Heart Disease Detection with Machine Learning Algorithms

One of the critical issues in medical data analysis is accurately predicting a patient’s risk of heart disease, which is vital for early intervention and reducing mortality rates. Early detection allows for timely treatment and continuous monitoring by healthcare providers, which is essential but often limited by the inability of medical professionals to provide constant patient supervision. Early detection of cardiac problems and continuous patient monitoring by physicians can help reduce death rates. Doctors cannot constantly have contact with patients, and heart disease detection is not always accurate. By offering a more solid foundation for prediction and decision-making based on data provided by healthcare sectors worldwide, machine learning (ML) could help physicians with the prediction and detection of HD. This study aims to use different feature selection strategies to produce an accurate ML algorithm for early heart disease prediction. We have chosen features using chi-square, ANOVA, and mutual information methods. The three feature groups chosen were SF-1, SF-2, and SF-3. The study employed ten machine learning algorithms to determine the most accurate technique and feature subset fit. The classification algorithms used include support vector machines (SVM), XGBoost, bagging, decision trees (DT), and random forests (RF). We evaluated the proposed heart disease prediction technique using a private dataset, a public dataset, and different cross-validation methods. We used the Synthetic Minority Oversampling Technique (SMOTE) to eliminate inconsistent data and discover the machine learning algorithm that achieves the most accurate heart disease predictions. Healthcare providers might identify early-stage heart disease quickly and cheaply with the proposed method. We have used the most effective ML algorithm to create a mobile app that instantly predicts heart disease based on the input symptoms. The experimental results demonstrated that the XGBoost algorithm performed optimally when applied to the combined datasets and the SF-2 feature subset. It had 97.57% accuracy, 96.61% sensitivity, 90.48% specificity, 95.00% precision, a 92.68% F1 score, and a 98% AUC. We have developed an explainable AI method based on SHAP approaches to understand how the system makes its final predictions.

Undernutrition among children under the age of five is a major public health concern, especially in developing countries. This study aimed to use machine learning (ML) algorithms to predict undernutrition and identify its associated factors. Secondary data analysis of the 2017 Multiple Indicator Cluster Survey (MICS) was performed using R and Python. The main outcomes of interest were undernutrition (stunting: height-for-age (HAZ) < -2 SD; wasting: weight-for-height (WHZ) < -2 SD; and underweight: weight-for-age (WAZ) < -2 SD). Seven ML algorithms were trained and tested: linear discriminant analysis (LDA), logistic model, support vector machine (SVM), random forest (RF), least absolute shrinkage and selection operator (LASSO), ridge regression, and extreme gradient boosting (XGBoost). The ML models were evaluated using the accuracy, confusion matrix, and area under the curve (AUC) receiver operating characteristics (ROC). In total, 8564 children were included in the final analysis. The average age of the children was 926 days, and the majority were females. The weighted prevalence rates of stunting, wasting, and underweight were 17%, 7%, and 12%, respectively. The accuracies of all the ML models for wasting were (LDA: 84%; Logistic: 95%; SVM: 92%; RF: 94%; LASSO: 96%; Ridge: 84%, XGBoost: 98%), stunting (LDA: 86%; Logistic: 86%; SVM: 98%; RF: 88%; LASSO: 86%; Ridge: 86%, XGBoost: 98%), and for underweight were (LDA: 90%; Logistic: 92%; SVM: 98%; RF: 89%; LASSO: 92%; Ridge: 88%, XGBoost: 98%). The AUC values of the wasting models were (LDA: 99%; Logistic: 100%; SVM: 72%; RF: 94%; LASSO: 99%; Ridge: 59%, XGBoost: 100%), for stunting were (LDA: 89%; Logistic: 90%; SVM: 100%; RF: 92%; LASSO: 90%; Ridge: 89%, XGBoost: 100%), and for underweight were (LDA: 95%; Logistic: 96%; SVM: 100%; RF: 94%; LASSO: 96%; Ridge: 82%, XGBoost: 82%). Age, weight, length/height, sex, region of residence and ethnicity were important predictors of wasting, stunting and underweight. The XGBoost model was the best model for predicting wasting, stunting, and underweight. The findings showed that different ML algorithms could be useful for predicting undernutrition and identifying important predictors for targeted interventions among children under five years in Ghana.

