Imaginary Finger Control Detection Algorithm Using Deep Learning with Brain Computer Interface (BCI)

Recent technological advancements allow deep learning to be employed in practically every aspect of life. Because deep learning techniques are so precise, they can be used in medicine to classify and detect various diseases. The coronavirus (SARSCoV2) epidemic has recently affected global health systems. One of the ways to diagnose SARSCoV2 is with a chest X-ray. This paper proposes a deep learning technique to distinguish SARSCoV2 positive and normal cases. In this study, we fine-tuned the deep learning models and hyperparameters, and the fine-tuned deep learning models performed significantly better. To classify X-ray images, we developed a system based on deep learning algorithms that includes five models: Xception, VGG19, ResNet50, DenseNet121, and Inception. We offer deep learning models and algorithms that have been trained and evaluated to support medical efforts and reduce medical staff workload when dealing with SARSCoV2. In addition, the classification model that was proposed yields positive results because it makes use of accurate classification of the SARSCoV2 disease based on medical images. Additionally, the performance of our proposed CNN classification method for medical imaging was evaluated using various edge-based neural networks. The accuracy of tertiary classification with CNN will decrease as the number of classes in the training network grows. In tertiary classification, which includes normal and SARSCoV2 positive images, the proposed model achieved a 0.9897 accuracy. The proposed algorithm achieves a high level of classification accuracy when using the DenseNet121 model for binary classification.

Insect taxonomy lies at the heart of many aspects of ecology, and identification tasks are challenging due to the enormous inter- and intraspecies variation of insects. Conventional methods used to study insect taxonomy are often tedious, time-consuming, labor intensive, and expensive, and recently, computer vision with deep learning algorithms has offered an alternative way to identify and classify insect images into their taxonomic levels. We designed the classification task according to the taxonomic ranks of insects—order, family, and genus—and compared the generalization of four state-of-the-art deep convolutional neural network (DCNN) architectures. The results show that different taxonomic ranks require different deep learning (DL) algorithms to generate high-performance models, which indicates that the design of an automated systematic classification pipeline requires the integration of different algorithms. The InceptionV3 model has advantages over other models due to its high performance in distinguishing insect order and family, which is having F1-score of 0.75 and 0.79, respectively. Referring to the performance per class, Hemiptera (order), Rhiniidae (family), and Lucilia (genus) had the lowest performance, and we discuss the possible rationale and suggest future works to improve the generalization of a DL model for taxonomic rank classification.

Background Machine learning (ML) algorithm support vector machine (SVM) performed better than Thrombolysis in Myocardial Infarction (TIMI) score for ASIAN STEMI patients. However, Deep Learning (DL) effectiveness in the multiethnic ASIAN population has yet to be determined. DL has automatic learning of the feature from a given dataset without the need to conduct feature selection. However, the selected features by the algorithm is black box. Identifying features associated with mortality is essential to recognize characteristics of patients with high risk for better patient management. Purpose To develop a DL algorithm for in-hospital mortality in multiethnic STEMI patients using predictors identified from the SVM algorithm. To investigate DL performance constructed using predictors from SVM feature extraction and expert-recommended predictors. Methods We constructed four algorithms; a) DL and SVM algorithms with predictors identified from the SVM variable importance b) DL and SVM using predictors based on expert recommendation. We used registry data from the National Cardiovascular Disease Database of 11397 patient's. Fifty parameters including demographics, cardiovascular risk, medications and clinical variables were considered. The Area under the curve (AUC) is the performance evaluation metric. Algorithms were validated against the TIMI and tested using the same validation data. SVM variable importance with backward elimination was used to select and rank important variables. Results DL algorithms outperform SVM and TIMI on the validation dataset; i) DL with SVM selected predictors (15 predictors, AUC = 0.97), ii) DL with expert-recommended predictors (16 predictors, AUC = 0.96), iii) SVM with selected predictors (15 predictors, AUC = 0.92), iv) SVM with expert-recommended predictors (AUC = 0.89) and TIMI (AUC = 0.82). Common predictors across SVM feature selection, expert-recommendation and TIMI are: age, heart rate, Killip class, fasting blood glucose, systolic blood pressure, comorbid diseases and ST-elevation. SVM feature selection also identified diuretics, PCI and pharmacotherapy drugs as predictors that improve mortality prediction in STEMI patients. Our findings suggest that the TIMI score underestimates patients risk of mortality. DL algorithm using selected predictors classified 35% of nonsurvival patients as high risk (risk probabilities >50%) compared to only 12.7% nonsurvival patients by TIMI (score >5) (Figure below). Conclusions In the ASIAN population, patients with STEMI can be better classified using the DL algorithm compared to the ML and TIMI score. Combining ML feature selection with DL allows the identification of distinct factors in a unique ASIAN population for better mortality prediction than relying solely on an expert recommendation as it is a very subjective approach. Continuous validation on population-specific algorithms using DL and ML is needed before implementing in a real clinical setting. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Technology Development Fund 1 TIMI performance on validation setDL performance on validation set

