Effects of Sertraline on Executive Function and Quality of Life in Patients with Advanced Cancer

Qol-P-03 - Quality of life in patients with mycosis fungoides and Sézary syndrome: a review of the literature

To evaluate the quality of life (QOL) in the patients with chronic hepatitis C (CHC) after PEG-Interferon a-2a therapy. A study based on 102 CHC patients (group A, before PEG- Interferon a-2a therapy, T0) and 44 healthy persons (group B) was carried out using the general quality of life inventory (GQOLI-74) questionnaire, and QOL were compared between the two groups. Patients in group A were divided into subgroup A1 (72 patients ) which was given PEG-Interferon a-2a plus Ribavirin for one year and subgroup A2 (30 patients) without any antivirus therapy. QOL of patients in these two subgroups was investigated using GQOLI-74 questionnaire on the end of PEG-Interferon a-2a plus Ribavirin therapy (T1) and half one year after the end of PEG-Interferon a-2a plus Ribavirin therapy (T2). QOL of CHC patients (group A1 and A2) were compared at T0, T1 and T2, respectively. Compared with group B, patients in group A had lower QOL (P < 0.05) on other scales and total scores of the GQOLI-74 questionnaire except psychological function(P > 0.05). Both on T1 and T2, patients in subgroup A1 had higher QOL on physical function, psychological function, social function and total scores than patients in subgroup A2 at the same time (P < 0.05). Patients in subgroup A1 at T1 had higher QOL on physical function, psychological function, social function and total scores than at T0 (P < 0.05). Patients in subgroup A1 at T2 had higher QOL on social function than that at T1 (P < 0.05). QOL of CHC patients is more impaired than healthy persons. PEG-Interferon a-2a therapy will improve the QOL.

BACKGROUND: There is an emerging role of various non-pharmacological strategies in the management of motor and non-motor symptoms of Parkinson’s disease (PD). OBJECTIVE: The aim of the study was to examine the effectiveness of Tai chi and Qigong on cognitive and motor functions, emotions, and quality of life in patients with PD. SUBJECTS AND METHODS: Seven subjects with mean age of 50.2 years, education of 11.71 years, and duration of PD of 6.03 years underwent four-week training of Qigong and Tai chi. They received one session per week under supervision and daily two 45-min practice sessions at home following instructions from the manual. Participants were assessed before and after intervention on neuropsychological tests, Unified Parkinson’s Disease Rating Scale (motor section), Hamilton Anxiety Rating Scale (HAM-A), Hamilton Depression Rating Scale (HAM-D), Epworth Sleepiness Scale (ESS), and Parkinson’s Disease Questionnaire (PDQ-39). RESULTS: There was a significant improvement in executive functions, verbal memory, and reduced scores on clinical scales (UPDRS III, HAM-A, PDQ-39). CONCLUSION: Combined practice of Tai chi and Qigong improves motor and non-motor symptoms of PD. However, well-designed randomized controlled trials and longitudinal studies are required to understand its full potential.

Critical limb ischemia (CLI) has a poor prognosis and adversely affects patients’ quality of life (QOL). Therapeutic angiogenesis may improve mobility, mortality, and QOL in CLI patients. However, the effectiveness of gene therapy on such patients’ QOL is unknown. DVC1-0101, a non-transmissible recombinant Sendai virus vector expressing human fibroblast growth factor-2 gene, demonstrated safety and efficacy in a phase I/II study of CLI patients. We investigated the effects of DVC1-0101 on QOL in this cohort. QOL was assessed using the Short Form-36 health survey version 2 (SF-36) in 12 patients at pre-administration, 28 days, and 3, 6, and 12 months post-treatment. We examined differences between pre and post-administration QOL scores and correlations between QOL scores and vascular parameters. Patients demonstrated low baselines scores on every SF-36 dimension. Post-treatment scores showed significant improvements in physical functioning at 3 and 6 months (P < 0.05), role-physical at 3, 6, and 12 months (P < 0.05), bodily pain at 1, 3, 6, and 12 months (P < 0.05), vitality at 1, 6, and 12 months (P < 0.05), and physical component summary at 6 and 12 months (P < 0.05). DVC1-0101-based gene therapy may improve QOL in CLI patients over a 6-month period.