SummaryAccurate prediction of the solubility of chemical substances in solvents remains a challenge. The sparsity of high-quality solubility data is recognized as the biggest hurdle in the development of robust data-driven methods for practical use. Nonetheless, the effects of the quality and quantity of data on aqueous solubility predictions have not yet been scrutinized. In this study, the roles of the size and the quality of data sets on the performances of the solubility prediction models are unraveled, and the concepts of actual and observed performances are introduced. In an effort to curtail the gap between actual and observed performances, a quality-oriented data selection method, which evaluates the quality of data and extracts the most accurate part of it through statistical validation, is designed. Applying this method on the largest publicly available solubility database and using a consensus machine learning approach, a top-performing solubility prediction model is achieved.

The accurate and early detection of coronary heart disease (CHD) is crucial for reducing mortality rates.This study evaluates the predictive performance of three machine learning models-Logistic Regression (LR), Random Forest (RF), and Support Vector Machine (SVM)-for classifying CHD.The models were trained on a comprehensive heart disease dataset and assessed using metrics such as Accuracy, Specificity, Sensitivity, F1-score, Negative Predictive Value, and Positive Predictive Value.Among the models, RF demonstrated the highest accuracy (93.5%), while SVM excelled in sensitivity (97.5%).The findings highlight the potential of machine learning techniques in clinical decision-making and personalized medicine.

Cervical cancer is a highly prevalent malignancy affecting women worldwide, ranking as the seventh most common cancer globally. This study aims to systematically review and analyze cervical cancer survival predictions using machine learning (ML) algorithms. A comprehensive search was conducted across Scopus and PubMed databases in February 2024. Extracted articles were screened using Hubmeta software, with duplicates and non-relevant studies excluded. The final selection, comprising 24 articles, focused on survival predictions through ML techniques. These studies, published mostly post-2019, included datasets ranging from 75 to 9,462 cervical cancer patients and up to 91,294 squamous cell samples. The most commonly applied ML models were Random Forest (RF), Neural Networks (NN), Support Vector Machines (SVM), Ensemble and Hybrid Learning, and Deep Learning (DL). The area under the curve (AUC) for these models ranged from 0.84 to 0.9875, demonstrating their strong predictive capabilities. Clinical patient records were the primary data source. Meta-analysis was performed on the extracted data using GraphPad Prism for descriptive statistics and One-Way ANOVA. No significant differences were found between group means, as evidenced by an R-squared value of 0.1459. This result indicates that the independent variable (year of study) explained only 14.59% of the variance in ML model performance. The study found that the use of ML models has increased over time, particularly with Convolutional Neural Networks (CNNs) such as the ResNet50 model, which demonstrated superior accuracy metrics, including over 90% accuracy for the ResNet152 variant. These findings suggest that integrating multi-dimensional data with ML models holds significant potential for improving survival predictions in cervical cancer patients. Future research is recommended to develop tailored ML algorithms with even higher predictive accuracy for cervical cancer survival.

Heart disease is one of the leading causes of death worldwide, making early detection essential for improving patient outcomes. With advancements in machine learning (ML), predictive models now offer a powerful way to assist doctors in diagnosing heart disease more accurately and efficiently. This study explores various ML algorithms, including Logistic Regression (LR), Random Forest (RF), Support Vector Machine (SVM), Decision Tree (DT), Naïve Bayes (NB), and K-Nearest Neighbors (KNN), to identify the most effective approach for heart disease prediction. Using the Cleveland Heart Disease Dataset, which contains 1,025 patient records with 14 medical attributes, we preprocessed the data, selected key features, and optimized model parameters. After evaluating the models with 10-fold cross-validation, the Random Forest model achieved the highest accuracy (98%), followed by Decision Tree (97%). These results highlight the potential of ML-based tools in clinical decision-making, helping doctors detect heart disease at an earlier stage and make informed treatment plans.

