Face pareidolia in male schizophrenia

IntroductionResearch on face tuning is of particular relevance during the Covid-19 pandemic leading to social isolation and anxiety, but also requiring social integrity. Face sensitivity represents an essential component of social competence. This ability is aberrant in most neuropsychiatric conditions. Studies in typically developing individuals enable to develop new tools for examination and better understanding non-verbal social cognition in neuropsychiatry.ObjectivesHere we used a novel set of Face-n-Thing images to address the following issues: (i) whether the ability to seeing faces in non-face images (face pareidolia) is affected by gender; and (ii) whether it is altered with changing display orientation. The main advantage of Face-n-Thing images is that face tuning occurs without being explicitly fostered by familiar elements.MethodsA newly developed Face-n-Thing task, on which images were shown either with canonical upright orientation or inverted 180º in the image plane, was administered to healthy females and males. On each trial, they have to indicate whether they have a face impression.ResultsFace impression was substantially impeded by display inversion in both males and females. With upright display orientation, no gender differences were found, whereas with inversion, Face-n-Thing images elicited face impression in females significantly more often.ConclusionsThe findings open a way for examination of face sensitivity and underwriting brain networks in neuropsychiatric conditions, most of which are gender-specific. Display inversion represents a proper control for face tuning in neuroimaging studies. Gender differences should be taken into account when conceiving studies in neuropsychiatric populations.DisclosureNo significant relationships.

Face pareidolia is a tendency to seeing faces in nonface images that reflects high tuning to a face scheme. Yet, studies of the brain networks underwriting face pareidolia are scarce. Here, we examined the time course and dynamic topography of gamma oscillatory neuromagnetic activity while administering a task with nonface images resembling a face. Images were presented either with canonical orientation or with display inversion that heavily impedes face pareidolia. At early processing stages, the peaks in gamma activity (40 to 45 Hz) to images either triggering or not face pareidolia originate mainly from the right medioventral and lateral occipital cortices, rostral and caudal cuneus gyri, and medial superior occipital gyrus. Yet, the difference occurred at later processing stages in the high-frequency range of 80 to 85 Hz over a set of the areas constituting the social brain. The findings speak rather for a relatively late neural network playing a key role in face pareidolia. Strikingly, a cutting-edge analysis of brain connectivity unfolding over time reveals mutual feedforward and feedback intra- and interhemispheric communication not only within the social brain but also within the extended large-scale network of down- and upstream regions. In particular, the superior temporal sulcus and insula strongly engage in communication with other brain regions either as signal transmitters or recipients throughout the whole processing of face-pareidolia images.

Face pareidolia, the phenomenon of seeing face-like patterns in non-face images, has a dual nature: Pareidolic patterns are experienced as face-like, even while observers can recognize the true nature of the stimulus (Stuart et al., 2024). Though pareidolic faces seem to result largely from the canonical arrangement of eye spots and a mouth, we hypothesized that competition between veridical and face-like interpretations of pareidolic patterns may constrain face pareidolia in natural scenes and textures. Specifically, we predicted that contrast negation, which disrupts multiple aspects of mid- to high-level recognition, may increase rates of face pareidolia in complex natural textures by weakening the veridical, non-face stimulus interpretation. We presented adult participants (N=27) and 5-12 year-old children (N=67) with a series of natural images depicting textures like grass, leaves, shells, and rocks. We asked participants to circle any patterns in each image that looked face-like, with no constraints on response time or pattern size, position, and orientation. We found that across our adult and child samples, contrast-negated images yielded more pareidolic face detections than positive images. We conclude that disrupting veridical object and texture recognition enhances pareidolia in children and adults by compromising half of the dual nature of a pareidolic pattern.

