Histopathological Image Diagnosis for Breast Cancer Diagnosis Based on Deep Mutual Learning

Deep learning (also known as deep structured learning, hierarchical learning, or deep machine learning) is a branch of machine learning based on a set of algorithms that attempt to model high-level abstractions in data by using a deep graph with multiple processing layers, composed of multiple linear and nonlinear transformations. Deep learning has been characterized as a class of machine learning algorithms with the following characteristics [257]: • They use a cascade of many layers of nonlinear processing units for feature extraction and transformation. Each successive layer uses the output from the previous layer as input. The algorithms may be supervised or unsupervised and applications include pattern analysis (unsupervised) and classification (supervised). • They are based on the (unsupervised) learning of multiple levels of features or representations of the data. Higher-level features are derived from lower-level features to form a hierarchical representation. • They are part of the broader machine learning field of learning representations of data. • They learn multiple levels of representations that correspond to different levels of abstraction; the levels form a hierarchy of concepts. These definitions have in common: multiple layers of nonlinear processing units and the supervised or unsupervised learning of feature representations in each layer, with the layers forming a hierarchy from low-level to high-level features. Various deep learning architectures such as deep neural networks, convolutional deep neural networks, deep belief networks (DBN), and recurrent neural networks have been applied to fields like computer vision, automatic speech recognition, natural language processing, audio recognition, and bioinformatics where they have been shown to produce state-of-the-art results on various tasks. In this chapter we start in Section 7.1 with an introduction, giving a brief history of this field, the relevant literature, and its applications. Then we study some basic concepts of deep learning such as convolutional neural networks, recurrent neural networks, backpropagation algorithm, restricted Boltzmann machines, and deep learning networks in Section 7.2. Then we illustrate three examples for Apache Spark implementation for mobile big data (MBD), user moving pattern extraction, and combination with nonparametric Bayesian learning, respectively, in Sections 7.3 through 7.5. Finally, we have summary in Section 7.6.

Simple SummaryBreast cancer is one of the leading causes of cancer death among women. Developing machine learning-based diagnosis models receives great attention from researchers and scientists using histopathology images. Deep learning (DL) algorithms automatically extract features from raw data through convolutional operations. The generalization of the DL models’ results relies on large datasets, although they eliminate the expert knowledge in the feature extraction stage. This work aimed to compare the performance of the features extracted via deep learning and a knowledge-based approach in breast cancer detection from histopathology images.Cancer develops when a single or a group of cells grows and spreads uncontrollably. Histopathology images are used in cancer diagnosis since they show tissue and cell structures under a microscope. Knowledge-based and deep learning-based computer-aided detection is an ongoing research field in cancer diagnosis using histopathology images. Feature extraction is vital in both approaches since the feature set is fed to a classifier and determines the performance. This paper evaluates three feature extraction methods and their performance in breast cancer diagnosis. Features are extracted by (1) a Convolutional Neural Network, (2) a transfer learning architecture VGG16, and (3) a knowledge-based system. The feature sets are tested by seven classifiers, including Neural Network (64 units), Random Forest, Multilayer Perceptron, Decision Tree, Support Vector Machines, K-Nearest Neighbors, and Narrow Neural Network (10 units) on the BreakHis 400× image dataset. The CNN achieved up to 85% for the Neural Network and Random Forest, the VGG16 method achieved up to 86% for the Neural Network, and the knowledge-based features achieved up to 98% for Neural Network, Random Forest, Multilayer Perceptron classifiers.

Convolutional Neural Network (CNN) models are a type of deep learning architecture introduced to achieve the correct classification of breast cancer. This paper has a two-fold purpose. The first aim is to investigate the various deep learning models in classifying breast cancer histopathology images. This study identified the most accurate models in terms of the binary, four, and eight classifications of breast cancer histopathology image databases. The different accuracy scores obtained for the deep learning models on the same database showed that other factors such as pre-processing, data augmentation, and transfer learning methods can impact the ability of the models to achieve higher accuracy. The second purpose of our manuscript is to investigate the latest models that have no or limited examination done in previous studies. The models like ResNeXt, Dual Path Net, SENet, and NASNet had been identified with the most cutting-edge results for the ImageNet database. These models were examined for the binary, and eight classifications on BreakHis, a breast cancer histopathology image database. Furthermore, the BACH database was used to investigate these models for four classifications. Then, these models were compared with the previous studies to find and propose the most state-of-the-art models for each classification. Since the Inception-ResNet-V2 architecture achieved the best results for binary and eight classifications, we have examined this model in our study as well to provide a better comparison result. In short, this paper provides an extensive evaluation and discussion about the experimental settings for each study that had been conducted on the breast cancer histopathology images.

