Emerging Trends in Hypertrophic Cardiomyopathy Research.

Pilocytic astrocytoma (PA) is a WHO grade I neoplasm with a favorable prognosis. It is the most common pediatric benign tumor. Recently, PA has attracted more and more attention and discussion from scholars. The aim of this study is to comprehensively generalize the evolution of this field over the past two decades through bibliometric analysis and to predict future research trends and hotspots. The literature over the last two decades (2004–2023) related to PA was obtained from the Web of Science Core Collection (WoSCC) database. Bibliometric analyses were conducted based on the following aspects: (1) Annual publication trends; (2) Publications, citations/co-citations of different countries/institutions/journals/authors; (3) the map of Bradford’s Law and Lotka’s Law for core journals and author productivity; (4) Co-occurrence, cluster, thematic map analysis of keywords. All analyses were performed on VOSviewer and R bibliometrix package, and Excel 2024. Our results showed that research on PA displayed a considerable development trend in the past 20 years. The USA had a leading position in terms of scientific outputs and collaborations. Meanwhile, German Cancer Research Center contributed the most publications. Child's Nervous System had the highest number of publications and Acta Neuropathologica was the most co-cited journal on this subject. Gutmann, D.H. and Louis, D.N. were the authors with the most articles and co-citations in this field. The research emphases were molecular mechanisms, neurofibromatosis, pilomyxoid astrocytoma, differential diagnosis, and therapy. We systematically analyzed the literature on PA from a bibliometric perspective. The demonstrated results of the knowledge mapping would provide valuable insights into the global research landscape.

The transversus abdominis plane block (TAP-B) has emerged as a key component of multimodal analgesic regimens aimed at mitigating perioperative pain in diverse abdominal surgeries. Despite its widespread clinical adoption, the precise analgesic efficacy of TAP-B remains a subject of ongoing debate and active scientific inquiry. Therefore, a systematic evaluation of TAP-B publication trends and emerging research directions is essential to guide future investigation and advance evidence-based practice. A comprehensive bibliometric analysis was conducted using the Web of Science Core Collection (WoSCC) database, covering TAP-B-related publications from January 2007 to May 2024. Extracted bibliographic data included authorship, institutional affiliation, country of origin, journal, funding source, research discipline, and research focus. Only original research articles were included, resulting in 702 publications for final analysis. Among the 702 eligible articles, the United States contributed the highest number of publications, followed by China and India. At the institutional level, the University of Copenhagen emerged as the most productive institution. Laffey JG and McDonnell JG were identified as the most prolific authors, while Surgical Endoscopy and Other Interventional Techniques published the highest number of TAP-B-related articles. Key research themes centered on perioperative analgesia, ultrasound-guided regional anesthesia, and laparoscopy. Emerging trends indicated growing interest in the analgesic mechanisms of TAP-B and its comparative efficacy with other novel truncal blocks, such as quadratus lumborum and erector spinae plane blocks. This bibliometric analysis provides a comprehensive overview of global research activity in TAP-B, identifying dominant themes, influential contributors, and evolving research frontiers. The findings underscore the significant role of TAP-B in modern regional anesthesia and multimodal analgesic regimens. Furthermore, this study highlights key research areas for future investigation aimed at optimizing the clinical application of TAP-B and its integration into evolving multimodal analgesia strategies.

BackgroundTumor necrosis factor-alpha (TNF-α) plays a dual role in pulmonary tuberculosis, mediating protective immune responses while also contributing to pathological tissue damage. This dichotomy has attracted considerable research interest in recent years. Nevertheless, a comprehensive bibliometric analysis in this specific field remains lacking. The present study aims to fill this gap by examining global research trends and identifying emerging hotspots related to TNF-α in pulmonary tuberculosis through bibliometric methods.MethodsRelevant literature published between 1990 and 2024 was retrieved from the Web of Science Core Collection (WoSCC) database. VOSviewer, CiteSpace, and R 4.3.3 were utilized for the analysis.ResultsA total of 1,200 articles were included in this study. The annual number of publications has consistently increased since 1990, with an average annual growth rate of 10.73%. These articles were authored by 6,129 researchers affiliated with 1,581 institutions across 83 countries/regions. The United States emerged as the leading contributor, ranking first in both total publications (TP =277) and citations [14,911]. The Indian Council of Medical Research was the most productive institution, with 83 articles. Kaplan G. was identified as the most influential author, ranking first in total citations (TC =2,348) and achieving an H-index of 17. The Journal of Immunology led the journals in both citations [4,332] and H-index [46]. The most frequently occurring keyword included “mycobacterium-tuberculosis”, “infection”, and “interferon-gamma”. Recent keyword bursts featured “biomarkers” [2019–2024] and “inflammation” [2022–2024].ConclusionsThis bibliometric analysis underscores the evolving focus of TNF-α research in pulmonary tuberculosis, transitioning from foundational studies on immune mechanisms to applied research aimed at diagnostics and biomarkers. Future research should aim to validate the effectiveness of TNF-α gene markers across different populations and disease stages, investigate their molecular mechanisms and interactions with other cytokines, and work towards optimizing personalized treatments and improving clinical management outcomes.