Enhancing the Social Impact of Contemporary Music with Neurotechnology

Deep learning has gained immense popularity in scientific computing, and its algorithms are widely used in complex problem-solving industries. Every deep learning algorithm use different types of neural networks to perform indented tasks. Deep learning (DL) algorithms have emerged from different machine learning and soft computing methodologies. Since then, a number of deep learning (DL) algorithms have been recently introduced in the scientific community and applied in various application fields. Today, the use of DLs has become indispensable due to their intelligence, effective learning, accuracy and reliability in model creation. However, a comprehensive list of DL algorithms has not yet been presented in the scientific literature. This article lists the most popular DL algorithms and their application areas. Deep learning uses ANN artificial neural networks to perform convoluted calculations on huge amounts of data. It is a type of machine learning based on the structure and function of the human brain. Deep learning algorithms train machines by learning from examples. Industries such as healthcare, e-commerce, entertainment and advertising often use deep learning.

Improving the performance of machine learning algorithms to overcome the curse of dimensionality while maintaining interpretability is still a challenging issue for researchers in artificial intelligence. Patch learning (PL), based on the improved adaptive network-based fuzzy inference system (ANFIS) and continuous local optimization for the input domain, is characterized by high accuracy. However, PL can only handle low-dimensional data set regression. Based on the parallel and serial ensembles, two deep patch learning algorithms with embedded adaptive fuzzy systems (DPLFSs) are proposed in this paper. First, using the maximum information coefficient (MIC) and Pearson's correlation coefficients for feature selection, the variables with the least relationship (linear or nonlinear) are excluded. Second, principal component analysis is used to reduce the complexity further of DPLFSs. Meanwhile, fuzzy C-means clustering is used to enhance the interpretability of DPLFSs. Then, an improved PL method is put forward for the training of each sub-fuzzy system in a fashion of bottom-up layer-by-layer, and finally, the structure optimization is performed to significantly improve the interpretability of DPLFSs. Experiments on several benchmark data sets show the advantages of a DPLFS: (1) it can handle medium-scale data sets; (2) it can overcome the curse of dimensionality faced by PL; (3) its precision and generalization are greatly improved; and (4) it can overcome the poor interpretability of deep learning networks. Compared with shallow and deep learning algorithms, DPLFSs have the advantages of interpretability, self-learning, and high precision. DPLFS1 is superior for medium-scale data; DPLFS2 is more efficient and effective for high-dimensional problems, has a faster convergence, and is more interpretable.

