Generative Recommendation Models: Progress and Directions

Generative large language models (LLMs) are a subset of transformers-based neural network architecture models. LLMs have successfully leveraged a combination of an increased number of parameters, improvements in computational efficiency, and large pre-training datasets to perform a wide spectrum of natural language processing (NLP) tasks. Using a few examples (few-shot) or no examples (zero-shot) for prompt-tuning has enabled LLMs to achieve state-of-the-art performance in a broad range of NLP applications. This article by the American Medical Informatics Association (AMIA) NLP Working Group characterizes the opportunities, challenges, and best practices for our community to leverage and advance the integration of LLMs in downstream NLP applications effectively. This can be accomplished through a variety of approaches, including augmented prompting, instruction prompt tuning, and reinforcement learning from human feedback (RLHF). Our focus is on making LLMs accessible to the broader biomedical informatics community, including clinicians and researchers who may be unfamiliar with NLP. Additionally, NLP practitioners may gain insight from the described best practices. We focus on 3 broad categories of NLP tasks, namely natural language understanding, natural language inferencing, and natural language generation. We review the emerging trends in prompt tuning, instruction fine-tuning, and evaluation metrics used for LLMs while drawing attention to several issues that impact biomedical NLP applications, including falsehoods in generated text (confabulation/hallucinations), toxicity, and dataset contamination leading to overfitting. We also review potential approaches to address some of these current challenges in LLMs, such as chain of thought prompting, and the phenomena of emergent capabilities observed in LLMs that can be leveraged to address complex NLP challenge in biomedical applications.

Recent advancements in Generative AI, such as Large Language Models (LLMs), have demonstrated remarkable success across various general tasks. Extensive studies have explored leveraging generative models in finance, but significant challenges persist. This half-day workshop explores potential approaches and research directions to address these challenges by equipping generative models with advanced Information Retrieval (IR) models. Specifically, this workshop seeks to provide a platform for discussing innovative ideas that facilitate the advancement of IR technology to enrich generative models in finance from four key perspectives: (i) financial IR techniques (ii) financial IR benchmarking and evaluation (iii) financial systems and agents/assistants (iv) and trustworthiness, privacy and security when applying financial IR and generative models. This workshop aims to deepen understanding, accelerate progress, and support the advancement of IR technology to enhance generative models to address financial challenges.

Mechanical metamaterials - engineered materials whose behavior is defined by their internal structure rather than their base material - have received great at- tention for the unusual properties they can exhibit. However, while the forward problem of predicting the mechanical behavior of a given metamaterial can be reliably done through simulation or experiments, the inverse problem - designing metamaterials with specific properties - remains difficult, especially for heteroge- neous metamaterials composed of multiple unit cells. This dissertation explores the use of generative machine learning to address this inverse design problem. The first part of the work investigates how inverse and generative models can be conditioned to produce unit cells with prescribed mechanical properties and how they can be used to generate multiple valid solutions for the same target. This is examined using a curved-beam metamaterial, which allows a compact geometric representation without complex design restrictions. The effect these restrictions have on the generative models is investigated in the second part. For this, a number of generative models—Variational Autoencoders, Generative Adversarial Networks, and Diffusion Models—are evaluated on a kirigami metamaterial where dependencies between the cuts cause intricate design constraints. The final part covers the challenges that arise when generative models are applied to heteroge- neous metamaterials, in which multiple unit cells are combined to create spatially varying mechanical properties. The results show that the applicability of generative models for the design of metamaterials strongly depends on the choice of geometric parameterization. Generative models make assumptions about their input data that generally hold for images, but can be invalid for metamaterials when complex dependencies be- tween the input parameters exist. B-splines can provide a representation without those dependencies and are therefore well suited to be paired up with generative models. Furthermore, it is also important how these geometrical parameters are sampled to create the training data for the generative models, as this sampling also affects the distribution of the properties in the training data. Overall, while generative machine learning models prove effective for the inverse design of mechanical metamaterials their successful application requires careful parameterization and selection of the training data.