Breast cancer is one of the most prevalent and chronic disease that affect women. To overcome this disease, effective medical treatment is required. Early detection of the disease plays an important role for suitable medication and survival of patient. To identify the breast cancer in the patients, standard imaging technique mammography is used. Due to the subtle and varied nature of cancer tissues interpreting mammogram images can be a challenge to doctors. Machine learning (ML) and Deep Learning (DL) techniques offer promising solutions that provide efficient breast cancer detection from mammograms. In this review paper a comprehensive review of ML and DL algorithms and their applications in mammogram image analysis are presented. Various supervised and unsupervised learning techniques, such as convolutional neural networks (CNNs), support vector machines (SVMs), random forests, and other popular ML and DL models are discussed in paper. The integration of these DL methods that are efficiently used in image preprocessing techniques, feature extraction, and classification strategies. The overall survey focusses on various performance metrics, datasets, and benchmarks used in existing studies. Further the strengths and limitations of different approaches used by various researchers are identified. By understating current research trends this paper aims to contribute to the ongoing development of more accurate and reliable breast cancer detection systems using advanced ML techniques.

Presented here are the results of an investigation conducted to determine the effectiveness of deep learning (DL)‐based systems utilizing the power of transfer learning for detecting breast cancer in histopathological images. It is shown that DL models that are not specifically developed for breast cancer detection can be trained using transfer learning to effectively detect breast cancer in histopathological images. The outcome of the analysis enables the selection of the best DL architecture for detecting cancer with high accuracy. This should facilitate pathologists to achieve early diagnoses of breast cancer and administer appropriate treatment to the patient. The experimental work here used the BreaKHis database consisting of 7909 histopathological pictures from 82 clinical breast cancer patients. The strategy presented for DL training uses various image processing techniques for extracting various feature patterns. This is followed by applying transfer learning techniques in the deep convolutional networks like ResNet, ResNeXt, SENet, Dual Path Net, DenseNet, NASNet, and Wide ResNet. Comparison with recent literature shows that ResNext‐50, ResNext‐101, DPN131, DenseNet‐169 and NASNet‐A provide an accuracy of 99.8%, 99.5%, 99.675%, 99.725%, and 99.4%, respectively, and outperform previous studies.

Breast cancer is the most common cancer worldwide with high death rate especially for women, early diagnosis can increase the survival opportunity with correct treatment in the hospital. The Computer-Assisted Diagnosis (CAD) system is of vital significant for improving the diagnostic accuracy as the diagnosis process is tedious and the result may be different between pathologists. In this paper, we proceed research on breast cancer histopathological images classification based on deep Convolutional Neural Network (CNN). The approach proposed in this work utilize CNN to extract features of histopathological images and classify the images into begin tumors and malignant tumors by softmax function. Eliminate overfitting phenomenon by data augmentation and fine tune technology while improving the performance of networks by cross validation training strategy. The experiments in this paper were conducted on BreaKHis database [4] available to scientific study from 2014 and the results proved the algorithm's advantage on accuracy.

ABSTRACTIn recent years, there has been a significant surge in the utilisation of deep learning and machine learning techniques for addressing complex and time‐intensive problems. The significance of employing deep learning becomes increasingly evident as the complexity of the problem increases. In the field of electromagnetics, the utilisation of deep learning techniques has exhibited exceptional efficacy across many applications, especially in wireless communications. In wireless communications, providing a structure that can simultaneously generate multiple beams and beamform them involves complexity and specific constraints. In this article, the time modulation technique is utilised to generate harmonics in the sidebands alongside the fundamental beam in various planar antenna arrays. By demonstrating the nonlinear shaping of the harmonic beams relative to each other, a novel approach is proposed that leverages deep learning techniques for the beamforming of both the fundamental beam and harmonic beams. In this regard, two models are proposed: a deep neural network (DNN) and a convolutional neural network (CNN). The input of CNN is comprised of two‐dimensional patterns of the main beam and harmonics. The input to DNN, on the other hand, includes useful details about the main beam and harmonics, such as their scanning angles, side lobe levels and directivities. The output of the models consists of the time modulation parameters of the array elements, including the pulse width and the pulse delay. The results demonstrate that DNN has achieved better accuracy and a shorter processing time in comprehending the relationship between the time modulation of array elements with different array dimensions and the radiation pattern of the fundamental beam and harmonic beams. Additionally, several samples are presented to evaluate the proposed model. The results demonstrate a high level of accuracy in fundamental beamforming, as well as in harmonic beamforming and beam steering.