Health-related quality of life in patients undergoing chronic hemodialysis has become a fundamental criterion for evaluating the effectiveness of treatments, promoting the overall well-being of this population. The study aims to identify the factors associated with health-related quality of life in patients with chronic kidney disease undergoing hemodialysis in Huancayo, Peru, from September to November 2022. Observational, descriptive, single-center, cross-sectional study in which sociodemographic data associated with health-related quality of life in hemodialysis patients were identified using the SF-36 instrument. The SF-36 questionnaire on health-related quality of life (HRQoL) was administered to 88 hemodialysis patients, of whom 68.2% were men, and 87.5% were undergoing outpatient dialysis. The main cause of chronic kidney disease was hypertension, affecting 46.6% of participants. Additionally, 80.7% had been on hemodialysis treatment for less than five years. In the bivariate analysis, significant differences were observed in the vitality dimension concerning educational level (p = 0.011) and sex (p = 0.049). Likewise, there was a significant difference between the average values of the emotional role dimension (p = 0.038) of the SF-36 in the nutritional status levels and a significant difference between the average total scores of the SF-36 in the salary levels (p = 0.048). The multivariate analysis identified correlations between nutritional status and pain; educational level and vitality; nutritional status and physical role; economic income; educational level and social function; and nutritional status and emotional role. Patients on hemodialysis have a total health-related quality of life score ranging from low to moderate (90.8%). The factors associated with a lower quality of life are being male, poor nutrition, low educational level, and a poor emotional state. Early identification of these factors will allow the development of interventions to improve these patients' quality of life. It is crucial to design interventions focused on improving nutrition and preventing mental health disorders, paying special attention to men with low educational levels.

Objective To explore the effect of persistent psychological intervention on negative emotions, immune function and quality of life to patients with ovarian cancer in biotherapy period. Methods A total of 80 ovarian cancer patients were randomly divided into the control group (biotherapy and routine nursing) and the intervention group (psychological intervention in addition to biotherapy and routine nursing). In the intervention group, Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD), and European organization for research and treatment of cancer quality of life questionnaire-30 (QLQ-C30) were used to measure the psychosomatic reaction, quality of life, and immune level by flow cytometry among ovarian cancer patients during biotherapy 3 weeks after and before psychological interventions. Results Three weeks after intervention, the scores of HAMD (9.27±3.15) and HAMA (10.17±3.06) in the intervention group were significantly lower than those in control group (16.93±10.49) and (18.97±6.24) (t=1.74, 1.78; P 0.05). Conclusions Persistent psychological intervention can improve the state of negative emotions and quality of life, and has positive effects on assisting cancer biotherapy. Key words: Ovarian neoplasms; Quality of life; Biotherapy; Psychological intervention

Objective: To explore the quality of life (QOL) of patients with spinal tumors and its influencing factors, so as to provide references for formulating targeted nursing interventions to improve their QOL. Methods: Eighty patients with spinal tumors admitted to our hospital from September 2022 to August 2023 were selected as the research subjects. All patients received surgical nursing care. Basic data of all patients were collected to identify the influencing factors of QOL in patients with spinal tumors, and logistic regression multivariate analysis was used for analysis. Results: The analysis showed that patients’ age, gender, number of involved vertebral bodies, concomitant underlying diseases, and primary tumors had no significant impact on the QOL of patients with spinal tumors (P > 0.05). However, factors such as pain severity, walking ability, self-care ability, physical function, social function, emotional role, and mental health were univariate influencing factors for QOL in these patients (P Conclusion: Clinical nursing should focus on early identification of factors such as pain severity, walking ability, self-care ability, physical function, social function, emotional role, and mental health. During the nursing care of spinal tumors, the impact of these factors should be emphasized, and targeted nursing interventions should be carried out to improve patients’ QOL.

