It's Not You, "It's Me": Sexual Experiences and Sexual Satisfaction in an ADHD Sample.

Risky driving behavior among individuals with Autism, ADHD, and typically developing persons

Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental condition, commonly associated with differences in attention, and/or hyperactivity and impulsiveness. A lesser known, but highly impactful characteristic of ADHD is emotional dysregulation, which causes difficulties in emotional expression and identification. An aspect of emotional dysregulation which remains relatively unexplored in ADHD, is rejection sensitivity. In people who experience rejection sensitivity, perceived rejection and/or criticism can evoke extreme dysphoria. To investigate the lived experience of rejection sensitivity in ADHD individuals, five undergraduate students participated in focus-group interviews. The subsequent thematic analysis revealed three key themes which encapsulated their experiences; withdrawal, masking, and bodily sensations. The participants explained how rejection sensitivity elicited unpleasant bodily sensations, anxiety, and misery, and how, in turn, they used masking to camouflage these feelings. They then discussed how the use of masking had caused them to become dissociated from themselves and to withdraw from others, which often resulted in loneliness. It was apparent that rejection sensitivity significantly impacts mental wellbeing, eliciting feelings such as anxiousness, despair, and embarrassment. In turn, social function is significantly impaired, alongside career opportunities, and daily life. Our findings indicate a need for deeper understanding of ADHD traits and emotional dysregulation, which may in turn lessen the presence of rejection sensitivity in ADHD individuals.

Individuals who have Attention Deficit/Hyperactivity Disorder (ADHD) experience adverse effects relating to driving; additionally, they experience deficits in scanning ability. The present study examined the effects of ADHD on eye tracking while driving. This study consisted of ten participants, of which, five have ADHD. It was hypothesized that individuals who have ADHD will make more saccadic eye movements and thus shorter fixations than individuals without ADHD (Control). Furthermore, it was hypothesized that despite the fact that individuals who have ADHD will make more saccadic eye movements than individuals without ADHD, those individuals with ADHD will commit more traffic violations including collisions compared to the control group. Findings indicated that hypothesis one was not supported by the data, whereas hypothesis two was supported in that ADHD individuals' had more collisions and committed more traffic violations than the control group. Additionally, a significant difference was found in the spatial distributions of the fixations between the ADHD and Control groups. The findings of this study could help better understand the factors involved in ADHD driving and could be used to train individuals with ADHD to become more aware of their surroundings and driving habits and thus become safer drivers.

P.3.023 - Efficacy of an omega-3/6 combination on specific learning abilities in children with mild to moderate inattentive ADHD - preliminary results

Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are two highly heritable neurodevelopmental disorders. Several lines of evidence point towards the presence of shared genetic factors underlying ASD and ADHD. We conducted genomic analyses of common risk variants (i.e. single nucleotide polymorphisms, SNPs) shared by ASD and ADHD, and those specific to each disorder. With the summary data from two GWAS, one on ASD (N=46,350) and another on ADHD (N=55,374) individuals, we used genomic structural equationmodelling and colocalization analysis to identify SNPs shared by ASD and ADHD and SNPs specific to each disorder. Functional genomic analyses were then conducted on shared and specific common genetic variants. Finally, we performed a bidirectional Mendelian randomization analysis to test whether the shared genetic risk between ASD and ADHD was interpretable in terms of reciprocal relationships between ASD and ADHD. We found that 37.5% of the SNPs associated with ASD (at p<1e-6) colocalized with ADHD SNPs and that 19.6% of the SNPs associated with ADHD colocalized with ASD SNPs. We identified genes mapped to SNPs that are specific to ASD or ADHD and that are shared by ASD and ADHD, including two novel genes INSM1 and PAX1. Our bidirectional Mendelian randomization analyses indicated that the risk of ASD was associated with an increased risk of ADHD and vice versa. Using multivariate genomic analyses, the present study uncovers shared and specific genetic variants associated with ASD and ADHD. Further functional investigation of genes mapped to those shared variants may help identify pathophysiological pathways and new targets for treatment.

Investigation of phase synchronization in functional brain networks of children with ADHD using nonlinear recurrence measure