Background: Cardiovascular diseases belong to the top three leading causes of mortality in the Philippines with 17.8 % of the total deaths. Lifestyle-related habits such as alcohol consumption, smoking, poor diet and nutrition, high sedentary behavior, overweight, and obesity have been increasingly implicated in the high rates of heart disease among Filipinos leading to a significant burden to the country's healthcare system. The objective of this study was to predict the presence of heart disease using various machine learning algorithms (support vector machine, naïve Bayes, random forest, logistic regression, decision tree, and adaptive boosting) evaluated on an anonymized publicly available cardiovascular disease dataset. Methodology: Various machine learning algorithms were applied on an anonymized publicly available cardiovascular dataset from a machine learning data repository (IEEE Dataport). A web-based application system named Heart Alert was developed based on the best machine learning model that would predict the risk of developing heart disease. An assessment of the effects of different optimization techniques as to the imputation methods (mean, median, mode, and multiple imputation by chained equations) and as to the feature selection method (recursive feature elimination) on the classification performance of the machine learning algorithms was made. All simulation experiments were implemented via Python 3.8 and its machine learning libraries (Scikit-learn, Keras, Tensorflow, Pandas, Matplotlib, Seaborn, NumPy). Results: The support vector machine without imputation and feature selection obtained the highest performance metrics (90.2% accuracy, 87.7% sensitivity, 93.6% specificity, 94.9% precision, 91.2% F1-score and an area under the receiver operating characteristic curve of 0.902) and was used to implement the heart disease prediction system (Heart Alert). Following very closely were random forest with mean or median imputation and logistic regression with mode imputation, all having no feature selection which also performed well. Conclusion: The performance of the best four machine learning models suggests that for this dataset, imputation technique for missing values may or may not be done. Likewise, recursive feature elimination for feature selection may not apply as all variables seem to be important in heart disease prediction. An early accurate diagnosis leading to prompt intervention efforts is very crucial as it improves the patient's quality of life and diminishes the risk of developing cardiac events.

Heart disease (HD) remains one of the leading causes of mortality worldwide, emphasizing the urgent need for accurate and timely diagnostic methods. Recent advances in machine learning (ML) have shown promising potential in improving clinical decision-making through predictive modeling. This study aimed to enhance HD prediction by applying selected ML algorithms with hyperparameter optimization to improve their accuracy and reliability. Four classifiers: Decision Tree (DT), Support Vector Machine (SVM), Random Forest (RF), and K-Nearest Neighbors (KNN) were implemented, and missing data were handled using the SimpleImputer technique to ensure robust preprocessing. Model performance was evaluated using standard metrics, including accuracy, precision, recall, F1-score, and the Receiver Operating Characteristic (ROC) curve. The experimental results demonstrated that all classifiers improved after hyperparameter tuning, with KNN achieving the highest accuracy of 96.0%, precision of 0.99, recall of 0.93, F1-score of 0.96, and ROC of 0.98. Comparative analysis revealed that the adopted approach outperformed existing methods reported in related literature, thereby confirming the effectiveness of hyperparameter optimization combined with preprocessing techniques in HD prediction. The study contributes to knowledge by highlighting the significance of optimized ML models in healthcare applications and recommends further validation with larger, diverse datasets for clinical integration.

One of the most serious diseases affecting people is heart disease, which also contributes significantly to the increasing death rate. Recently, Machine Learning (ML) methods have been utilized to detect and identify several types of heart disease, these methods can assist in enhancing the accuracy of heart disease classification. In this research, total ten machine learning (ML) models that’s are used, the first ML technique is Random Forest (rf) second ML technique is Decision Tree (dt), third is Support Vector Machine (svm) fourth ML techniques is K-Nearest Neighbors (knn), fifth ML technique is Logistics Regression (lr) and respectively Extra Trees Classifier (et), Gradient Boosting Classifier (gbc), Naive Bayes (nb), Ridge Classifier (ridge) and tenth ML technique is Linear Discriminant Analysis (ldr) are implemented. In addition, Recursive Feature Elimination (RFE) feature assortment method is used to find the significant features and enhance the efficiency of detecting heart disease using two text-based datasets. Finally, a detailed comparison will be implemented to presented that after smearing the feature selection method to recognize the most efficient model for detecting heart disease and then specify its severity. Some parameters, including accurateness, exactness, recollection, and F1-score, are offered to comparation the efficiency of each classifier. The actual outcomes of this research that improved the classification accurateness.

