direct-object clitic pronouns--are precisely those that are problematic for Italian-speaking children with SLI. Along with their grammatical requirements, these two morpheme types present a significant phonological/prosodic challenge for these children. To replicate the findings with young typically developing Italian children and to determine whether real word repetition is also more predictive of the use of these two morpheme types than is non-word repetition in a group of Italian-speaking children with SLI. Seventeen Italian-speaking children with SLI and 17 younger typically developing children matched for mean length of utterance participated in tasks of real word and non-word repetition as well as tasks requiring the production of direct-object clitic pronouns and present-tense third-person plural inflections. Children with SLI were less accurate than their younger peers on all measures. Importantly, for the younger typically developing children, real word repetition explained a significant amount of variance in the use of third-person plural inflections and direct-object clitic pronouns. For the children with SLI, in contrast, non-word repetition was a significant predictor, whereas real word repetition was not a contributing factor. It is argued that in Italian SLI, the grammatical details showing the greatest weakness present phonological/prosodic obstacles as well as grammatical challenges to these children. Consequently, non-word repetition emerges as a predictor of these grammatical weaknesses in SLI, unlike the profile observed in typically developing Italian children.

Association of specific language impairment candidate genes CMIP and ATP2C2 with developmental dyslexia in Chinese population

This study reports experimental data on the acquisition of the mass-count distinction by Dutch-speaking children with specific language impairment (SLI). While verbal morphosyntax is known to be impaired in SLI, nominal morphosyntax has received less attention. The mass-count distinction provides an interesting test ground: count can have a plural morpheme: bal-en (‘balls’), but mass cannot: *deeg-en (‘doughs’). Flexible nouns can easily occur in either mass or count syntax (pizza/pizza-s). Finally, object-mass nouns (e.g. furniture) are syntactically mass, but quantify over individuals, and are hypothesized to have a lexical [+individual] feature (Bale &amp;amp; Barner 2004). Typically developing (TD) Dutch-acquiring children become sensitive to the mass-count distinction around age 6 (van Witteloostuijn 2013).Hypothesizing that the primary impairment of SLI is in morphosyntax, and not in lexical-semantics, we predict that Dutch-speaking children with SLI older than 6 have most problems with the interpretation of flexible nouns (relying solely on morphosyntax), some problems interpreting classical count and mass nouns (supported by convention/world knowledge), and least problems interpreting object–mass nouns (relying solely on their lexical [+individual] feature). Quantity judgments based on count and mass nouns were collected from 28 Dutch children with SLI aged between 6 and 14 years old and 28 individually age-matched TD children. Confirming our predictions, the children with SLI scored significantly lower than their TD controls on flexible nouns, and, albeit to a lesser extent, on classical nouns. This underscores the (nominal) morphological deficit in SLI. In contrast, no difference between groups was found on object-mass nouns.

Children with specific language impairment (SLI) often experience word-learning difficulties, which are suggested to originate in the early stage of word learning: fast mapping. Some previous research indicates significantly poorer fast mapping capabilities in children with SLI compared with typically developing (TD) counterparts, with a range of methodological factors impacting on the consistency of this finding. Research has explored key issues that might underlie fast mapping difficulties in children with SLI, with strong theoretical support but little empirical evidence for the role of phonological short-term memory (STM). Additionally, further research is required to explore the influence of receptive vocabulary on fast mapping capabilities. Understanding the factors associated with fast mapping difficulties that are experienced by children with SLI may lead to greater theoretically driven word-learning intervention. To investigate whether children with SLI demonstrate significant difficulties with fast mapping, and to explore the related factors. It was hypothesized that children with SLI would score significantly lower on a fast mapping production task compared with TD children, and that phonological STM and receptive vocabulary would significantly predict fast mapping production scores in both groups of children. Twenty-three children with SLI (mean = 64.39 months, SD = 4.10 months) and 26 TD children (mean = 65.92 months, SD = 2.98) were recruited from specialist language and mainstream schools. All participants took part in a unique, interactive fast-mapping task whereby nine novel objects with non-word labels were presented and production accuracy was assessed. A non-word repetition test and the Peabody Picture Vocabulary Test-Fourth Edition (PPVT-IV) were also administered as measures of phonological STM capacity and receptive vocabulary, respectively. Results of the fast-mapping task indicated that children with SLI had significantly poorer fast mapping production scores than TD children. Scores from the non-word repetition task were also significantly lower for the SLI group, revealing reduced phonological STM capacity. Phonological STM capacity and receptive vocabulary emerged as significant predictors of fast mapping performance when the group data were combined in a multiple regression analysis. These results suggest that the word-learning difficulties experienced by children with SLI may originate at the fast mapping stage, and that phonological STM and receptive vocabulary significantly predict fast mapping ability. These findings contribute to the theoretical understanding of word-learning difficulties in children with SLI and may inform lexical learning intervention.

