Efficient SnS/MWCNT Composites for Sensitive and Selective Detection of Tinidazole and Acetaminophen

An electrochemical sensor based on electro-polymerization of caffeic acid and Zn/Ni-ZIF-8–800 on glassy carbon electrode for the sensitive detection of acetaminophen

The detection of acetaminophen (ACOP) and its toxic hydrolyzed product p-aminophenol (4-AP) is very significant for clinical diagnosis and quality control of drug formulation. In this study, a novel electrochemical sensor based on MoS2 embedding triangular Ag nanoplates (Tri-AgNPs) coated MOF-808 was developed for simultaneous and sensitive detection of ACOP and 4-AP. The morphology and structure MOF-808@MoS2/Tri-AgNPs nanocomposite were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy dispersive spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS) and so on. The electrochemical and electrocatalytic properties of the composite electrode were evaluated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The experimental results demonstrated that the constructed sensor had excellent electrochemical performance for ACOP and 4-AP detection due to the synergistic interaction among MOF-808, MoS2 and Tri-AgNPs. The proposed sensor exhibited a wide linear range (1–450 μM) and low limits of detection for detection of ACOP (0.054 μM) and 4-AP (0.046 μM). At the same time, the sensor also showed outstanding repeatability, reproducibility, stability and selectivity. In addition, MOF-808@MoS2/Tri-AgNPs/GCE was also employed to determine ACOP and 4-AP in acetaminophen tablets and Yellow River water samples with satisfactory recovery rates, which indicated the feasibility of the developed electrochemical sensor in the actual sample analysis.

A dual-template molecularly imprinted electrochemical sensor assisted with BO-XGBoost algorithm for simultaneous determination of dopamine and acetaminophen

Sensitive Detection of Acetaminophen with Graphene-Based Electrochemical Sensor

Facile synthesis of Au-embedded porous carbon from metal-organic frameworks and for sensitive detection of acetaminophen in pharmaceutical products

We have developed a method for the rapid collection and detection of leukemia cells using a novel two-nanoparticle assay with aptamers as the molecular recognition element. An aptamer sequence was selected using a cell-based SELEX strategy in our laboratory for CCRF-CEM acute leukemia cells that, when applied in this method, allows for specific recognition of the cells from complex mixtures including whole blood samples. Aptamer-modified magnetic nanoparticles were used for target cell extraction, while aptamer-modified fluorescent nanoparticles were simultaneously added for sensitive cell detection. Combining two types of nanoparticles allows for rapid, selective, and sensitive detection not possible by using either particle alone. Fluorescent nanoparticles amplify the signal intensity corresponding to a single aptamer binding event, resulting in improved sensitivity over methods using individual dye-labeled probes. In addition, aptamer-modified magnetic nanoparticles allow for rapid extraction of target cells not possible with other separation methods. Fluorescent imaging and flow cytometry were used for cellular detection to demonstrate the potential application of this method for medical diagnostics.

We present a novel immobilization technique via physical adsorption of biomolecules onto a sensing surface. The immobilization technique utilizes the competitive nature of protein adsorption onto the surface, offering the selectivity and sensitivity in detecting a target molecule. The SPR (Surface Plasmon Resonance) sensorgrams show that three human serum proteins, albumin, Immunoglobulin G (IgG) and fibrinogen, have different adsorption strengths to the surface and the competitive adsorption of individuals controls the exchange sequence. Using the competitive adsorption and exchange, we demonstrate that IgG is selectively and sensitively detected.

Cyanotoxins, produced by cyanobacteria, pose serious genotoxic, hepatotoxic, nephrotoxic, and neurotoxic risks in aquatic ecosystems. Among these, cylindrospermopsin (CYN), known for its high water solubility and bioaccumulation potential, significantly threatens public health and environmental safety. Anthropogenic eutrophication and climate‐induced environmental changes have significantly intensified the frequency and severity of cyanobacterial blooms, thereby underscoring the necessity for rapid and reliable detection strategies for CYN. Aptamer‐based electrochemical biosensors offer selective and sensitive detection, with performance reliant on effective aptamer immobilization and electrode conductivity. Pencil graphite electrodes (PGEs) provide a novel, low‐cost, conductive, and easily modifiable alternative to commonly used noble‐metal‐based platforms, such as gold nanoparticles. This study reports the fabrication of an electrochemical aptasensor by modifying PGE with poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) to increase surface area and enable effective immobilization of the CYN‐specific aptamer (cynApt). Electrochemical characterization of the PGE/PEDOT:PSS/cynApt biosensor platform was conducted using cyclic voltammetry (CV), while CYN detection was performed using differential pulse voltammetry (DPV). The developed PGE/PEDOT:PSS/cynApt sensor achieved a limit of detection of 0.154 ng mL−1 in deionized water and 0.224 ng mL−1 in lake water, with a linear response range of 0.25 to 2.5 ng mL−1. The sensor also demonstrated high selectivity against other cyanotoxins, such as okadaic acid and saxitoxin (STX). These results highlight the potential of the proposed aptasensor for sensitive and selective cylindrospermopsin (CYN) detection in environmental monitoring applications.

Thienothiophene based AIE-Active bulky materials for sensitive explosive detection

Sensitive detection of acetone and hydrogen sulfide levels in exhaled human breath, serving as breath markers for some diseases such as diabetes and halitosis, may offer useful information for early diagnosis of these diseases. Exhaled breath analyzers using semiconductor metal oxide (SMO) gas sensors have attracted much attention because they offer low cost fabrication, miniaturization, and integration into portable devices for noninvasive medical diagnosis. However, SMO gas sensors often display cross sensitivity to interfering species. Therefore, selective real-time detection of specific disease markers is a major challenge that must be overcome to ensure reliable breath analysis. In this work, we report on highly sensitive and selective acetone and hydrogen sulfide detection achieved by sensitizing electrospun SnO2 nanofibers with reduced graphene oxide (RGO) nanosheets. SnO2 nanofibers mixed with a small amount (0.01 wt %) of RGO nanosheets exhibited sensitive response to hydrogen sulfide (Rair/Rgas = 34 at 5 ppm) at 200 °C, whereas sensitive acetone detection (Rair/Rgas = 10 at 5 ppm) was achieved by increasing the RGO loading to 5 wt % and raising the operation temperature to 350 °C. The detection limit of these sensors is predicted to be as low as 1 ppm for hydrogen sulfide and 100 ppb for acetone, respectively. These concentrations are much lower than in the exhaled breath of healthy people. This demonstrates that optimization of the RGO loading and the operation temperature of RGO-SnO2 nanocomposite gas sensors enables highly sensitive and selective detection of breath markers for the diagnosis of diabetes and halitosis.

Graphene oxide and dextran capped gold nanoparticles based surface plasmon resonance sensor for sensitive detection of concanavalin A

Development of core-shell magnetic molecularly imprinted polymer-based electrochemical sensor for sensitive and selective detection of ezetimibe

Metal-organic frameworks (MOFs): A review of volatile organic compounds (VOCs) detection.

Chapter 5 - Nanomaterials and signal amplification toward foodborne pathogen biosensor

Nanoparticle-based electrochemiluminescence immunosensor with enhanced sensitivity for cardiac troponin I using N-(aminobutyl)-N-(ethylisoluminol)-functionalized gold nanoparticles as labels