Background The Self-Report Wender-Reimherr Adult Attention Deficit Disorder Scale (SR-WRAADDS) assesses the same 7 attention-deficit/ hyperactivity disorder (ADHD) domains as the interviewer-administered WRAADDS. Methods A normative sample was recruited, and additional participants came from trials involving ADHD, anxiety, or depression. Using the investigator-administered WRAADDS, participants in the ADHD sample were classified as ADHD inattentive presentation or ADHD emotional dys-regulation presentation. Results In the ADHD sample, the SR-WRAADDS correlated with the investigator-rated version WRAADDS ( P &lt; .001). In comparing adults with ADHD with normal controls, all SR-WRAADDS domains demonstrated discriminate validity ( P &lt; .001); a cut point was identified yielding sensitivity of 97% and specificity of 89%. In comparison, in screening for ADHD in depression or anxiety disorders, sensitivity was 87% and specificity, 49%. Internal consistency was satisfactory (Cronbach α = 0.78; split-half reliability r = 0.92). Factor analysis yielded a 2-factor solution: one reflected emotional dysregulation; the other, inattention and disorganization. Detecting ADHD emotional dysregulation presentation within the ADHD sample, as the “disorder-of-interest,” SR-WRAADDS and the investigator-rated WRAADDS agreement was 72% (sensitivity, 87%; specificity, 49%). The SR-WRAADDS detected a methylphenidate vs placebo treatment effect ( P &lt; .001). Conclusions The psychometric properties of the SR-WRAADDS support its use in research and clinical practice. Emotional domains are integral to its assessment of adult ADHD.

Considerable research documents that even young children possess stigma about mental illness, which may affect how they evaluate peers with mental health conditions. This study examined children’s pre-existing perceptions of Attention Deficit/Hyperactivity Disorder (ADHD) behaviors as predictors of their subsequent sociometric judgments of classmates with ADHD in a 2-week summer day camp. Participants were previously unacquainted children ages 6.8–9.8 years (113 typically-developing and 24 with ADHD; 48.2% boys; 81% White). Children initially more inclined to interact with a hypothetical classmate with ADHD gave fewer “dislike” nominations to real-life classmates with ADHD at camp. Children who initially believed that ADHD symptoms were uncontrollable gave more “dislike” nominations and lower liking ratings to classmates with ADHD when those classmates displayed severe ADHD symptoms. For children who had ADHD, their attribution of uncontrollability for ADHD symptoms predicted fewer “like” nominations and more “dislike” nominations given to classmates with ADHD. Lastly, children who initially reported they would help a hypothetical classmate with ADHD gave higher liking ratings to classmates with ADHD. These results were found after statistical control of the actual level of ADHD behaviors displayed by the classmates with ADHD. In summary, other children’s pre-existing or stigmatizing perceptions of ADHD behaviors may contribute, in part, to the substantial peer rejection typically experienced by ADHD populations. Findings have implications for understanding peer problems in children with this common mental health condition.

Semantic conflicts are resolved differently by adults with and without ADHD

Introduction Being involved in a romantic relationship has consistently been associated with better general well-being and life satisfaction, relational and sexual satisfaction, and sexual function. Research indicates that these relationships also buffer women against negative mental and sexual health outcomes after traumatic experiences. Regardless of quality, the presence of a romantic relationship is associated with better general and sexual outcomes for women. Though it has been well established that romantic relationships are positively associated with better sexual and general well-being for heterosexual individuals, the influence of relationship status on other important indicators of sexual well-being has received significantly less attention. Research has not assessed sexual well-being by self-schemas and sexual excitation and inhibition propensities. Given the associations of sexual schemas and sexual excitation and inhibition with sexual function and satisfaction, these two constructs are important to consider when evaluating sexual well-being for women. Additionally, it is imperative to consider nonconsensual sexual experiences (NSEs) when evaluating women’s sexual well-being as 20% of women in the U.S. experience an NSE in their lifetime. NSEs are known to negatively impact sexual excitation and inhibition, self-schemas, and sexual and general well-being. Objective The current study expands upon existing research on sexual well-being by including measures of excitation and inhibition and sexual schemas as well as considering participants’ NSE history. Filling these gaps in the extant literature could prove important for understanding the combined effects of relationship status and NSE history on women’s sexual well-being. Methods The data for the current study was taken from a larger assessment of female sexuality in February and July of 2016. Data from 1152 women was analyzed in the current study. The women completed assessments of previous consensual and nonconsensual sexual experiences using the Nonconsensual Sexual Experiences Inventory, sexual excitation and inhibition using the Sexual Excitation and Sexual Inhibition Inventory for Women, sexual self-schemas using the Sexual Self-Schema Scale and relationship status. Results The results from an ANOVA and subsequent independent t-test pairwise comparisons indicate significant differences in sexual schemas and excitation and inhibition propensities across various relationship statuses (p values &amp;lt; 0.05). After Bonferroni corrections, there were a few significant findings. Women in married or cohabitating relationships report significantly more conservative/embarrassed sexual self-schemas than single women. Single women with NSE histories also reported significantly lower scores on the “setting” excitation subscale of the SESII-W compared to single women with no NSE histories. Conclusions The results indicate that women conceptualize their sexual schemas and experience facilitators and inhibitors of arousal differently across various relationship statuses. Consistent with previous literature, married and cohabitating women reported more conservative/embarrassed self-schemas. Interestingly, single women with an NSE history reported that sex in novel or public settings was less activating for their sexual arousal than the sexual setting for women with no NSE histories. These findings highlight the importance of considering relationship status and NSE history when examining sexual well-being, sexual self-schemas, and sexual excitation and inhibition. Disclosure No