Children with specific language impairment (SLI) show particular difficulty comprehending and producing object (Who did the bear follow?) relative to subject (Who followed the tiger?) wh-questions. To determine if school-age children with SLI, relative to children with typical development (TD), show a more distinct unevenness, or asymmetry, in the comprehension of these questions. In addition, this study examined whether the sustained left-anterior negativity (LAN) in event-related potentials (ERP) could be used as a marker for atypical processing of these questions in children with SLI. The LAN effect signals the greater working memory processes for maintaining in memory the dislocated object in object wh-questions and reflects working memory capacity in adults. It was predicted that the amplitude of the LAN would be greater in children with SLI, reflecting the characteristic low working memory capacity in this population. The concomitance of these behavioural and electrophysiological effects would suggest that the subject-object asymmetry in SLI should be investigated in relation to poor working memory skills. Groups including 13 children with SLI, 17 same-age TD children and 18 normal adults completed an auditory sentence comprehension task requiring button responses while continuous electroencephalography (EEG) was collected. Accuracy for subject and object questions was calculated. The mean amplitude values of the ERP data for the wh-questions were examined to identify differential processing of subject and object questions. TD children demonstrated asymmetrical comprehension of subject and object wh-questions, whereas children with SLI comprehended both question types poorly and adults did not show subject-object asymmetry. ERP waveforms spanning the wh-dependency revealed a large and widespread sustained anterior positivity for object relative to subject questions in the TD group, indicating differential processing of these questions. This effect was attenuated and non-significant in the SLI group. The adults' grand average waveforms showed the expected LAN effect, which was opposite in polarity relative to the children, although it only approached significance. The finding of less differential processing of subject and object wh-questions in SLI relative to TD children suggests inefficient maintenance of sentential information in working memory for object questions in SLI. Whereas behavioural methods did not identify subject-object asymmetry in SLI, the more fine-grained method of ERPs elucidated this effect. Further analysis of working memory as the basis for the subject-object asymmetry in SLI is critical for identifying appropriate intervention targets for this population.

Objectives: This study examined whether there is a significant relationship between Korean Brief Parent Report (KBPR) and Working Memory (phonological loop, episodic buffer); and investigated the significant predictor of children’s language ability.Methods: A total of 52 children from 4 to 6 years old participated in this study composed of children with Specific Language Impairment (SLI), and typically developing (TD) children. Experimental tasks including KBPR, Non-Word Repetition (NWR), Word List Recall and a Symmetric-Asymmetric Matrix were used. One-way ANOVA, correlational, and multiple stepwise regression analysis were used.Results: 1) There was a significant difference between groups in section B (Current abilities) and C (Behavior patterns and activity preferences). 2) There was a statistically significant difference in phonological loop and linguistic episodic buffer (EB). 3) The correlation between each section score of KBPR and working memory in the TD group showed consistent linguistic sentential order in the EB task with all the other sections except for section A. In the SLI group, section A had correlation with phonological loop, section B had correlation with linguistic EB, and section C had correlation with non-linguistic EB 4) The most significant predictor of the KBPR total score in the TD group was linguistic sentential order EB, and in the SLI group was phonological loop.Conclusion: Both the KBPR score and working memory task competency of the SLI and TD groups showed significant differences. In addition, the meaningful predictor in the total score of KBPR in each group respectively was NWR in the SLI group and linguistic sentential order EB in the TD group.

