Early Development of Infant Brain Complex Network

(1) Background: Programming of atherosclerosis results in vascular structure and function alterations, which may be attributed to fetal exposure to maternal tobacco smoking, alcohol consumption and several lifestyle factors in the first few years of life. This review aims to study the effects of teratogen exposure in utero on vascular dysfunction in offspring and consider mediators and pathways originating from the fetal environment. (2) Methods: Eligible studies were identified in the PubMed, Scopus and Web of Science databases. After the full-text screening, 20 articles were included in the narrative synthesis. (3) Results: The literature presents evidence supporting the detrimental effects of fetal exposure to tobacco smoking on vascular alterations in both human and animal studies. Alcohol exposure impaired endothelial dilation in animal studies, but human studies on both tobacco and alcohol exposure are still sparse. Reduction in nitric oxide (NO) bioavailability and alterations in the epigenome in infants through the upregulation of pro-oxidative and proinflammatory genes may be the common denominators. (4) Conclusion: While maternal smoking and alcohol consumption have more negative outcomes on the infant in the short term, several factors during the first few years of life may mediate the development of vascular dysfunction. Therefore, more prospective studies are needed to ascertain the long-term effects of teratogen exposure, specifically in South Africa.

Brain development during early life in healthy individuals is rapid and dynamic, indicating that this period plays a very important role in neural and functional development. The frontal and temporal lobes are known to play a particularly important role in cognition. The study of healthy frontal and temporal lobe development in children is therefore of considerable importance. A better understanding of how these brain regions develop could also aid in the diagnosis and treatment of neurodevelopmental disorders. Some devel-opmental studies have used magnetic resonance imaging (MRI) to examine infant brains, but it remains the case that relatively little is known about cortical brain development in the first few years of life. In the present study we examined whole brain, temporal lobe and frontal lobe developmental trajectories from infancy to early adulthood in healthy individuals, considering gender and brain hemisphere differences. We performed a cross-sectional, longitudinal morphometric MRI study of 114 healthy individuals (54 females and 60 males) aged 1 month to 25 years old (mean age ± SD 8.8 ± 6.9). We measured whole brain, temporal and frontal lobe gray matter (GM)/white matter (WM) volumes, following previously used protocols. There were significant non-linear age-related volume changes in all regions. Peak ages of whole brain, temporal lobe and frontal lobe development occurred around pre-adolescence (9-12 years old). GM volumes for all regions increased significantly as a function of age. Peak age was nevertheless lobe specific, with a pattern of earlier peak ages for females in both temporal and frontal lobes. Growth change in whole brain GM volume was larger in males than in females. However, GM volume growth changes for the temporal and frontal lobes showed a somewhat different pattern. GM volume for both temporal and frontal lobes showed a greater increase in females until around 5-6 years old, at which point this tendency reversed (GM volume changes in males became greater), with male GM volume increasing for a longer time than that of females. WM volume growth changes were similar across regions, all increasing rapidly until early childhood but slowing down thereafter. All regions displayed significant rightward volumetric asymmetry regardless of sex. Furthermore, the right temporal and frontal lobes showed a greater volumetric increase than the left for the first several years, with this tendency reversing at around 6 years of age. In addition, the left frontal and temporal lobes increased in volume for a longer period of time. Taken together, these findings indicated that brain developmental trajectories differ depending on brain region, sex and brain hemisphere. Gender-related factors such as sex hormones and functional laterality may affect brain development.

Caregiving relationships with infants and children are among the most common and most complex human social interactions. Adults' perceptions of children's mental capacities have important consequences for the well-being of children in their care-particularly in the first few years of life, when children's communication skills are limited and caregivers must infer children's rapidly developing thoughts, feelings, and needs. In a series of studies, we assessed how US adults conceptualize the development of the human mind over the first five years of life. Exploratory factor analysis identified four core capacities that anchored participants' representations of the developing human mind: bodily sensation (e.g., hunger, pain), negative affect (e.g., distress, frustration), social connection (e.g., love, learning from others), and cognition and control (e.g., planning, self-control). Participants believed that these capacities were present to different degrees at birth, followed different developmental trajectories, and were driven by different developmental mechanisms, such as biological "preprogramming," physical maturation, passive observation, and social learning. The current studies shed light on this fascinating and understudied aspect of "mind perception" among US adults, in turn highlighting possibilities for theory-based interventions to encourage developmentally appropriate parenting behaviors.

The central nervous system undergoes profound and predictable developmental changes during the first few years of life that provide the structural and functional elements necessary for normal neurological development. The establishment and maturation of white matter pathways is a critical component of the developing nervous system. Diffusion tensor imaging (DTI) offers a noninvasive and quantitative means for the evaluation of white matter changes. DTI has contributed to the evaluation of a number of childhood leukoencephalopathies; it has also been used to follow brain maturation in abnormal states, such as premature birth or early brain injury. Furthermore, it has helped characterize the relation between white matter integrity and cognitive abilities. In the future, DTI is expected to play an increasingly large role in defining developmental abnormalities at an early age and in assessing therapies for pediatric disorders such as leukodystrophies.

