Impact of Quality Control on Production System Performance

In the paper the idea of the system of production flow and quality control and its data model is presented. There are distinguished the functional moduls of preparing technological processes’ variants, of production scheduling, and of quality control. The solution is dedicated to the enterprises characterized by a make-to-order production approach, which have to react flexibly to changing production conditions and the backlog of orders.

Using data from a large cross-section of British establishments, we ask how different firm characteristics are associated with the predicted benefits to organizational performance from using team production. To compute the predicted benefits from using team production, we estimate structural models for financial performance, labor productivity, and product quality, treating the firm’s choices of whether or not to use teams and whether or not to grant teams autonomy as endogenous. One of the main results is that many firm characteristics are associated with larger predicted benefits from teams to labor productivity and product quality but smaller predicted benefits to financial performance. For example, this is true for union recognition as measured by the number of recognized unions in an establishment. Similarly, when a particular firm characteristic is associated with lower benefits from teams to labor productivity or product quality, the same characteristic is frequently associated with higher predicted benefits to financial performance. This is true for the degree of financial participation and employee ownership and also for establishment size and a number of industries. These results highlight the advantages of analyzing broader measures of organizational performance that are more inclusive of the wide spectrum of benefits and costs associated with teams than the labor productivity measures frequently studied in the teams literature. JEL Categories:

Enhancing the efficiency and stability of industrial dough production is achievable through the implementation of innovative technologies that optimise quality and reduce costs. The objective of this study was to evaluate the efficiency of the OptiMix-360 system for industrial dough production by integrating technologies such as gravimetric dosing, premixers, and dough mixers and to determine its impact on improving productivity and final product quality. The research methodology was based on an experimental approach that assessed the efficiency of the OptiMix-360 system compared to traditional methods by measuring product quality parameters and process performance under different operating conditions. The study analysed the effectiveness of the GraviFlow Master, TORNADO-2, and ProMix D-Helix equipment based on performance indicators, energy consumption, dosing accuracy, and final product quality when these technologies were integrated into the production process. The implementation of the OptiMix-360 system resulted in a significant productivity increase to 1500 kg/h, a 30% reduction in energy consumption, and consistent dough batch quality. The gravimetric dosing system ensured an accuracy of <0.1%, enhancing composition stability, while the TORNADO-2 premixer improved flour hydration and gluten formation, positively affecting the texture and strength of the final product. The production process was stabilised, and product quality fluctuations were minimised due to automation and adaptive settings. The obtained results confirmed the effectiveness of the OptiMix-360 system in industrial practice. This technology not only improved dough quality but also reduced energy consumption costs and increased productivity. The application of the OptiMix-360 system in the food industry holds high potential for improving production efficiency, reducing energy costs, and ensuring consistent product quality

PurposeThis study aims to develop analytical models that consider product quality and production volume as essential drivers for profitability in the marketplace. It also considers product demand and price dynamics to understand related nuances backed by empirical validation.Design/methodology/approachThe pricing mechanism is influenced by production quality, while product demand is influenced by both price and quality. The study considers cost elements, including production cost and quality loss cost which in turn are influenced by production volume and product quality. It establishes analytical conditions for optimal product quality and applies them to numerical analyses considering four distinct industry settings.FindingsThe study reveals that unique solutions exist for optimal product quality at each production level in four industry scenarios. The optimal production volume depends on product quality, and empirical research validates these findings from analytical models and numerical analysis.Originality/valueThis study represents a pioneering effort to investigate operational strategies in both analytical and empirical contexts, thus contributing to the existing body of knowledge in this area.

There have been presented the study results on the effect of pre-sowing seed ozonation of narrowleaf lupin (Lupinus angustifolius) and common oat on their germination energy, germination capacity, productivity and product quality. The study was carried out in the period from 2018 to 2020 in laboratory and field conditions of the Kostroma RIA, the branch of the FSBSI “Russian Potato Research Center named after A.G. Lorkh”. The purpose of the current study was to find out the efficiency of pre-sowing seed treatment with an ozone-air flow and treatment with a biological product for their germination energy, germination capacity, productivity and product quality. The objects of the study were the common oats variety ‘Yakov’ and the narrowleaf lupin variety ‘Belozerny 110’. The seeds of the lupin-oat mixture were ozonized at a dose of 5.0 mg/m3 for 15 minutes and 30 minutes using an RIOS-10(20)-0.5 ozonizer. For comparison, the seeds were treated with the biological product ‘Fitosporin-M’. Ultimately, there were identified the best parameters of the pre-sowing seed treatment of the lupin-oat mixture. On average, over the years of study, pre-sowing seed ozonation greatly improves the germination energy of agricultural crops on 4.8–8.3%, laboratory germination was improved on 3.0–5.0%. The largest green mass productivity of lupin-oat mixture during pre-sowing seed treatment for three years was 26.1 t/ha in the variant with an ozone dose of 5.0 mg/m3 for 15 minutes, which was more than control on 29.2%. In the variant with ozonation time increase to 30 minutes, the average productivity was 23.2 t/ha, which was 14.8% more than in the control. Pre-sowing seed ozonation contributed to dry matter increase on 14.2–19.0%; crude protein yield increased on 32.8–53.2%; crude protein percentage in grain increased on 14.1–16.8%; metabolizable energy increased on 3.7–5,1%; fodder units increased on 4.3–6.5% compared to control. When treating seeds with a biological product ‘Fitosporin-M’, the average productivity was 22.8 t/ha, which was on 12.9% more than control, an increase in dry matter was on 16.6%, an increase in crude protein yield was on 19.6%, an increase in crude protein percentage in grain was on 0.8%, an increase in metabolizable energy was on 1.9%, an increase in fodder units was on 1.0%.