Breast cancer detection is a highly fatal disease and is normally detected considering histopathological images (HPIs). However, the complexity of the HPIs makes it challenging to detect breast cancer accurately. Further, manual detection is highly time-consuming and subjective and depends on the experience of the medical professionals. To overcome these issues, an effective deep learning (DL) method for detecting breast cancer from HPIs is proposed. Here, the proposed approach is realized using various processes, such as pre-processing, blood cell segmentation, feature extraction, and classification. Segmentation is accomplished using the SegAN, and classification is performed using the deep convolutional neural network (DCNN). Both networks are trained using the proposed invasive water Ebola optimization (IWEO) algorithm. The efficiency of breast cancer detection is improved by using various features, such as shape features, histogram of gradients (HOG) and local gradient patterns (LGP). Further, the IWEO-DCNN is inspected for its dominance by considering measures, such as accuracy, test negative rate (TNR) and test positive rate (TPR), and the experimental results show that the IWEO-DCNN attained a maximal accuracy of 0.963, TNR of 0.963 and TPR of 0.950.

Recent advancements in deep learning, particularly convolutional networks, have rapidly become the preferred methodology for analyzing medical images, facilitating tasks like disease segmentation, classification, and pattern quantification. Central to these advancements is the capacity to leverage hierarchical feature representations acquired solely from data. This comprehensive review meticulously examines a variety of deep learning techniques applied across diverse healthcare domains, delving into the intricate realm of medical imaging to unveil concealed patterns through strategic deep learning methodologies. Encompassing a range of diseases, including Alzheimer’s, breast cancer, brain tumors, glaucoma, heart murmurs, retinal microaneurysms, colorectal liver metastases, and more, the analysis emphasizes contributions succinctly summarized in a tabular form.The table provides an overview of various deep learning approaches applied to different diseases, incorporating methodologies, datasets, and outcomes for each condition.Notably, performance metrics such as accuracy, specificity, sensitivity, and other crucial measures underscore the achieved results. Specifically, an in-depth discussion is conducted on the Convolutional Neural Network (CNN) owing to its widespread adoption as a paramount tool in computer vision tasks. Moreover, an exhaustive exploration encompasses deep learning classification approaches, procedural aspects of medical image processing, as well as a thorough examination of key features and characteristics. At the end, we delve into a range of research challenges and put forth potential avenues for future improvements in the field.

This article explains how deep learning and machine learning techniques are being utilized to replace humans in a variety of activities, like item classification and sound addition. It emphasizes handwritten text recognition (HTR), which involves computers interpreting handwritten content from sources like paper documents and touchscreens. For recognizing handwritten digits, the study analyzes three algorithms: support vector machines (SVM), multilayer perception (MLP), and convolutional neural networks (CNN). This comparison aims to evaluate the correctness and execution times of different approaches. The evaluation is based on parameters like the dataset used, the number of epochs, algorithm complexity, accuracy, and hardware specifications. The study compares the effectiveness of CNN, Multilayer Perception (MLP), and Support Vector Machines using handwritten digits from the MNIST dataset. It evaluates these algorithms based on criteria such as runtime, complexity, rate of precision, the count of epochs, and the quantity of hidden layers specifically within deep learning techniques. SVM had the highest training data accuracy, but CNN outperformed others on the test dataset. The article’s primary goal is to identify the most precise model for recognizing handwritten digits. It achieves this by assessing the performance of different algorithms and comparing them based on various characteristics.