Objective Over the past three decades, temporomandibular joint (TMJ) arthrocentesis has evolved from a mechanical lavage procedure into a sophisticated treatment standard incorporating principles of biological modulation and regenerative medicine. The aim of this study is to analyze the global TMJ arthrocentesis literature between 1989 and 2025 using bibliometric methods, thereby objectively mapping the procedure’s technical evolution, clinical paradigm shifts (the transition from Axis I to Axis II), and the migration of research focus from surgical technique to biopsychosocial management. Materials and Methods Data were retrieved from the Web of Science Core Collection (WoSCC) database on January 13 2026. A total of 792 original articles and reviews, identified through a comprehensive search strategy, were analyzed using VOSviewer and R-Bibliometrix software regarding annual growth rate, citation networks, conceptual structure, and global collaboration dynamics. Results The literature was found to be expanding with an annual growth rate of 12.1%, peaking in 2024 in terms of both publication count (n = 74) and citations (n = 1952). While the USA (n = 111) remains the most productive country, Turkey (n = 107) ranks second, demonstrating its strong clinical activity in the field. In citation networks, Nitzan’s “anchored disc” theory (n = 314 citations) maintains its central position; however, the rise of Schiffman’s DC/TMD criteria (n = 125 citations) and Manfredini’s psychosocial studies indicates that success is now contingent more upon patient phenotype than physical parameters. Furthermore, the concepts of “ultrasound guidance” and “regenerative agents” (PRP, HA) have dominated the literature in recent years. Conclusion The TMJ arthrocentesis literature is undergoing a dynamic transformation characterized by surgical minimization and technological integration. Research trends corroborate that the concept of “mechanical success” has yielded to a holistic treatment model constituted by accurate patient selection (Axis II), imaging guidance, and biological regeneration.

Obesity has become a significant public health concern, strongly linked to various diseases, particularly gynecologic and breast cancers. This bibliometric review aims to analyze global research trends on overweight women, particularly those with gynecologic and breast cancers, to identify research hotspots, key contributors, and emerging areas of study. A comprehensive bibliometric analysis was conducted using the Web of Science Core Collection (WoSCC) database, covering the period from January 2013 to September 2024. Articles were screened and analyzed using tools such as VOSviewer and Biblioshiny platform, with metrics including publication volume, citation analysis, and co-authorship networks. Key areas of focus were global research trends, leading countries, institutions, authors, journals, and keyword analysis. A total of 1452 publications were analyzed. Research activity on the association between obesity and gynecologic/breast cancer has steadily increased, with the United States leading in publications and citations, followed by China and Italy. Core journals included Breast Cancer Research and Treatment and Gynecologic Oncology. Key research areas identified through keyword analysis include the relationship between body mass index (BMI) and cancer risk, survival rates in cancer patients, physical activity, and the role of adipose tissue inflammation in tumor progression. Emerging topics include extracellular vesicles and cancer-associated fibroblasts. Global research on the relationship between obesity and female-specific cancers has shown significant growth. The findings highlight BMI, survival, and physical activity as central themes. Future research should explore the molecular mechanisms linking obesity to cancer and evaluate weight loss interventions for cancer prevention and treatment.

The aim of this study was to investigate the research trends, patterns of opportunistic infections in rheumatoid arthritis (RA) and their impact on patient management strategies, especially in the context of the widespread use of DMARDs. Research papers on RA and opportunistic infections were analysed by performing a literature search in the Web of Science Core Collection (WoSCC) database, covering the period from January 1, 1994 to December 31, 2023. Bibliometric analyses were performed using VOS viewer and Cite Space software, including country and institution analyses, journal and co-citation journal analyses, author and co-citation author analyses, and key word co-occurrence and clustering analyses. Two hundred and ninety-three research papers were analysed, and it was found that research publications on RA-associated opportunistic infections have shown a general upward trend over the past three decades, with a significant increase especially between 2007 and 2021. Japan, the United States, and China have the highest research output in this area, with institutions such as Yang Ming University and Taichung Veterans General Hospital being more active. Key word analysis revealed 'infection', 'risk', 'treatment', and 'infliximab' as research hotspots. Cluster analysis showed that tuberculosis, latent tuberculosis infection and hepatitis B virus were the focus of attention. Research on opportunistic infections in RA has shown a clear trend of growth and extensive international collaboration, reflecting a deep understanding of the risk of opportunistic infections in RA patients treated with DMARDs. Future studies should strengthen the identification of high-risk patient groups, the use of biomarkers, the balance of safety and efficacy in treatment regimens, and patient education to promote the optimisation of RA management strategies.