BackgroundMachine learning (ML) algorithm support vector machine (SVM) performed better than Thrombolysis in Myocardial Infarction (TIMI) score for ASIAN STEMI patients. However, Deep Learning (DL) effectiveness in the multiethnic ASIAN population has yet to be determined. DL has automatic learning of the feature from a given dataset without the need to conduct feature selection. However, the selected features by the algorithm is black box. Identifying features associated with mortality is essential to recognize characteristics of patients with high risk for better patient management.PurposeTo develop a DL algorithm for in-hospital mortality in multiethnic STEMI patients using predictors identified from the SVM algorithm. To investigate DL performance constructed using predictors from SVM feature extraction and expert-recommended predictors.MethodsWe constructed four algorithms; a) DL and SVM algorithms with predictors identified from the SVM variable importance b) DL and SVM using predictors based on expert recommendation. We used registry data from the National Cardiovascular Disease Database of 11397 patient's. Fifty parameters including demographics, cardiovascular risk, medications and clinical variables were considered. The Area under the curve (AUC) is the performance evaluation metric. Algorithms were validated against the TIMI and tested using the same validation data. SVM variable importance with backward elimination was used to select and rank important variables.ResultsDL algorithms outperform SVM and TIMI on the validation dataset; i) DL with SVM selected predictors (15 predictors, AUC = 0.97), ii) DL with expert-recommended predictors (16 predictors, AUC = 0.96), iii) SVM with selected predictors (15 predictors, AUC = 0.92), iv) SVM with expert-recommended predictors (AUC = 0.89) and TIMI (AUC = 0.82). Common predictors across SVM feature selection, expert-recommendation and TIMI are: age, heart rate, Killip class, fasting blood glucose, systolic blood pressure, comorbid diseases and ST-elevation. SVM feature selection also identified diuretics, PCI and pharmacotherapy drugs as predictors that improve mortality prediction in STEMI patients. Our findings suggest that the TIMI score underestimates patients risk of mortality. DL algorithm using selected predictors classified 35% of nonsurvival patients as high risk (risk probabilities >50%) compared to only 12.7% nonsurvival patients by TIMI (score >5) (Figure below).ConclusionsIn the ASIAN population, patients with STEMI can be better classified using the DL algorithm compared to the ML and TIMI score. Combining ML feature selection with DL allows the identification of distinct factors in a unique ASIAN population for better mortality prediction than relying solely on an expert recommendation as it is a very subjective approach. Continuous validation on population-specific algorithms using DL and ML is needed before implementing in a real clinical setting.Funding AcknowledgementType of funding sources: Public grant(s) – National budget only. Main funding source(s): Technology Development Fund 1TIMI performance on validation setDL performance on validation set

Feature mining for encrypted malicious traffic detection with deep learning and other machine learning algorithms

Variation in human brains creates difficulty in implementing electroencephalography into universal brain–machine interfaces. Conventional electroencephalography systems typically suffer from motion artefacts, extensive preparation time and bulky equipment, while existing electroencephalography classification methods require training on a per-subject or per-session basis. Here, we introduce a fully portable, wireless, flexible scalp electronic system, incorporating a set of dry electrodes and a flexible membrane circuit. Time-domain analysis using convolutional neural networks allows for accurate, real-time classification of steady-state visually evoked potentials in the occipital lobe. Compared to commercial systems, the flexible electronics show the improved performance in detection of evoked potentials due to significant reduction of noise and electromagnetic interference. The two-channel scalp electronic system achieves a high information transfer rate (122.1 ± 3.53 bits per minute) with six human subjects, allowing for wireless, real-time, universal electroencephalography classification for an electric wheelchair, a motorized vehicle and a keyboard-less presentation. Brain–machine interfaces using steady-state visually evoked potentials (SSVEPs) show promise in therapeutic applications. With a combination of innovations in flexible and soft electronics and in deep learning approaches to classify potentials from two channels and from any subject, a compact, wireless and universal SSVEP interface is designed. Subjects can operate a wheelchair in real time with eye movements while wearing the new brain–machine interface.