Breast cancer remains one of the principal reasons of death among women worldwide, highlighting the critical requirement for primary and exact diagnosis to expand patient persistence rates. Manual clarification of histopathological slides is frequently subjective, time-consuming, and prone to inter-observer unpredictability. Recent developments in machine learning (ML) and deep learning (DL) techniques have renovated histopathological image analysis by qualifying automated, consistent, and reproducible diagnostic systems. This review analysis thoroughly observes research from 2018 to 2025, covering advanced methods for breast cancer detection based on histopathological images, with feature extraction, feature selection, and classification strategies, and medical image investigations. In this study compares existing ML methods, convolutional neural networks (CNN), vision transformers (ViT), graph convolutional networks (GCN), ensemble learning and hybrid frameworks across numerous standard and multiple benchmark datasets. Performance comparisons encompass filter-based, wrapper-based, hybrid, and ensemble learning models. In this study highlights the benefits of AI-driven diagnostic systems such as enhanced accuracy, scalability, and consistency, while addressing key challenges including data discrepancy, inadequate interpretability, and high computational cost. This comparative review highlights publicly accessible datasets, standard architectures, and emerging techniques in explainable artificial intelligence, ViT, and federated learning. Finally, potential directions for future research are drawn to guide researchers, clinicians, and developers in the direction of proceeding intelligent systems for breast cancer histopathological diagnosis.

Breast cancer is the most prevalent cancer globally and presents a significant threat to human health. The low survival rate for advanced stages highlights the importance of early and accurate diagnosis. Pathology images, providing insights into cancer's cellular aggressiveness, are crucial for breast cancer diagnosis. Advances in deep learning have transformed automated medical image diagnosis. However, traditional deep learning methods, reliant on large labeled datasets, face challenges with the typically small size of medical image datasets. To overcome this, our study combines deep transfer learning (DTL) with convolutional neural networks(CNN). We utilize and enhance a ResNet50 model pretrained on a large dataset. Additionally, we apply four different deep transfer learning methods to feature extraction and classification of the BreakHis dataset, aiming to determine if breast cancer is benign or malignant. Ultimately, our system achieved the best average accuracy rates under four different magnifications: 98.57%, 96.83%, 97.76%, and 97.16%. These results demonstrate the accuracy and potential of deep transfer learning in classifying breast cancer histopathological images and its promising application in tumor prediction.

Medulloblastoma (MB) is a dangerous malignant pediatric brain tumor that could lead to death. It is considered the most common pediatric cancerous brain tumor. Precise and timely diagnosis of pediatric MB and its four subtypes (defined by the World Health Organization (WHO)) is essential to decide the appropriate follow-up plan and suitable treatments to prevent its progression and reduce mortality rates. Histopathology is the gold standard modality for the diagnosis of MB and its subtypes, but manual diagnosis via a pathologist is very complicated, needs excessive time, and is subjective to the pathologists’ expertise and skills, which may lead to variability in the diagnosis or misdiagnosis. The main purpose of the paper is to propose a time-efficient and reliable computer-aided diagnosis (CADx), namely MB-AI-His, for the automatic diagnosis of pediatric MB and its subtypes from histopathological images. The main challenge in this work is the lack of datasets available for the diagnosis of pediatric MB and its four subtypes and the limited related work. Related studies are based on either textural analysis or deep learning (DL) feature extraction methods. These studies used individual features to perform the classification task. However, MB-AI-His combines the benefits of DL techniques and textural analysis feature extraction methods through a cascaded manner. First, it uses three DL convolutional neural networks (CNNs), including DenseNet-201, MobileNet, and ResNet-50 CNNs to extract spatial DL features. Next, it extracts time-frequency features from the spatial DL features based on the discrete wavelet transform (DWT), which is a textural analysis method. Finally, MB-AI-His fuses the three spatial-time-frequency features generated from the three CNNs and DWT using the discrete cosine transform (DCT) and principal component analysis (PCA) to produce a time-efficient CADx system. MB-AI-His merges the privileges of different CNN architectures. MB-AI-His has a binary classification level for classifying among normal and abnormal MB images, and a multi-classification level to classify among the four subtypes of MB. The results of MB-AI-His show that it is accurate and reliable for both the binary and multi-class classification levels. It is also a time-efficient system as both the PCA and DCT methods have efficiently reduced the training execution time. The performance of MB-AI-His is compared with related CADx systems, and the comparison verified the powerfulness of MB-AI-His and its outperforming results. Therefore, it can support pathologists in the accurate and reliable diagnosis of MB and its subtypes from histopathological images. It can also reduce the time and cost of the diagnosis procedure which will correspondingly lead to lower death rates.

Mitosis detection and classification for breast cancer diagnosis: What we know and what is next.

Automated invasive ductal carcinoma detection based using deep transfer learning with whole-slide images