Recent advancements in large language models (LLMs) have raised concerns about inference costs, increasing the need for research into model compression. While knowledge distillation (KD) is a prominent method for this, research on KD for generative language models like LLMs is relatively sparse, and the approach of distilling student-friendly knowledge, which has shown promising performance in KD for classification models, remains unexplored in generative language models. To explore this approach, we propose PromptKD, a simple yet effective method that utilizes prompt tuningfor the first time in KD -to enable generative language models to transfer student-friendly knowledge. Unlike previous works in classification that require fine-tuning the entire teacher model for extracting student-friendly knowledge, PromptKD achieves similar effects by adding a small number of prompt tokens and tuning only the prompt with student guidance. Extensive experiments on instruction-following datasets show that PromptKD achieves state-ofthe-art performance while adding only 0.0007% of the teacher's parameters as prompts. Further analysis suggests that distilling student-friendly knowledge alleviates exposure bias effectively throughout the entire training process, leading to performance enhancements. 1

Evaluating gpt-4 for zero-shot classification of bleeding and clotting events: Can large language models serve as second reviewers?

Large language models (LLMs) have emerged as a milestone in the realm of machine learning, offering groundbreaking capabilities in understanding human language with remarkable coherence and versatility. Their application spans a multitude of domains, ranging from text classification to information extraction. Such models are first pre-trained on vast data corpora to learn general language patterns and then are fine-tuned on specific downstream tasks. Despite their impressive capabilities, LLMs encounter several limitations, including sub-optimal performance in understanding the domain-specific language of drug labels, limited performance in analyzing class-imbalanced data, and high computational complexity of training. Human prescription drug labeling contains a summary of the essential scientific information needed for the safe and effective use of the drug and includes critical information about drug products, such as pharmacokinetics and adverse events. Automatic information extraction from drug labels can facilitate processes such as finding the adverse reaction of the drugs or finding the interaction of one drug with another drug. Although LLMs are an interesting solution to perform this task, because of their training on generic data, they may not possess the depth of knowledge or the ability required to understand the language in such a specialized field. To address this issue, this work presents the developed PharmBERT, which is a BERT model specifically pretrained on the drug labels, publicly available online for the NLP community. We demonstrate that our model outperforms models such as vanilla BERT, ClinicalBERT, and BioBERT in multiple NLP tasks in the drug label domain. Another shortcoming of LLMs lies in their handling of class-imbalanced data, leading to a subpar performance in identifying and accurately responding to minority classes. This class-imbalance can skew the model's learning process, favoring majority classes, and thus diminishing its effectiveness in recognizing and appropriately addressing less represented categories. To cope with these challenges, we present a simple modification of standard fine-tuning. Specifically, we propose a two-stage fine-tuning. In Stage 1, we fine-tune the final layer of the pretrained model with class-balanced augmented data, generated using ChatGPT. As a large generative language model, ChatGPT is capable of generating novel yet contextually similar responses to a given text sample, which makes it an excellent candidate for data augmentation. In Stage 2, we perform the standard fine-tuning. Our modification has several benefits: (1) it leverages pretrained representations by only fine-tuning a small portion of the model parameters while keeping the rest untouched; (2) it allows the model to learn an initial representation of the specific task; and importantly (3) it protects the learning of tail classes from being at a disadvantage during the model updating. The experimental results show that the proposed two-stage fine-tuning outperforms vanilla fine-tuning and state-of-the-art methods on the above datasets. The third issue of LLMs is the high computational complexity of training. Due to the large number of parameters in many state-of-the-art LLMs, such as Bidirectional Encoder Representations from Transformers (BERT), the process of fine-tuning exhibits a high level of intricacy. One attractive solution to this issue is parameter-efficient fine-tuning, which means only fine-tuning a small portion of the model and not changing the rest. However, the question that which portion of the BERT model is the most important one for fine-tuning remains unanswered. Here, we first analyze different components in the BERT model to see which one undergoes the most change after fine-tuning. We show that output LayerNorm changes more than other components when finetuned for different General Language Understanding Evaluation (GLUE) tasks. Then we show that only fine-tuning this component reaches a comparable, or in some cases better, performance to full fine-tuning and other parameter-efficient fine-tuning methods. Moreover, we use Fisher information to find out which parameters in LayerNorm are the most important ones and show that with a small performance degradation, many NLP tasks in the GLUE benchmark can be solved by fine-tuning only a small, selected portion of LayerNorm. In summary, LLMs hold immense potential to redefine and enhance various fields, including drug-label analysis, but they also suffer from limitations like sub-optimal performance in understanding domain-specific texts of drug labels, not learning minority classes in the class-imbalanced data, and high computational complexity. In this thesis, for each one of these shortcomings, first, the problem is analyzed and then a solution is provided.