Some non–randomized constructed comparison groups for evaluating age–related outcomes of intervention programs

BackgroundWith an increasing prevalence of obesity in young children globally, there is an urgent need for the development of effective early interventions. A previous Healthy Beginnings Trial using a nurse-led home visiting program has demonstrated that providing mothers with evidence-based advice can improve maternal practice regarding obesity prevention, and can reduce Body Mass Index (BMI) in the first few years of life. However, the costs for scale-up of home visiting limit its population reach. This trial aims to determine the efficacy of Communicating Healthy Beginnings Advice by Telephone (CHAT) to mothers with infants in improving infant feeding practices and preventing the early onset of childhood overweight and obesity.Methods/DesignWe propose a 3-arm randomised controlled trial (RCT) with a consecutive sample of 1056 mothers with their newborn children in New South Wales (NSW) Australia. Pregnant women who are between weeks 28 and 34 of their pregnancy will be invited to participate in the CHAT trial. Informed consent will be obtained, and after baseline data collection, participants will be randomly allocated to the telephone intervention, text messaging intervention, or the control group. The intervention comprises telephone consultations or text messages, together with 6 intervention packages being mailed at specific times from the third trimester of pregnancy until 12 months post birth. The main trial outcome measures include a) duration of breastfeeding, b) timing of introduction of solids, c) nutrition behaviours, physical activity and television viewing, and d) weight and BMI z-score at 12 and 24 months, e) cost-effectiveness, as well as f) feasibility and acceptability of the interventions.DiscussionThe results will ascertain whether early intervention using telephone consultation or text messaging together with staged mailed intervention resources can be feasible and effective in improving infant feeding practices, physical activity and reducing children’s BMI in the early years of life. If proven to be feasible, effective as well as cost-effective, the trial results will inform a series of recommendations for policy and practice related to promoting healthy infant feeding and physical activity in young children in the first years of life.Trial registrationThe CHAT Trial is registered with the Australian Clinical Trial Registry (ACTRN12616001470482p). It was registered on October 21, 2016.

Born equal? The distribution of government Medicare spending for children

Primary antibody immunodeficiency in children: Clinical presentation and outcome

Three-Generation Family Households and Child Wellbeing Natasha V. Pilkauskas The skills acquired in the first few years of life are critical in preparing children for school and for long term development. Families play a primary role in the development of cognitive and social skills as well as physical health. Changes in family structure that have occurred over the last several decades have resulted in fewer children growing up in a two parent married household; however, few children are raised by just one parent. Many children spend time in a three-generation family household, in which a grandparent, parent and child coreside. To date, little research has described the prevalence or correlates of three-generation family households or looked at the association between three-generation family coresidence and child wellbeing during early childhood. To fill this gap in the literature this dissertation was structured around three empirical chapters (papers) and the findings from those studies are described below. Paper 1/Chapter 2: Describe Patterns in Three-generation Coresidence and Investigate Correlates of Coresidence by Mother’s Relationship Status at Birth Using data from the Fragile Families and Child Wellbeing Study (N = 4,898), Chapter 2 investigates how the share, correlates, transition patterns, and duration of three-generation households vary by mother’s relationship status at birth. Nine percent of married mothers, 17% of cohabiting mothers, and 45% of single mothers live in a three-generation family household at the time of the child’s birth. Incidence over time is much higher and most common among single-mother households: Sixty percent live in a three-generation family household at least 1 wave. Economic need, culture, and generational needs are associated with living in a threegeneration household; correlates vary by mother’s relationship status. Three-generation family households are short lived, and transitions are frequent. Kin support through coresidence is an important source of support for families with young children and in particular families in which the parents are unwed at the time of their child’s birth. Paper 2/Chapter 3: Investigate the Association between Living in a Stable and Unstable Threegeneration Family Household and Child Cognitive, Socioemotional and Health Outcomes at Age 3: Differences by Race/Ethnicity and Relationship Status. Chapter 3 investigates to what extent stable and unstable three-generation family households (grandparent, parent, child) are associated with child health, socioemotional and academic wellbeing over the first three years of a child’s life. Using longitudinal data from the Fragile Families and Child Wellbeing Study (N=4,009) differences in the association by mother’s relationship status and race/ethnicity are investigated. Results suggest stable threegeneration family households are associated with child wellbeing whereas unstable or transitory three-generation households are not. Living in a stable three-generation family household is protective against child behavior problems for married families but detrimental for single or Black mothers. Stable three-generation coresidence is associated with higher PPVT scores but also higher odds of being overweight for some groups. Paper 3/Chapter 4: Investigate the Association between Living in a Stable and Unstable Threegeneration Family Household and School Readiness at Age 5: Differences by Race/Ethnicity. Using nationally representative data from the Early Childhood Longitudinal Study – Birth Cohort (N~10,700), Chapter 4 investigates the associations between stable and unstable (or transitory) three-generation coresidence over the first five years of life and school readiness, and how those associations vary by race/ethnicity. With a few exceptions, the findings suggest that three-generation family coresidence is not associated with cognitive development, psychomotor development, or physical health. However, coresidence with a grandparent is associated with a higher likelihood of obesity across all race/ethnicities, as well as more externalizing behavior for Whites and less externalizing behavior for Hispanics. Although differences between stable and unstable coresidence are mostly insignificant, stability appears to matter for behavior, but in different ways for Black and Asian children. Black children who unstably coreside and Asian children who stably coreside with a grandparent experience more internalizing and less prosocial and positive learning behaviors.