Face pareidolia, the perception of illusory faces in everyday objects, often includes social characteristics such as gender, age and emotion. However, it is unclear whether the characteristics of object face pareidolia are influenced by selection bias and/or the semantic characteristics of object images. The current study uses static and dynamic synthetic visual noise—an evocative but minimal stimulus—to examine the social characteristics associated with pareidolic faces in an unbiased way. Experiment 1 (N = 40) directly compared face pareidolia in objects and static, vertically symmetrical noise, finding social traits in both. Faces in synthetic noise appeared older and angrier than those seen in objects. Experiment 2 (N = 30) examined pareidolia in symmetrical and random dynamic noise, showing similar results to static noise. Our results provide ‘context-free’ insight into the perceptual and cognitive biases that influence the processing of ambiguous stimuli in human vision.

ObjectiveThe differential diagnosis of schizophrenia (SZ) versus autism spectrum disorder (ASD) can be clinically challenging because accumulating evidence suggests both clinical and biological overlaps between them. The aim of this study was to compare Rorschach profiles between young adults with SZ and those with ASD.MethodsWe evaluated quantitative tendencies on the Rorschach test among 20 patients diagnosed with SZ and 20 diagnosed with ASD. Both groups were matched for age, sex, and intelligence quotient.ResultsWe found significant differences in six response variables on the Rorschach comprehensive system. Those with SZ had significantly higher scores on D score, adjusted D score (Adj D), developmental quality code reflecting ordinary response (DQo), and form quality minus (FQ −) than those with ASD. In contrast, those with SZ had significantly lower scores on the active and developmental quality code reflecting synthesized response (DQ+) subscales than those with ASD.ConclusionThe present findings reveal that individuals with SZ might have more stress tolerance, stronger perception distortions, and simpler and poorer recognition than those with ASD. We suggest that the Rorschach test might be a useful tool for differentiating between SZ and ASD.

Delusions are marked, fixed beliefs that are incongruent with reality. Delusions, with comorbid hallucinations, are a hallmark of certain psychotic disorders (e.g., schizophrenia). Delusions can present transdiagnostically, in neurodegenerative (e.g., Alzheimer's disease and fronto-temporal dementia), nervous system disorders (e.g., Parkinson's disease) and across other psychiatric disorders (e.g., bipolar disorder). The burden of delusions is severe and understanding the heterogeneity of delusions may delineate a more valid nosology of not only psychiatric disorders but also neurodegenerative and nervous system disorders. We systematically reviewed structural neuroimaging studies reporting on delusions in four disorder types [schizophrenia (SZ), bipolar disorder (BP), Alzheimer's disease (AD), and Parkinson's disease (PD)] to provide a comprehensive overview of neural changes and clinical presentations associated with delusions. Twenty-eight eligible studies were identified. This review found delusions were most associated with gray matter reductions in the dorsolateral prefrontal cortex (SZ, BP, and AD), left claustrum (SZ and AD), hippocampus (SZ and AD), insula (SZ, BP, and AD), amygdala (SZ and BP), thalamus (SZ and AD), superior temporal gyrus (SZ, BP, and AD), and middle frontal gyrus (SZ, BP, AD, and PD). However, there was a great deal of variability in the findings of each disorder. There is some support for the current dopaminergic hypothesis of psychosis, but we also propose new hypotheses related to the belief formation network and cognitive biases. We also propose a standardization of assessments to aid future transdiagnostic study approaches. Future studies should explore the neural and biological underpinnings of delusions to hopefully, inform future treatment.