The current study assessed independent and combined effects of SLI and bilingualism on tasks tapping into verbal short-term memory (vSTM) with varying linguistic load in two languages (Russian and Hebrew). The study explored the extent to which the presence of SLI is related to limited vSTM storage and bilingualism is associated with reduced vocabulary size.A total of 190 monolingual and bilingual children aged 5;5–6;8 participated in the current study: 108 sequential Russian-Hebrew bilinguals (18 with SLI), 48 Hebrew monolinguals (13 with SLI) and 34 Russian monolinguals (14 with SLI). Children performed three repetition tasks: forward-digit span (FWD), non-word repetition (NWR) and sentence repetition (SRep); bilingual children were tested in both of their languages.Results indicated a negative effect of SLI on all experimental tasks tapping into vSTM. The effect of SLI rose as a function of increased linguistic load. Regarding bilingualism, no effect was found on the measure of vSTM with the lowest linguistic load (FWD), while its effect was robust once the linguistic load was increased (SRep). The results reported in this study bring evidence that lower performance on measures of vSTM in children with SLI and bilingual children stem from different sources. Although, children with SLI have limitations of vSTM, deficient vSTM cannot fully account for the linguistic difficulties observed in children with SLI. As for bilingualism, it does not affect verbal storage when the linguistic load is minimal, while poor performance in bilingual children on tasks with greater linguistic load is attributed to smaller vocabulary sizes.

Objective Many studies report a deficit in working memory in children with Developmental Dyslexia (DD) and Developmental Coordination Disorder (DCD) compared to children with Typical Development (TD). In this study, we questioned the working memory profile of children with co-occurring Developmental Dyslexia and Developmental Coordination Disorder (DD-DCD). First, we hypothesized that children with DD would have a more substantial deficit in verbal working memory, while children with DCD would have a more substantial deficit in visuospatial working memory. For the comorbid group, we postulated a deficit in both the verbal and visuospatial domains. Second, we determined whether we could correctly distinguish between the four groups based on their working memory profiles. Method 47 children with DD, 22 children with DCD, 27 children with DD-DCD, and 42 TD children aged from 7.6 to 12.6 years were tested on the phonological loop, the visuospatial sketchpad, and the central executive using the Digit Span and Wechsler’s Block-tapping tests. Results Children with DD had a deficit in verbal working memory including a specific deficit in the phonological loop and children with DCD had a deficit in visuospatial working memory. Comorbid children had poorer performance in verbal working memory (like group with DD) and in visuospatial working memory (like group with DCD). Exploratory cluster analysis resulted in four subgroups: (1) one cluster with good working memory performance made up of most of the TD children; (2) one cluster with a phonological loop deficit mainly made up of the children with DD; (3) one cluster with poor visuospatial working memory capacities mostly made up of the children with DCD (± DD) and (4) one cluster with average performance made up of children from all the groups. Conclusion Our results underline the importance of taking comorbidity into account when testing working memory in children with learning disabilities.