Radiology report generation (RRG) produces detailed textual descriptions for radiographs, serving as a crucial task for medical analysis and diagnosis. Most existing RRG approaches naturally follow the multimodal text generation paradigm, where autoregressive models are utilized to perform token-by-token report generation and thus are potentially risky in generating invalid content while being limited in low information processing speed. Although advanced architectures, such as pre-trained models and large language models (LLMs), are applied for RRG and achieve good performance, they still face the aforementioned risk and speed limitation, especially that LLMs may introduce hallucinations. Consider that radiology reports are highly patternized, sentences in them convey specific meanings independently and are frequently reused, we propose a new extractive radiograph reporting (ERR) workflow and design a dedicated framework that efficiently and accurately extracts appropriate sentences from existing radiological cases for report generation. Our approach employs a memory module to store important medical information and enhance the encoding for input radiograph with better cross-modal representations, which are used to match sentences for the extraction process. We conducted experiments on two widely used benchmark datasets, with the results demonstrating that our approach outperforms strong baselines and achieves comparable results with existing state-of-the-art generative models. Analyses further confirm that our ERR approach not only produces reports with reliable content but also ensures high training and inference efficiency.

<sec><title>Objective</title> As urban design faces increasing demands for contextual responsiveness, iterative optimization, and data-informed reasoning, integrating artificial intelligence into the design process has gained renewed relevance. Among emerging technologies, generative artificial intelligence (GAI) shows strong potential for automating content creation and simulating spatial configurations. This research provides a comprehensive review of recent developments in the application of GAI to urban design. The research identifies representative technical pathways, their respective intervention stages, and the functional mechanisms by which generative models are reshaping the design workflow. This research presents a structured, theory-informed synthesis of how different generative models contribute to tasks such as intention modeling, spatial reasoning, and performance-driven design. Building on design thinking and a descriptive lens informed by the technology acceptance model (TAM), the research examines how model type, data modality, and task characteristics affect GAI’s functional role, usability, and acceptance. Particular attention is given to mapping deployment forms, from isolated tools to coordinated multi-model workflows, and to characterizing cross-cutting challenges of controllability, transparency, and contextual adaptability in urban design settings. </sec><sec><title>Methods</title> Following the PRISMA protocol, the research conducts a multi-stage literature review combining automated search and expert screening. A total of 125 peer-reviewed articles and high-impact preprints are selected from Web of Science, CNKI, arXiv, and selected industry sources, covering the period from 2014 to July 2025. Search terms such as “generative AI”, “AIGC”, “GAN”, “diffusion model”, “variational autoencoder”, “autoregressive model”, “large language model”, and urban-related keywords are used in various combinations. Based on the collected literature, four types of generative models are summarized as image-driven, language-driven, structure-driven, and feedback-optimized models, according to their application characteristics in urban design tasks. These types are aligned with four stages of the design process: preliminary analysis, scheme generation, evaluation and decision-making, and outcome expression. On this basis, a two-dimensional framework to examine how different GAI pathways intervene across tasks is formed. To refine the mapping, each design stage is further broken down into three representative sub-tasks. Preliminary analysis includes public demand analysis, urban data enhancement, case/task framing, and spatial element recognition. Scheme generation covers design intention modeling, spatial layout generation, and 3D form construction. The evaluation and decision-making stage includes multi-objective optimization, scheme evaluation, and scenario prediction. The final expression stage involves textual documentation, 2D representation, and visual rendering. A quantitative analysis is also conducted to show the distribution of model types over design stages, identify common combinations, and trace the evolution of research focus over time. TAM informs a descriptive synthesis of perceived usefulness (PU) and perceived ease of use (PEU) across model types to illuminate adoption patterns. </sec><sec><title>Results</title> The findings reveal that GAI models are increasingly integrated into urban design workflows but exhibit uneven adoption across task types and modalities. Image-driven models dominate in both early-stage analysis and final visual representation due to their high interpretability, usability, and compatibility with existing design practices. Language-driven models are commonly used in public demand analysis, participatory planning, and scenario scripting, enabled by the rise of large language models (LLMs) such as ChatGPT and DeepSeek. Structure-driven models, though less prevalent, show promise in generating street networks, land-parcel layouts, and spatial typologies using graph-based logic. Feedback-optimized models, which rely on reinforcement learning, evolutionary algorithms, and performance simulation are the least adopted, but demonstrate strong potential in multi-objective optimization and iterative decision-making. Recent research indicates an increasing use of multi-model workflows, such as text-to-image pipelines integrated with urban simulation or feedback loops. While GAI applications increasingly support design iteration, their adoption is heavily influenced by the controllability, explainability, and contextual adaptability of models. PU and PEU vary significantly by model type, with image-driven models rated highest and structure-driven and feedback-optimized models facing usability challenges due to complexity and low transparency. </sec><sec><title>Conclusion</title> Although GAI has demonstrated broad applicability across the urban design process, current implementations are largely procedural and auxiliary in nature. Most models recombine existing inputs rather than construct original logic, and few possess autonomous reasoning or normative awareness. This limits their role to content augmentation rather than conceptual guidance in design development. Moreover, issues such as opaque decision logic, lack of domain-specific knowledge embedding, and poor adaptability to local planning norms hinder practical adoption. Addressing these challenges requires multi-level efforts: 1) Construct structured, regionally grounded urban design datasets; 2) improve model interpretability, controllability, and responsiveness to professional input; and 3) develop modular, multi-model systems that support seamless interaction across design stages. Human – AI collaboration mechanisms — especially those based on iterative prompts and semantic feedback-must be enhanced to enable AI not just as a tool, but as an active design partner. This review offers a comprehensive reference for scholars and practitioners seeking to understand how GAI is reshaping the logic, structure, and agency of urban design. </sec>