The cause of schizophrenia (SZ) is unknown and no single region of the brain can be pinpointed as an area of primary pathology. Rather, SZ results from dysfunction of multiple neurotransmitter systems and miswiring between brain regions. It is necessary to elucidate how communication between regions is disrupted to advance our understanding of SZ pathology. The nucleus accumbens (NAcc) is a prime region of interest, where inputs from numerous brain areas altered in SZ are integrated. Aberrant signaling in the NAcc is hypothesized to cause symptoms of SZ, but it is unknown if these abnormalities are actually present. Electron microscopy was used to study the morphology of synaptic connections in SZ. The NAcc core and shell of 6 SZ subjects and 8 matched controls were compared in this pilot study. SZ subjects had a 19% increase in the density of asymmetric axospinous synapses (characteristic of excitatory inputs) in the core, but not the shell. Both groups had similar densities of symmetric synapses (characteristic of inhibitory inputs). The postsynaptic densities of asymmetric synapses had 22% smaller areas in the core, but not the shell. These results indicate that the core receives increased excitatory input in SZ, potentially leading to dysfunctional dopamine neurotransmission and cortico-striatal-thalamic stimulus processing. The reduced postsynaptic density size of asymmetric synapses suggests impaired signaling at these synapses. These findings enhance our understanding of the role the NAcc might play in SZ and the interaction of glutamatergic and dopaminergic abnormalities in SZ.

Signal detection theory--as developed in electrical engineering and based on statistical decision theory--was first applied to human sensory discrimination 40 years ago. The theoretical intent was to provide a valid model of the discrimination process; the methodological intent was to provide reliable measures of discrimination acuity in specific sensory tasks. An analytic method of detection theory, called the relative operating characteristic (ROC), can isolate the effect of the placement of the decision criterion, which may be variable and idiosyncratic, so that a pure measure of intrinsic discrimination acuity is obtained. For the past 20 years, ROC analysis has also been used to measure the discrimination acuity or inherent accuracy of a broad range of practical diagnostic systems. It was widely adopted by methodologists in the field of information retrieval, is increasingly used in weather forecasting, and is the generally preferred method in clinical medicine, primarily in radiology. This book attends to both themes, ROC analysis in the psychology laboratory and in practical diagnostic settings, and to their essential unity. The focus of this book is on detection and recognition as fundamental tasks that underlie most complex behaviors. As defined here, they serve to distinguish between two alternative, confusable stimulus categories, which may be perceptual or cognitive categories in the psychology laboratory, or different states of the world in practical diagnostic tasks. This book on signal detection theory in psychology was written by one of the developers of the theory, who co-authored with D.M. Green the classic work published in this area in 1966 (reprinted in 1974 and 1988). This volume reviews the history of the theory in engineering, statistics, and psychology, leading to the separate measurement of the two independent factors in all discrimination tasks, discrimination acuity and decision criterion. It extends the previous book to show how in several areas of psychology--in vigilance and memory--what had been thought to be discrimination effects were, in reality, effects of a changing criterion. The book shows that data plotted in terms of the relative operating characteristic have essentially the same form across the wide range of discrimination tasks in psychology. It develops the implications of this ROC form for measures of discrimination acuity, pointing up the valid ones and identifying several common, but invalid, ones. The area under the binormal ROC is seen to be supported by the data; the popular measures d' and percent correct are not. An appendix describes the best, current programs for fitting ROCs and estimating their parameters, indices, and standard errors. The application of ROC analysis to diagnostic tasks is also described. Diagnostic accuracy in a wide range of tasks can be expressed in terms of the ROC area index. Choosing the appropriate decision criterion for a given diagnostic setting--rather than considering some single criterion to be natural and fixed--has a major impact on the efficacy of a diagnostic process or system. Illustrated here by separate chapters are diagnostic systems in radiology, information retrieval, aptitude testing, survey research, and environments in which imminent dangerous conditions must be detected. Data from weather forecasting, blood testing, and polygraph lie detection are also reported. One of these chapters describes a general approach to enhancing the accuracy of diagnostic systems.

