Immunity and Ayurveda

Motor delay image recognition based on deep learning and human skeleton model

Acupuncture in pain management

Urogenital System Damaging Manifestations of 3 Human Infected Coronaviruses.

The Extensive Study of Adygean Ethno- Music and Sound Therapy in the North Caucasus Mountains Influenced the Hypothetical Design of a Therapeutical Sound System Capable of Creating Balance and Symmetry in the Human Body With Energetically Forced, Sympathetic Resonance and Entrainment

In order to record the mechanical movements of heart and aorta, an apparatus for rheography was originated for trial by our research group. Having examined this apparatus and method. we made studies on the rheograms of the healthy and of the arrhythmic patients followed by considerations of its clinical significances. 1) On rheography the A.C. bridge has been used as a transducer, i.e. one electrode is placed on the anterior chest wall and another on the back, positioning so that the heart or aorta to become in between them, connecting both to one arm of A.C. bridge, and 40 KC more or less frequency A.C. was transmitted. This apparatus is possible to record the mechanical movements of heart or aorta by the fluctuation of unbalanced current of A.C. bridge caused through the changes of impedance between the both electrodes. 2) An impedance equivalent to that of human body has been measured and have noticed that the values of phase angles of human body impedance are constantly negative and its absolute values decrease in accordance with the frequency increase. Hence, it became known that this A.C. bridge requires relatively simple composition : i.e. the arm of fixed impedance value is necessary for resistance only, and the other arm for adjustment may be joined in series both resistance and capacitance. 3) Having studied the characteristics of the A.C. bridge as a transducer, we have also noticed that the fluctuation of unbalanced current of the A.C. bridge is in proportion to the human body, in case the arm impedance fluctuation joined to body compared to the electrodes impedance, is negligibly small. Theoretically and from the results of our experimental researches, the bridge with equal absolute value of impedance on every arm was found to be most sensitive and advantageous for this experiment, from the viewpoint of this apparatus structure. On the other hand, through the outcome of our examination on the convergent loci of the A.C. bridge, the A.C. bridge as a transducer has been also recognized as most sensitive in case used in the slightly unbalanced state. Whereas, when recording the rheograms of heart or aorta, we have arrived at the conclusion that it is most advantageous to be recorded in the unbalanced state of slightly increased resistance and capacitance (from the balanced state). 4) We have devised a calibrating method to calibrate the fluctuation of impedance between the 2 electrodes as a vector; That is, the determination of vector value induced from the deviated curve which is caused by changing resistance and capacitance of the arm for adjustment respectively in the course of recording. 5) The A.C. distribution in a piece of fish-flesh was examined. Also we further studied the wave forms of rheograms by placing electrodes on several parts of human body. From these experiments in case a small electrode is uesd, we have recognized that the current density of the place adjacent to the electrode was greatest.

Equilibrium is a very complex function and involves many systems, including the somatic-sensory, vestibular and visual systems. The condition of balance is maintained until the gravity center falls into the perimeter of support, defined as the ground level of the support base. Equilibrium loss is at the root of the risk of falling down, and represents a public health issue associated with remarkable costs for hospitalization, risk of residual disability and death for the elderly. Osteopathy can be a good ally that allows the human body to oppose gravitational force in a functional and ergonomic way. Osteopathy represents a medical approach complementary to healthcare and could be a non-invasive approach to improve and support traditional medicine in different physiological and pathological conditions. The aim of this study is to evaluate the cause-effect relationship between Manipulative Osteopathic Treatment (OMT) and its effects on equilibrium through stabilometric examinations. The 63 chosen subjects, including 23 females and 40 males, were between 18 and 45 years old, with a mean age of 29. Subjects were randomly divided into two groups: Manipulative Osteopathic Treatment (OMT) and Non Touch group (NON TOUCH). We can confirm that the tonic-postural response was more marked in the OMT group, with a statistic relevance both for the ellipse surface and the tangle length, with better stability and consequent energy saving in treated subjects. There were not statistically relevant variations for the NON TOUCH group. Therefore, it seems that Manipulative Osteopathic Treatment (OMT) influences stabilometry. However, posture influence due to Manipulative Osteopathic Treatment (OMT) should be evaluated with short- and long-term follow-ups, and with a larger sample size to test the administration of osteopathic treatments, in order to define an adequate work plan time period to prevent equilibrium loss.