Deep Learning (DL) algorithms have become the de facto Machine Learning (ML) algorithm for large scale data analysis. DL algorithms are computationally expensive -- even distributed DL implementations which use MPI require days of training (model learning) time on commonly studied datasets. Long running DL applications become susceptible to faults -- requiring development of a fault tolerant system infrastructure, in addition to fault tolerant DL algorithms. This raises an important question: What is needed from MPI for designing fault tolerant DL implementations? In this paper, we address this problem for permanent faults. We motivate the need for a fault tolerant MPI specification by an in-depth consideration of recent innovations in DL algorithms and their properties, which drive the need for specific fault tolerance features. We present an in-depth discussion on the suitability of different parallelism types (model, data and hybrid); a need (or lack thereof) for check-pointing of any critical data structures; and most importantly, consideration for several fault tolerance proposals (user-level fault mitigation (ULFM), Reinit) in MPI and their applicability to fault tolerant DL implementations. We leverage a distributed memory implementation of Caffe, currently available under the Machine Learning Toolkit for Extreme Scale (MaTEx). We implement our approaches by extending MaTEx-Caffe for using ULFM-based implementation. Our evaluation using the ImageNet dataset and AlexNet, and GoogLeNet neural network topologies demonstrates the effectiveness of the proposed fault tolerant DL implementation using OpenMPI based ULFM.

Undoubtedly one of the most important strands of the brain-computer interface (BCI) method is an alternate communication method via brain signals. BCI converts electroencephalogram (EEG) signals from a perception of activity in the brain into user action utilising software and hardware. BCI has piqued the interest of researchers in a wide range of disciplines, such as cognitive science, deep learning, pattern matching, drug treatment medicine, etc. Patients suffering from neuro and cognitive disorders can be assisted through BCI, potentially enabling communication via gestures or just mental imagination. In this paper, a novel combination of Discrete Wavelet Transform (DWT) for extracting the best features and Long Short-Term Memory (LSTM) based Recurrent Neural Network (RNN) is adopted for classifying the EEG signals acquired during standing, walking and running on a treadmill. The dataset used is freely downloaded from Open Science Framework repository. The proposed DWT-LSTMRNN method delivers 96.7% accuracy while classifying four different signals, and thus has the potential to be investigated further on BCI competition datasets that will pave way for a real-time application.

BackgroundPattern of emphysema at chest CT, scored visually by using the Fleischner Society system, is associated with physiologic impairment and mortality risk.PurposeTo determine whether participant-level emphysema pattern could predict impairment and mortality when classified by using a deep learning method.Materials and MethodsThis retrospective analysis of Genetic Epidemiology of COPD (COPDGene) study participants enrolled between 2007 and 2011 included those with baseline CT, visual emphysema scores, and survival data through 2018. Participants were partitioned into nonoverlapping sets of 2407 for algorithm training, 100 for validation and parameter tuning, and 7143 for testing. A deep learning algorithm using convolutional neural network and long short-term memory architectures was trained to classify pattern of emphysema according to Fleischner criteria. Deep learning scores were compared with visual scores and clinical parameters including pulmonary function tests. Cox proportional hazard models were used to evaluate relationships between emphysema scores and survival. The algorithm was also tested by using CT and clinical data in 1962 participants enrolled in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study.ResultsA total of 7143 COPDGene participants (mean age ± standard deviation, 59.8 years ± 8.9; 3734 men and 3409 women) were evaluated. Deep learning emphysema classifications were associated with impaired pulmonary function tests, 6-minute walk distance, and St George's Respiratory Questionnaire at univariate analysis (P < .001 for each). Testing in the ECLIPSE cohort showed similar associations (P < .001). In the COPDGene test cohort, deep learning emphysema classification improved the fit of linear mixed models in the prediction of these clinical parameters compared with visual scoring (P < .001). Compared with participants without emphysema, mortality was greater in participants classified by the deep learning algorithm as having any grade of emphysema (adjusted hazard ratios were 1.5, 1.7, 2.9, 5.3, and 9.7, respectively, for trace, mild, moderate, confluent, and advanced destructive emphysema; P < .05).ConclusionDeep learning automation of the Fleischner grade of emphysema at chest CT is associated with clinical measures of pulmonary insufficiency and the risk of mortality.© RSNA, 2019Online supplemental material is available for this article.

