EHDEN - D1.5 - Results of "validation" Use Case 1 study

Abstract

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Healthcare data, generated through the delivery of normal clinical care is increasingly being used to investigate the use of drugs in real life. As part of previous research with EHDEN, we had investigated treatment patterns of patients with asthma, COPD or asthma-COPD overlap. For this research, data from the IPCI database, a Dutch primary care database, was used. IPCI data was mapped to the OMOP CDM which allows the generation of one software script to explore treatment patterns which can then be run on other data sources. As a follow-up to our research on the treatment patterns of asthma & COPD, we wanted to explore whether the study population, as selected using IPCI data mapped to the OMOP CDM was similar to IPCI source data (thus not mapped to the OMOP CDM). To do so, we defined criteria for our study period, study population and exposure cohorts and extracted the data (IPCI source & IPCI CDM). Some differences in number of patients were identified but these could be attributed to the fact that IPCI CDM applies quality standards which result in some patients being excluded. For example, diagnoses with missing dates and multiple prescriptions of the same drug on the same day are disregarded. The remaining differences between IPCI source and IPCI CDM were related to discrepancies in mapping drugs from ATC code to RxNorm, which is challenging for inhalation therapy.