We evaluated the association between attention deficit hyperactivity disorder (ADHD) and the age of onset of psychoactive substance use disorders (PSUD) in adults with ADHD. We hypothesized that ADHD and psychiatric comorbidity would be risk factors for early onset PSUD. We compared 120 referred adults having a clinical diagnosis of childhood-onset ADHD with 268 non-ADHD adults. All diagnoses were obtained using DSM-III-R based structured psychiatric interviews. We used group comparisons of age at onset and Cox proportional hazard models to examine the development of PSUD over time. ADHD was associated with earlier onset of PSUD independently of psychiatric comorbidity. Conduct and juvenile bipolar disorders conferred a significantly increased risk for early onset PSUD independently of ADHD. Psychiatric disorders commonly emerged before the onset of PSUD in both groups. Persistent ADHD with and without psychiatric comorbidity was associated with adolescent onset PSUD. In addition, comorbidity with conduct and juvenile bipolar disorders predicted very early onset PSUD in both ADHD and non-ADHD individuals. These findings confirm and extend previous findings documenting important associations between PSUD and psychiatric comorbidity including persistent ADHD.

Studies report the variable prevalence of attention deficit hyperactivity disorder (ADHD) in incarcerated populations. The aim of this meta-analysis was to determine the prevalence of ADHD in these populations. Primary research studies reporting the prevalence (lifetime/current) of ADHD in incarcerated populations were identified. The meta-analysis used a mixed log-binomial model, including fixed effects for each covariate and a random study effect, to estimate the significance of various risk factors. Forty-two studies were included in the analysis. ADHD prevalence was higher with screening diagnoses versus diagnostic interview (and with retrospective youth diagnoses versus current diagnoses). Using diagnostic interview data, the estimated prevalence was 25.5% and there were no significant differences for gender and age. Significant country differences were noted. Compared with published general population prevalence, there is a fivefold increase in prevalence of ADHD in youth prison populations (30.1%) and a 10-fold increase in adult prison populations (26.2%).

Although there has been extensive research in the area of Attention-deficit Hyperactivity Disorder (ADHD), the estimated prevalence of this disorder ranges from 1% to 20%. This variability is due in part to variations in how one defines ADHD and the difficulty of precisely measuring the features of the syndrome. Additionally, problems of differential diagnosis and comorbidity of ADHD with other disorders may impact resultant prevalence rates. The present study was conducted in order to examine the impact of various qualitative and quantitative differences in the diagnostic process on the prevalence of ADHD in samples of children in special education and children referred to a tertiary-care specialty clinic for learning disabilities (LD) and ADHD. Of particular interest was the prevalence of ADHD with no other psychopathology (“pure” ADHD) in the two samples. Children with pure ADHD made up only 15.8% of the special education sample (teacher rating only). In contrast, the prevalence of pure ADHD in the specialty clinic sample ranged from 35.6% (teacher rating only) to 11.9% (parent rating only). Only 5.9% were rated by both teacher and parent as pure ADHD. The clinical and methodological implications of these findings are discussed in terms of the criteria for diagnosis of ADHD and implications for future research.

Genetic Risk for Conduct Disorder Symptom Subtypes in an ADHD Sample: Specificity to Aggressive Symptoms

ObjectiveThe synaptosomal-associated protein of 25 kDa (SNAP-25) gene is a presynaptic plasma membrane protein and an integral component of the vesicle docking and fusion machinery mediating secretion of neurotransmitters. Previously, several studies reported association between SNAP-25 and attention deficit hyperactivity disorder (ADHD). We investigated whether these SNAP-25 polymorphisms (MnlI T/G and DdelI T/C) were also associated with ADHD in the Turkish population.MethodsOur study comprised unrelated 139 subjects who met DSM-IV criteria for ADHD and 73 controls and all were of Turkish origin. Genetic analyses were performed and patients were evaluated with Wender-Utah Rating Scale and Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale.ResultsSNAP-25 DdelI polymorphism was not associated with ADHD but there was a statistically significant difference between ADHD patients and controls for SNAP-25 MnlI polymorphism. For SNAP-25 MnlI polymorphism patients with G/G genotype of the SNAP-25 gene MnlI polymorphism had higher Wender-Utah scores and higher scores in the 1st and 3rd parts of adult ADD/ADHD Scale.ConclusionWe detected a significant association of the MnlI polymorphism in our ADHD sample which was similar to previous findings. Our study also revealed that SNAP-25 MnlI polymorphism was also associated with symptom severity of ADHD. This study is also, the first report on the association of SNAP-25 with ADHD in the Turkish population.