Existence theorems for perturbed abstract measure differential equations

Controllability and observability of linear time delayed systems have been studied, and various definitions and criteria have been presented since the 1960s. However, the lack of an analytical solution approach has limited the applicability of the existing theories. Recently, the solution to systems of linear delay differential equations has been derived using the matrix Lambert W function, in a form similar to the transition matrix in ordinary differential equations. The criteria for controllability and observability, and their Gramians, for systems of delay differential equations using the solution in terms of the matrix Lambert W function are presented for the first time and illustrated with examples.

In the paper we consider the systems of delay differential equations, which are mathematical models of many technical processes with delay in time. An explicit fifth-order hybrid method for systems of delay differential equations for the variable step of numerical integration is constructed. This algorithm is based on the most commonly used explicit fifth-order Runge-Kutta methods for ordinary systems of differential equations and the construction of Newton polynomials for the prehistory of the model and Taylor formula. The basic principles of construction of such explicit hybrid methods of higher orders of convergence are given. An accurate estimate of the local error of numerical integration by this method is obtained. This algorithm allows the use of numerical integration steps greater than the magnitude of the delay or procedures for adjusting the magnitude of the step depending on the calculation error. Such a problem of numerical integration of time-delay dynamical systems occurs when the time interval is large enough compared to the delay. Implicit continuous Runge-Kutta methods were previously used for numerical integration such problems, which complicated the numerical algorithm, because nonlinear systems of equations have to be solved at each step of numerical integration. The explicit hybrid method constructed by us for systems of delay differential equations is convenient for programming, has a high speed of calculation of numerical solution, in comparison with implicit methods for such models of problems. Also, this method has no restrictions on the magnitude of the delay, in contrast to the hybrid methods with decomposition in Taylor series for delay. The method obtained by us can be used to construct maps of dynamic modes in the study of regular and chaotic behavior of time-delay dynamical systems.

Analysis and Control of Time Delayed Systems via the Lambert W Function

In this paper, we extend a system of coupled first order non-linear system of delay differential equations (DDEs) arising in modeling of stoichiometry of tumour dynamics, to a system of diffusion-reaction system of partial delay differential equations (PDDEs). Since tumor cells are further modified by blood supply through the vascularization process, we determine the local uniform steady states of the homogeneous tumour growth model with respect to the vascularization process. We show that the steady states are globally stable, determine the existence of Hopf bifurcation of the homogeneous tumour growth model with respect to the vascularization process. We derive, analyse and implement a fitted operator finite difference method (FOFDM) to solve the extended model. This FOFDM is analyzed for convergence and we observe seen that it has second-order accuracy. Some numerical results confirming theoretical observations are also presented. These results are comparable with those obtained in the literature.

A system of delay differential equation is proposed to account the effect of delay in the predator–prey model of interacting population. In this article, the modified ratio-dependent Bazykin model with delay in predator equation has been considered. The essential mathematical features of the proposed model are analyzed with the help of equilibria, local and global stability analysis, and bifurcation theory. The parametric space under which the system enters into a Hopf-bifurcation has been investigated. Global stability results are obtained by constructing suitable Lyapunov functions. We derive the explicit formulae for determining the stability, direction, and other properties of bifurcating periodic solutions by using normal form and central manifold theory. Using the global Hopf-bifurcation result of Wu (Trans. Am. Math. Soc., 350:4799–4838, 1998) for functional differential equations, the global existence of periodic solutions has been established. Our analytical findings are supported by numerical experiments. Biological implication of the analytical findings are discussed in the conclusion section.

We consider a system of delay differential equations with a delayed excitatory feedback loop and instantaneous damping. We develop the Cao–Krisztin–Walther technique and establish the existence and uniqueness of periodic solutions with prescribed oscillation frequencies (characterized by the values of a discrete Lyapunov functional). We then use the Poincare-Bendixson theorem due to Mallet-Paret and Sell to show that the global attractor of such a system is the union of the unstable sets of stationary points and periodic orbits.

This paper studies fractional differential equations (FDEs) with mixed fractional derivatives. Existence, uniqueness, stability, and asymptotic results are derived.

In this work, we study the existence and uniqueness of solutions for a coupled problem of two-sequential random fractional differential equations. The considered problem allows us to obtain the classical Hermite random differential equation as a special case. Using the Banach contraction principle, we prove new existence and uniqueness results. New results on the Ulam-Hyers stability are also discussed.

Hematopoietic Model with Moving Boundary Condition and State Dependent Delay: Applications in Erythropoiesis

<abstract><p>In this paper, we investigate a coupled system of Hilfer-type nonlinear proportional fractional differential equations supplemented with mixed multi-point and integro-multi-point boundary conditions. We used standard methods from functional analysis and especially fixed point theory. Two existence results are established using the Leray-Schauder's alternative and the Krasnosel'skii's fixed point theorem, while the existence of a unique solution is achieved via the Banach's contraction mapping principle. Finally, numerical examples are constructed to illustrate the main theoretical results. Our results are novel, wider in scope, produce a variety of new results as special cases and contribute to the existing literature on nonlocal systems of nonlinear $ \psi $-Hilfer generalized fractional proportional differential equations.</p></abstract>