Recent advancements in bone tissue biomarker research have identified 2 promising molecules: Dickkopf-1 and secreted Frizzled-Related Protein 5. This study aims to evaluate the levels of these biomarkers in gingival crevicular fluid in periodontal health, gingivitis, and periodontitis and to assess the effects of non-surgical periodontal treatment on these biomarkers. A total of 99 adult subjects were included in this study, divided into 3 groups: 33 periodontally healthy individuals, 33 with gingivitis, and 33 with periodontitis. Patients in the gingivitis and periodontitis groups received non-surgical periodontal treatment. Periodontal clinical parameters were recorded, and gingival crevicular fluid levels of biomarkers were analyzed by enzyme-linked immunosorbent assay at baseline and 6-8 weeks post-treatment. Pre-treatment Dickkopf-1 levels were found to be highest in the periodontitis group (p<0.001). Conversely, secreted Frizzled-Related Protein 5 levels were highest in the healthy group (p<0.001). Post-treatment, a statistically significant reduction in Dickkopf-1 levels was observed in the gingivitis (p=0.015) and periodontitis (p<0.001) groups, while secreted Frizzled-Related Protein 5 levels significantly increased (respectively, p=0.008 and p<0.001). A statistically significant weak negative correlation was identified between total Dickkopf-1 and secreted Frizzled-Related Protein 5 levels (τ=-0.117, p=0.027). Receiver operating characteristic curve analysis to assess diagnostic performance between periodontal health and periodontitis revealed an area under the curve of 0.938 for Dickkopf-1 and 0.803 for secreted Frizzled-Related Protein 5. These biomarkers could serve as valuable biomarkers in the pathogenesis of periodontal disease. Non-surgical periodontal treatment significantly affects the levels of these biomarkers, indicating their potential utility in monitoring therapeutic outcomes. In the human body, bone tissue is in a state of constant balance of production and destruction. This balance supports the maintenance of the mechanical integrity of the skeleton and the regulation of calcium and phosphorus levels. Bone markers have been developed to monitor various bone diseases and the effect of treatments without any interventional procedures. Dickkopf-1 (Dkk-1) and secreted Frizzled-Related Protein 5 (sFRP5) are two of the current bone markers that play a role in the balance of bone formation and destruction in the human body. The presence of these molecules in periodontal diseases, which cause inflammation and bone destruction in the gingiva surrounding the teeth, is not yet clear. In this study, Dkk-1 and sFRP5 levels were investigated in periodontal diseases, and the effect of treatment of periodontal diseases on these molecules was evaluated. In the transition from periodontal disease to health, Dkk-1 levels decreased while sFRP5 levels increased. Consistent with these results, Dkk-1 levels decreased in all groups after treatment, while sFRP5 levels increased. In conclusion, Dkk-1 and sFRP5 may serve as valuable markers for the early diagnosis of periodontal disease, and non-surgical periodontal treatment may significantly affect the levels of these markers, demonstrating their potential utility in monitoring treatment outcomes.

The purpose of the study is to examine issues arising in the legislation of Kazakhstan and law enforcement practice governing legal relations between the parties to the surrogacy agreement. The theoretical and practical significance of the study lies in the fact that its results can be taken into account by legislators when amending and supplementing legislative acts on healthcare issues, by practitioners when drafting surrogacy agreements, theorists when preparing teaching materials on medical and reproductive law, and citizens when exercising their constitutional right to health protection through the use of surrogacy. The study concludes that the existing difficulties in the application of surrogacy arise, first, from the fact that surrogacy remains outside the scope of comprehensive state legal regulation. Second, to the legal conflicts, gaps, and other defects in the legislation of Kazakhstan regulating the application of assisted reproductive methods and technologies legal conflicts, gaps, and other defects that prevent citizens from exercising their constitutional right to reproductive health, motherhood, and fatherhood, as well as the regulation of legal relations between persons involved in the use of surrogacy. Third, uncertainty or misunderstanding of the procedure itself for fertilizing male and female sex cells outside the human body, the procedure for transferring and implanting a human embryo into a gestational carrier – a third party providing services for carrying a pregnancy and giving birth to children who are genetically unrelated to them – as well as the legal nature and all essential terms of a surrogacy agreement, such as: the main subject and object, the scope of rights and obligations of the parties, and the limits and measures of responsibility of the participants in the process. The reliability of the obtained results is ensured by the chosen methodological basis of the research, which includes a set of general scientific theoretical and special private practical methods of cognition.

Microbial dysbiosis and epigenetics modulation in cancer development – A chemopreventive approach

The suppression of reproductive function is known to occur in women engaging in activities that require high energetic expenses, such as sport participation and subsistence work. It is still unclear, however, if reproductive suppression is a response to high levels of energy expenditure, or only to the resulting state of negative energy balance. To our knowledge, this study provides the first evidence that work-related energy expenditure alone, without associated negative energy balance, can lead to the suppression of reproductive function in women. We document suppression of ovarian function expressed as lowered salivary progesterone levels in women from an agricultural community who work hard, but remain in neutral energy balance. We propose two alternative evolutionary explanations (the 'pre-emptive ovarian suppression' hypothesis and the 'constrained down-regulation' hypothesis) for the observed results.