Aim/Purpose: The study investigates the factors influencing the acceptance and utilisation of large language models (LLMs) (predictor variables of LLM usage), such as ChatGPT, in Learning design by instructional designers and university-teaching academics from various countries. Background: Large language models (LLMs) have exploded onto the scene, transforming the landscape of learning design. Instructional designers and university teaching academics have been overburdened with content creation for their teaching programmes, and the arrival of LLM models will help in this regard by developing more interactive content that drives student engagement and, in turn, contributes to student success. Since LLMs are a relatively new phenomenon, little is known about the factors influencing their acceptance in learning design; therefore, this research is needed, as learning design principles are the bedrock of student engagement and success. Methodology: A cross-sectional correlational quantitative study was employed. Data was collected using an online questionnaire posted on social media, including LinkedIn, from 203 instructional designers and university teaching academics. Purposive and snowball sampling methods were used to target instructional designers and university teaching academics at colleges and universities worldwide. Participants were asked to share the survey link with fellow instructional designers and university-teaching academics in their communities. The factor structure of the data was determined using exploratory factor analysis. Nonetheless, the factor structure derived from the LLMs did not entirely reflect the original configuration of the Unified Theory of Acceptance and Use of Technology (UTAUT3), as certain predictors appeared to coalesce, indicating LLMs’ unique nature in learning design. Confirmatory factor analysis was used to verify the fit of the data on the measurement model. First-order and second-order structural modelling were used to identify the structural relationships among the variables. Contribution: The study determines significant factors for the acceptance of LLMs by instructional designers and academic teaching staff in learning design, enabling possible opportunities for best practices in the field through interventions to optimize LLM usage. The study applies the technology acceptance model to the emerging LLM technology and extends the technology acceptance model by adding the trust construct as a predictor variable. Findings: The structural analysis results indicated that the ingrained LLM practices, LLM peer-driven expectations, innovative propensity towards LLM adoption, reliability and provider trust in LLMs, and ease of use and support influenced perceived LLM benefits and usage, but community standards and infrastructure had no influence. The second-order structural equation modelling indicated that perceived LLM benefits and usage and ingrained LLM habits contributed most to the learning design. Recommendations for Practitioners: Teaching academics and instructional designers must use LLMs in designing content, assessments, and interactive learning activities, and attend LLM training workshops on prompting and best practices in integrating LLMs into learning and teaching to see their benefits; hence, regular use of LLMs will then lead to trust and innovation in LLMs usage, enhancing learning design and improving student learning outcomes. Recommendation for Researchers: Researchers must use mixed methods approaches to have a deeper understanding of the factors influencing LLMs. Since habit and perceived LLM benefits and usage contributed the most variance to learning design, researchers must investigate strategies that optimise these factors in learning design, such as effective intervention strategies that can help form positive LLM habits. In addition, the findings provide researchers with a starting point for future research. Further researchers must investigate interventions that optimise the influence of personal innovativeness and trust that contributed the least variance to learning design, hence unlocking the potential of LLMs in learning design through innovation, responsible, and ethical use. Impact on Society: The use of LLMs in learning design has a high possibility of transforming education, specifically the learning design landscape. Using LLMs will free up more time for teaching academics and instructional designers so that they spend more time on higher-order thinking skill demands. Consequently, the students will be exposed to more engaging and interactive content, resulting in improved learning outcomes. Future Research: Future research must include context-derived external variables in technology acceptance models, such as levels of prompting competencies, to provide a deeper understanding of LLMs. In addition, future research must be based on the application and impact of LLMs on student engagement and success, and their attainment of 21st-century skills.