Introduction: Mendelian randomization (MR) is an innovative epidemiological research method. In order to summarize and clarify the research status of MR related to cardiovascular disease (CVD) and point out the possible future development direction, we conducted a comprehensive and multidimensional bibliometric analysis of the literature published in this field from 2003 to 2024. Methods: We analyzed 1,870 articles published between 2003 and 2024 from the Web of Science Core Collection (WoSCC) using VOSviewer, R software, bibliometric online analysis tool, and CiteSpace software. Results: CVD-related MR research demonstrated an overall upward trend, with the USA leading in terms of publication output, followed by the UK and China. The most prolific institution in this field was the University of Bristol, and Smith GD, who had the highest number of publications (n = 103), was also affiliated with this institution. The European Heart Journal (36 publications, 5,023 citations) was the most cited journal. Related topics of frontiers will still focus on MR, coronary heart disease, heart failure, C-reactive protein, cholesterol, and body mass index. Conclusions: As the scope of MR studies continues to expand, especially the number of measurable features continues to increase, the need for rigorous methods and critical interpretation of MR findings becomes increasingly apparent. However, this ease of use can compromise the reliability of study results due to methodological flaws and publication bias, thereby affecting the perceived significance of the results. Nonetheless, with the emergence of large genetic datasets supporting two-sample MR, resources such as MR-Base and PhenoScanner, MR remains a powerful method for identifying potential pathogenic features in cardiometabolic and other diseases. In addition, it plays a crucial role in prioritizing drug targets for entry into clinical trials.

The application of digital technology in jaw reconstruction is clinically significant as it enhances surgical precision and patient outcomes. This study aimed to conduct a comprehensive bibliometric analysis to explore global research trends, hotspots, and future directions in the application of digital technology for jaw reconstruction. This study employs a bibliometric analysis design, utilizing a retrospective approach. The data were sourced from the Web of Science Core Collection (WoSCC) database, focusing on publications related to digital technology in jaw reconstruction from 1995 to 2024. The final sample includes 1069 articles authored by 4781 authors from 3081 institutions. Data analyses were conducted using VOSviewer, CiteSpace, and the R package "Bibliometrix." The analysis revealed a total of 1069 articles, with publication trends showing a peak in 2022. China produced the most articles, while the United States led in citations. The most productive institutions were based in Italy, Germany, and China, and key contributing authors included Marchetti Claudio and Ciocca Leonardo. Journal of Cranio-Maxillofacial Surgery had the highest H-index among journals. Keyword co-occurrence revealed hotspots like "implants" and "computer-aided design," while burst terms such as "virtual surgical planning" and "3D printing" signaled emerging frontiers. This bibliometric analysis examined the global research landscape on digital technology in jaw reconstruction, identifying key developments such as rapid prototyping, virtual surgical planning, and 3D printing. Future research should focus on integrating these technologies into clinical workflows, reducing costs, improving training, and addressing regulatory challenges.

The study was aimed at systematically analyzing the research status and trends of pelvic organ prolapse (POP) using bibliometrics. We retrieved documents published between 1975 and 2022 from the Web of Science Core Collection (WoSCC) database, and manually selected them for bibliometric analyses of country, institution, journal, highly locally cited documents and research trends based on co-citation clustering and keywords using the R Bibliometricx package and CiteSpace software. A total of 5,703 publications were included. Although the number of annual publications on POP increased, the trend of annual publication reached an obvious plateau in the first half of the 2010s. The USA, China, the UK, the University of Michigan, the University of Pittsburgh, and the University of Sydney were the top three countries and institutions with the most publications respectively. International Urogynecology Journal, American Journal of Obstetrics and Gynecology, and Obstetrics and Gynecology were the journals with the most extensive academic influence on the field of POP research. The international cooperation was lacking and the highly cited documents focused on high-level, evidence-based studies. Epidemiological studies and surgical treatment have achieved a plateau or decline. Recent studies have focused on conservative treatment, physical therapy, and minimally invasive surgery. In addition to evidence-based medicine studies, tissue engineering is the future direction of POP. This study used bibliometric analyses to provide insights into the status and potential research directions of POP. More high-quality, evidence-based medicine studies and in-depth tissue engineering research should be propelled forward.