We consider mathematical models of infectious diseases built by G. I. Marchuk in his well-known book on immunology. These models are in the form of systems of ordinary delay differential equations. We add a distributed control in one of the equations describing the dynamics of the antibody concentration rate. Distributed control looks here naturally since the change of this concentration rather depends on the corresponding average value of the difference of the current and normal antibody concentrations on the time interval than on their difference at the point t only. Choosing this control in a corresponding form, we propose some ideas of the stabilization in the cases, where other methods do not work. The main idea is to reduce the stability analysis of a given integro-differential system of the order n, to one of the auxiliary systems of the order \(n+m\), where m is a natural number, which is “easy” for this analysis in a corresponding sense. Results for these auxiliary systems allow us to make conclusions for the given integro-differential system of the order n. We concentrate our attempts in the analysis of the distributed control in an integral form. An idea of reducing integro-differential systems to systems of ordinary differential equations is developed. We present results about the exponential stability of stationary points of integro-differential systems using the method based on the presentation of solution with the help of the Cauchy matrix. Various properties of integro-differential systems are studied by this way. Methods of the general theory of functional differential equations developed by N. V. Azbelev and his followers are used. One of them is the Azbelev W-transform. We propose ideas allowing to achieve faster convergence to stationary point using a distributed control. We obtain estimates of solutions using estimates of the Cauchy matrices.

In this thesis we investigate the existence of solutions to boundary value problems (BVPs) for nonlinear systems of first-order ordinary differential equations (ODEs) and difference equations. The thesis is divided into two parts. Part one is devoted to the study of difference equations where two types of problems are studied. First, we derive the existence of solutions to first-order systems of difference equations that arise when one applies the trapezoidal rule to approximate solutions of second-order scalar ODEs. Strict discrete lower solutions are used with maximum principle arguments in the discrete problem to obtain a priori bounds on solutions. The a priori bounds on difference quotients for solutions of the discrete problem are obtained from the Bernstein-Nagumo condition. We use homototopy to find solutions of the discrete amroximations. Second, motivated by Ma [60] we consider existence and uniqueness of solutions to difference equations which arise as discrete approximations to three-point BVPs for systems of first-order ODES after employing the Euler method. Several existence and uniqueness results for three-point BVPs are established, using the contraction mapping theorem and the Brouwer fixed point theorem in Rn. In part two, two types of problems for systems of first-order ODES are analyzed. First, we study the existence of a unique solution to a system of first-order differentia1 equations under multi-point BVPs with nonlinear boundary conditions. We prove the existence and uniqueness of solutions for a system of first-order three-point BVP under which the properties of linear three-point BVP are preserved under small nonlinear perturbations of both the differentia1 equation and the boundary conditions. The method of proof of the existence of solutions using the Banach contraction mapping principle is similar to that used by Rodriguez [75], who studied the discrete analogue of this BVP. Second, motivated by Cronin 120,211 we investigate the existence of solutions to three-point BVPs in perturbed systems of first-order ODEs at resonance where the associated homogeneous linear problem has nontrivial solutions. Based on the second part of the investigation of three-point BVPs in perturbed systems of first-order ODEs at resonance, four different results were obtained: (i) The existence of solutions via a version of the Brouwer Fixed Point Theorem which is due to Miranda. (ii) The existence of solutions to the problem through the application of the Implicit Function Theorem. These two results extend the work of Feng and Webb [34], and Gupta [39] for the problems at resonance in Euclidean 2-space. (iii) Existence results for three-point BVPs at resonance for general BVPs through the application of Brouwer degree theory; we show the degree is non zero through the application of Borsuk's Theorem for one problem and through a result of Cronin involving pairs of polynomials in two variables whose terms of highest order have no common factors. (iv) The existence of solutions to the entrainment of frequency problem in Euclidean 2-space. We will investigate conditions under which entrainment of frequency for three-point as well as two-point BVPs by adapting the work of Cronin in periodic case. We will describe such conditions and then show the degree is non zero through a result of Cronin involving pairs of polynomials in two variables whose terms of lowest order have no common factors.

The work presents the analysis of the free boundary value problem related to the one-dimensional invasion model of new species in biofilm reactors. In the framework of continuum approach to mathematical modelling of biofilm growth, the problem consists of a system of non-linear hyperbolic partial differential equations governing the microbial species growth and a system of semi-linear elliptic partial differential equations describing the substrate trends. The model is completed with a system of elliptic partial differential equations governing the diffusion and reaction of planktonic cells, which are able to switch their mode of growth from planktonic to sessile when specific environmental conditions are found. Two systems of non-linear differential equations for the substrate and planktonic cells mass balance within the bulk liquid are also considered. The free boundary evolution is governed by a differential equation that accounts for detachment. The qualitative analysis is performed and a uniqueness and existence result is presented. Furthermore, two special models of biological and engineering interest are discussed numerically. The invasion of Anammox bacteria in a constituted biofilm inhabiting the deammonification units of the wastewater treatment plants is simulated. Numerical simulations are run to evaluate the influence of the colonization process on biofilm structure and activity.

SOME RESULTS IN FUNCTIONAL INTEGRAL EQUATIONS IN A BANACH SPACE

Criteria of global attraction in systems of delay differential equations with mixed monotonicity