ObjectiveEnhanced technology in computer and internet has driven scale and quality of data to be improved in various areas including healthcare sectors. Machine Learning (ML) has played a pivotal role in efficiently analyzing those big data, but a general misunderstanding of ML algorithms still exists in applying them (e.g., ML techniques can settle a problem of small sample size, or deep learning is the ML algorithm). This paper reviewed the research of diagnosing mental illness using ML algorithm and suggests how ML techniques can be employed and worked in practice.MethodsResearches about mental illness diagnostic using ML techniques were carefully reviewed. Five traditional ML algorithms-Support Vector Machines (SVM), Gradient Boosting Machine (GBM), Random Forest, Naïve Bayes, and K-Nearest Neighborhood (KNN)-frequently used for mental health area researches were systematically organized and summarized.ResultsBased on literature review, it turned out that Support Vector Machines (SVM), Gradient Boosting Machine (GBM), Random Forest, Naïve Bayes, and K-Nearest Neighborhood (KNN) were frequently employed in mental health area, but many researchers did not clarify the reason for using their ML algorithm though every ML algorithm has its own advantages. In addition, there were several studies to apply ML algorithms without fully understanding the data characteristics.ConclusionResearchers using ML algorithms should be aware of the properties of their ML algorithms and the limitation of the results they obtained under restricted data conditions. This paper provides useful information of the properties and limitation of each ML algorithm in the practice of mental health.

Heart disease is among the conditions that people suffer from most frequently. Millions of people worldwide pass away each year as a result of it, making it one of the main causes of mortality. Heart disease can be characterised by issues with the heart valves, heart failure, arrhythmias, and coronary artery disease. Heart disease comes in more than 30 distinct forms. By allowing for prompt intervention and the right kind of care, early and precise cardiac disease prediction can greatly improve patient outcomes. In this model, we investigate the application of machine learning techniques for anticipating cardiac disease. We investigate a large dataset made up of patient details, such as demographics, medical histories, and clinical measures. It is absolutely mind-blowing to think that machine learning algorithms could one day properly forecast when cardiac disease will start and how to diagnose it. Machine learning techniques including logistic regression, decision trees, XGBoost, gradient boosting, random forests, support vector machines (SVMs), and artificial neural networks (ANNs) are utilised to construct predictive models. A hybrid model including ANN, gradient boost, Decision Tree, SVM, random forests, &amp; Logistic Regression makes up the forecasting model. To increase the model's accuracy. To manage missing values, normalise features and solve class imbalance. The dataset has been pre-processed. The best accurate heart disease predictions are found using feature selection approaches. Area under the receiver's operating characteristic curve, recall, accuracy, and precision are some of the performance measures used for training and evaluating the models. The major goal of this model is to put out a novel strategy for creating a model that successfully solves practical issues

In rehabilitation research, machine learning (ML) algorithms are being increasingly applied to predict the ability of patients with stroke and other acquired brain injuries to perform activities of daily living (ADL). However, many previous studies have relied on complex data, such as imaging or blood tests, which require advanced equipment and specialized expertise and are difficult to apply in general clinical settings. We aimed to predict ADL independence in patients with stroke and other acquired brain injuries at the start of rehabilitation using routine assessment data. This retrospective study involved 379 patients with stroke or other acquired brain injuries who received rehabilitation at our hospital between September 2008 and August 2022. Three ML models - support vector machine (SVM), random forest (RF), and Light Gradient-Boosting Machine (LightGBM) - were used to classify Functional Independence Measure scores. Predictors included age, sex, Japan Coma Scale score, and Brunnstrom recovery stage. All models performed above chance, with SVM achieving the highest F1 score (0.862), followed by RF (0.857) and LightGBM (0.838). Analysis of variance revealed a significant effect of the classifier on performance (P < .001), with SVM and RF significantly outperforming LightGBM. SHapley Additive exPlanations analysis identified lower- and upper-limb Brunnstrom recovery stage, impaired consciousness, and age as key predictive features. ML algorithms can accurately predict ADL independence using initial rehabilitation assessment data without reliance on advanced medical technologies. The use of these algorithms may enhance clinical decision-making, and they may be particularly valuable in resource-limited settings.