Background Pediatric eye diseases, especially myopia and other refractive errors as well as binocular vision disorders, have evolved into a pressing global public health concern. Effective caregiver-targeted eye health education is crucial for the early prevention and long-term management of these conditions. However, conventional educational approaches often struggle to deliver actionable and accessible guidance. Emerging artificial intelligence (AI) technologies, particularly large language models (LLMs), present novel opportunities to address this gap. Methods A mixed-methods design was conducted in this study. On one hand, a bibliometric analysis was conducted on publications related to pediatric eye health education from 2015 to 2025, using the Web of Science Core Collection and PubMed databases, with visualization implemented via Bibliometrix and CiteSpace software. On the other hand, a cross-sectional online questionnaire survey was administered to guardians of children aged 1–6 years to systematically assess their key concerns about pediatric eye diseases, knowledge levels, information sources, and preferences for educational formats. Results A total of 111 publications were included in the bibliometric analysis, which revealed a significant surge in research output after 2020. Traditional themes such as vision screening and patient education remained central, while AI- and LLM-related topics have emerged as recent research hotspots. China and the United States led in terms of publication volume, whereas several countries with lower output demonstrated higher average citation impact. Among 328 valid survey responses, guardians showed high concern for myopia, astigmatism, and strabismus but lacked sufficient practical knowledge regarding preventive pharmacological strategies and correct eye drop administration. Additionally, child-friendly, visualized, interactive, and online educational formats were strongly preferred. Conclusion By integrating bibliometric trends with the actual needs of caregivers, this study demonstrates that the growing role of AI and LLMs in pediatric eye health education reflects both technological advancement and unmet demands for personalized, actionable educational content. These findings provide an evidence-based foundation for the development of AI-driven pediatric eye health education tools, emphasizing the necessity of clinical oversight, ethical governance, and equitable access in future practice.

BackgroundTetanus is a severe but vaccine-preventable disease controlled by tetanus toxoid (TT) immunization and tetanus immunoglobulin (TIG) therapy. Although maternal–neonatal tetanus has been eliminated in many regions, coverage gaps and sporadic cases persist in low-resource settings. As a longstanding component of global immunization and a key conjugate carrier platform, tetanus research remains essential despite advances in novel vaccine technologies. However, the global research landscape on tetanus vaccines and immunoglobulins remains unmapped.ObjectiveThis study aimed to conduct a comprehensive bibliometric analysis of publications on TT and TIG from 2000 to 2025, to characterize research dynamics, leading contributors, and thematic evolution.MethodsWe retrieved publications from the Web of Science Core Collection (SCI-Expanded) for 2000–2025 using relevant keywords (“tetanus vaccine*” OR “tetanus toxoid*” OR “tetanus immunoglobulin*” OR “tetanus immune globulin*” OR “tetanus antitoxin*”). Following screening, 2,949 English-language articles and reviews were included. Bibliometric analyses (publication trends, funding agencies, co-authorship, co-citation, and keyword co-occurrence) were performed using VOSviewer, CiteSpace, and the bibliometrix R package.ResultsA total of 2,949 publications were analyzed. Annual output remained stable (mean ≈ 113.4), with citations peaking in 2021 (n=7,291). The USA led in volume (1,130 papers), while Switzerland achieved the highest impact (88.41 citations/article). The Centers for Disease Control and Prevention (CDC) and University of Oxford emerged as central hubs, with GlaxoSmithKline (GSK) illustrating the role of industry-academic partnerships. A strategic funding shift occurred around 2010: while the National Institutes of Health (NIH) drives foundational research, the Bill & Melinda Gates Foundation (BMGF) has become the engine for translational equity. Evolutionary trends show a shift from early cellular mechanisms toward maternal immunization coverage, implementation determinants in low- and middle-income countries (LMICs), and the expanding utility of tetanus toxoid (TT) as a conjugate vaccine carrier.ConclusionTetanus research has evolved into a dynamic model for modern vaccinology, bridging classical immunization and next-generation technology. Beyond maternal protection, the field is expanding toward conjugate platforms and recombinant biologics. Achieving global elimination requires aligning these biotechnological innovations with equitable implementation strategies in low-resource settings.