Knee osteoarthritis is a leading cause of pain and functional limitation in adults. Neuromuscular exercise (NEMEX) programs are designed to improve sensorimotor control and functional joint stabilization. This study evaluated the effects of a NEMEX program on pain, range of motion, and quality of life in knee osteoarthritis patients. A repeated measure quasi-experimental study with a control group was conducted at an outpatient orthopedic clinic. Sixty adult knee osteoarthritis patients were conveniently sampled, with 30 in the intervention group receiving the NEMEX program and 30 in the control group. Outcomes were assessed at baseline, post-intervention, and 2-month follow-up using the Knee Range of Motion Assessment, Western Ontario and McMaster Universities Osteoarthritis Index, and Knee Osteoarthritis Quality of Life Questionnaire. The general linear model (GLM) showed the intervention group had significant improvements in knee flexion (F = 44.106, η2 = 0.432), extension (F = 43.972, η2 = 0.431), and total range of motion (F = 69.411, η2 = 0.545) compared to controls (p < 0.001). Pain scores improved more in the intervention group (F = 201.037, η2 = 0.776). The intervention group also improved stiffness (F = 77.547, η2 = 0.572) and physical function (F = 127.420, η2 = 0.687). Physical activities (F = 164.155, η2 = 0.739) and mental health (F = 76.279, η2 = 0.568) showed significant group differences, but social functioning had a more negligible effect (F = 25.164, η2 = 0.303). These findings indicate that the NEMEX program effectively improved the range of motion, reduced pain, and enhanced quality of life in patients with knee osteoarthritis. However, the effect on social functioning was more minor. The program appears to have positively impacted the physical and psychosocial aspects of the participants' health and well-being. These findings support incorporating NEMEX into Knee osteoarthritis rehabilitation to enhance functionality, lower discomfort, improve patient outcomes, and improve the general QOL for those managing this illness.

Assessment of Quality of Life in Chinese Patients with Chronic Lymphocytic Leukemia

Although several studies have determined quality of life in patients with lung cancer, there is still little information about the use of generic questionnaires [e.g. the 36-item Short Form health survey (SF-36)] and utility questionnaires [e.g. the EuroQOL instrument (EQ-5D)] in this disease. To (i) measure quality of life and utility in patients with non-small cell lung cancer (NSCLC) using the SF-36 and the EuroQOL questionnaires; (ii) to evaluate the impact of some clinical variables on quality of life and utility; (iii) to assess the correlation between the measurements produced by the 2 questionnaires. Cross-sectional study. 95 patients from 15 Italian hospitals with NSCLC (93% male, mean age 62 years) completed both questionnaires. The mean scores for the 8 domains of the SF-36 ranged from 20.8 (physical role) to 63.0 (social functioning). The mean physical and mental summed scores of the SF-36 were 36.8 [standard deviation (SD) 9.8] and 43.0 (SD 11.5), respectively. The EuroQOL mean score was 0.58 (SD 0.32) in the self-classifier (SC) version and 0.58 (SD 0.20) in the visual analogue scale (VAS) version. Among the clinical variables that affected quality of life and utility, the presence of metastasis had the greatest impact: patients with metastasis had statistically significantly lower scores for 2 domains of the SF-36 (physical functioning, p = 0.009; bodily pain, p = 0.016), for the physical component summed score of the SF-36 (p = 0.015) and for both utility estimates (EuroQOL-SC, p = 0.027; EuroQOL-VAS, p = 0.038) than patients without metastasis. Both the SC and VAS EuroQOL scores showed a statistically significant correlation with each of the 8 domains of the SF-36. The scores for both the SF-36 and the EuroQOL in patients with NSCLC were considerably worse (relative differences ranging from -8 to -73%) than the corresponding values (normative data) previously reported for healthy individuals. Our study quantified the degree to which quality of life is impaired in patients with NSCLC, showed that the presence of metastasis had an important role, and indicated a strong correlation between the measurements produced by the 2 questionnaires. The EuroQOL measurements obtained from these patients will aid evaluation of the cost-utility ratio for NSCLC therapies.

ABSTRACTBackground: This study aimed to evaluate the effects of nursing quality control combined with intensified psychological care on negative emotions and health outcomes in patients undergoing blood purification.Methods: Patients who underwent blood purification at the Affiliated Hospital of Jiangnan University (China) from January 2021 to December 2023 were enrolled and assigned to either a control or an intervention group using a random number table. Both groups received standard care, while the intervention group additionally received nursing quality control and intensified psychological care. Outcomes compared between groups included negative emotions (assessed by the Hamilton Anxiety Scale and Hamilton Depression Scale scores), quality of life (SF-36), treatment adherence, and complication rates.Results: Prior to the treatment, both groups (150 patients in each) were comparable in the Hamilton Anxiety Scale, the Hamilton Depression Scale, and SF-36 scores. After the treatment, the intervention group showed significantly greater reduction in the Hamilton Anxiety Scale (15.89 vs. 7.19) and Hamilton Depression Scale (12.22 vs. 4.74) scores, and greater improvements in SF-36 scores, particularly in physical functioning (37.99 vs. 22.61) and mental health (34.48 vs. 18.95). Moreover, treatment adherence was significantly higher in the intervention group (98.67% vs 70%), while the complication rate was markedly lower (10% vs. 35.33%). All differences were statistically significant (p < 0.001).Conclusions: Nursing quality control combined with intensified psychological care significantly improves negative emotional states and quality of life in patients undergoing blood purification, while also enhancing treatment adherence and reducing the incidence of complications.