Natural language is poised to become a key medium for human-machine interactions in the era of large language models. In the field of biochemistry, tasks such as property prediction and molecule mining are critically important yet technically challenging. Bridging molecular expressions in natural language and chemical language can significantly enhance the interpretability and ease of these tasks. Moreover, it can integrate chemical knowledge from various sources, leading to a deeper understanding of molecules. Recognizing these advantages, we introduce the concept of conversational molecular design, a novel task that utilizes natural language to describe and edit target molecules. To better accomplish this task, we develop ChatMol, a knowledgeable and versatile generative pretrained model. This model is enhanced by incorporating experimental property information, molecular spatial knowledge, and the associations between natural and chemical languages. Several typical solutions including large language models (e.g. ChatGPT) are evaluated, proving the challenge of conversational molecular design and the effectiveness of our knowledge enhancement approach. Case observations and analysis offer insights and directions for further exploration of natural-language interaction in molecular discovery. Codes and data are provided in https://github.com/Ellenzzn/ChatMol/tree/main.

As large language models (LLMs) achieve remarkable success in natural language processing (NLP) domains, LLM-enhanced recommender systems have received much attention and are being actively explored currently. In this article, we focus on adapting and enhancing large language models for recommendation tasks. First and foremost, we identify and formulate the lifelong sequential behavior incomprehension problem for LLMs in recommendation realms, i.e., LLMs fail to effectively extract useful information from a pure textual context of long user behavior sequence, even if the length of context is well below the context limitation of LLMs. To address such an issue and improve the recommendation performance of LLMs, we propose a novel framework, namely, R etrieval- e nhanced L arge La nguage models Plus (ReLLaX), which provides full-stack optimization from three perspectives, i.e., data, prompt, and parameter. For data-level enhancement, we design semantic user behavior retrieval (SUBR) to reduce the heterogeneity of the behavior sequence, thus lowering the difficulty for LLMs to extract the essential information from user behavior sequences. Although SUBR can improve the data quality, further increase in the sequence length will still raise its heterogeneity to a level where LLMs can no longer comprehend it. Hence, we further propose to perform prompt-level and parameter-level enhancement, with the integration of conventional recommendation models (CRMs). As for prompt-level enhancement, we apply soft prompt augmentation (SPA) to explicitly inject collaborative knowledge from CRMs into the prompt. The item representations of LLMs are thus more aligned with recommendation, helping LLMs better explore the item relationships in the sequence and facilitating comprehension. Finally, for parameter-level enhancement, we propose component fully-interactive LoRA (CFLoRA). By enabling sufficient interaction between the LoRA atom components, the expressive ability of LoRA is extended, making the parameters effectively capture more sequence information. Moreover, we present new perspectives to compare current LoRA-based LLM4Rec methods, i.e., from both a composite and a decomposed view. We theoretically demonstrate that the ways they employ LoRA for recommendation are degraded versions of our CFLoRA, with different constraints on atom component interactions. Extensive experiments are conducted on three real-world public datasets to demonstrate the superiority of ReLLaX compared with existing baseline models, as well as its capability to alleviate lifelong sequential behavior incomprehension. Our code is available. 1