Being able to measure 3-D flow velocity and volumetric flow rate effectively in the cardiovascular system is valuable but remains a significant challenge in both clinical practice and research. Currently, there has not been an effective and practical solution to the measurement of volume flow using ultrasound imaging systems due to challenges in existing 3-D imaging techniques and high system cost. In this study, a new technique for quantifying volumetric flow rate from the cross-sectional imaging plane of the blood vessel was developed by using speckle decorrelation (SDC), 2-D high-frame-rate imaging with a standard 1-D array transducer, microbubble contrast agents, and ultrasound imaging velocimetry (UIV). Through SDC analysis of microbubble signals acquired with a very high frame rate and by using UIV to estimate the two in-plane flow velocity components, the third and out-of-plane velocity component can be obtained over time and integrated to estimate volume flow. The proposed technique was evaluated on a wall-less flow phantom in both steady and pulsatile flow. UIV in the longitudinal direction was conducted as a reference. The influences of frame rate, mechanical index (MI), orientation of imaging plane, and compounding on velocity estimation were also studied. In addition, an in vivo trial on the abdominal aorta of a rabbit was conducted. The results show that the new system can estimate volume flow with an averaged error of 3.65% ± 2.37% at a flow rate of 360 mL/min and a peak velocity of 0.45 m/s, and an error of 5.03% ± 2.73% at a flow rate of 723 mL/min and a peak velocity of 0.8 m/s. The accuracy of the flow velocity and volumetric flow rate estimation directly depend on the imaging frame rate. With a frame rate of 6000 Hz, a velocity up to 0.8 m/s can be correctly estimated. A higher mechanical index (MI = 0.42) is shown to produce greater errors (up to 21.78±0.49%, compared to 3.65±2.37% at MI = 0.19). An in vivo trial, where velocities up to 1 m/s were correctly measured, demonstrated the potential of the technique in clinical applications.

ObjectiveIntracranial stenting for stent-assisted coiling of aneurysms requires adequate follow-up imaging. The aim of this in vitro study was to compare in-stent artificial luminal narrowing on contrast-enhanced MR angiograms (CE-MRA) when applying Neuroform® and Enterprise® stents for stent-assisted coiling.Materials and MethodsTwo intracranial nitinol stents (Enterprise® and Neuroform®) were placed in silicon tubes and then imaged at 3 T and 1.5 T by the use of a T1-weighted three-dimensional spoiled gradient-echo sequence with minimal TR and TE. CE-MRAs were obtained by using different imaging planes, voxel sizes, and bandwidths, and with or without parallel imaging. Artificial lumen narrowing (ALN) was calculated and the results were compared.ResultsLower magnetic field strength, axial plane perpendicular to axis of stent, and wider bandwidth resulted in a lower ALN on CE-MRA for both stents. Larger voxel size resulted in lower ALN for Neuroform® stent. The parallel imaging acceleration factor did not affect ALN. The mean ALN was lower for Neuroform®, but it was not significant by a paired t test.ConclusionCE-MRA of the stented lumen of vascular phantom was partially impaired with ALN. Consequently, image plane orientation, magnetic field strength, bandwidth, and voxel size should be adjusted appropriately to reduce ALN.

A sample of acutely hospitalized paranoid and nonparanoid schizophrenics and another sample of paranoid and nonparanoid schizophrenics studied at follow-up were compared on measures of cognitive functioning, disordered thinking, and drive dominated thinking using the WAIS, the Rorschach test, the object sorting test, and an overall index of outcome functioning (N = 67). Results suggested that cognitive regression is related more to acute psychological disturbance than to the presence or absence of paranoia, that the presence of socialized drive dominated thinking during the acute phase is related to better posthospital adjustment at follow-up, and that paranoid schizophrenics show better cognitive functioning after the acute phase. Results did not support the theory that suggests an etiological relation between homosexual conflict and paranoia.

A longitudinal study on intrinsic connectivity of hippocampus associated with positive symptom in first-episode schizophrenia

Similarities in serum oxidative stress markers and inflammatory cytokines in patients with overt schizophrenia at early and late stages of chronicity

Role of rs6313 and rs1799978 variants as pharmacogenomic biomarkers in Greek, Italian and Croatian schizophrenia patients

Gastric dysmotility in healthy first-degree relatives of patients with schizophrenia