What memory systems underlie grammar in children, and do these differ between typically developing (TD) children and children with specific language impairment (SLI)? Whilst there is substantial evidence linking certain memory deficits to the language problems in children with SLI, few studies have investigated multiple memory systems simultaneously, examining not only possible memory deficits but also memory abilities that may play a compensatory role. This study examined the extent to which procedural, declarative, and working memory abilities predict receptive grammar in 45 primary school aged children with SLI (30 males, 15 females) and 46 TD children (30 males, 16 females), both on average 9;10 years of age. Regression analyses probed measures of all three memory systems simultaneously as potential predictors of receptive grammar. The model was significant, explaining 51.6% of the variance. There was a significant main effect of learning in procedural memory and a significant group × procedural learning interaction. Further investigation of the interaction revealed that procedural learning predicted grammar in TD but not in children with SLI. Indeed, procedural learning was the only predictor of grammar in TD. In contrast, only learning in declarative memory significantly predicted grammar in SLI. Thus, different memory systems are associated with receptive grammar abilities in children with SLI and their TD peers. This study is, to our knowledge, the first to demonstrate a significant group by memory system interaction in predicting grammar in children with SLI and their TD peers. In line with Ullman’s Declarative/Procedural model of language and procedural deficit hypothesis of SLI, variability in understanding sentences of varying grammatical complexity appears to be associated with variability in procedural memory abilities in TD children, but with declarative memory, as an apparent compensatory mechanism, in children with SLI.

Autism spectrum disorder (ASD) and specific language impairment (SLI) are two neurodevelopmental disorders characterized by deficits in verbal and nonverbal communication skills. These skills are thought to develop largely through implicit—or automatic—learning mechanisms. The aim of the current paper was to investigate the role of implicit learning abilities in the atypical development of communication skills in ASD and SLI. In the current study, we investigated Response Times (RTs) and Event Related Potentials (ERPs) during implicit learning on a Serial Reaction Time (SRT) task in a group of typically developing (TD) children (n = 17), a group of autistic children (n = 16), and a group of children with SLI (n = 13). Findings suggest that learning in both ASD and SLI are similar to that in TD. However, electrophysiological findings suggest that autistic children seem to rely mainly on more automatic processes (as reflected by an N2b component), whereas the children with SLI seem to rely on more controlled processes (as reflected by a P3 component). The TD children appear to use a combination of both learning mechanisms. These findings suggest that clinical interventions should aim at compensating for an implicit learning deficit in children with SLI, but not in children with ASD. Future research should focus on developmental differences in implicit learning and related neural correlates in TD, ASD, and SLI. Autism Res2018, 11: 1050–1061. © 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc.Lay SummaryAutism and Specific Language Impairment (SLI) are two disorders characterized by problems in social communication and language. Social communication and language are believed to be learned in an automatic way. This is called “implicit learning.” We have found that implicit learning is intact in autism. However, in SLI there seems different brain activity during implicit learning. Maybe children with SLI learn differently, and maybe this different learning makes it more difficult for them to learn language.

Excessive crowding in the visual periphery has been demonstrated in children with developmental dyslexia (DD). However, less is known about crowding in the fovea, even though foveal crowding is at least equally important, as reading is mostly accomplished through foveal vision. Here we used a special set of digitstimuli (Pelli fonts) to measure foveal crowding in DD and DD + ADHD children, and compared it to that in TD (typically developing) and ADHD children. We also used the Chinese reading acuity charts (C-READ) to assess the maximum reading speed and reading acuity, along with tests to evaluate cognitive attributes including phonological awareness, rapid automatized naming, morphological awareness, and orthographic knowledge. The results indicate significantly stronger foveal crowding in the DD and DD + ADHD groups, as well as in the ADHD group, than in the TD group. Furthermore, the DD and DD + ADHD groups exhibited poorer maximum reading speed and reading acuity compared to the ADHD and TD groups.Within the two DD groups, theslower maximum reading speed and higher reading acuitycan be predicted bystronger foveal crowding. In addition, the DD and DD + ADHD groups performed the worst in four cognitive skills, with the DD group showing negative correlations between foveal crowding and performances across all these skills. Our findings thus move beyond previously well-documented peripheral crowding in dyslexia, and the easy administration of the Pelli-font-based crowding test may be useful for early diagnosis of developmental dyslexia in young children.