A study was made of the longitudinal growth pattern of 29 girls and 36 boys with constitutional tall stature (CTS) from birth to age 9 years. In these children, all of whom had a normal birth length, there was very rapid growth during the first 4 years of life, following which growth velocity dropped to normal and remained parallel to the 50th percentile. In the 49 subjects for whom actual final height was also obtained there was a very good agreement between this and the final height as predicted by Tanner's method from the height at ages 4 and 8 years. Significant differences were found between the mean maternal, paternal and mid-parental height and the tall stature of their offspring, but there was a very good correlation between the individual patients final height and their parental heights. The findings of this study stress the importance of periodical measurements of length and height in all children during the first few years of life so as to have appropriate data on which to base future considerations of possible therapy.

Cockroach-induced IL9, IL13, and IL31 expression and the development of allergic asthma in urban children

The most common pediatric mitochondrial disease is Leigh syndrome, an episodic, subacute neurodegeneration that can lead to death within the first few years of life, for which there are no proven general therapies. Mice lacking the complex I subunit, Ndufs4, develop a fatal progressive encephalopathy resembling Leigh syndrome and die at ≈60 d of age. We previously reported that continuously breathing normobaric 11% O2 from an early age prevents neurological disease and dramatically improves survival in these mice. Here, we report three advances. First, we report updated survival curves and organ pathology in Ndufs4 KO mice exposed to hypoxia or hyperoxia. Whereas normoxia-treated KO mice die from neurodegeneration at about 60 d, hypoxia-treated mice eventually die at about 270 d, likely from cardiac disease, and hyperoxia-treated mice die within days from acute pulmonary edema. Second, we report that more conservative hypoxia regimens, such as continuous normobaric 17% O2 or intermittent hypoxia, are ineffective in preventing neuropathology. Finally, we show that breathing normobaric 11% O2 in mice with late-stage encephalopathy reverses their established neurological disease, evidenced by improved behavior, circulating disease biomarkers, and survival rates. Importantly, the pathognomonic MRI brain lesions and neurohistopathologic findings are reversed after 4 wk of hypoxia. Upon return to normoxia, Ndufs4 KO mice die within days. Future work is required to determine if hypoxia can be used to prevent and reverse neurodegeneration in other animal models, and to determine if it can be provided in a safe and practical manner to allow in-hospital human therapeutic trials.

BackgroundCataracts are a major cause of childhood blindness globally. Although surgically treatable, it is unclear whether children would benefit from such interventions beyond the first few years of life, which...

Psychiatric patients have been shown to differ from the normal population in important features of early development. Numerous clinical investigations reviewed by Bowlby 3 have indicated that the development of mental illness may be traceable to conditions and events occurring early in life. Two statistical studies 1,2 have shown a relationship between maternal bereavement during the first few years of life and the subsequent development of psychiatric illness. A number of other statistical studies, summarized later in the present paper, have tested whether psychotic patients differ from the normal population in the distribution of months of birth. One reason why such studies have been done is undoubtedly the ease of collecting the data. Mental hospitals routinely attempt to record the date of birth of every patient; the accurate month of birth is usually obtainable from the patient or a close relative. The monthly

Chronic granulomatous disease (CGD) is a rare congenital immunodeficiency characterized by recurrent bacterial and fungal infections as well as granuloma formation. The manifestations of this disease can involve single or multiple organ systems. The lungs are the most commonly affected organ; however, lymphatic, hepatic, skeletal, gastrointestinal, genitourinary, head and neck, and central nervous system involvement have also been described. Most patients present with symptoms in their first few years of life. Due to the nonspecific manner in which patients present, the pediatric radiologist may be among the first to recognize the pattern of infection, inflammation, and granuloma formation leading to a diagnosis of CGD. The purpose of this paper is to review the imaging findings of CGD that can manifest throughout the body.