After radical prostatectomy (RP), one-third of patients will experience biochemical recurrence (BCR), which is associated with subsequent metastasis and cancer-specific mortality. We employed machine learning (ML) algorithms to predict BCR after RP, and compare them with traditional regression models and nomograms. Utilizing a prospective Uro-oncology registry, 18 clinicopathological parameters of 1130 consecutive patients who underwent RP (2009-2018) were recorded, yielding over 20,000 data points for analysis. The data set was split into a 70:30 ratio for training and validation. Three ML models: Naïve Bayes (NB), random forest (RF), and support vector machine (SVM) were studied, and compared with traditional regression models and nomograms (Kattan, CAPSURE, John Hopkins [JHH]) to predict BCR at 1, 3, and 5 years. Over a median follow-up of 70.0 months, 176 (15.6%) developed BCR, at a median time of 16.0 months (interquartile range [IQR]: 11.0-26.0). Multivariate analyses demonstrated strongest association of BCR with prostate-specific antigen (PSA) (p: 0.015), positive surgical margins (p < 0.001), extraprostatic extension (p: 0.002), seminal vesicle invasion (p: 0.004), and grade group (p < 0.001). The 3 ML models demonstrated good prediction of BCR at 1, 3, and 5 years, with the area under curves (AUC) of NB at 0.894, 0.876, and 0.894, RF at 0.846, 0.875, and 0.888, and SVM at 0.835, 0.850, and 0.855, respectively. All models demonstrated (1) robust accuracy (>0.82), (2) good calibration with minimal overfitting, (3) longitudinal consistency across the three time points, and (4) inter-model validity. The ML models were comparable to traditional regression analyses (AUC: 0.797, 0.848, and 0.862) and outperformed the three nomograms: Kattan (AUC: 0.815, 0.798, and 0.799), JHH (AUC: 0.820, 0.757, and 0.750) and CAPSURE nomograms (AUC: 0.706, 0.720, and 0.749) (p < 0.001). Supervised ML algorithms can deliver accurate performances and outperform nomograms in predicting BCR after RP. This may facilitate tailored care provisions by identifying high-risk patients who will benefit from multimodal therapy.

Predictive artificial intelligence (AI) models for the assessment of factors and trends related to disease prevalence, prognosis, and the risk prediction of mortality in the early phases, seem to be effective techniques. Machine learning (ML) algorithms as a branch of AI methods have had a considerable role in controlling and management of COVID-19 and previous pandemics. The present study estimates the mortality risk among COVID-19 patients based on ML algorithms, prediction of outcomes in new cases, and also determines the top significant features related to morality in the patients. In this retrospective research, 7115 patients with confirmed COVID-19 disease were included in the study. The information was collected from 35 different hospitals across Khorasan-Razavi province, Northeast of Iran during 20 February 2020 - 21 June 2021. We employed random forests (RF), decision tree (DT), artificial neural networks (ANN), support vector machines (SVM), logistic regression (LR), and boosted trees (BT) ML algorithms. Our findings indicated that the RF model had better performance in different criteria. The RF algorithm had area under curve (AUC) of 88%, accuracy of 96%, precision of 96%, sensitivity of 99%, and specificity of 80%. Intubation, SpO2, age, time from symptoms, loss of consciousness, reception season, and diabetes were the seven ordered and significant predictors of the risk of COVID-19 patients’ death. RF model can aid in clinical decision-making and limited resource allocation. This model needs to be externally validated in larger populations, more features, and multicenter settings. Received: August 4, 2023Accepted: September 13, 2023

Air pollution in Macau has become a serious problem following the Pearl River Delta’s (PRD) rapid industrialization that began in the 1990s. With this in mind, Macau needs an air quality forecast system that accurately predicts pollutant concentration during the occurrence of pollution episodes to warn the public ahead of time. Five different state-of-the-art machine learning (ML) algorithms were applied to create predictive models to forecast PM2.5, PM10, and CO concentrations for the next 24 and 48 h, which included artificial neural networks (ANN), random forest (RF), extreme gradient boosting (XGBoost), support vector machine (SVM), and multiple linear regression (MLR), to determine the best ML algorithms for the respective pollutants and time scale. The diurnal measurements of air quality data in Macau from 2016 to 2021 were obtained for this work. The 2020 and 2021 datasets were used for model testing, while the four-year data before 2020 and 2021 were used to build and train the ML models. Results show that the ANN, RF, XGBoost, SVM, and MLR models were able to provide good performance in building up a 24-h forecast with a higher coefficient of determination (R2) and lower root mean square error (RMSE), mean absolute error (MAE), and biases (BIAS). Meanwhile, all the ML models in the 48-h forecasting performance were satisfactory enough to be accepted as a two-day continuous forecast even if the R2 value was lower than the 24-h forecast. The 48-h forecasting model could be further improved by proper feature selection based on the 24-h dataset, using the Shapley Additive Explanations (SHAP) value test and the adjusted R2 value of the 48-h forecasting model. In conclusion, the above five ML algorithms were able to successfully forecast the 24 and 48 h of pollutant concentration in Macau, with the RF and SVM models performing the best in the prediction of PM2.5 and PM10, and CO in both 24 and 48-h forecasts.