Background Physical activity has been shown to lower the risk of prostate cancer (PCa) incidence, the second most frequent malignant tumor in males globally, and to improve the prognosis of cancer patients. However, no research on bibliometric analysis has been conducted in this field yet. This study aims to map the global research landscape concerning physical activity and PCa, pinpoint current hotspots, and predict future frontiers. Method From January 1, 2014 to June 25, 2024, physical activity and PCa‐related original and reviewed literature were obtained from the Web of Science Core Collection (WoSCC) database. CiteSpace, VOSviewer, and the bibliometrix R software package were used in the visualization research. The authors that published the most papers in this field, the journals that published the most papers, the nations that published the most papers, and the keywords were examined using bibliometric methods like Price’s Law, Bradford’s Law, Lotka’s Law, and Zipf’s Law. Result In terms of publication volume, the United States led all other nations, with Robert U. Newton being identified as a key contributing author in this research domain. In addition, Supportive Care in Cancer was the most attractive journal. Association of Leisure Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults, it is regarded as the most valuable article in this field. “Androgen deprivation therapy (ADT),” “quality of life,” “fatigue,” “survivorship,” “diet,” “nutrition,” and “obesity” have been the hotspots in the treatment of PCa in recent years. The research trends in the coming years will mainly focus on “metabolic syndrome,” “urinary incontinence,” “home‐based exercise,” and “prostate‐specific antigen (PSA).” Conclusion Physical activity can reduce the negative impact on patients after castration therapy for PCa and the sequelae, such as urinary incontinence after radical prostatectomy. These findings support the inclusion of home exercise in standard PCa care, providing a practical and safe option for enhancing the health and well‐being of PCa survivors.

BackgroundStudies of ventricular arrhythmia (VA) have drawn much scholarly attention over the past two decades. Our study aimed to assess the current situation and detect the changing research trends of VA quantitatively and qualitatively.Materials and methodsAll the information used in our statistical and bibliometric analysis were collected and summarized from papers retrieved from the Web of Science Core Collection (WoSCC) database on December 22, 2021 using certain criteria. Visual analytics were realized using CiteSpace, VOSviewer, the bibliometrix R package, and the bibliometric online analysis platform.ResultsA total of 6,897 papers (6,711 original articles, 182 proceedings papers, three book chapters, and one data paper) were published in 796 journals that concentrated on the research areas of cardiovascular and critical care medicine. The most productive country and influential institution was the USA and the Mayo Clinic, respectively. Heart Rhythm (551 articles and 8,342 local citations) published the most manuscripts. The keyword co-occurrence and co-citation network of references analyses revealed that the most popular terms were ventricular tachycardia, ventricular fibrillation, catheter ablation, implantable cardioverter defibrillator (ICD), and sudden cardiac death (SCD). Further, the burst detection analysis demonstrated that topics strongly associated with clinical prognosis, such as meta-analysis, long-term outcomes, and impact, were new concerns.ConclusionOur study offers a comprehensive picture of VA research and provides profound insights into the current research status. Moreover, we show that new topics within the VA research field have focused more on prognosis and evidence-based clinical guidelines.

Alzheimer's disease (AD) is characterized by the presence of gray matter lesions and alterations in white matter. This study aims to investigate the research related to white matter in the context of AD from a Bibliometric standpoint. Regular and review articles focusing on the research pertaining to Alzheimer's disease (AD) and white matter were extracted from the Web of Science Core Collection (WOSCC) database, covering the period from its inception to 10th July 2023. The "Bibliometrix" R package was employed to summarize key findings, to quantify the occurrence of top keywords, and to visualize the collaborative network among countries. Furthermore, VOSviewer software was utilized to conduct co-authorship and co-occurrence analyses. CiteSpace was employed to identify the most influential references and keywords based on their citation bursts. The retrieval of AD- and white matter-related publications was conducted by the Web of Science Core Collection. Bibliometric analysis and visualization, including the examination of annual publication distribution, prominent countries, active institutions and authors, core journals, co-cited references, and keywords, were carried out by using VOSviewer, CiteSpace, the Bibliometrix Package, and the ggplot2 Package. The quality and impact of publications were assessed using the total global citation score and total local citation score. A total of 5,714 publications addressing the intersection of Alzheimer's disease (AD) and white matter were included in the analysis. The majority of publications originated from the United States, China, and the United Kingdom. Prominent journals were heavily featured in the publication output. In addition to "Alzheimer's disease" and "white matter," "mild cognitive impairment," "MRI" and "atrophy" had been frequently utilized as "keywords." This Bibliometric investigation delineated a foundational knowledge framework that encompasses countries, institutions, authors, journals, and articles within the AD and white matter research domain spanning from 1981 to 2023. The outcomes provide a comprehensive perspective on the broader landscape of this research field.

Structural and temporal dynamics analysis of neural circuit from 2002 to 2022: A bibliometric analysis