P0166 Presence of stoma nurse and quality of life of colorectal cancer patients with fecal ostomy in the early postoperative phase

Background: Multiple Sclerosis (MS) is affected by cognitive and emotional factors. The aim of this study was to investigate the relationship between sensitivity to anxiety and executive functions and the Quality of Life (QoL) of MS patients using path analysis. Methods: This descriptive correlational research was done on all patients with MS in Gorgan MS Association in 2020. The sample size was considered to be 290 people according to the sample selection formula and based on the values obtained from the previous study selected by simple random sampling. To collect data, the Executive Functions Questionnaire of Nejati (2013), QoL questionnaire of McGuigan &amp; Hutchinson (2004), and Sensitivity to Anxiety Questionnaires of Taylor and Cox (1998) were used. Path analysis with SPSS v. 18 and AMOS v. 23 software was used to analyze the data. Results: The results showed that the executive functions had a positive relationship with QoL in MS patients and sensitivity to anxiety had a negative relationship with QoL in MS patients. Also, mediating role of the anxiety sensitivity variable in the relationship between executive functions with QoL in MS patients was confirmed (P≤0.01). Conclusion: The present study indicated the importance of cognitive factors, such as executive functions, and emotional factors, such as sensitivity to anxiety in explaining the QoL in MS patients.

Rheumatic heart disease (RHD) is an inflammatory disease of the heart, and it has major cause of morbidity and mortality in developing countries. It has significant impact on the quality of life of RHD patients. Objective: To assess the Quality of life in patients with chronic Rheumatic heart disease. Materials and methods: This prospective observational study was conducted at the Safdarjung Hospital, New Delhi for a period of 18 months. Study subjects are the patients who were diagnosed with chronic rheumatic heart disease at the outpatient department. A total of 500 subjects suffering from RHD and 100 Controls without RHD were identified during the study period. SF-36 health survey questionnaire was used to interview the subjects. The scores of health survey questionnaire was analysed descriptively and ANOVA is used to find out the significant differences. SPSS version-20 was used for data analysis. Results: Out of 600 subjects, 500 were the cases and 100 were the controls. 54.4% were males and 45.8% were females. Majority of the cases were belonged to the age group 36–40 years (19%) with the mean age group 35.7±9.2 years. 80% of the subjects were identified with moderate rheumatic heart disease and 20% were severe. Physical functioning, role of limitations due to physical health and emotional problems, social functioning and health change has shown the significant difference. Conclusion: It was seen that most of the domains of SF-36 were significant from which we can conclude that there is the relation between RHD and quality of life. Considering the poor quality of life in rheumatic heart disease patients, multimodal approach (psychiatric consultation, enrolment in mental support group, and occupational help) to provide overall care to a rheumatic heart disease patient should be considered.

To quantify the postoperative quality of life in patients following surgical treatment for vestibular schwannoma. Patient self-assessment using the short form 36 (SF36) multidimensional quality of life health questionnaire. Sex- and age-matched normalized scores were calculated using a standardized process and accepted normative data. Tertiary referral skull base unit. An 80% response rate (90 patients) was achieved. The postoperative quality of life in vestibular schwannoma patients, as quantified by seven of the eight SF36 health scales was less than the appropriate matched healthy standard. Comparison of a variety of preoperative patients and tumor factors-different operative approaches (translabyrinthine and retrosigmoid), tumor size (group cut of points of tumor diameter 1.5 mm and 2.5 mm), patient sex, and ranking of patient age-showed no statistically significant difference in measured quality of life outcomes for each of these traditional predictors. Reduced quality of life in patients after surgical treatment for vestibular schwannoma, coupled with the low tumor growth rates and minimal preoperative symptoms, supports a conservative approach to patient management. The advantages and disadvantages of a variety of approaches used to measure the quality of life after surgical treatment of vestibular schwannoma and their impact on clinical decision making for patients, are discussed.