Purpose This study aims to explore the integration of large language models (LLMs) and vision-language models (VLMs) in robotics, highlighting their potential benefits and the safety challenges they introduce, including robustness issues, adversarial vulnerabilities, privacy concerns and ethical implications. Design/methodology/approach This survey conducts a comprehensive analysis of the safety risks associated with LLM- and VLM-powered robotic systems. The authors review existing literature, analyze key challenges, evaluate current mitigation strategies and propose future research directions. Findings The study identifies that ensuring the safety of LLM-/VLM-driven robots requires a multi-faceted approach. While current mitigation strategies address certain risks, gaps remain in real-time monitoring, adversarial robustness and ethical safeguards. Originality/value This study offers a structured and comprehensive overview of the safety challenges in LLM-/VLM-driven robotics. It contributes to ongoing discussions by integrating technical, ethical and regulatory perspectives to guide future advancements in safe and responsible artificial intelligence-driven robotics.

Traditional computational approaches to design chemical species are limited by the need to compute properties for a vast number of candidates, e.g., by discriminative modeling. Therefore, inverse design methods aim to start from the desired property and optimize a corresponding chemical structure. From a machine learning viewpoint, the inverse design problem can be addressed through so-called generative modeling. Mathematically, discriminative models are defined by learning the probability distribution function of properties given the molecular or material structure. In contrast, a generative model seeks to exploit the joint probability of a chemical species with target characteristics. The overarching idea of generative modeling is to implement a system that produces novel compounds that are expected to have a desired set of chemical features, effectively sidestepping issues found in the forward design process. In this contribution, we overview and critically analyze popular generative algorithms like generative adversarial networks, variational autoencoders, flow, and diffusion models. We highlight key differences between each of the models, provide insights into recent success stories, and discuss outstanding challenges for realizing generative modeling discovered solutions in chemical applications.

ObjectiveTo explore whether large language models (LLMs) Generated Pre-trained Transformer (GPT)-3 and ChatGPT can write clinical letters and predict management plans for common orthopaedic scenarios.DesignFifteen scenarios were generated and ChatGPT...

The rapid growth of biomedical literature poses challenges for manual knowledge curation and synthesis. Biomedical Natural Language Processing (BioNLP) automates the process. While Large Language Models (LLMs) have shown promise in general domains, their effectiveness in BioNLP tasks remains unclear due to limited benchmarks and practical guidelines. We perform a systematic evaluation of four LLMs—GPT and LLaMA representatives—on 12 BioNLP benchmarks across six applications. We compare their zero-shot, few-shot, and fine-tuning performance with the traditional fine-tuning of BERT or BART models. We examine inconsistencies, missing information, hallucinations, and perform cost analysis. Here, we show that traditional fine-tuning outperforms zero- or few-shot LLMs in most tasks. However, closed-source LLMs like GPT-4 excel in reasoning-related tasks such as medical question answering. Open-source LLMs still require fine-tuning to close performance gaps. We find issues like missing information and hallucinations in LLM outputs. These results offer practical insights for applying LLMs in BioNLP.