In an attempt to develop a high producing mammalian cell line expressing CNTO736, a Glucagon like peptide-1-antibody fusion protein (also known as a Glucagon like peptide-1 MIMETIBODY), we have noted that the N-terminal GLP-1 portion of the MIMETIBODY was susceptible to proteolytic degradation during cell culture, which resulted in an inactive product. Therefore, a number of parameters that had an effect on productivity as well as product quality were examined. Results suggest that the choice of the host cell line had a significant effect on the overall product quality. Product expressed in mouse myeloma host cell lines had a lesser degree of proteolytic degradation and variability in O-linked glycosylation as compared to that expressed in CHO host cell lines. The choice of a specific CHOK1SV derived clone also had an effect on the product quality. In general, molecules that exhibited minimal N-terminal clipping had increased level of O-linked glycosylation in the linker region, giving credence to the hypothesis that O-linked glycosylation acts to protect against proteolytic degradation. Moreover, products with reduced potential for N-terminal clipping had longer in vivo serum half-life. These findings suggest that early monitoring of product quality should be an essential part of production cell line development and therefore, has been incorporated in our process of cell line development for this class of molecules.

Quality transitivity and traceability system of herbal medicine products based on quality markers

This research aimed to determine the change of cutting knives decision depending on knife wear phenomena, anditseffect on hammer mill productivity and product quality. It can be done by tracing the knives wear stages and determine its safe time range to replace the knives. The experiments were done in El-Serw village Damietta Governorate from 2014 to 2016, by grinding both of corn ear and dough as popular agricultural productive using the traditional hammer mill. The studied variables also are four concaves hole diameters (2.5, 4.0, 8.0 and 12.0 mm), five operating hours of new knife, 150, 200, 250 and 300 h for corn ear. While, for dough, are used two concaves hole diameters (2.5 and 4.0 mm) and operating hours of new knife, 200, 400, 600 and 800 h. The measurement includes specifications of knives, product quality and hammer mill performance. The research recommended that the hammer mill knives must replacement after 220 operating hours to grind corn ear and 600 operating hours to grind dough which represents the safe limit time to keep product quantity and quality in accepted state.

PERFORMANCE EVALUATION OF PRODUCTION SYSTEMS MONITORED BY STATISTICAL PROCESS CONTROL AND OFF-LINE INSPECTIONS

Media preparation parameters contribute significantly to media quality, cell culture performance, productivity, and product quality. Establishing proper media preparation procedures is critical for ensuring a robust CHO cell culture process. Process analytical technology (PAT) enables unique ways to quantify assessments and improve media quality. Here, cell culture media were prepared under a wide range of temperatures (40-80°C) and pH (7.6-10.0). Media quality profiles were compared using three real-time PATs: Fourier-transform infrared (FTIR) spectroscopy, Raman spectroscopy, and excitation-emission matrix (EEM) spectroscopy. FTIR and Raman spectroscopies identified shifts in media quality under high preparation temperature (80°C) and at differing preparation pH which negatively impacted monoclonal antibody (mAb) production. In fed-batch processes for production of three different mAbs, viable cell density (VCD) and cell viability were mostly unaffected under all media preparation temperatures, while titer and cell specific productivity of mAb decreased when cultured in basal and feed media prepared at 80°C. High feed preparation pH alone was tolerated but cell growth and productivity profiles deviated from the control condition. Further, charge variants (main, acidic, basic species) and glycosylation (G0F, afucosylation, and high mannose) were examined. Statistically significant differences were observed for one or more of these quality attributes with any shifts in media preparation. In this study, we demonstrated strong associations between media preparation conditions and cell growth, productivity, and product quality. The rapid evaluation of media by PAT implementation enabled more comprehensive understanding of different parameters on media quality and consequential effects on CHO cell culture.

High-count cashmere is the inevitable requirement of the high-end yarn cashmere products.To the short of the high-count cashmere yarn production and the difficult of spinning,From raw material selection, technological process, equipment transformation, parameter optimization, temperature and humidity control and other aspects,we analysised the high-ount cashmere yarn production process and quality control system,The development of the woolen 48Nm cashmere yarn has been done,it is of first class.

