Immune Response

Abstract

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The gastrointestinal epithelium is believed to induce tolerance in Dept. Microbiology, Univerity College, Galway, Eire epithelial T cells under normal conditions. During inflammation, Purpose. IL-8 secretion is induced in gastric epithelial cell epithelial cells may become immunogenic and have the potential to lines by H. pylori (Hp) in a strain-specific manner. The activate CD4+ T cells. The induction of anergy or reactivity may be response of gastric epithelial cells to lipopolysaccharide controlled by the differential expression of adhesion molecules (LPS) of gastrointestinal flora is relevant to both Hp-induced necessary for T cell activation. As there is a marked infiltration of chronic gastritis and bacterial overgrowth in the achlorhy- the gastric epithelium with activated CD4 T cells during infection effects of LPS from different bacteria on IL-B secretion from with H. pylor;, we have studied the effect of cytokines induced gastric and colonic cell lines.