A novel approach is introduced to explain the appearance of telepathy‐like effects as the consequence of disturbances in the normal equilibration or ‘equilibrated non‐equilibrium’ of ordinary human experience. A new electromagnetic version of Freud’s psychoanalytic model is proposed, which begins by treating the mind as a charged object that interacts with others and the environment in a generally balanced pairwise fashion. If the brain is assigned a net charge for a given state of mind, there may be considered to be a balancing of superego, ego, and id level interactions. A temporary altered state of consciousness may result from an over or undercharged experience (from a social perturbation or unconscious wish) that would otherwise be processed during normal habituated experience as part of interdependent behavior during conscious awareness or sleep. Deviations from the normal “equilibration” of such balanced charge states that are not immediately cathected or decathected during personal interactions may result in the deceptive perception of telepathy or a neurosis‐like symptom, perhaps in the form of a remembered dream. However, a genuine telepathy‐like phenomenon may be postulated to exist due to synchronistic effects when considering the unique aspects of synchronous human behavior and possible subconscious information acquisition through inference. Electrochemical charges and energies may be assigned to the thoughts, emotions and actions of the human body and these may often be psychologically and socially coordinated and coherent with others: two people may change state at the same time. A macroscopically relevant coherence may result in approximately simultaneous thoughts and actions, and even a form of knowledge, between separated people.

Human rights bodies formulate highly specific orders to minimize the risk of State non-compliance. However, specificity comes at a cost, reducing State autonomy when local agents implement measures on the ground. This article develops the concept of specificity in human rights reparations and analyses the specificity formulas deployed by the Inter-American Court of Human Rights in structural measures as a form of positive subsidiarity. We employ qualitative data analysis software to process 322 measures of non-repetition ordered by the Inter-American Court through to the end of 2020. This analysis identifies two modes of specificity: process-based, which defines procedures for compliance, and outcome-based, which sets the goals for the State. After coding over 800 segments of text from Court decisions, we outline an exhaustive legal framework with 26 process-based categories and 2 outcome-based forms of specificity. We conclude that outcome-based specificity can help courts balance positive subsidiarity and State autonomy in the design of reparations.

BackgroundOsteosarcoma is a primary malignant tumor that seriously affects the health and life of patients. It is of great clinical significance to explore the molecular mechanism of osteosarcoma development and develop the corresponding therapeutic targets. Th1/Th2 cytokines in the normal human body are in a state of dynamic balance. When this balance is destroyed, it is related to many diseases such as a tumor, autoimmune disease, microbial infection, transplant rejection, among many others.MethodThe model of mouse tumor-associated macrophage (TAM) was induced by being co-cultured with inducer granulocyte-macrophage colony stimulating factor (GM-CSF) and osteosarcoma S180 cells. The Notch1 knockout mice were obtained by gene targeting technology. The distribution of M1- and M2-type TAMs in the tumor was visualized by immunofluorescence staining. And the western-blot testing was used to detect and quantified the protein level of Notch1 and Th1/Th2-type cytokines.ResultsIn this study, the polarization of TAMs to the M2 phenotype occurred after coculture with osteosarcoma S180 cells and secretion level Th1/Th2-type cytokines changed. Also, the expression level of Notch1 reduced significantly. Further, the critical transcription factor Notch1 of the Notch signaling pathway was knocked out in mice. The tumor volume of Notch1 knockout mice was significantly more extensive than of the control mice. The results of microstructural observation on tumor showed that M2-type TAMs infiltrated into tumor increased with increased expression of Th2-type cytokines, but M1-type TAMs reduced with reduced expression of Th1-type cytokines.ConclusionsAccording to our results, the Notch signal transduction pathway participates in tumor occurrence and growth with a negative role by maintaining Th1/Th2 balance.

This program is to improve the traditional germ cell culture technology, and expected to develop and validate the innovative germ cell microfluidic culture technology. The main concept is to use the in vitro microfluidic chip to mimic the fluid growth environment in the living body, and to shape the growth environment of the zygote cells into a bionic concept in the uterus. The main objective is to design to the most suitable growth conditions, the importance of which is to increase the chance of zygote cell culture to maturity and greatly improve the maturity of zygotic cells. Assist Reproductive technology is a related technology for in vitro washing, culturing and storage of human germ cells. The main method is to use an artificial culture medium that mimics the human body fluid of the human reproductive system to perform in vitro washing, culture, and storage of reproductive gametophytic cells. The project will be divided into three parts: 1. Bionic microfluidic chip design and production; 2. Biocompatibility and materialization analysis; 3. Germ cell chip efficacy verification. Therefore, this project will develop a continuous microfluidic chip, using a continuous microfluidic channel to simulate the growth of human germ cells in the fertility tube to the zygotic germ cell growth environment, and hope to improve the artificial reproductive technology success rate and pregnancy rate. Reduce the cost of repeated artificial reproduction, and eventually, develop into medical-grade products and promote local technology to the international market.

Considerable attention has been devoted to God's body in the Hebrew Bible, but its widely differing representations have not been addressed. This article sketches out a typology of three types of divine bodies, based on different scales, locations, and settings in life: a natural "human" body; a superhuman-sized "liturgical" body; and a "cosmic" or "mystical" body.