This article describes the optimization of cultivation factor settings, that is the shaking rate and working volume in 50 mL spin tubes for a Chinese hamster ovary cell line expressing recombinant human alpha-erythropoietin, using a response D-optimal surface method. The main objectives of the research were, firstly, to determine a setting in which the product titer and product quality attributes in spin tubes are equivalent to those in 250 mL shake flasks in a seven day batch and, secondly, to find a setting in which the product titer is maximal. The model for product titer prediction as a function of shaking rate and working volume in the defined design space was successfully applied to the optimization of cultivation conditions in spin tubes for the tested cell line. Subsequently, validation experiments were carried out simultaneously in spin tubes, shake flasks and bench scale bioreactors to compare cell culture performance parameters such as growth, productivity and product quality attributes in the form of isoform profiles and glycan antennarity structures. The results of the experiments showed that similar cell culture performance and product quality could be achieved in spin tubes when compared to shake flasks. Additionally, bioreactor titers could be reproduced in spin tubes at high shaking rates and low working volumes, but with differing product quality. Cultivation at lower shaking rates in spin tubes and shake flasks produced a glycoprotein with a product quality slightly comparable to that from bioreactors, but with titers being only two thirds.

Volumetric productivity and product quality are two key performance indicators for any biopharmaceutical cell culture process. In this work, we showed proof-of-concept for improving both through the use of alternating tangential flow perfusion seed cultures coupled with high-seed fed-batch production cultures. First, we optimized the perfusion N-1 stage, the seed train bioreactor stage immediately prior to the production bioreactor stage, to minimize the consumption of perfusion media for one CHO cell line and then successfully applied the optimized perfusion process to a different CHO cell line. Exponential growth was observed throughout the N-1 duration, reaching >40 × 10(6) vc/mL at the end of the perfusion N-1 stage. The cultures were subsequently split into high-seed (10 × 10(6) vc/mL) fed-batch production cultures. This strategy significantly shortened the culture duration. The high-seed fed-batch production processes for cell lines A and B reached 5 g/L titer in 12 days, while their respective low-seed processes reached the same titer in 17 days. The shortened production culture duration potentially generates a 30% increase in manufacturing capacity while yielding comparable product quality. When perfusion N-1 and high-seed fed-batch production were applied to cell line C, higher levels of the active protein were obtained, compared to the low-seed process. This, combined with correspondingly lower levels of the inactive species, can enhance the overall process yield for the active species. Using three different CHO cell lines, we showed that perfusion seed cultures can optimize capacity utilization and improve process efficiency by increasing volumetric productivity while maintaining or improving product quality.

Sclerotium rolfsii ATCC 15205 was cultivated in continuous culture (48 l reactor volume) for scleroglucan production. The maximum volumetric productivity (QP max) amounted to 7.2 g/ld and was more than twice as high as in comparable batchwise cultivations. In addition, the relation between (a) volumetric productivity (QP [g/ld]) and product yield (YGlucan/Glucose [1]), (b) volumetric productivity and product quality (MW [g/mol]), and (c) product quality and impeller tip speed (Nd [m/s]) was studied in continuous culture. It was found, that an increase in volumetric productivity led to a decline in product yield and product quality. Furthermore, an impeller tip speed of >0.7 m/s decreased the attainable product quality considerably. Based on these results, the impact of the operational setpoint of the process in terms of oxygen supply and reactor scale on the economics of scleroglucan production was discussed. In contrast to batchwise cultivation, scleroglucan production in continuous culture proved to be not feasible under non-aseptic conditions.

The objectives are to review results and experiences from interdisciplinary research projects in Research Centre for the Management of Animal Production and Health (CEPROS) concerning scientific content, organisation, and collaboration. The Centre has been founded as a result of an agreement between four institutions: the Danish Institute of Agricultural Sciences (DIAS), the Danish Veterinary Laboratory (DVL), the Danish Veterinary Institute for Virus Research (DVIV) and The Royal Veterinary and Agricultural University (KVL). CEPROS is a "research centre without walls" and is physically located as an integrated part of the four institutions named above. The Centre has close collaboration with the industry. The superior goals of the Centre are to co-ordinate fundamental and applied research and simultaneously integrate the veterinary and the production oriented livestock research within animal health and welfare, taking into consideration the production economics and reduced use of medication. The assignment of the Centre is to initiate and carry out research, aiming to investigate the influence of breeding and production systems on animal health and welfare as well as on production and product quality. The Centre has since 1997 established 16 interdisciplinary research projects dealing with cattle, pigs, poultry, or mink. The scientific content can be divided into three research clusters: A. Management of animal production and health in production systems, B: Pathogenesis of production diseases, and C. Animal health economics. In Cluster A, the physical environments of production systems have been investigated, broader definitions of the concept health have been established and used in identification of risk factors. Cluster B has investigated physiological, immunological and genetic mechanisms behind development of production diseases and how to apply this knowledge in disease prevention. The cluster in animal health economics has developed decision support tools for disease control in swine and cattle herds. The interdisciplinary research groups organised in a centre without walls are found very useful for dealing with complex issues. The initial phases in the projects may be long as it takes time for different researchers to define common goals and identify methods. The individual researcher must get some insight in other disciplines without loosing his/her own area of expertise. In order to reach a synthesis of the different parts of a project, it is important that the project is well organised and there is participation of researchers with both specialised insight and researchers with a more broad insight in the problems. It is also important that the integration process is balanced, and not too many research disciplines are included in the same project.