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that causes progressive loss of voluntary movement, including the ability to speak. As the disease rapidly progresses, there is a need for augmented and alternative communication that removes physical barriers required for engagement. Brain-Computer Interfaces (BCI) are a technology that allow for communication using only brain signals in response to visual stimuli. This project aimed to design an accessible and practical BCI for continuous, at-home use, and to increase BCI usability by using familiar facial stimuli to elicit a stronger brain response. The overall goal for enhancement of BCI usability is to maximize ease of use for individuals with ALS and their caregivers so that BCI technologies can make a useful impact and improve the everyday lives of people with ALS. In this project, a new miniaturized and low-cost P300 BCI system was designed using wireless and battery-operated EEG neuroimaging, modular software, and the use of an individualized BCI presentation stimuli. A 3-dimensional virtual environment platform was integrated as a navigational control output mechanism that executes commands received from the BCI to move a user's avatar in a virtual maze. Together, these form the virtual environment BCI (veBCI). The BCI stimuli presentation consisted of a custom approach of integrating different human face images with the aim of increasing user engagement and elicited brain activity, and therefore improving BCI online accuracy. The impact and effectiveness of the approach was tested via a verification BCI study in which 6 different stimuli conditions were utilized: male celebrity face, female celebrity face, male stranger face, female stranger face, a family member/close friend of the participant, and blank/no face as a control. A total of 16 volunteers (average age 56.5 and eight diagnosed with ALS) used the BCI system with all 6 face conditions in ecologically valid settings. Results indicate that this new miniaturized BCI is usable for both people with ALS and healthy controls. Significant differences existed in the amplitude of the P300 response in ALS and healthy controls. Additionally, differences between male and female participants demonstrated the potential role of personalization to optimize the visually evoked potential response and further increase BCI online accuracy. In conclusion, a home-use P300 BCI system was developed with a new generation of miniaturized, low-cost, and mobile neuroimaging running on an embedded computational platform. BCI stimuli with human face inclusion could help personalization of the BCI. Furthermore, virtual environments provide unique new ways to implement BCI output beyond typical spelling tasks and communication. Future work could focus on developing dedicated online signal processing to eliminate noise and improve online accuracy during home use.

BackgroundDeep learning (DL) based solutions have been proposed for interpretation of several imaging modalities including radiography, CT, and MR. For chest radiographs, DL algorithms have found success in the evaluation of abnormalities such as lung nodules, pulmonary tuberculosis, cystic fibrosis, pneumoconiosis, and location of peripherally inserted central catheters. Chest radiography represents the most commonly performed radiological test for a multitude of non-emergent and emergent clinical indications. This study aims to assess accuracy of deep learning (DL) algorithm for detection of abnormalities on routine frontal chest radiographs (CXR), and assessment of stability or change in findings over serial radiographs.Methods and findingsWe processed 874 de-identified frontal CXR from 724 adult patients (> 18 years) with DL (Qure AI). Scores and prediction statistics from DL were generated and recorded for the presence of pulmonary opacities, pleural effusions, hilar prominence, and enlarged cardiac silhouette. To establish a standard of reference (SOR), two thoracic radiologists assessed all CXR for these abnormalities. Four other radiologists (test radiologists), unaware of SOR and DL findings, independently assessed the presence of radiographic abnormalities. A total 724 radiographs were assessed for detection of findings. A subset of 150 radiographs with follow up examinations was used to asses change over time. Data were analyzed with receiver operating characteristics analyses and post-hoc power analysis.ResultsAbout 42% (305/ 724) CXR had no findings according to SOR; single and multiple abnormalities were seen in 23% (168/724) and 35% (251/724) of CXR. There was no statistical difference between DL and SOR for all abnormalities (p = 0.2–0.8). The area under the curve (AUC) for DL and test radiologists ranged between 0.837–0.929 and 0.693–0.923, respectively. DL had lowest AUC (0.758) for assessing changes in pulmonary opacities over follow up CXR. Presence of chest wall implanted devices negatively affected the accuracy of DL algorithm for evaluation of pulmonary and hilar abnormalities.ConclusionsDL algorithm can aid in interpretation of CXR findings and their stability over follow up CXR. However, in its present version, it is unlikely to replace radiologists due to its limited specificity for categorizing specific findings.

Brain-Computer Interface: Current and Emerging Rehabilitation Applications